Assessment of Olea europaea L. fruit extracts: Phytochemical characterization and anticancer pathway investigation

Biomedicine and Pharmacotherapy

Volumn 90, Issue , 2017, Pages 179-186

  Maalej, Amina ^a   Bouallagui, Zouhaier ^a   Hadrich, Fatma ^a   Isoda, Hiroko ^b   Sayadi, Sami ^a  

^a CENTRE DE BIOTECHNOLOGIE DE SFAX   (Tunisia)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Anticancer effect; Antioxidant effect; Caco 2 cells; HepG2 cells; Olive fruit extracts; Polyphenols

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ANTINEOPLASTIC AGENT; ANTIOXIDANT; APIGENIN; GLUCOSIDE; HYDROXYTYROSOL; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE; OLEA EUROPAEA EXTRACT; OLEUROPEIN; PLANT EXTRACT; POLYPHENOL; PROTEIN KINASE B; PROTEIN P53; QUERCETIN; RUTOSIDE; TYROSOL; UNCLASSIFIED DRUG; PHYTOCHEMICAL;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL LINE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; CULTIVAR; DNA FRAGMENTATION; DPPH RADICAL SCAVENGING ASSAY; FLOW CYTOMETRY; FRUIT; HUMAN; HUMAN CELL; IC50; OLIVE TREE; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; CACO-2 CELL LINE; CELL CYCLE S PHASE; CHEMISTRY; DRUG EFFECTS; HEP-G2 CELL LINE; METABOLISM;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CACO-2 CELLS; CELL PROLIFERATION; FRUIT; HEP G2 CELLS; HUMANS; OLEA; PHYTOCHEMICALS; PLANT EXTRACTS; POLYPHENOLS; S PHASE;

EID: 85016166446     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.03.034     Document Type: Article

References (45)

1. [1] Green, P.S., A revision of Olea L. (Oleaceae). Kew Bull 57 (2002), 91–140.
2. [2] Sakouhi, F., Harrabi, S., Absalon, C., Sbei, K., Boukhchina, S., Kallel, H., α-Tocopherol and fatty acids contents of some Tunisian table olives (Olea europea L.): changes in their composition during ripening and processing. Food Chem. 108 (2008), 833–839.
3. [3] Owen, H., Haubner, R.W., Würtele, R., Hull, G., Spiegelhalder, E., Bartsch, B., Olives and olive oil in cancer prevention. Eur. J. Cancer Prev. 13 (2004), 319–326.
4. [4] Zern, T.L., Fernandez, M.L., Cardioprotective effects of dietary polyphenols. J. Nutr. 135 (2005), 2291–2294.
5. [5] Juan, M.E., Wenzel, U., Ruiz-Gutierrez, V., Daniel, H., Planas, J.M., Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells. J. Nutr. 136 (2006), 2553–2557.
6. [6] Knasmüller, S., Parzefall, W., Sanyal, R., Ecker, S., Schwab, C., Uhl, M., Mersch-Sundermann, V., Williamson, G., Hietsch, G., Langer, T., Darroudi, F., Natarajan, A.T., Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens. Mutat. Res. 402 (1998), 185–202.
7. [7] Tumwine, L.K., Kagimu, M., Ocama, P., Segamwenge, I., Masiira-Mukasa, N., Wamala, D., Dworak, O., Opio, C.K., Atypical presentation of colon adenocarcinoma: a case report. J. Med. Case Rep., 6, 2012, 58.
8. [8] Borrás-Linares, I., Pérez-Sánchez, A., Lozano-Sánchez, J., Catalán, E.B., Arráez-Román, D., Cifuentes, A., Micol, V., Carretero, A.S., A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells. Food Chem. Toxicol. 80 (2015), 215–222.
9. [9] Seçme, M., Eroğlu, C., Dodurga, Y., Bağcı, G., Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells. Gene 585 (2016), 93–99.
10. [10] Sarkar, F.H., Li, Y., Cell signaling pathways altered by natural chemopreventive agents. Mutat. Res. 555 (2004), 53–64.
11. [11] Hill, M.M., Hemmings, B.A., Inhibition of protein kinase B/Akt: implications for cancer therapy. Pharmacol. Ther. 93 (2002), 243–251.
12. [12] Vivanco, I., Sawyers, C.L., The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2 (2002), 489–501.
13. [13] el-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W., Vogelstein, B., WAF1, a potential mediator of p53 tumor suppression. Cell 75 (1993), 817–825.
14. [14] el-Deiry, W.S., Regulation of p53 downstream genes. Semin. Cancer Biol. 8 (1998), 345–357.
15. [15] Slinkard, K., Singleton, V.L., Total phenol analysis: automation and comparison with manual methods. Am. J. Enol. Vitic. 28 (1977), 49–55.
16. [16] Meda, A., Lamien, C.E., Romito, M., Millogo, J., Nacoulma, O.G., Determination of the total phenolic flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem. 91 (2005), 571–577.
17. [17] Souilem, S., Kobayashi, I., Neves, M.A., Jlaiel, L., Isoda, H., Sayadi, S., Nakajima, M., Interfacial characteristics and microchannel emulsification of oleuropein-containing triglyceride oil–water systems. Food Res. Int. 62 (2014), 467–475.
18. [18] Bouallagui, Z., Han, J., Isoda, H., Sayadi, S., Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells. Food Chem. Toxicol. 49 (2011), 179–184.
19. [19] Chang, F., Lee, J.T., Navolanic, P.M., Steelman, L.S., Shelton, J.G., Blalock, W.L., Franklin, R.A., McCubrey, J.A., Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17 (2003), 590–603.
20. [20] Bouaziz, M., Lassoued, S., Bouallagui, Z., Smaoui, S., Gargoubi, A., Dhouib, A., Sayadi, S., Synthesis and recovery of high bioactive phenolics from table-olive brine process wastewater. Bioorg. Med. Chem. 16 (2008), 9238–9246.
21. [21] Li, P., Dietz, R., von Harsdorf, R., Reactive oxygen species induce apoptosis of vascular smooth muscle cell. FEBS Lett. 404 (1997), 249–252.
22. [22] Kang, K.A., Wang, Z.H., Zhang, R., Piao, M.J., Kim, K.C., Kang, S.S., Kim, Y.W., Lee, J., Park, D., Hyun, J.W., Myricetin protects cells against oxidative stress-induced apoptosis via regulation of PI3K/Akt and MAPK signaling pathways. Int. J. Mol. Sci. 11 (2010), 4348–4360.
23. [23] Fico, A., Paglialunga, F., Cigliano, L., Abrescia, P., Verde, P., Martini, G., Iaccarino, I., Filosa, S., Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis. Cell Death Differ. 11 (2004), 823–831.
24. [24] Ogaly, H.A., Khalaf, A.A., Ibrahim, M.A., Galal, M.K., Abd-Elsalam, R.M., Influence of green tea extract on oxidative damage and apoptosis induced by deltamethrin in rat brain. Neurotoxicol. Teratol. 50 (2015), 23–31.
25. [25] Sousa, A., Malheiro, R., Casal, S., Bento, A., Pereira, J.A., Optimal harvesting period for cvs. Madural and Verdeal Transmontana, based on antioxidant potential and phenolic composition of olives. LWT – Food Sci. Technol. 62 (2015), 1120–1126.
26. [26] de la Puerta, R., Martínez Domínguez, M.E., Ruíz-Gutíerrez, V., Flavill, J.A., Hoult, J.R., Effects of virgin olive oil phenolics on scavenging of reactive nitrogen species and upon nitrergic neurotransmission. Life Sci. 69 (2001), 1213–1222.
27. [27] Visioli, F., Bellomo, G., Galli, C., Free radical-scavenging properties of olive oil polyphenols. Biochem. Biophys. Res. Commun. 247 (1998), 60–64.
28. [28] Slamenová, D., Horváthová, E., Wsólová, L., Sramková, M., Navarová, J., Investigation of anti-oxidative, cytotoxic DNA-damaging and DNA-protective effects of plant volatiles eugenol and borneol in human-derived HepG2, Caco-2 and VH10 cell lines. Mutat. Res. 677 (2009), 46–52.
29. [29] Yi, W., Akoh, C.C., Fischer, J., Krewer, G., Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis. Food Res. Int. 39 (2006), 628–638.
30. [30] Salla, S., Sunkara, R., Ogutu, S., Walker, L.T., Verghese, M., Antioxidant activity of papaya seed extracts against H2O2 induced oxidative stress in HepG2 cells. LWT – Food Sci. Technol. 66 (2016), 293–297.
31. [31] Allouche, Y., Warleta, F., Campos, M., Sánchez-Quesada, C., Uceda, M., Beltrán, G., Gaforio, J.J., Antioxidant antiproliferative, and pro-apoptotic capacities of pentacyclic triterpenes found in the skin of olives on MCF-7 human breast cancer cells and their effects on DNA damage. J. Agric. Food Chem. 59 (2011), 121–130.
32. [32] Chavez-Santoscoy, R.A., Gutierrez-Uribe, J.A., Serna-Saldívar, S.O., Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices. Plant Foods Hum. Nutr. 64 (2009), 146–152.
33. [33] Loizzo, M.R., Said, A., Tundis, R., Hawas, U.W., Rashed, K., Menichini, F., Frega, N.G., Menichini, F., Antioxidant and antiproliferative activity of Diospyros lotus L. extract and isolated compounds. Plant Foods Hum. Nutr. 64 (2009), 264–270.
34. [34] Conforti, F., Ioele, G., Statti, G.A., Marrelli, M., Ragno, G., Menichini, F., Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants. Food Chem. Toxicol. 46 (2008), 3325–3332.
35. [35] Abe, R., Beckett, J., Nixon, A., Rochier, A., Yamashita, N., Sumpio, B., Olive oil polyphenol oleuropein inhibits smooth muscle cell proliferation. Eur. J. Vasc. Endovasc. Surg. 41 (2011), 814–820.
36. [36] Chen, T., Hao, J., He, J., Zhang, J., Li, Y., Liu, R., Li, L., Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells. Food Chem. 138 (2013), 1034–1041.
37. [37] Forbes-Hernández, T.Y., Giampieri, F., Gasparrini, M., Mazzoni, L., Quiles, J.L., Alvarez-Suarez, J.M., Battino, M., The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms. Food Chem. Toxicol. 68 (2014), 154–182.
38. [38] Ulukaya, E., Acilan, C., Yilmaz, Y., Apoptosis: why and how does it occur in biology?. Cell Biochem. Funct. 29 (2011), 468–480.
39. [39] Isoda, H., Motojima, H., Onaga, S., Samet, I., Villareal, M.O., Han, J., Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells. Chem. Biol. Interact. 220 (2014), 269–277.
40. [40] Lim, D.Y., Cho, H.J., Kim, J., Nho, C.W., Lee, K.W., Park, J.H.Y., Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. BMC Gastroenterol., 12, 2012, 9.
41. [41] McCubrey, J.A., Steelman, L.S., Abrams, S.L., Lee, J.T., Chang, F., Bertrand, F.E., Navolanic, P.M., Terrian, D.M., Franklin, R.A., D'Assoro, A.B., Salisbury, J.L., Mazzarino, M.C., Stivala, F., Libra, M., Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv. Enzyme Regul. 46 (2006), 249–279.
42. [42] Cuevas, B.D., Abell, A.N., Johnson, G.L., Role of mitogen-activated protein kinase kinases in signal integration. Oncogene 26 (2007), 3159–3171.
43. [43] Barbaro, B., Toietta, G., Maggio, R., Arciello, M., Tarocchi, M., Galli, A., Balsano, C., Effects of the olive-derived polyphenol oleuropein on human health. Int. J. Mol. Sci. 15 (2014), 18508–18524.
44. [44] Granado-Serrano, A.B., Angeles Martín, M., Bravo, L., Goya, L., Ramos, S., Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells. Mol. Nutr. Food Res. 52 (2008), 457–464.
45. [45] Xavier, C.P.R., Pereira-Wilson, C., Medicinal plants of the genuses Salvia and Hypericum are sources of anticolon cancer compounds: effects on PI3K/Akt and MAP kinases pathways. Pharm. Nutr. 4 (2015), 112–122.