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Volumn 2, Issue 4, 2016, Pages 244-255

Sodium-glucose cotransporter 2 inhibition: Cardioprotection by treating diabetes-a translational viewpoint explaining its potential salutary effects

Author keywords

Antidiabetic agent; CV event; Diabetes mellitus; Heart failure; Hyperglycaemia; SGLT2 inhibition

Indexed keywords

SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; URIC ACID; ANTIDIABETIC AGENT; CARDIOTONIC AGENT; SLC5A2 PROTEIN, HUMAN;

EID: 85016021198     PISSN: 20556837     EISSN: 20556845     Source Type: Journal    
DOI: 10.1093/ehjcvp/pvw009     Document Type: Review
Times cited : (40)

References (135)
  • 1
    • 65949103197 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7
  • 2
    • 84864283226 scopus 로고    scopus 로고
    • SGLT2 inhibition in diabetes mellitus: Rationale and clinical prospects
    • Ferrannini E, Solini A. SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects. Nat Rev Endocrinol 2012;8:495-502.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 495-502
    • Ferrannini, E.1    Solini, A.2
  • 3
    • 77953821528 scopus 로고    scopus 로고
    • Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-Analysis of 102 prospective studies
    • Collaboration TERF. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-Analysis of 102 prospective studies. Lancet 2010;375:2215-2222.
    • (2010) Lancet , vol.375 , pp. 2215-2222
    • Terf, C.1
  • 4
    • 0032908858 scopus 로고    scopus 로고
    • Hyperglycemia and cardiovascular disease in type 2 diabetes
    • Laakso M. Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 1999;48:937-942.
    • (1999) Diabetes , vol.48 , pp. 937-942
    • Laakso, M.1
  • 5
    • 0034844049 scopus 로고    scopus 로고
    • WHO Multinational Study Group. Mortality and causes of death in the WHO multinational study of vascular disease in diabetes
    • Morrish NJ, Wang S-L, Stevens LK, Fuller JH, Keen H, WHO Multinational Study Group. Mortality and causes of death in the WHO multinational study of vascular disease in diabetes. Diabetologia 2001;44:S14-S21.
    • (2001) Diabetologia , vol.44 , pp. S14-S21
    • Morrish, N.J.1    Wang, S.-L.2    Stevens, L.K.3    Fuller, J.H.4    Keen, H.5
  • 6
    • 0034477674 scopus 로고    scopus 로고
    • Chronic complications in diabetes mellitus
    • Kikkawa R. Chronic complications in diabetes mellitus. Br J Nutr 2000;84(Suppl. S2):S183-S185.
    • (2000) Br J Nutr , vol.84 , pp. S183-S185
    • Kikkawa, R.1
  • 9
    • 0034942447 scopus 로고    scopus 로고
    • Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications
    • Porte D Jr. Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications. Diabetes Metab Res Rev 2001;17:181-188.
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 181-188
    • Porte, D.1
  • 10
    • 0031823401 scopus 로고    scopus 로고
    • Importance of glucose control
    • Edelman SV. Importance of glucose control. Med Clin North Am 1998;82:665-687.
    • (1998) Med Clin North Am , vol.82 , pp. 665-687
    • Edelman, S.V.1
  • 11
    • 79960959816 scopus 로고    scopus 로고
    • Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: Meta-Analysis of randomised controlled trials
    • Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassai B, Erpeldinger S, Wright JM, Gueyffier F, Cornu C. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-Analysis of randomised controlled trials. BMJ 2011;343:d4169.
    • (2011) BMJ , vol.343 , pp. d4169
    • Boussageon, R.1    Bejan-Angoulvant, T.2    Saadatian-Elahi, M.3    Lafont, S.4    Bergeonneau, C.5    Kassai, B.6    Erpeldinger, S.7    Wright, J.M.8    Gueyffier, F.9    Cornu, C.10
  • 12
    • 79651473537 scopus 로고    scopus 로고
    • Renal glucose reabsorption inhibitors to treat diabetes
    • Bailey CJ. Renal glucose reabsorption inhibitors to treat diabetes. Trends Pharmacol Sci 2011;32:63-71.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 63-71
    • Bailey, C.J.1
  • 13
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) UK Prospective Diabetes Study (UKPDs) Group
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDs) Group. Lancet 1998;352:854-865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 14
    • 84887948455 scopus 로고    scopus 로고
    • Variable effects of anti-diabetic drugs in animal models of myocardial ischemia and remodeling: A translational perspective for the cardiologist
    • Yin M, Westenbrink BD, Meissner M, van Gilst WH, de Boer RA. Variable effects of anti-diabetic drugs in animal models of myocardial ischemia and remodeling: A translational perspective for the cardiologist. Int J Cardiol 2013;169:385-393.
    • (2013) Int J Cardiol , vol.169 , pp. 385-393
    • Yin, M.1    Westenbrink, B.D.2    Meissner, M.3    Van Gilst, W.H.4    De Boer, R.A.5
  • 16
    • 34548420712 scopus 로고    scopus 로고
    • Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): A randomised controlled trial
    • Patel A. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): A randomised controlled trial. Lancet 2007;370:829-840.
    • (2007) Lancet , vol.370 , pp. 829-840
    • Patel, A.1
  • 18
    • 84864844848 scopus 로고    scopus 로고
    • Diabetes and hypertension: The bad companions
    • Ferrannini E, Cushman WC. Diabetes and hypertension: The bad companions. Lancet 2012;380:601-610.
    • (2012) Lancet , vol.380 , pp. 601-610
    • Ferrannini, E.1    Cushman, W.C.2
  • 19
    • 84870399547 scopus 로고    scopus 로고
    • A new class of drug for the management of type 2 diabetes: Sodium glucose co-Transporter inhibitors glucuretics
    • Chan HWE, Ashan B, Jayasekera P, Collier A, Ghosh S. A new class of drug for the management of type 2 diabetes: sodium glucose co-Transporter inhibitors: "glucuretics". Diabetes Metab Syndr Clin Res Rev 2012;6:224-228.
    • (2012) Diabetes Metab Syndr Clin Res Rev , vol.6 , pp. 224-228
    • Hwe, C.1    Ashan, B.2    Jayasekera, P.3    Collier, A.4    Ghosh, S.5
  • 21
    • 77954242599 scopus 로고    scopus 로고
    • SGLT2 inhibition-A novel strategy for diabetes treatment
    • Chao EC, Henry RR. SGLT2 inhibition-A novel strategy for diabetes treatment. Nat Rev Drug Discov 2010;9:551-559.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 551-559
    • Chao, E.C.1    Henry, R.R.2
  • 22
    • 84892518091 scopus 로고    scopus 로고
    • SGLT-2 inhibitors: A new mechanism for glycemic control
    • Chao EC. SGLT-2 inhibitors: A new mechanism for glycemic control. Clin Diabetes 2014;32:4-11.
    • (2014) Clin Diabetes , vol.32 , pp. 4-11
    • Chao, E.C.1
  • 25
    • 84941243068 scopus 로고    scopus 로고
    • Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
    • Ferrannini E, DeFronzo RA. Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes. Eur Heart J 2015;36:2288-2296.
    • (2015) Eur Heart J , vol.36 , pp. 2288-2296
    • Ferrannini, E.1    DeFronzo, R.A.2
  • 26
    • 79952209559 scopus 로고    scopus 로고
    • Glucose handling by the kidney
    • Mather A, Pollock C. Glucose handling by the kidney. Kidney Int 2011;79:S1-S6.
    • (2011) Kidney Int , vol.79 , pp. S1-S6
    • Mather, A.1    Pollock, C.2
  • 27
    • 0035146344 scopus 로고    scopus 로고
    • Renal gluconeogenesis its importance in human glucose homeostasis
    • Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis its importance in human glucose homeostasis. Diabetes Care 2001;24:382-391.
    • (2001) Diabetes Care , vol.24 , pp. 382-391
    • Gerich, J.E.1    Meyer, C.2    Woerle, H.J.3    Stumvoll, M.4
  • 28
    • 64749094872 scopus 로고
    • Effect of diabetes and insulin on the maximum capacity of the renal tubules to reabsorb glucose
    • Farber SJ, Berger EY, Earle DP. Effect of diabetes and insulin on the maximum capacity of the renal tubules to reabsorb glucose. J Clin Invest 1951;30:125-129.
    • (1951) J Clin Invest , vol.30 , pp. 125-129
    • Farber, S.J.1    Berger, E.Y.2    Earle, D.P.3
  • 29
    • 0015122757 scopus 로고
    • Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects
    • Mogensen CE. Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects. Scand J Clin Lab Invest 1971;28:101-109.
    • (1971) Scand J Clin Lab Invest , vol.28 , pp. 101-109
    • Mogensen, C.E.1
  • 30
    • 34547449243 scopus 로고    scopus 로고
    • Regulatory mechanisms of Na+/glucose cotransporters in renal proximal tubule cells
    • Lee YJ, Lee YJ, Han HJ. Regulatory mechanisms of Na+/glucose cotransporters in renal proximal tubule cells. Kidney Int 2007;72:S27-S35.
    • (2007) Kidney Int , vol.72 , pp. S27-S35
    • Lee, Y.J.1    Lee, Y.J.2    Han, H.J.3
  • 31
    • 33846023326 scopus 로고    scopus 로고
    • Active sugar transport in health and disease
    • Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. J Intern Med 2007;261:32-43.
    • (2007) J Intern Med , vol.261 , pp. 32-43
    • Wright, E.M.1    Hirayama, B.A.2    Loo, D.F.3
  • 33
    • 0034926379 scopus 로고    scopus 로고
    • Status of glucose transporters in the mammalian kidney and renal development
    • Wallner EI, Wada J, Tramonti G, Lin S, Kanwar YS. Status of glucose transporters in the mammalian kidney and renal development. Ren Fail 2001;23:301-310.
    • (2001) Ren Fail , vol.23 , pp. 301-310
    • Wallner, E.I.1    Wada, J.2    Tramonti, G.3    Lin, S.4    Kanwar, Y.S.5
  • 34
    • 0028044629 scopus 로고
    • The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose
    • Kanai Y, Lee WS, You G, Brown D, Hediger MA. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J Clin Invest 1994;93:397-404.
    • (1994) J Clin Invest , vol.93 , pp. 397-404
    • Kanai, Y.1    Lee, W.S.2    You, G.3    Brown, D.4    Hediger, M.A.5
  • 37
    • 84905238756 scopus 로고    scopus 로고
    • The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension
    • Gembardt F, Bartaun C, Jarzebska N, Mayoux E, Todorov VT, Hohenstein B, Hugo C. The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension. Am J Physiol Renal Physiol 2014;307:F317-F325.
    • (2014) Am J Physiol Renal Physiol , vol.307 , pp. F317-F325
    • Gembardt, F.1    Bartaun, C.2    Jarzebska, N.3    Mayoux, E.4    Todorov, V.T.5    Hohenstein, B.6    Hugo, C.7
  • 38
    • 84865479822 scopus 로고    scopus 로고
    • Why do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?
    • Liu JJ, Lee T, DeFronzo RA. Why do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans? Diabetes 2012;61:2199-2204.
    • (2012) Diabetes , vol.61 , pp. 2199-2204
    • Liu, J.J.1    Lee, T.2    DeFronzo, R.A.3
  • 39
    • 84940839344 scopus 로고    scopus 로고
    • Type 2 diabetes, SGLT2 inhibitors, and glucose secretion
    • Hattersley AT, Thorens B. Type 2 diabetes, SGLT2 inhibitors, and glucose secretion. N Engl J Med 2015;373:974-976.
    • (2015) N Engl J Med , vol.373 , pp. 974-976
    • Hattersley, A.T.1    Thorens, B.2
  • 42
    • 33644688031 scopus 로고    scopus 로고
    • Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
    • Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes 2005;54:3427-3434.
    • (2005) Diabetes , vol.54 , pp. 3427-3434
    • Rahmoune, H.1    Thompson, P.W.2    Ward, J.M.3    Smith, C.D.4    Hong, G.5    Brown, J.6
  • 48
    • 4544284779 scopus 로고    scopus 로고
    • Long-Term outcome of renal glucosuria type 0: The original patient and his natural history
    • Scholl-Bürgi S, Santer R, Ehrich JHH. Long-Term outcome of renal glucosuria type 0: The original patient and his natural history. Nephrol Dial Transplant 2004;19: 2394-2396.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 2394-2396
    • Scholl-Bürgi, S.1    Santer, R.2    Jhh, E.3
  • 49
    • 75749094398 scopus 로고    scopus 로고
    • Familial renal glucosuria and SGLT2: From a mendelian trait to a therapeutic target
    • Santer R, Calado J. Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol 2010;5:133-141.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 133-141
    • Santer, R.1    Calado, J.2
  • 52
    • 84877922239 scopus 로고    scopus 로고
    • Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: Preclinical and clinical data
    • Kurosaki E, Ogasawara H. Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: preclinical and clinical data. Pharmacol Ther 2013;139:51-59.
    • (2013) Pharmacol Ther , vol.139 , pp. 51-59
    • Kurosaki, E.1    Ogasawara, H.2
  • 53
    • 84898434447 scopus 로고    scopus 로고
    • Evaluating SGLT2 inhibitors for type 2 diabetes: Pharmacokinetic and toxicological considerations
    • Scheen AJ. Evaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations. Expert Opin Drug Metab Toxicol 2014;10:647-663.
    • (2014) Expert Opin Drug Metab Toxicol , vol.10 , pp. 647-663
    • Scheen, A.J.1
  • 54
    • 52649083832 scopus 로고    scopus 로고
    • Remogliflozin etabonate, in a novel category of selective low-Affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
    • Fujimori Y, Katsuno K, Nakashima I, Ishikawa-Takemura Y, Fujikura H, Isaji M. Remogliflozin etabonate, in a novel category of selective low-Affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther 2008;327:268-276.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 268-276
    • Fujimori, Y.1    Katsuno, K.2    Nakashima, I.3    Ishikawa-Takemura, Y.4    Fujikura, H.5    Isaji, M.6
  • 55
    • 84884554260 scopus 로고    scopus 로고
    • Tofogliflozin, a novel sodium-glucose co-Transporter 2 inhibitor, improves renal and pancreatic function in db/db mice
    • Nagata T, Fukuzawa T, Takeda M, Fukazawa M, Mori T, Nihei T, Honda K, Suzuki Y, Kawabe Y. Tofogliflozin, a novel sodium-glucose co-Transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol 2013;170: 519-531.
    • (2013) Br J Pharmacol , vol.170 , pp. 519-531
    • Nagata, T.1    Fukuzawa, T.2    Takeda, M.3    Fukazawa, M.4    Mori, T.5    Nihei, T.6    Honda, K.7    Suzuki, Y.8    Kawabe, Y.9
  • 56
    • 84901830673 scopus 로고    scopus 로고
    • Canagliflozin: A review of its use in patients with type 2 diabetes mellitus
    • Plosker GL. Canagliflozin: A review of its use in patients with type 2 diabetes mellitus. Drugs 2014;74:807-824.
    • (2014) Drugs , vol.74 , pp. 807-824
    • Plosker, G.L.1
  • 59
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial. Lancet 2010;375:2223-2233.
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 60
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, phase 3 trial
    • Ferrannini E, Ramos SJ, Salsali A, Tang W, List JF. Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care 2010;33:2217-2224.
    • (2010) Diabetes Care , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.J.2    Salsali, A.3    Tang, W.4    List, J.F.5
  • 61
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck MA, Prato SD, Meier JJ, Durán-García S, Rohwedder K, Elze M, Parikh SJ. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care 2011;34: 2015-2022.
    • (2011) Diabetes Care , vol.34 , pp. 2015-2022
    • Nauck, M.A.1    Prato, S.D.2    Meier, J.J.3    Durán-García, S.4    Rohwedder, K.5    Elze, M.6    Parikh, S.J.7
  • 62
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial
    • Strojek K, Yoon KH, Hruba V, Elze M, Langkilde AM, Parikh S. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab 2011;13:928-938.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 928-938
    • Strojek, K.1    Yoon, K.H.2    Hruba, V.3    Elze, M.4    Langkilde, A.M.5    Parikh, S.6
  • 63
    • 84860218907 scopus 로고    scopus 로고
    • Dapagliflozin, metformin XR, or both: Initial pharmacotherapy for type 2 diabetes, a randomised controlled trial
    • Henry RR, Murray AV, Marmolejo MH, Hennicken D, Ptaszynska A, List JF. Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract 2012;66:446-456.
    • (2012) Int J Clin Pract , vol.66 , pp. 446-456
    • Henry, R.R.1    Murray, A.V.2    Marmolejo, M.H.3    Hennicken, D.4    Ptaszynska, A.5    List, J.F.6
  • 64
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    • Rosenstock J, Aggarwal N, Polidori D, Zhao Y, Arbit D, Usiskin K, Capuano G, Canovatchel W. Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care 2012;35:1232-1238.
    • (2012) Diabetes Care , vol.35 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3    Zhao, Y.4    Arbit, D.5    Usiskin, K.6    Capuano, G.7    Canovatchel, W.8
  • 65
    • 84885954870 scopus 로고    scopus 로고
    • Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: A randomised, double-blind, placebo-controlled, phase 3 trial
    • Roden M, Weng J, Eilbracht J, Delafont B, Kim G, Woerle HJ, Broedl UC. Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: A randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol 2013;1:208-219.
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 208-219
    • Roden, M.1    Weng, J.2    Eilbracht, J.3    Delafont, B.4    Kim, G.5    Woerle, H.J.6    Broedl, U.C.7
  • 66
    • 84885952950 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: A 24-week, randomized, double-blind, placebo-controlled trial
    • Investigators, on behalf of the EMPA-REG MET Trial
    • Häring H-U, Merker L, Seewaldt-Becker E, Weimer M, Meinicke T, Woerle HJ, Investigators, on behalf of the EMPA-REG MET Trial. Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: A 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care 2013;36:3396-3404.
    • (2013) Diabetes Care , vol.36 , pp. 3396-3404
    • Häring, H.-U.1    Merker, L.2    Seewaldt-Becker, E.3    Weimer, M.4    Meinicke, T.5    Woerle, H.J.6
  • 67
    • 84879795546 scopus 로고    scopus 로고
    • A phase iib randomized, placebo-controlled study of the sglt2 inhibitor empagliflozin in patients with type 2 diabetes
    • Ferrannini E, Seman L, Seewaldt-Becker E, Hantel S, Pinnetti S, Woerle HJ. A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes. Diabetes Obes Metab 2013;15:721-728.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 721-728
    • Ferrannini, E.1    Seman, L.2    Seewaldt-Becker, E.3    Hantel, S.4    Pinnetti, S.5    Woerle, H.J.6
  • 68
    • 84901455931 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin in patients with type 2 diabetes: A 24-week, randomized, doubleblind, placebo-controlled trial
    • Investigators, on behalf of the EMPA-REG MET Trial
    • Häring H-U, Merker L, Seewaldt-Becker E, Weimer M, Meinicke T, Broedl UC, Investigators, on behalf of the EMPA-REG MET Trial. Empagliflozin as add-on to metformin in patients with type 2 diabetes: A 24-week, randomized, doubleblind, placebo-controlled trial. Diabetes Care 2014;37:1650-1659.
    • (2014) Diabetes Care , vol.37 , pp. 1650-1659
    • Häring, H.-U.1    Merker, L.2    Seewaldt-Becker, E.3    Weimer, M.4    Meinicke, T.5    Broedl, U.C.6
  • 69
    • 84892477577 scopus 로고    scopus 로고
    • Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: A 24-week, randomized, placebocontrolled trial
    • On behalf of the EMPA-REG PIOTM trial investigators
    • Kovacs CS, Seshiah V, Swallow R, Jones R, Rattunde H, Woerle HJ, Broedl UC, on behalf of the EMPA-REG PIOTM trial investigators. Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: A 24-week, randomized, placebocontrolled trial. Diabetes Obes Metab 2014;16:147-158.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 147-158
    • Kovacs, C.S.1    Seshiah, V.2    Swallow, R.3    Jones, R.4    Rattunde, H.5    Woerle, H.J.6    Broedl, U.C.7
  • 70
    • 84892488179 scopus 로고    scopus 로고
    • Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: Efficacy and safety over 2 years
    • for the Dapagliflozin 006 Study Group
    • Wilding JPH, Woo V, Rohwedder K, Sugg J, Parikh S, for the Dapagliflozin 006 Study Group. Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years. Diabetes Obes Metab 2014;16:124-136.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 124-136
    • Jph, W.1    Woo, V.2    Rohwedder, K.3    Sugg, J.4    Parikh, S.5
  • 71
    • 84898791440 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone
    • Forst T, Guthrie R, Goldenberg R, Yee J, Vijapurkar U, Meininger G, Stein P. Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone. Diabetes Obes Metab 2014;16:467-477.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 467-477
    • Forst, T.1    Guthrie, R.2    Goldenberg, R.3    Yee, J.4    Vijapurkar, U.5    Meininger, G.6    Stein, P.7
  • 73
    • 84919491900 scopus 로고    scopus 로고
    • Canagliflozin in Asian patients with type 2 diabetes on metformin alone or metformin in combination with sulphonylurea
    • Ji L, Han P, Liu Y, Yang G, Dieu Van NK, Vijapurkar U, Qiu R, Meininger G. Canagliflozin in Asian patients with type 2 diabetes on metformin alone or metformin in combination with sulphonylurea. Diabetes Obes Metab 2015;17:23-31.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 23-31
    • Ji, L.1    Han, P.2    Liu, Y.3    Yang, G.4    Dieu Van, N.K.5    Vijapurkar, U.6    Qiu, R.7    Meininger, G.8
  • 75
    • 84892959743 scopus 로고    scopus 로고
    • The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
    • Cherney DZ, Perkins BA, Soleymanlou N, Har R, Fagan N, Johansen O et al. The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus. Cardiovasc Diabetol 2014;13:28.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 28
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3    Har, R.4    Fagan, N.5    Johansen, O.6
  • 76
    • 79952221451 scopus 로고    scopus 로고
    • Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans
    • List JF, Whaley JM. Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans. Kidney Int 2011;79:S20-S27.
    • (2011) Kidney Int , vol.79 , pp. S20-S27
    • List, J.F.1    Whaley, J.M.2
  • 77
    • 69549095914 scopus 로고    scopus 로고
    • A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers applicability of a novel insulin-independent treatment
    • Wilding JPH, Norwood P, Tjoen C, Bastien A, List JF, Fiedorek FT. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers applicability of a novel insulin-independent treatment. Diabetes Care 2009;32:1656-1662.
    • (2009) Diabetes Care , vol.32 , pp. 1656-1662
    • Jph, W.1    Norwood, P.2    Tjoen, C.3    Bastien, A.4    List, J.F.5    Fiedorek, F.T.6
  • 78
    • 84861079280 scopus 로고    scopus 로고
    • Effects of SGLT2 inhibitors on cardiovascular outcomes
    • Foote C, Perkovic V, Neal B. Effects of SGLT2 inhibitors on cardiovascular outcomes. Diab Vasc Dis Res 2012;9:117-123.
    • (2012) Diab Vasc Dis Res , vol.9 , pp. 117-123
    • Foote, C.1    Perkovic, V.2    Neal, B.3
  • 81
    • 77953181310 scopus 로고    scopus 로고
    • Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: Effects on glycaemic control and body weight
    • Zhang L, Feng Y, List J, Kasichayanula S, Pfister M. Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metab 2010;12:510-516.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 510-516
    • Zhang, L.1    Feng, Y.2    List, J.3    Kasichayanula, S.4    Pfister, M.5
  • 83
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapagliflozin, an SGLT2 inhibitor, on HbA1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • Rosenstock J, Vico M, Wei L, Salsali A, List JF. Effects of dapagliflozin, an SGLT2 inhibitor, on HbA1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care 2012;35:1473-1478.
    • (2012) Diabetes Care , vol.35 , pp. 1473-1478
    • Rosenstock, J.1    Vico, M.2    Wei, L.3    Salsali, A.4    List, J.F.5
  • 84
    • 84887191925 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia
    • Rosenstock J, Seman LJ, Jelaska A, Hantel S, Pinnetti S, Hach T, Woerle HJ. Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia. Diabetes Obes Metab 2013;15:1154-1160.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 1154-1160
    • Rosenstock, J.1    Seman, L.J.2    Jelaska, A.3    Hantel, S.4    Pinnetti, S.5    Hach, T.6    Woerle, H.J.7
  • 85
    • 84860252876 scopus 로고    scopus 로고
    • Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    • Devineni D, Morrow L, Hompesch M, Skee D, Vandebosch A, Murphy J, Ways K, Schwartz S. Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin. Diabetes Obes Metab 2012;14:539-545.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 539-545
    • Devineni, D.1    Morrow, L.2    Hompesch, M.3    Skee, D.4    Vandebosch, A.5    Murphy, J.6    Ways, K.7    Schwartz, S.8
  • 86
    • 84876344111 scopus 로고    scopus 로고
    • Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: A dose-finding study
    • Wilding JPH, Ferrannini E, Fonseca VA, Wilpshaar W, Dhanjal P, Houzer A. Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: A dose-finding study. Diabetes Obes Metab 2013;15: 403-409.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 403-409
    • Jph, W.1    Ferrannini, E.2    Fonseca, V.A.3    Wilpshaar, W.4    Dhanjal, P.5    Houzer, A.6
  • 87
    • 84940110139 scopus 로고    scopus 로고
    • Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: A randomized, doubleblind, phase 3 study
    • Leiter LA, Yoon K-H, Arias P, Langslet G, Xie J, Balis DA, Millington D, Vercruysse F, Canovatchel W, Meininger G. Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: A randomized, doubleblind, phase 3 study. Diabetes Care 2015;38:355-364.
    • (2015) Diabetes Care , vol.38 , pp. 355-364
    • Leiter, L.A.1    Yoon, K.-H.2    Arias, P.3    Langslet, G.4    Xie, J.5    Balis, D.A.6    Millington, D.7    Vercruysse, F.8    Canovatchel, W.9    Meininger, G.10
  • 88
    • 84876938443 scopus 로고    scopus 로고
    • The potential of sodium glucose cotransporter 2 (SGLT2) inhibitors to reduce cardiovascular risk in patients with type 2 diabetes (T2DM
    • Basile JN. The potential of sodium glucose cotransporter 2 (SGLT2) inhibitors to reduce cardiovascular risk in patients with type 2 diabetes (T2DM). J Diabetes Complications 2013;27:280-286.
    • (2013) J Diabetes Complications , vol.27 , pp. 280-286
    • Basile, J.N.1
  • 89
    • 84891851923 scopus 로고    scopus 로고
    • Longterm safety and efficacy of empagliflozin, sitagliptin, and metformin an activecontrolled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
    • Ferrannini E, Berk A, Hantel S, Pinnetti S, Hach T, Woerle HJ, Broedl UC. Longterm safety and efficacy of empagliflozin, sitagliptin, and metformin an activecontrolled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes. Diabetes Care 2013;36:4015-4021.
    • (2013) Diabetes Care , vol.36 , pp. 4015-4021
    • Ferrannini, E.1    Berk, A.2    Hantel, S.3    Pinnetti, S.4    Hach, T.5    Woerle, H.J.6    Broedl, U.C.7
  • 90
    • 84858323889 scopus 로고    scopus 로고
    • Longterm efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: A randomized trial
    • Wilding JPH, Woo V, Soler NG, Pahor A, Sugg J, Rohwedder K, Parikh S. Longterm efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: A randomized trial. Ann Intern Med 2012;156:405-415.
    • (2012) Ann Intern Med , vol.156 , pp. 405-415
    • Jph, W.1    Woo, V.2    Soler, N.G.3    Pahor, A.4    Sugg, J.5    Rohwedder, K.6    Parikh, S.7
  • 92
    • 82455213037 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-Transporter 2, in patients with type 2 diabetes mellitus
    • Schwartz SL, Akinlade B, Klasen S, Kowalski D, Zhang W, Wilpshaar W. Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-Transporter 2, in patients with type 2 diabetes mellitus. Diabetes Technol Ther 2011;13:1219-1227.
    • (2011) Diabetes Technol Ther , vol.13 , pp. 1219-1227
    • Schwartz, S.L.1    Akinlade, B.2    Klasen, S.3    Kowalski, D.4    Zhang, W.5    Wilpshaar, W.6
  • 93
    • 84922108911 scopus 로고    scopus 로고
    • Ipragliflozin in combination with metformin for the treatment of Japanese patients with type 2 diabetes: ILLUMINATE, a randomized, double-blind, placebo-controlled study
    • Kashiwagi A, Kazuta K, Goto K, Yoshida S, Ueyama E, Utsuno A. Ipragliflozin in combination with metformin for the treatment of Japanese patients with type 2 diabetes: ILLUMINATE, a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab 2015;17:304-308.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 304-308
    • Kashiwagi, A.1    Kazuta, K.2    Goto, K.3    Yoshida, S.4    Ueyama, E.5    Utsuno, A.6
  • 95
    • 84903528312 scopus 로고    scopus 로고
    • Longterm treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice
    • Terami N, Ogawa D, Tachibana H, Hatanaka T, Wada J, Nakatsuka A et al. Longterm treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. PLoS One 2014;9:e100777.
    • (2014) PLoS One , vol.9 , pp. e100777
    • Terami, N.1    Ogawa, D.2    Tachibana, H.3    Hatanaka, T.4    Wada, J.5    Nakatsuka, A.6
  • 97
    • 84903511385 scopus 로고    scopus 로고
    • Improved glucose control with weight loss, lower insulin doses, and no increased hypoglycemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately controlled type 2 diabetes
    • Rosenstock J, Jelaska A, Frappin G, Salsali A, Kim G, Woerle HJ et al. Improved glucose control with weight loss, lower insulin doses, and no increased hypoglycemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately controlled type 2 diabetes. Diabetes Care 2014;37:1815-1823.
    • (2014) Diabetes Care , vol.37 , pp. 1815-1823
    • Rosenstock, J.1    Jelaska, A.2    Frappin, G.3    Salsali, A.4    Kim, G.5    Woerle, H.J.6
  • 99
    • 0025780331 scopus 로고
    • Hyperinsulinaemia: The key feature of a cardiovascular and metabolic syndrome
    • Ferrannini E, Haffner SM, Mitchell BD, Stern MP. Hyperinsulinaemia: The key feature of a cardiovascular and metabolic syndrome. Diabetologia 1991;34:416-422.
    • (1991) Diabetologia , vol.34 , pp. 416-422
    • Ferrannini, E.1    Haffner, S.M.2    Mitchell, B.D.3    Stern, M.P.4
  • 104
    • 77954189321 scopus 로고    scopus 로고
    • The impact of weight gain on motivation, compliance, and metabolic control in patients with type 2 diabetes mellitus
    • Pi-Sunyer FX. The impact of weight gain on motivation, compliance, and metabolic control in patients with type 2 diabetes mellitus. Postgrad Med 2009;121:94-107.
    • (2009) Postgrad Med , vol.121 , pp. 94-107
    • Pi-Sunyer, F.X.1
  • 105
    • 79955605399 scopus 로고    scopus 로고
    • M, ed. Diabetes-Perspectives in Drug Therapy. Berlin/Heidelberg Springer. (Handbook of Experimental Pharmacology) (5 October) 2015
    • Schwanstecher C, Schwanstecher M. Targeting type 2 diabetes. In Schwanstecher M, ed. Diabetes-Perspectives in Drug Therapy. Berlin/Heidelberg: Springer; 2011. p1-33. (Handbook of Experimental Pharmacology). http://link. springer.com/chapter/10.1007/978-3-642-17214-4-1 (5 October 2015).
    • (2011) Targeting Type 2 Diabetes Schwanstecher , pp. 1-33
    • Schwanstecher, C.1    Schwanstecher, M.2
  • 107
    • 84892479365 scopus 로고    scopus 로고
    • Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
    • Bolinder J, Ljunggren Ö, Johansson L, Wilding J, Langkilde AM, Sjöström CD, Sugg J, Parikh S. Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Diabetes Obes Metab 2014;16: 159-169.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 159-169
    • Bolinder, J.1    Ljunggren, Ö.2    Johansson, L.3    Wilding, J.4    Langkilde, A.M.5    Sjöström, C.D.6    Sugg, J.7    Parikh, S.8
  • 110
    • 70349656069 scopus 로고    scopus 로고
    • Assessment of sympathetic cardiovascular drive in human hypertension achievements and perspectives
    • Grassi G. Assessment of sympathetic cardiovascular drive in human hypertension achievements and perspectives. Hypertension 2009;54:690-697.
    • (2009) Hypertension , vol.54 , pp. 690-697
    • Grassi, G.1
  • 111
    • 33846108745 scopus 로고    scopus 로고
    • Sympathetic overdrive and cardiovascular risk in the metabolic syndrome
    • Grassi G. Sympathetic overdrive and cardiovascular risk in the metabolic syndrome. Hypertens Res 2006;29:839-847.
    • (2006) Hypertens Res , vol.29 , pp. 839-847
    • Grassi, G.1
  • 112
    • 84942294658 scopus 로고    scopus 로고
    • Impact of empagliflozin added on to basal insulin in type 2 diabetes inadequately controlled on basal insulin: A 78-week randomized, double-blind, placebo-controlled trial
    • EMPA-REG BASALTM trial investigators
    • Rosenstock J, Jelaska A, Zeller C, Kim G, Broedl UC, Woerle HJ; EMPA-REG BASALTM trial investigators. Impact of empagliflozin added on to basal insulin in type 2 diabetes inadequately controlled on basal insulin: A 78-week randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab 2015; 17:936-948.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 936-948
    • Rosenstock, J.1    Jelaska, A.2    Zeller, C.3    Kim, G.4    Broedl, U.C.5    Woerle, H.J.6
  • 113
    • 84945455839 scopus 로고    scopus 로고
    • Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
    • Chilton R, Tikkanen I, Cannon CP, Crowe S, Woerle HJ, Broedl UC, Johansen OE. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab 2015; 17:1180-1193.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1180-1193
    • Chilton, R.1    Tikkanen, I.2    Cannon, C.P.3    Crowe, S.4    Woerle, H.J.5    Broedl, U.C.6    Johansen, O.E.7
  • 115
    • 84892588641 scopus 로고    scopus 로고
    • SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice
    • Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, Koepsell H, Thomson SC, Rieg T. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. Am J Physiol Renal Physiol 2014;306:F194-F204.
    • (2014) Am J Physiol Renal Physiol , vol.306 , pp. F194-F204
    • Vallon, V.1    Gerasimova, M.2    Rose, M.A.3    Masuda, T.4    Satriano, J.5    Mayoux, E.6    Koepsell, H.7    Thomson, S.C.8    Rieg, T.9
  • 116
    • 0033529386 scopus 로고    scopus 로고
    • Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study
    • Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study. Ann Intern Med 1999; 131:7-13.
    • (1999) Ann Intern Med , vol.131 , pp. 7-13
    • Culleton, B.F.1    Larson, M.G.2    Kannel, W.B.3    Levy, D.4
  • 117
    • 79956095353 scopus 로고    scopus 로고
    • Evidence linking hypoglycemic events to an increased risk of acute cardiovascular events in patients with type 2 diabetes
    • Johnston SS, Conner C, Aagren M, Smith DM, Bouchard J, Brett J. Evidence linking hypoglycemic events to an increased risk of acute cardiovascular events in patients with type 2 diabetes. Diabetes Care 2011;34:1164-1170.
    • (2011) Diabetes Care , vol.34 , pp. 1164-1170
    • Johnston, S.S.1    Conner, C.2    Aagren, M.3    Smith, D.M.4    Bouchard, J.5    Brett, J.6
  • 119
    • 0033052842 scopus 로고    scopus 로고
    • Hematocrit level and associated mortality in hemodialysis patients
    • Ma JZ, Ebben J, Xia H, Collins AJ. Hematocrit level and associated mortality in hemodialysis patients. J Am Soc Nephrol 1999;10:610-619.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 610-619
    • Ma, J.Z.1    Ebben, J.2    Xia, H.3    Collins, A.J.4
  • 121
    • 3042831462 scopus 로고    scopus 로고
    • Haemoglobin predicts survival in patients with chronic heart failure: A substudy of the ELITE II trial
    • Sharma R, Francis DP, Pitt B, Poole-Wilson PA, Coats AJS, Anker SD. Haemoglobin predicts survival in patients with chronic heart failure: A substudy of the ELITE II trial. Eur Heart J 2004;25:1021-1028.
    • (2004) Eur Heart J , vol.25 , pp. 1021-1028
    • Sharma, R.1    Francis, D.P.2    Pitt, B.3    Poole-Wilson, P.A.4    Ajs, C.5    Anker, S.D.6
  • 122
    • 3042856282 scopus 로고    scopus 로고
    • Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes
    • Klausen K, Borch-Johnsen K, Feldt-Rasmussen B, Jensen G, Clausen P, Scharling H, Appleyard M, Jensen JS. Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes. Circulation 2004;110:32-35.
    • (2004) Circulation , vol.110 , pp. 32-35
    • Klausen, K.1    Borch-Johnsen, K.2    Feldt-Rasmussen, B.3    Jensen, G.4    Clausen, P.5    Scharling, H.6    Appleyard, M.7    Jensen, J.S.8
  • 124
    • 79952721660 scopus 로고    scopus 로고
    • Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members
    • Chen J, Williams S, Ho S, Loraine H, Hagan D, Whaley JM, Feder JN. Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members. Diabetes Ther 2010;1:57-92.
    • (2010) Diabetes Ther , vol.1 , pp. 57-92
    • Chen, J.1    Williams, S.2    Ho, S.3    Loraine, H.4    Hagan, D.5    Whaley, J.M.6    Feder, J.N.7
  • 126
    • 27144461138 scopus 로고    scopus 로고
    • Increased prevalence of third-degree atrioventricular block in patients with type II diabetes mellitus
    • Movahed M-R, Hashemzadeh M, Jamal MM. Increased prevalence of third-degree atrioventricular block in patients with type II diabetes mellitus. Chest 2005;128: 2611-2614.
    • (2005) Chest , vol.128 , pp. 2611-2614
    • Movahed, M.-R.1    Hashemzadeh, M.2    Jamal, M.M.3
  • 127
    • 84922005208 scopus 로고    scopus 로고
    • Dapagliflozin reduces the amplitude of shortening and Ca(2+) transient in ventricular myocytes from streptozotocin-induced diabetic rats
    • Hamouda NN, Sydorenko V, Qureshi MA, Alkaabi JM, Oz M, Howarth FC. Dapagliflozin reduces the amplitude of shortening and Ca(2+) transient in ventricular myocytes from streptozotocin-induced diabetic rats. Mol Cell Biochem 2015;400: 57-68.
    • (2015) Mol Cell Biochem , vol.400 , pp. 57-68
    • Hamouda, N.N.1    Sydorenko, V.2    Qureshi, M.A.3    Alkaabi, J.M.4    Oz, M.5    Howarth, F.C.6
  • 128
    • 80052805929 scopus 로고    scopus 로고
    • Evaluation of the effect of dapagliflozin on cardiac repolarization: A thorough QT/QTc study
    • Carlson GF, Tou CKP, Parikh S, Birmingham BK, Butler K. Evaluation of the effect of dapagliflozin on cardiac repolarization: A thorough QT/QTc study. Diabetes Ther 2011;2:123-132.
    • (2011) Diabetes Ther , vol.2 , pp. 123-132
    • Carlson, G.F.1    Ckp, T.2    Parikh, S.3    Birmingham, B.K.4    Butler, K.5
  • 129
    • 84964696031 scopus 로고    scopus 로고
    • Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice
    • Lin B, Koibuchi N, Hasegawa Y, Sueta D, Toyama K, Uekawa K, Ma M, Nakagawa T, Kusaka H, Kim-Mitsuyama S. Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice. Cardiovasc Diabetol 2014;13: 148.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 148
    • Lin, B.1    Koibuchi, N.2    Hasegawa, Y.3    Sueta, D.4    Toyama, K.5    Uekawa, K.6    Ma, M.7    Nakagawa, T.8    Kusaka, H.9    Kim-Mitsuyama, S.10
  • 130
    • 77952480033 scopus 로고    scopus 로고
    • Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis
    • Kaneto H, Katakami N, Matsuhisa M, Matsuoka T. Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators Inflamm 2010; 2010:e453892.
    • (2010) Mediators Inflamm , vol.2010 , pp. e453892
    • Kaneto, H.1    Katakami, N.2    Matsuhisa, M.3    Matsuoka, T.4
  • 131
    • 2442421194 scopus 로고    scopus 로고
    • Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? the common soil hypothesis revisited
    • Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 2004;24:816-823.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 816-823
    • Ceriello, A.1    Motz, E.2
  • 132
  • 133
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HAW. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008;359: 1577-1589.
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Haw, N.5
  • 135
    • 84885171560 scopus 로고    scopus 로고
    • The clinical efficacy and safety of sodium glucose cotransporter-2 inhibitors in adults with type 2 diabetes mellitus
    • Riser Taylor S, Harris KB. The clinical efficacy and safety of sodium glucose cotransporter-2 inhibitors in adults with type 2 diabetes mellitus. Pharmacother J Hum Pharmacol Drug Ther 2013;33:984-999.
    • (2013) Pharmacother J Hum Pharmacol Drug Ther , vol.33 , pp. 984-999
    • Riser Taylor, S.1    Harris, K.B.2


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