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Volumn 9, Issue 2, 2012, Pages 117-123

Effects of SGLT2 inhibitors on cardiovascular outcomes

Author keywords

Cardiovascular outcomes; Clinical trials; SGLT2; Sodium glucose transporters

Indexed keywords

ANTIDIABETIC AGENT; CANAGLIFLOZIN; DAPAGLIFLOZIN; EGT 0001442; EMPAGLIFLOZIN; ERTUGLIFLOZIN; GLIMEPIRIDE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; IPRAGLIFLOZIN; ISIS 388626; LIPID; LUSEOGLIFLOZIN; LX 4211; METFORMIN; MOLECULE TRANSPORT AGENT; PIOGLITAZONE; REMOGLIFLOZIN ETABONATE; SERGLIFLOZIN ETABONATE; SITAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; TOFOGLIFLOZIN; TRIACYLGLYCEROL; TS 071; UNCLASSIFIED DRUG;

EID: 84861079280     PISSN: 14791641     EISSN: 17528984     Source Type: Journal    
DOI: 10.1177/1479164112441190     Document Type: Review
Times cited : (61)

References (46)
  • 2
    • 75449091856 scopus 로고    scopus 로고
    • Apple trees to sodium glucose co-transporterinhibitors: A review of SGLT2 inhibition
    • White JR. Apple trees to sodium glucose co-transporterinhibitors: a review of SGLT2 inhibition. Clinical Diabetes 2010; 28: 5-10.
    • (2010) Clinical Diabetes , vol.28 , pp. 5-10
    • White, J.R.1
  • 4
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissues sensitivity to insulin in diabetic rats
    • Rossetti L, Smith D, Shulman GI, Papachristou D and DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 1987; 79: 1510-1515. (Pubitemid 17099657)
    • (1987) Journal of Clinical Investigation , vol.79 , Issue.5 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.I.3
  • 5
    • 75749094398 scopus 로고    scopus 로고
    • Familial renal glucosuria and SGLT2: From a mendelian trait to a therapeutic target
    • Santer R and Calado J. Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol 2010; 5: 133-141.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 133-141
    • Santer, R.1    Calado, J.2
  • 8
    • 79651473537 scopus 로고    scopus 로고
    • Renal glucose reabsorption inhibitors to treat diabetes
    • Bailey CJ. Renal glucose reabsorption inhibitors to treat diabetes. Trends Pharmacol Sci 2011; 32: 63-71.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 63-71
    • Bailey, C.J.1
  • 9
    • 0015122757 scopus 로고
    • Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects
    • Mogensen CE. Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects. Scand J Clin Lab Invest 1971; 28: 101-109.
    • (1971) Scand J Clin Lab Invest , vol.28 , pp. 101-109
    • Mogensen, C.E.1
  • 11
    • 33644688031 scopus 로고    scopus 로고
    • Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
    • DOI 10.2337/diabetes.54.12.3427
    • Rahmoune H, Thompson PW, Ward JM, Smith CD, et al. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes 2005; 54: 3427-3434. (Pubitemid 43334332)
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3427-3434
    • Rahmoune, H.1    Thompson, P.W.2    Ward, J.M.3    Smith, C.D.4    Hong, G.5    Brown, J.6
  • 12
    • 84861088228 scopus 로고    scopus 로고
    • Dapagliflozin tablets 5 and 10mg
    • Food and Drug Administration FDA Briefing Document NDA 202293 Products DoMae (ed)
    • Food and Drug Administration. FDA Briefing Document NDA 202293. Dapagliflozin tablets 5 and 10mg. In: Products DoMae (ed). Silver Spring: Food and Drug Administration, 2011.
    • (2011) Silver Spring: Food and Drug Administration
  • 13
    • 84861037672 scopus 로고    scopus 로고
    • In vitro properties and in vivo effect on urinary glucose excretion of BI 10773, a novel selective SGLT2inhibitor
    • Abstract 521-P
    • Grempler R. In vitro properties and in vivo effect on urinary glucose excretion of BI 10773, a novel selective SGLT2inhibitor. Diabetes 2009; 58: Abstract 521-P.
    • (2009) Diabetes , vol.58
    • Grempler, R.1
  • 14
    • 79651470669 scopus 로고    scopus 로고
    • JNJ-28431754/TA-7284, an SGLT inhibitor, lowersblood glucose and reduces body weight in obese and type 2 diabetic animal models
    • Abstract 534-P
    • Liang Y. JNJ-28431754/TA-7284, an SGLT inhibitor, lowersblood glucose and reduces body weight in obese and type 2 diabetic animal models. Diabetes 2009; 58: Abstract 534-P.
    • (2009) Diabetes , vol.58
    • Liang, Y.1
  • 15
    • 67449084943 scopus 로고    scopus 로고
    • Dapagliflozin: An emerging treatment option in type 2 diabetes
    • Kipnes M. Dapagliflozin: an emerging treatment option in type 2 diabetes. Expert Opinion on Investigational Drugs 2009; 18: 327-334.
    • (2009) Expert Opinion on Investigational Drugs , vol.18 , pp. 327-334
    • Kipnes, M.1
  • 16
    • 84861088227 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes mellitus (T2DM)
    • abstract 0999-P
    • Inagaki N, Kondo K, Iwasaki T et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes mellitus (T2DM). Diabetes 2011; 60 (Supp 1): abstract 0999-P.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Inagaki, N.1    Kondo, K.2    Iwasaki, T.3
  • 17
    • 77957593008 scopus 로고    scopus 로고
    • Canagliflozin, an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control and lowers body weight in subjects with type 2 diabetes (T2D) on metformin
    • Orlando, abstract77-OR
    • Rosenstock J, Arbit D, Usiskin K, Capuano G and Canovatchel W. Canagliflozin, an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control and lowers body weight in subjects with type 2 diabetes (T2D) on metformin. American Diabetes Association, Orlando 2010: abstract77-OR.
    • (2010) American Diabetes Association
    • Rosenstock, J.1    Arbit, D.2    Usiskin, K.3    Capuano, G.4    Canovatchel, W.5
  • 18
    • 84861079902 scopus 로고    scopus 로고
    • Canagliflozin, an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control, lowers body weight and improves beta cell function in subjects with type 2 diabetes on background metformin (T2D) on metformin
    • Rosenstock J, Polidori D, Zhao Y, Sha S, Arbit D, Usiskin K, Capuano G and Canovatchel W. Canagliflozin, an inhibitor of sodium glucose co-transporter 2 (SGLT2), improves glycemic control, lowers body weight and improves beta cell function in subjects with type 2 diabetes on background metformin (T2D) on metformin. Diabetologia 2010; 53 (SUPPL. 1): S1-S556.
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1
    • Rosenstock, J.1    Polidori, D.2    Zhao, Y.3    Sha, S.4    Arbit, D.5    Usiskin, K.6    Capuano, G.7    Canovatchel, W.8
  • 19
    • 79960311276 scopus 로고    scopus 로고
    • The potent and highly effective selective sodium-glucose co-transporter (SGLT-2) inhibitor BI 10773 is safe and efficacious as monotherapy in patients with type 2 diabetes mellitus
    • Ferrannini E, Seman L, Seewadt-Becker E, et al. The potent and highly effective selective sodium-glucose co-transporter (SGLT-2) inhibitor BI 10773 is safe and efficacious as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 2010; 53: S1-S556.
    • (2010) Diabetologia , vol.53
    • Ferrannini, E.1    Seman, L.2    Seewadt-Becker, E.3
  • 20
    • 84871634800 scopus 로고    scopus 로고
    • Efficacyand safety of BI10773, a new sodium glucose cotransporter-2 (SGLT-2) inhibitor, in type 2 diabetes inadequately controlled on metformin
    • Rosenstock J, Jelaska A, Seman L, Pinneti S, et al. Efficacyand safety of BI10773, a new sodium glucose cotransporter-2 (SGLT-2) inhibitor, in type 2 diabetes inadequately controlled on metformin. Diabetes 2011; 60 (SUPPL. 1): A235-A352.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Rosenstock, J.1    Jelaska, A.2    Seman, L.3    Pinneti, S.4
  • 21
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, doubleblind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, Bastien A and List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, doubleblind, placebo-controlled trial. Lancet 2010; 375: 2223-2233.
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 22
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, phase 3 trial
    • Ferrannini E, Ramos SJ, Salsali A, Tang W and List JF. Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care 2010; 33: 2217-2224.
    • (2010) Diabetes Care , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.J.2    Salsali, A.3    Tang, W.4    List, J.F.5
  • 23
    • 79952221451 scopus 로고    scopus 로고
    • Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans
    • List JF and Whaley JM. Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans. Kidney Int Suppl 2011: S20-S27.
    • (2011) Kidney Int Suppl
    • List, J.F.1    Whaley, J.M.2
  • 24
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List JF, Woo V, Morales E, Tang W and Fiedorek FT. Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care 2009; 32: 650-657.
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.T.5
  • 25
    • 79952726733 scopus 로고    scopus 로고
    • Dapagliflozin vs glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin: 52-week results of a double-blind, randomised controlled trial
    • Nauck M, Prato SD, Rohwedder K, Elze M and Parikh S.Dapagliflozin vs glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin: 52-week results of a double-blind, randomised controlled trial. Diabetologia 2010; 53: S1-S556.
    • (2010) Diabetologia , vol.53
    • Nauck, M.1    Prato, S.D.2    Rohwedder, K.3    Elze, M.4    Parikh, S.5
  • 26
    • 84861030350 scopus 로고    scopus 로고
    • Long-term efficacy of dapagliflozin as add-on to metformin (MET) in T2DM inadequately controlled with MET alone
    • Bailey C, Gross J, Yadav M, et al. Long-term efficacy of dapagliflozin as add-on to metformin (MET) in T2DM inadequately controlled with MET alone. Diabetes 2011; 60 (SUPPL. 1): A235-A352.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Bailey, C.1    Gross, J.2    Yadav, M.3
  • 27
    • 84860480449 scopus 로고    scopus 로고
    • Long-term efficacy and safety of add-on dapagliflozin vs add-on glipizide in patients with T2DM inadequately controlled with metformin: 2-year results
    • Nauck M, Prato SD, Rohwedder K, et al. Long-term efficacy and safety of add-on dapagliflozin vs add-on glipizide in patients with T2DM inadequately controlled with metformin: 2-year results. Diabetes 2010; 60 (SUPPL. 1): A235-A352.
    • (2010) Diabetes , vol.60 , Issue.SUPPL. 1
    • Nauck, M.1    Prato, S.D.2    Rohwedder, K.3
  • 28
    • 79952731529 scopus 로고    scopus 로고
    • Sustained effectiveness of dapagliflozin over 48 weeks in patients with type 2 diabetes poorly controlled with insulin
    • Orlando
    • Wilding J, Woo V, Soler N, et al. Sustained effectiveness of dapagliflozin over 48 weeks in patients with type 2 diabetes poorly controlled with insulin. American Diabetes Association. Orlando, 2010.
    • (2010) American Diabetes Association
    • Wilding, J.1    Woo, V.2    Soler, N.3
  • 29
    • 84861088227 scopus 로고    scopus 로고
    • Canagliflozin, anovel inhibitor of sodium glucose co-transporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes mellitus (T2DM)
    • Inagaki N, Kondo K, Iwasaki T, et al. Canagliflozin, anovel inhibitor of sodium glucose co-transporter 2 (SGLT2) improves glycemic control and reduces body weight in Japanese type 2 diabetes mellitus (T2DM). Diabetes 2011; 60 (SUPPL. 1): A582-A643.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Inagaki, N.1    Kondo, K.2    Iwasaki, T.3
  • 30
    • 0036937335 scopus 로고    scopus 로고
    • Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)
    • DOI 10.1007/s00439-002-0820-5
    • van den Heuvel LP, Assink K, Willemsen M and Monnens L. Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2). Hum Genet 2002; 111: 544-547. (Pubitemid 36075086)
    • (2002) Human Genetics , vol.111 , Issue.6 , pp. 544-547
    • Van Den Heuvel, L.P.1    Assink, K.2    Willemsen, M.3    Monnens, L.4
  • 31
    • 47149118686 scopus 로고    scopus 로고
    • Sodium glucose co-transporter 2 inhibitors: Blocking renal tubular reabsorption of glucose to improve glycaemic control in patients with diabetes
    • DOI 10.1111/j.1742-1241.2008.01829.x
    • Jabbour SA and Goldstein BJ. Sodium glucose co-transporter 2 inhibitors: blocking renal tubular reabsorption of glucoseto improve glycaemic control in patients with diabetes. Int J Clin Pract 2008; 62: 1279-1284. (Pubitemid 351977622)
    • (2008) International Journal of Clinical Practice , vol.62 , Issue.8 , pp. 1279-1284
    • Jabbour, S.A.1    Goldstein, B.J.2
  • 32
    • 77956579687 scopus 로고    scopus 로고
    • Rosiglitazone: What went wrong?
    • Cohen D. Rosiglitazone: what went wrong? BMJ 2010; 341: c4848.
    • (2010) BMJ , vol.341
    • Cohen, D.1
  • 33
    • 79956217900 scopus 로고    scopus 로고
    • Risk of bladder cancer among iabetic patients treated with pioglitazone. Interim report of a longitudinal cohort study
    • Lewis J, Ferrara A, Peng T, et al. Risk of bladder cancer among iabetic patients treated with pioglitazone. Interim report of a longitudinal cohort study. Diabetes Care 2011 34: 916-922.
    • (2011) Diabetes Care , vol.34 , pp. 916-922
    • Lewis, J.1    Ferrara, A.2    Peng, T.3
  • 35
    • 70349881450 scopus 로고    scopus 로고
    • Intensive glucosecontrol and macrovascular outcomes in type 2 diabetes
    • Turnbull F, Abraira C, Anderson R, et al. Intensive glucosecontrol and macrovascular outcomes in type 2 diabetes. Diabetologia 2009; 52: 2288-2298.
    • (2009) Diabetologia , vol.52 , pp. 2288-2298
    • Turnbull, F.1    Abraira, C.2    Anderson, R.3
  • 36
    • 67650082354 scopus 로고    scopus 로고
    • Use of blood pressure loweringdrugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    • Law M, Morris J and Wald N. Use of blood pressure loweringdrugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009; 338.
    • (2009) BMJ , vol.338
    • Law, M.1    Morris, J.2    Wald, N.3
  • 37
    • 0035031042 scopus 로고    scopus 로고
    • Current therapies and emerging targets for the treatment of diabetes
    • DOI 10.2174/1381612013397915
    • Wagman AS and Nuss JM. Current therapies and emerging targets for the treatment of diabetes. Curr Pharm Des 2001;7: 417-450. (Pubitemid 32409729)
    • (2001) Current Pharmaceutical Design , vol.7 , Issue.6 , pp. 417-450
    • Wagman, A.S.1    Nuss, J.M.2
  • 38
    • 38949210220 scopus 로고    scopus 로고
    • Effect of a multifactorial intervention on mortality in type 2 diabetes
    • DOI 10.1056/NEJMoa0706245
    • Gaede P, Lund-Andersen H, Parving H-H and Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 2008; 358: 580-591. (Pubitemid 351214285)
    • (2008) New England Journal of Medicine , vol.358 , Issue.6 , pp. 580-591
    • Gaede, P.1    Lund-Andersen, H.2    Parving, H.-H.3    Pedersen, O.4
  • 39
    • 34047115790 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Erratum appears
    • Kahn SE, Haffner SM, Heise MA, et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.[Erratum appears in N Engl J Med 2007; 356 :1387-1388].
    • (2007) N Engl J Med , vol.356 , pp. 1387-1388
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3
  • 40
    • 33845405222 scopus 로고    scopus 로고
    • N Engl J Med 2006; 355: 2427-2443.
    • (2006) N Engl J Med , vol.355 , pp. 2427-2443
  • 42
    • 77954189321 scopus 로고    scopus 로고
    • The impact of weight gain on motivation, compliance, and metabolic control in patients with type 2 diabetes mellitus
    • Pi-Sunyer FX. The impact of weight gain on motivation, compliance, and metabolic control in patients with type 2 diabetes mellitus. Postgrad Med 2009; 121: 94-107.
    • (2009) Postgrad Med , vol.121 , pp. 94-107
    • Pi-Sunyer, F.X.1
  • 43
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • DOI 10.1038/nature05482, PII NATURE05482
    • Kahn SE, Hull RL and Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444: 840-846. (Pubitemid 46024990)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 44
    • 64749114317 scopus 로고    scopus 로고
    • Committee CDACPGS. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes: Response to Nathan et al
    • author reply e37-38
    • Woo V and Committee CDACPGS. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes: response to Nathan et al. Diabetes Care 2009; 32: e34; author reply e37-38.
    • (2009) Diabetes Care , vol.32
    • Woo, V.1


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