-
1
-
-
0037129380
-
Nonalcoholic fatty liver disease
-
P. Angulo Nonalcoholic fatty liver disease N Engl J Med 346 2002 1221 1231
-
(2002)
N Engl J Med
, vol.346
, pp. 1221-1231
-
-
Angulo, P.1
-
2
-
-
77953857048
-
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
-
C.J. Bailey, J.L. Gross, A. Pieters, A. Bastien, and J.F. List Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial Lancet 375 2010 2223 2233
-
(2010)
Lancet
, vol.375
, pp. 2223-2233
-
-
Bailey, C.J.1
Gross, J.L.2
Pieters, A.3
Bastien, A.4
List, J.F.5
-
3
-
-
84858020943
-
Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
-
J. Bolinder, O. Ljunggren, J. Kullberg, L. Johansson, J. Wilding, and A.M. Langkilde Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin J Clin Endocrinol Metab 97 2012 1020 1031
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. 1020-1031
-
-
Bolinder, J.1
Ljunggren, O.2
Kullberg, J.3
Johansson, L.4
Wilding, J.5
Langkilde, A.M.6
-
4
-
-
84877920040
-
-
Bristol-Myers Squibb, and AstraZeneca. Endocrinologic and Metabolic Drugs Advisory Committee, U.S. Food and Drug Administration
-
Bristol-Myers Squibb, and AstraZeneca Background document; dapagliflozin Endocrinologic and Metabolic Drugs Advisory Committee, U.S. Food and Drug Administration 2011
-
(2011)
Background document; Dapagliflozin
-
-
-
5
-
-
79952721660
-
Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members
-
J. Chen, S. Williams, S. Ho, H. Loraine, D. Hagan, and J.M. Whaley Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members Diabetes Ther 1 2010 57 92
-
(2010)
Diabetes Ther
, vol.1
, pp. 57-92
-
-
Chen, J.1
Williams, S.2
Ho, S.3
Loraine, H.4
Hagan, D.5
Whaley, J.M.6
-
6
-
-
84864371186
-
Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats
-
J.J. Devenny, H.E. Godonis, S.J. Harvey, S. Rooney, M.J. Cullen, and M.A. Pelleymounter Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats Obesity (Silver Spring) 20 2012 1645 1652
-
(2012)
Obesity (Silver Spring)
, vol.20
, pp. 1645-1652
-
-
Devenny, J.J.1
Godonis, H.E.2
Harvey, S.J.3
Rooney, S.4
Cullen, M.J.5
Pelleymounter, M.A.6
-
8
-
-
84877924519
-
-
European Medicines Agency Procedure no.: EMEA/H/C/002322 2012
-
European Medicines Agency Assessment report Forxiga. Dapagliflozin. Procedure no.: EMEA/H/C/002322 2012
-
(2012)
Assessment Report Forxiga. Dapagliflozin
-
-
-
9
-
-
64749094872
-
Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose
-
S.J. Farber, E.Y. Berger, and D.P. Earle Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose J Clin Invest 30 1951 125 129
-
(1951)
J Clin Invest
, vol.30
, pp. 125-129
-
-
Farber, S.J.1
Berger, E.Y.2
Earle, D.P.3
-
10
-
-
84876803427
-
Renal glucose handling: Impact of chronic kidney disease and SGLT2 inhibition in patients with type 2 diabetes mellitus
-
10.2337/dc12-1503
-
E. Ferrannini, S.A. Veltkamp, R.A. Smulders, and T. Kadokura Renal glucose handling: Impact of chronic kidney disease and SGLT2 inhibition in patients with type 2 diabetes mellitus Diabetes Care 2013 10.2337/dc12-1503
-
(2013)
Diabetes Care
-
-
Ferrannini, E.1
Veltkamp, S.A.2
Smulders, R.A.3
Kadokura, T.4
-
11
-
-
84876899238
-
Active- and placebo-controlled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus
-
10.1016/j.jdiacomp.2012.11.005
-
V. Fonseca, E. Ferrannini, J. Wilding, W. Wilpshaar, P. Dhanjal, and G. Ball Active- and placebo-controlled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus J Diabetes Complications 2012 10.1016/j.jdiacomp.2012. 11.005
-
(2012)
J Diabetes Complications
-
-
Fonseca, V.1
Ferrannini, E.2
Wilding, J.3
Wilpshaar, W.4
Dhanjal, P.5
Ball, G.6
-
12
-
-
84877919808
-
FDA briefing document NDA 202293
-
Food and Drug Adminstration
-
Food and Drug Adminstration FDA briefing document NDA 202293 Dapagliflozin tablets 5 and 10 mg 2011
-
(2011)
Dapagliflozin Tablets 5 and 10 Mg
-
-
-
13
-
-
52649083832
-
Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
-
Y. Fujimori, K. Katsuno, I. Nakashima, Y. Ishikawa-Takemura, H. Fujikura, and M. Isaji Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models J Pharmacol Exp Ther 327 2008 268 276
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 268-276
-
-
Fujimori, Y.1
Katsuno, K.2
Nakashima, I.3
Ishikawa-Takemura, Y.4
Fujikura, H.5
Isaji, M.6
-
14
-
-
73349138902
-
Future perspectives for insulinotropic agents in the treatment of type 2 diabetes-DPP-4 inhibitors and sulphonylureas
-
B. Gallwitz, and H.U. Haering Future perspectives for insulinotropic agents in the treatment of type 2 diabetes-DPP-4 inhibitors and sulphonylureas Diabetes Obes Metab 12 2010 1 11
-
(2010)
Diabetes Obes Metab
, vol.12
, pp. 1-11
-
-
Gallwitz, B.1
Haering, H.U.2
-
15
-
-
33749821010
-
Diabetic microvascular complications: Can patients at risk be identified? A review
-
A. Girach, D. Manner, and M. Porta Diabetic microvascular complications: Can patients at risk be identified? A review Int J Clin Pract 60 2006 1471 1483
-
(2006)
Int J Clin Pract
, vol.60
, pp. 1471-1483
-
-
Girach, A.1
Manner, D.2
Porta, M.3
-
16
-
-
84875130718
-
Ipragliflozin reduces A1C and body weight in type 2 diabetes patients who have inadequate glycemic control on metformin alone: ILLUMINATE study
-
K. Goto, A. Kashiwagi, K. Kazuta, S. Yoshida, E. Ueyama, and A. Utsuno Ipragliflozin reduces A1C and body weight in type 2 diabetes patients who have inadequate glycemic control on metformin alone: ILLUMINATE study American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA) 2012
-
(2012)
American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA)
-
-
Goto, K.1
Kashiwagi, A.2
Kazuta, K.3
Yoshida, S.4
Ueyama, E.5
Utsuno, A.6
-
17
-
-
83655184724
-
Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: Characterisation and comparison with other SGLT-2 inhibitors
-
R. Grempler, L. Thomas, M. Eckhardt, F. Himmelsbach, A. Sauer, and D.E. Sharp Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: Characterisation and comparison with other SGLT-2 inhibitors Diabetes Obes Metab 14 2012 83 90
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 83-90
-
-
Grempler, R.1
Thomas, L.2
Eckhardt, M.3
Himmelsbach, F.4
Sauer, A.5
Sharp, D.E.6
-
18
-
-
48249146624
-
Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
-
S. Han, D.L. Hagan, J.R. Taylor, L. Xin, W. Meng, and S.A. Biller Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats Diabetes 57 2008 1723 1729
-
(2008)
Diabetes
, vol.57
, pp. 1723-1729
-
-
Han, S.1
Hagan, D.L.2
Taylor, J.R.3
Xin, L.4
Meng, W.5
Biller, S.A.6
-
19
-
-
78650686769
-
Serum uric acid as a new player in the development of diabetic nephropathy
-
P. Hovind, P. Rossing, R.J. Johnson, and H.H. Parving Serum uric acid as a new player in the development of diabetic nephropathy J Ren Nutr 21 2011 124 127
-
(2011)
J Ren Nutr
, vol.21
, pp. 124-127
-
-
Hovind, P.1
Rossing, P.2
Johnson, R.J.3
Parving, H.H.4
-
20
-
-
84860492610
-
Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus
-
M. Imamura, K. Nakanishi, T. Suzuki, K. Ikegai, R. Shiraki, and T. Ogiyama Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus Bioorg Med Chem 20 2012 3263 3279
-
(2012)
Bioorg Med Chem
, vol.20
, pp. 3263-3279
-
-
Imamura, M.1
Nakanishi, K.2
Suzuki, T.3
Ikegai, K.4
Shiraki, R.5
Ogiyama, T.6
-
21
-
-
84866268783
-
Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
-
S.E. Inzucchi, R.M. Bergenstal, J.B. Buse, M. Diamant, E. Ferrannini, and M. Nauck Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetes Care 35 2012 1364 1379
-
(2012)
Diabetes Care
, vol.35
, pp. 1364-1379
-
-
Inzucchi, S.E.1
Bergenstal, R.M.2
Buse, J.B.3
Diamant, M.4
Ferrannini, E.5
Nauck, M.6
-
22
-
-
79958255267
-
SGLT2 inhibitors: Molecular design and potential differences in effect
-
M. Isaji SGLT2 inhibitors: Molecular design and potential differences in effect Kidney Int Suppl 2011 S14 S19
-
(2011)
Kidney Int Suppl
-
-
Isaji, M.1
-
24
-
-
80052189619
-
Diabetes field cautiously upbeat despite possible setback for leading SGLT2 inhibitor
-
D. Jones Diabetes field cautiously upbeat despite possible setback for leading SGLT2 inhibitor Nat Rev Drug Discov 10 2011 645 646
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 645-646
-
-
Jones, D.1
-
25
-
-
84864615705
-
Ipragliflozin (ASP1941), a selective sodium-dependent glucose cotransporter 2 inhibitor, safely stimulates urinary glucose excretion without inducing hypoglycemia in healthy Japanese subjects
-
T. Kadokura, M. Saito, A. Utsuno, K. Kazuta, S. Yoshida, and S. Kawasaki Ipragliflozin (ASP1941), a selective sodium-dependent glucose cotransporter 2 inhibitor, safely stimulates urinary glucose excretion without inducing hypoglycemia in healthy Japanese subjects Diabetol Int 2 2011 172 182
-
(2011)
Diabetol Int
, vol.2
, pp. 172-182
-
-
Kadokura, T.1
Saito, M.2
Utsuno, A.3
Kazuta, K.4
Yoshida, S.5
Kawasaki, S.6
-
26
-
-
84874075297
-
-
American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA)
-
T. Kadowaki, S. Ikeda, Y. Takano, O. Cynshi, A.D. Christ, and V. Boerlin Tofogliflozin, a novel and selective SGLT2 inhibitor improves glycemic control and lowers body weight in patients with type 2 diabetes mellitus inadequately controlled on stable metformin or diet and exercise alone American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA) 2012
-
(2012)
Tofogliflozin, a Novel and Selective SGLT2 Inhibitor Improves Glycemic Control and Lowers Body Weight in Patients with Type 2 Diabetes Mellitus Inadequately Controlled on Stable Metformin or Diet and Exercise Alone
-
-
Kadowaki, T.1
Ikeda, S.2
Takano, Y.3
Cynshi, O.4
Christ, A.D.5
Boerlin, V.6
-
27
-
-
0026033325
-
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression
-
B.B. Kahn, G.I. Shulman, R.A. DeFronzo, S.W. Cushman, and L. Rossetti Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression J Clin Invest 87 1991 561 570
-
(1991)
J Clin Invest
, vol.87
, pp. 561-570
-
-
Kahn, B.B.1
Shulman, G.I.2
Defronzo, R.A.3
Cushman, S.W.4
Rossetti, L.5
-
28
-
-
77951143723
-
(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl] -1-thio-d-glucito l (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment
-
H. Kakinuma, T. Oi, Y. Hashimoto-Tsuchiya, M. Arai, Y. Kawakita, and Y. Fukasawa (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1- thio-d-glucito l (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment J Med Chem 53 2010 3247 3261
-
(2010)
J Med Chem
, vol.53
, pp. 3247-3261
-
-
Kakinuma, H.1
Oi, T.2
Hashimoto-Tsuchiya, Y.3
Arai, M.4
Kawakita, Y.5
Fukasawa, Y.6
-
29
-
-
0028044629
-
The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose
-
Y. Kanai, W.S. Lee, G. You, D. Brown, and M.A. Hediger The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose J Clin Invest 93 1994 397 404
-
(1994)
J Clin Invest
, vol.93
, pp. 397-404
-
-
Kanai, Y.1
Lee, W.S.2
You, G.3
Brown, D.4
Hediger, M.A.5
-
30
-
-
84888323804
-
Ipragliflozin reduced HbA1c and body weight in Japanese type 2 diabetes mellitus patients who have inadequate glycaemic control on sulfonylurea or pioglitazone alone
-
A. Kashiwagi, T. Shiga, N. Akiyama, K. Kazuta, H. Ogasawara, and S. Yoshida Ipragliflozin reduced HbA1c and body weight in Japanese type 2 diabetes mellitus patients who have inadequate glycaemic control on sulfonylurea or pioglitazone alone The European Association for the Study of Diabetes, 48th Annual Meeting. Berlin, Germany 2012
-
(2012)
The European Association for the Study of Diabetes, 48th Annual Meeting. Berlin, Germany
-
-
Kashiwagi, A.1
Shiga, T.2
Akiyama, N.3
Kazuta, K.4
Ogasawara, H.5
Yoshida, S.6
-
31
-
-
84892151789
-
Ipragliflozin improved glycaemic control with additional benefits of reductions of body weight and blood pressure in Japanese patients with type 2 diabetes mellitus: BRIGHTEN study
-
A. Kashiwagi, Y. Takinami, K. Kazuta, S. Yoshida, A. Utsuno, and I. Nagase Ipragliflozin improved glycaemic control with additional benefits of reductions of body weight and blood pressure in Japanese patients with type 2 diabetes mellitus: BRIGHTEN study The European Association for the Study of Diabetes, 47th Annual Meeting. Lisbon, Portugal 2011
-
(2011)
The European Association for the Study of Diabetes, 47th Annual Meeting. Lisbon, Portugal
-
-
Kashiwagi, A.1
Takinami, Y.2
Kazuta, K.3
Yoshida, S.4
Utsuno, A.5
Nagase, I.6
-
32
-
-
79952993665
-
ASP1941, a novel, selective SGLT2 inhibitor, was effective and safe in Japanese healthy volunteers and patients with type 2 diabetes mellitus
-
A. Kashiwagi, A. Utsuno, K. Kazuta, S. Yoshida, and S. Kageyama ASP1941, a novel, selective SGLT2 inhibitor, was effective and safe in Japanese healthy volunteers and patients with type 2 diabetes mellitus American Diabetes Association, 70th Scientific Sessions. Orlando (FL) 2010
-
(2010)
American Diabetes Association, 70th Scientific Sessions. Orlando (FL)
-
-
Kashiwagi, A.1
Utsuno, A.2
Kazuta, K.3
Yoshida, S.4
Kageyama, S.5
-
33
-
-
33845873376
-
Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level
-
K. Katsuno, Y. Fujimori, Y. Takemura, M. Hiratochi, F. Itoh, and Y. Komatsu Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level J Pharmacol Exp Ther 320 2007 323 330
-
(2007)
J Pharmacol Exp Ther
, vol.320
, pp. 323-330
-
-
Katsuno, K.1
Fujimori, Y.2
Takemura, Y.3
Hiratochi, M.4
Itoh, F.5
Komatsu, Y.6
-
34
-
-
79955635827
-
SGLT inhibitors as new therapeutic tools in the treatment of diabetes
-
R.K. Kinne, and F. Castaneda SGLT inhibitors as new therapeutic tools in the treatment of diabetes Handb Exp Pharmacol 105-126 2011
-
(2011)
Handb Exp Pharmacol
, vol.105-126
-
-
Kinne, R.K.1
Castaneda, F.2
-
35
-
-
0018486448
-
Effects of intraluminal d-glucose and probenecid on urate absorption in the rat proximal tubule
-
T.F. Knight, H.O. Senekjian, S. Sansom, and E.J. Weinman Effects of intraluminal d-glucose and probenecid on urate absorption in the rat proximal tubule Am J Physiol 236 1979 F526 F529
-
(1979)
Am J Physiol
, vol.236
-
-
Knight, T.F.1
Senekjian, H.O.2
Sansom, S.3
Weinman, E.J.4
-
36
-
-
67349180574
-
Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
-
B. Komoroski, N. Vachharajani, D. Boulton, D. Kornhauser, M. Geraldes, and L. Li Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects Clin Pharmacol Ther 85 2009 520 526
-
(2009)
Clin Pharmacol Ther
, vol.85
, pp. 520-526
-
-
Komoroski, B.1
Vachharajani, N.2
Boulton, D.3
Kornhauser, D.4
Geraldes, M.5
Li, L.6
-
37
-
-
67349275999
-
Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
-
B. Komoroski, N. Vachharajani, Y. Feng, L. Li, D. Kornhauser, and M. Pfister Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus Clin Pharmacol Ther 85 2009 513 519
-
(2009)
Clin Pharmacol Ther
, vol.85
, pp. 513-519
-
-
Komoroski, B.1
Vachharajani, N.2
Feng, Y.3
Li, L.4
Kornhauser, D.5
Pfister, M.6
-
38
-
-
79952715438
-
In vitro and in vivo pharmacological properties of ASP1941, a novel, potent and selective SGLT2 inhibitor
-
E. Kurosaki, A. Tahara, M. Yokono, D. Yamajuku, T. Takasu, and M. Imamura In vitro and in vivo pharmacological properties of ASP1941, a novel, potent and selective SGLT2 inhibitor American Diabetes Association, 70th Scientific Sessions. Orlando (FL) 2010
-
(2010)
American Diabetes Association, 70th Scientific Sessions. Orlando (FL)
-
-
Kurosaki, E.1
Tahara, A.2
Yokono, M.3
Yamajuku, D.4
Takasu, T.5
Imamura, M.6
-
39
-
-
84905501972
-
Ipragliflozin (ASP1941), a novel SGLT2 inhibitor, demonstrates beneficial effects on nonalcoholic fatty liver disease in animal models
-
E. Kurosaki, T. Takasu, S. Yamazaki, K. Koide, N. Maeda, and A. Hastings Ipragliflozin (ASP1941), a novel SGLT2 inhibitor, demonstrates beneficial effects on nonalcoholic fatty liver disease in animal models American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA) 2012
-
(2012)
American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA)
-
-
Kurosaki, E.1
Takasu, T.2
Yamazaki, S.3
Koide, K.4
Maeda, N.5
Hastings, A.6
-
40
-
-
0028234548
-
+/glucose cotransporter. Re-evaluation of function and distribution of expression
-
+/glucose cotransporter. Re-evaluation of function and distribution of expression J Biol Chem 269 1994 12032 12039
-
(1994)
J Biol Chem
, vol.269
, pp. 12032-12039
-
-
Lee, W.S.1
Kanai, Y.2
Wells, R.G.3
Hediger, M.A.4
-
41
-
-
35348891586
-
Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells
-
Y.J. Lee, Y.J. Lee, and H.J. Han Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells Kidney Int Suppl S27-35 2007
-
(2007)
Kidney Int Suppl
-
-
Lee, Y.J.1
Lee, Y.J.2
Han, H.J.3
-
42
-
-
84857099986
-
Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
-
Y. Liang, K. Arakawa, K. Ueta, Y. Matsushita, C. Kuriyama, and T. Martin Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models PLoS One 7 2012 e30555
-
(2012)
PLoS One
, vol.7
, pp. 30555
-
-
Liang, Y.1
Arakawa, K.2
Ueta, K.3
Matsushita, Y.4
Kuriyama, C.5
Martin, T.6
-
43
-
-
65349196064
-
Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
-
J.F. List, V. Woo, E. Morales, W. Tang, and F.T. Fiedorek Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes Diabetes Care 32 2009 650 657
-
(2009)
Diabetes Care
, vol.32
, pp. 650-657
-
-
List, J.F.1
Woo, V.2
Morales, E.3
Tang, W.4
Fiedorek, F.T.5
-
44
-
-
84865479822
-
Why do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?
-
J.J. Liu, T. Lee, and R.A. DeFronzo Why do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans? Diabetes 61 2012 2199 2204
-
(2012)
Diabetes
, vol.61
, pp. 2199-2204
-
-
Liu, J.J.1
Lee, T.2
Defronzo, R.A.3
-
45
-
-
84861886161
-
Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin- induced diabetic rats, a model of type 1 diabetes mellitus
-
G. Luippold, T. Klein, M. Mark, and R. Grempler Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats, a model of type 1 diabetes mellitus Diabetes Obes Metab 14 2012 601 607
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 601-607
-
-
Luippold, G.1
Klein, T.2
Mark, M.3
Grempler, R.4
-
46
-
-
77957254503
-
The novel sodium glucose transporter 2 inhibitor dapagliflozin sustains pancreatic function and preserves islet morphology in obese, diabetic rats
-
F.R. Macdonald, J.E. Peel, H.B. Jones, R.M. Mayers, L. Westgate, and J.M. Whaley The novel sodium glucose transporter 2 inhibitor dapagliflozin sustains pancreatic function and preserves islet morphology in obese, diabetic rats Diabetes Obes Metab 12 2010 1004 1012
-
(2010)
Diabetes Obes Metab
, vol.12
, pp. 1004-1012
-
-
MacDonald, F.R.1
Peel, J.E.2
Jones, H.B.3
Mayers, R.M.4
Westgate, L.5
Whaley, J.M.6
-
47
-
-
41649087328
-
Discovery of dapagliflozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes
-
W. Meng, B.A. Ellsworth, A.A. Nirschl, P.J. McCann, M. Patel, and R.N. Girotra Discovery of dapagliflozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes J Med Chem 51 2008 1145 1149
-
(2008)
J Med Chem
, vol.51
, pp. 1145-1149
-
-
Meng, W.1
Ellsworth, B.A.2
Nirschl, A.A.3
McCann, P.J.4
Patel, M.5
Girotra, R.N.6
-
48
-
-
84860391886
-
Kidney: Its impact on glucose homeostasis and hormonal regulation
-
A. Mitrakou Kidney: Its impact on glucose homeostasis and hormonal regulation Diabetes Res Clin Pract 93 Suppl. 1 2011 S66 S72
-
(2011)
Diabetes Res Clin Pract
, vol.93
, Issue.SUPPL. 1
-
-
Mitrakou, A.1
-
49
-
-
0015122757
-
Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects
-
C.E. Mogensen Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects Scand J Clin Lab Invest 28 1971 101 109
-
(1971)
Scand J Clin Lab Invest
, vol.28
, pp. 101-109
-
-
Mogensen, C.E.1
-
50
-
-
84868095962
-
Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2, improves serum glucose profiles in type 1 diabetes
-
S. Mudaliar, D.A. Armstrong, A.A. Mavian, R. O'Connor-Semmes, P.K. Mydlow, and J. Ye Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2, improves serum glucose profiles in type 1 diabetes Diabetes Care 35 2012 2198 2200
-
(2012)
Diabetes Care
, vol.35
, pp. 2198-2200
-
-
Mudaliar, S.1
Armstrong, D.A.2
Mavian, A.A.3
O'Connor-Semmes, R.4
Mydlow, P.K.5
Ye, J.6
-
51
-
-
84891559200
-
Changes in insulin sensitivity as measured by glucose disposal rate and acute insulin secretion with the sodium glucose co-transporter 2 inhibitor dapagliflozin
-
S. Mudaliar, R.R. Henry, G. Boden, S. Smith, A.G. Chalamandaris, and N. Iqbal Changes in insulin sensitivity as measured by glucose disposal rate and acute insulin secretion with the sodium glucose co-transporter 2 inhibitor dapagliflozin The European Association for the Study of Diabetes, 47th Annual Meeting. Lisbon, Portugal 2011
-
(2011)
The European Association for the Study of Diabetes, 47th Annual Meeting. Lisbon, Portugal
-
-
Mudaliar, S.1
Henry, R.R.2
Boden, G.3
Smith, S.4
Chalamandaris, A.G.5
Iqbal, N.6
-
52
-
-
77956319973
-
Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus
-
S. Nomura, S. Sakamaki, M. Hongu, E. Kawanishi, Y. Koga, and T. Sakamoto Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus J Med Chem 53 2010 6355 6360
-
(2010)
J Med Chem
, vol.53
, pp. 6355-6360
-
-
Nomura, S.1
Sakamaki, S.2
Hongu, M.3
Kawanishi, E.4
Koga, Y.5
Sakamoto, T.6
-
53
-
-
84866336965
-
Discovery of tofogliflozin, a novel C-Arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes
-
Y. Ohtake, T. Sato, T. Kobayashi, M. Nishimoto, N. Taka, and K. Takano Discovery of tofogliflozin, a novel C-Arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes J Med Chem 55 2012 7828 7840
-
(2012)
J Med Chem
, vol.55
, pp. 7828-7840
-
-
Ohtake, Y.1
Sato, T.2
Kobayashi, T.3
Nishimoto, M.4
Taka, N.5
Takano, K.6
-
54
-
-
0032850016
-
+-glucose cotransporters, may provide a novel approach to treating diabetes
-
+-glucose cotransporters, may provide a novel approach to treating diabetes Diabetes 48 1999 1794 1800
-
(1999)
Diabetes
, vol.48
, pp. 1794-1800
-
-
Oku, A.1
Ueta, K.2
Arakawa, K.3
Ishihara, T.4
Nawano, M.5
Kuronuma, Y.6
-
55
-
-
39149145482
-
Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004
-
K.L. Ong, B.M. Cheung, L.Y. Wong, N.M. Wat, K.C. Tan, and K.S. Lam Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004 Ann Epidemiol 18 2008 222 229
-
(2008)
Ann Epidemiol
, vol.18
, pp. 222-229
-
-
Ong, K.L.1
Cheung, B.M.2
Wong, L.Y.3
Wat, N.M.4
Tan, K.C.5
Lam, K.S.6
-
56
-
-
33847016066
-
Human obesity and insulin resistance: Lessons from experiments of nature
-
S. O'Rahilly Human obesity and insulin resistance: Lessons from experiments of nature Biochem Soc Trans 35 2007 33 36
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 33-36
-
-
O'Rahilly, S.1
-
58
-
-
79960995107
-
Macrovascular effects and safety issues of therapies for type 2 diabetes
-
J. Plutzky Macrovascular effects and safety issues of therapies for type 2 diabetes Am J Cardiol 108 2011 25B 32B
-
(2011)
Am J Cardiol
, vol.108
-
-
Plutzky, J.1
-
59
-
-
84877865378
-
Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion
-
D. Polidori, S. Sha, S. Mudaliar, T.P. Ciaraldi, A. Ghosh, and N. Vaccaro Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA) 2012
-
(2012)
American Diabetes Association, 72th Scientific Sessions. Philadelphia PA)
-
-
Polidori, D.1
Sha, S.2
Mudaliar, S.3
Ciaraldi, T.P.4
Ghosh, A.5
Vaccaro, N.6
-
60
-
-
84888039616
-
Treatment with canagliflozin (CANA), a Sodium Glucose Co-transporter 2 (SGLT2) inhibitor, for 26 weeks improves indices of beta-cell function (BCF)
-
D. Polidori, Y. Zhao, M. Alba, and E. Ferrannini Treatment with canagliflozin (CANA), a Sodium Glucose Co-transporter 2 (SGLT2) inhibitor, for 26 weeks improves indices of beta-cell function (BCF) American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA) 2012
-
(2012)
American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA)
-
-
Polidori, D.1
Zhao, Y.2
Alba, M.3
Ferrannini, E.4
-
61
-
-
33644688031
-
Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
-
H. Rahmoune, P.W. Thompson, J.M. Ward, C.D. Smith, G. Hong, and J. Brown Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes Diabetes 54 2005 3427 3434
-
(2005)
Diabetes
, vol.54
, pp. 3427-3434
-
-
Rahmoune, H.1
Thompson, P.W.2
Ward, J.M.3
Smith, C.D.4
Hong, G.5
Brown, J.6
-
62
-
-
84861781220
-
Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
-
J. Rosenstock, N. Aggarwal, D. Polidori, Y. Zhao, D. Arbit, and K. Usiskin Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes Diabetes Care 35 2012 1232 1238
-
(2012)
Diabetes Care
, vol.35
, pp. 1232-1238
-
-
Rosenstock, J.1
Aggarwal, N.2
Polidori, D.3
Zhao, Y.4
Arbit, D.5
Usiskin, K.6
-
63
-
-
84862875221
-
Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
-
J. Rosenstock, M. Vico, L. Wei, A. Salsali, and J.F. List Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy Diabetes Care 35 2012 1473 1478
-
(2012)
Diabetes Care
, vol.35
, pp. 1473-1478
-
-
Rosenstock, J.1
Vico, M.2
Wei, L.3
Salsali, A.4
List, J.F.5
-
65
-
-
0023571397
-
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
-
L. Rossetti, G.I. Shulman, W. Zawalich, and R.A. DeFronzo Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats J Clin Invest 80 1987 1037 1044
-
(1987)
J Clin Invest
, vol.80
, pp. 1037-1044
-
-
Rossetti, L.1
Shulman, G.I.2
Zawalich, W.3
Defronzo, R.A.4
-
66
-
-
0023275573
-
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
-
L. Rossetti, D. Smith, G.I. Shulman, D. Papachristou, and R.A. DeFronzo Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats J Clin Invest 79 1987 1510 1515
-
(1987)
J Clin Invest
, vol.79
, pp. 1510-1515
-
-
Rossetti, L.1
Smith, D.2
Shulman, G.I.3
Papachristou, D.4
Defronzo, R.A.5
-
67
-
-
10744229025
-
Molecular analysis of the SGLT2 gene in patients with renal glucosuria
-
R. Santer, M. Kinner, C.L. Lassen, R. Schneppenheim, P. Eggert, and M. Bald Molecular analysis of the SGLT2 gene in patients with renal glucosuria J Am Soc Nephrol 14 2003 2873 2882
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 2873-2882
-
-
Santer, R.1
Kinner, M.2
Lassen, C.L.3
Schneppenheim, R.4
Eggert, P.5
Bald, M.6
-
68
-
-
82455213037
-
Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus
-
S.L. Schwartz, B. Akinlade, S. Klasen, D. Kowalski, W. Zhang, and W. Wilpshaar Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus Diabetes Technol Ther 13 2011 1219 1227
-
(2011)
Diabetes Technol Ther
, vol.13
, pp. 1219-1227
-
-
Schwartz, S.L.1
Akinlade, B.2
Klasen, S.3
Kowalski, D.4
Zhang, W.5
Wilpshaar, W.6
-
69
-
-
84875137677
-
Luseogliflozin (TS-071), a selective SGLT2 inhibitor, improves glycemic control and lowers body weight in Japanese patients with type 2 diabetes mellitus
-
Y. Seino, T. Sasaki, A. Fukatsu, Y. Samukawa, S. Sakai, and T. Watanabe Luseogliflozin (TS-071), a selective SGLT2 inhibitor, improves glycemic control and lowers body weight in Japanese patients with type 2 diabetes mellitus American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA) 2012
-
(2012)
American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA)
-
-
Seino, Y.1
Sasaki, T.2
Fukatsu, A.3
Samukawa, Y.4
Sakai, S.5
Watanabe, T.6
-
70
-
-
79956331954
-
Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
-
S. Sha, D. Devineni, A. Ghosh, D. Polidori, S. Chien, and D. Wexler Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects Diabetes Obes Metab 13 2011 669 672
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 669-672
-
-
Sha, S.1
Devineni, D.2
Ghosh, A.3
Polidori, D.4
Chien, S.5
Wexler, D.6
-
71
-
-
77649144555
-
Pioglitazone: Side effect and safety profile
-
P. Shah, and S. Mudaliar Pioglitazone: Side effect and safety profile Expert Opin Drug Saf 9 2010 347 354
-
(2010)
Expert Opin Drug Saf
, vol.9
, pp. 347-354
-
-
Shah, P.1
Mudaliar, S.2
-
72
-
-
0014864211
-
Effect of phloridzin on uric acid excretion in man
-
M.D. Skeith, L.A. Healey, and R.E. Cutler Effect of phloridzin on uric acid excretion in man Am J Physiol 219 1970 1080 1082
-
(1970)
Am J Physiol
, vol.219
, pp. 1080-1082
-
-
Skeith, M.D.1
Healey, L.A.2
Cutler, R.E.3
-
73
-
-
79960847840
-
Nonalcoholic fatty liver disease and diabetes mellitus: Pathogenesis and treatment
-
B.W. Smith, and L.A. Adams Nonalcoholic fatty liver disease and diabetes mellitus: Pathogenesis and treatment Nat Rev Endocrinol 7 2011 456 465
-
(2011)
Nat Rev Endocrinol
, vol.7
, pp. 456-465
-
-
Smith, B.W.1
Adams, L.A.2
-
74
-
-
80052524011
-
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial
-
K. Strojek, K.H. Yoon, V. Hruba, M. Elze, A.M. Langkilde, and S. Parikh Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial Diabetes Obes Metab 13 2011 928 938
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 928-938
-
-
Strojek, K.1
Yoon, K.H.2
Hruba, V.3
Elze, M.4
Langkilde, A.M.5
Parikh, S.6
-
75
-
-
84861536065
-
Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice
-
M. Suzuki, K. Honda, M. Fukazawa, K. Ozawa, H. Hagita, and T. Kawai Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice J Pharmacol Exp Ther 341 2012 692 701
-
(2012)
J Pharmacol Exp Ther
, vol.341
, pp. 692-701
-
-
Suzuki, M.1
Honda, K.2
Fukazawa, M.3
Ozawa, K.4
Hagita, H.5
Kawai, T.6
-
76
-
-
84861544136
-
Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo
-
A. Tahara, E. Kurosaki, M. Yokono, D. Yamajuku, R. Kihara, and Y. Hayashizaki Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo Naunyn Schmiedebergs Arch Pharmacol 385 2012 423 436
-
(2012)
Naunyn Schmiedebergs Arch Pharmacol
, vol.385
, pp. 423-436
-
-
Tahara, A.1
Kurosaki, E.2
Yokono, M.3
Yamajuku, D.4
Kihara, R.5
Hayashizaki, Y.6
-
77
-
-
84891560076
-
Luseogliflozin (TS-071), a novel, potent and selective SGLT2 inhibitor, prevents diabetic retinopathy in rats
-
T. Takahashi, M. Onishi, H. Yamashita, E. Gunji, T. Takeda, and H. Tomoike Luseogliflozin (TS-071), a novel, potent and selective SGLT2 inhibitor, prevents diabetic retinopathy in rats American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA) 2012
-
(2012)
American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA)
-
-
Takahashi, T.1
Onishi, M.2
Yamashita, H.3
Gunji, E.4
Takeda, T.5
Tomoike, H.6
-
78
-
-
84891556971
-
Ipragliflozin, a novel SGLT2-selective inhibitor, improves glycemic control and reduces body fat in the diabetic Goto-Kakizaki (GK) rats
-
T. Takasu, Y. Hayashizaki, J. Hirosumi, H. Minoura, N. Amino, and E. Kurosaki Ipragliflozin, a novel SGLT2-selective inhibitor, improves glycemic control and reduces body fat in the diabetic Goto-Kakizaki (GK) rats American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA) 2012
-
(2012)
American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA)
-
-
Takasu, T.1
Hayashizaki, Y.2
Hirosumi, J.3
Minoura, H.4
Amino, N.5
Kurosaki, E.6
-
79
-
-
84891556137
-
ASP1941, a novel SGLT2-selective inhibitor, exerts anti-obesity effects by increasing fatty acid oxidation in diet-induced obesity rats
-
T. Takasu, Y. Hayashizaki, K. Mitsuoka, M. Yokono, R. Kihara, and S. Miyoshi ASP1941, a novel SGLT2-selective inhibitor, exerts anti-obesity effects by increasing fatty acid oxidation in diet-induced obesity rats American Diabetes Association, 71th Scientific Sessions. San Diego (CA) 2011
-
(2011)
American Diabetes Association, 71th Scientific Sessions. San Diego (CA)
-
-
Takasu, T.1
Hayashizaki, Y.2
Mitsuoka, K.3
Yokono, M.4
Kihara, R.5
Miyoshi, S.6
-
80
-
-
84891557786
-
ASP1941, a novel, potent and selective SGLT2 inhibitor, improves hemoglobin A1c and symptoms of diabetes in animal models
-
T. Takasu, A. Tahara, M. Yokono, Y. Hayashizaki, E. Kurosaki, and M. Imamura ASP1941, a novel, potent and selective SGLT2 inhibitor, improves hemoglobin A1c and symptoms of diabetes in animal models American Diabetes Association, 70th Scientific Sessions. Orlando (FL) 2010
-
(2010)
American Diabetes Association, 70th Scientific Sessions. Orlando (FL)
-
-
Takasu, T.1
Tahara, A.2
Yokono, M.3
Hayashizaki, Y.4
Kurosaki, E.5
Imamura, M.6
-
81
-
-
83655167071
-
Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats
-
L. Thomas, R. Grempler, M. Eckhardt, F. Himmelsbach, A. Sauer, and T. Klein Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats Diabetes Obes Metab 14 2012 94 96
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 94-96
-
-
Thomas, L.1
Grempler, R.2
Eckhardt, M.3
Himmelsbach, F.4
Sauer, A.5
Klein, T.6
-
82
-
-
84255185190
-
Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat
-
S.C. Thomson, T. Rieg, C. Miracle, H. Mansoury, J. Whaley, and V. Vallon Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat Am J Physiol Regul Integr Comp Physiol 302 2012 R75 R83
-
(2012)
Am J Physiol Regul Integr Comp Physiol
, vol.302
-
-
Thomson, S.C.1
Rieg, T.2
Miracle, C.3
Mansoury, H.4
Whaley, J.5
Vallon, V.6
-
83
-
-
84891556622
-
Systematic review and meta-analysis of the efficacy and safety of SGLT2 inhibitors in patients with type 2 diabetes mellitus
-
A. Tsapas, D. Vassilakou, E. Athanasiadou, and T. Karagiannis Systematic review and meta-analysis of the efficacy and safety of SGLT2 inhibitors in patients with type 2 diabetes mellitus The European Association for the Study of Diabetes, 48th Annual Meeting. Berlin, Germany 2012
-
(2012)
The European Association for the Study of Diabetes, 48th Annual Meeting. t Berlin, Germany
-
-
Tsapas, A.1
Vassilakou, D.2
Athanasiadou, E.3
Karagiannis, T.4
-
84
-
-
15544383811
-
+-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki rats
-
+-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki rats Life Sci 76 2005 2655 2668
-
(2005)
Life Sci
, vol.76
, pp. 2655-2668
-
-
Ueta, K.1
Ishihara, T.2
Matsumoto, Y.3
Oku, A.4
Nawano, M.5
Fujita, T.6
-
85
-
-
78651406659
-
SGLT2 mediates glucose reabsorption in the early proximal tubule
-
V. Vallon, K.A. Platt, R. Cunard, J. Schroth, J. Whaley, and S.C. Thomson SGLT2 mediates glucose reabsorption in the early proximal tubule J Am Soc Nephrol 22 2011 104 112
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 104-112
-
-
Vallon, V.1
Platt, K.A.2
Cunard, R.3
Schroth, J.4
Whaley, J.5
Thomson, S.C.6
-
86
-
-
84857248030
-
Renal function in diabetic disease models: The tubular system in the pathophysiology of the diabetic kidney
-
V. Vallon, and S.C. Thomson Renal function in diabetic disease models: The tubular system in the pathophysiology of the diabetic kidney Annu Rev Physiol 74 2012 351 375
-
(2012)
Annu Rev Physiol
, vol.74
, pp. 351-375
-
-
Vallon, V.1
Thomson, S.C.2
-
87
-
-
77952907032
-
The global burden of diabetes and its complications: An emerging pandemic
-
S. van Dieren, J.W. Beulens, Y.T. van der Schouw, D.E. Grobbee, and B. Neal The global burden of diabetes and its complications: An emerging pandemic Eur J Cardiovasc Prev Rehabil 17 Suppl. 1 2010 S3 S8
-
(2010)
Eur J Cardiovasc Prev Rehabil
, vol.17
, Issue.SUPPL. 1
-
-
Van Dieren, S.1
Beulens, J.W.2
Van Der Schouw, Y.T.3
Grobbee, D.E.4
Neal, B.5
-
88
-
-
80155181454
-
Effect of Ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects
-
S.A. Veltkamp, T. Kadokura, W.J. Krauwinkel, and R.A. Smulders Effect of Ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects Clin Drug Investig 31 2011 839 851
-
(2011)
Clin Drug Investig
, vol.31
, pp. 839-851
-
-
Veltkamp, S.A.1
Kadokura, T.2
Krauwinkel, W.J.3
Smulders, R.A.4
-
89
-
-
74949093195
-
Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents
-
W.N. Washburn Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents Expert Opin Ther Pat 19 2009 1485 1499
-
(2009)
Expert Opin Ther Pat
, vol.19
, pp. 1485-1499
-
-
Washburn, W.N.1
-
90
-
-
84876344111
-
Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: A dose-finding study
-
10.1111/dom.12038
-
J.P. Wilding, E. Ferrannini, V.A. Fonseca, W. Wilpshaar, P. Dhanjal, and A. Houzer Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: A dose-finding study Diabetes Obes Metab 2012 10.1111/dom.12038
-
(2012)
Diabetes Obes Metab
-
-
Wilding, J.P.1
Ferrannini, E.2
Fonseca, V.A.3
Wilpshaar, W.4
Dhanjal, P.5
Houzer, A.6
-
91
-
-
84875204252
-
Safety and efficacy of empagliflozin as monotherapy or add-on to metformin in a 78-week open-label extension study in patients with type 2 diabetes
-
H.J. Woerle, E. Ferrannini, A. Berk, M. Manun'ebo, S. Pinnetti, and U.C. Broedl Safety and efficacy of empagliflozin as monotherapy or add-on to metformin in a 78-week open-label extension study in patients with type 2 diabetes American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA) 2012
-
(2012)
American Diabetes Association, 72th Scientific Sessions. Philadelphia (PA)
-
-
Woerle, H.J.1
Ferrannini, E.2
Berk, A.3
Manun'Ebo, M.4
Pinnetti, S.5
Broedl, U.C.6
-
93
-
-
78651349221
-
Biology of human sodium glucose transporters
-
E.M. Wright, D.D. Loo, and B.A. Hirayama Biology of human sodium glucose transporters Physiol Rev 91 2011 733 794
-
(2011)
Physiol Rev
, vol.91
, pp. 733-794
-
-
Wright, E.M.1
Loo, D.D.2
Hirayama, B.A.3
-
94
-
-
0036368517
-
Molecular basis for glucose-galactose malabsorption
-
E.M. Wright, E. Turk, and M.G. Martin Molecular basis for glucose-galactose malabsorption Cell Biochem Biophys 36 2002 115 121
-
(2002)
Cell Biochem Biophys
, vol.36
, pp. 115-121
-
-
Wright, E.M.1
Turk, E.2
Martin, M.G.3
-
95
-
-
79961228970
-
TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity
-
K. Yamamoto, S. Uchida, K. Kitano, N. Fukuhara, L. Okumura-Kitajima, and E. Gunji TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity Br J Pharmacol 164 2011 181 191
-
(2011)
Br J Pharmacol
, vol.164
, pp. 181-191
-
-
Yamamoto, K.1
Uchida, S.2
Kitano, K.3
Fukuhara, N.4
Okumura-Kitajima, L.5
Gunji, E.6
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