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Volumn 139, Issue 1, 2013, Pages 51-59

Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: Preclinical and clinical data

Author keywords

Glucosuria; Kidney; oral hypoglycemic agents; SGLT2 inhibitor; Sodium glucose cotransporter 2; Type 2 diabetes mellitus

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; HEMOGLOBIN A1C; IPRAGLIFLOZIN; LUSEOGLIFLOZIN; SODIUM GLUCOSE COTRANSPORTER 2; TOFOGLIFLOZIN;

EID: 84877922239     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.04.003     Document Type: Review
Times cited : (124)

References (95)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • P. Angulo Nonalcoholic fatty liver disease N Engl J Med 346 2002 1221 1231
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • C.J. Bailey, J.L. Gross, A. Pieters, A. Bastien, and J.F. List Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial Lancet 375 2010 2223 2233
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 3
    • 84858020943 scopus 로고    scopus 로고
    • Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    • J. Bolinder, O. Ljunggren, J. Kullberg, L. Johansson, J. Wilding, and A.M. Langkilde Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin J Clin Endocrinol Metab 97 2012 1020 1031
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1020-1031
    • Bolinder, J.1    Ljunggren, O.2    Kullberg, J.3    Johansson, L.4    Wilding, J.5    Langkilde, A.M.6
  • 4
    • 84877920040 scopus 로고    scopus 로고
    • Bristol-Myers Squibb, and AstraZeneca. Endocrinologic and Metabolic Drugs Advisory Committee, U.S. Food and Drug Administration
    • Bristol-Myers Squibb, and AstraZeneca Background document; dapagliflozin Endocrinologic and Metabolic Drugs Advisory Committee, U.S. Food and Drug Administration 2011
    • (2011) Background document; Dapagliflozin
  • 5
    • 79952721660 scopus 로고    scopus 로고
    • Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members
    • J. Chen, S. Williams, S. Ho, H. Loraine, D. Hagan, and J.M. Whaley Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members Diabetes Ther 1 2010 57 92
    • (2010) Diabetes Ther , vol.1 , pp. 57-92
    • Chen, J.1    Williams, S.2    Ho, S.3    Loraine, H.4    Hagan, D.5    Whaley, J.M.6
  • 6
    • 84864371186 scopus 로고    scopus 로고
    • Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats
    • J.J. Devenny, H.E. Godonis, S.J. Harvey, S. Rooney, M.J. Cullen, and M.A. Pelleymounter Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats Obesity (Silver Spring) 20 2012 1645 1652
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 1645-1652
    • Devenny, J.J.1    Godonis, H.E.2    Harvey, S.J.3    Rooney, S.4    Cullen, M.J.5    Pelleymounter, M.A.6
  • 8
    • 84877924519 scopus 로고    scopus 로고
    • European Medicines Agency Procedure no.: EMEA/H/C/002322 2012
    • European Medicines Agency Assessment report Forxiga. Dapagliflozin. Procedure no.: EMEA/H/C/002322 2012
    • (2012) Assessment Report Forxiga. Dapagliflozin
  • 9
    • 64749094872 scopus 로고
    • Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose
    • S.J. Farber, E.Y. Berger, and D.P. Earle Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose J Clin Invest 30 1951 125 129
    • (1951) J Clin Invest , vol.30 , pp. 125-129
    • Farber, S.J.1    Berger, E.Y.2    Earle, D.P.3
  • 10
    • 84876803427 scopus 로고    scopus 로고
    • Renal glucose handling: Impact of chronic kidney disease and SGLT2 inhibition in patients with type 2 diabetes mellitus
    • 10.2337/dc12-1503
    • E. Ferrannini, S.A. Veltkamp, R.A. Smulders, and T. Kadokura Renal glucose handling: Impact of chronic kidney disease and SGLT2 inhibition in patients with type 2 diabetes mellitus Diabetes Care 2013 10.2337/dc12-1503
    • (2013) Diabetes Care
    • Ferrannini, E.1    Veltkamp, S.A.2    Smulders, R.A.3    Kadokura, T.4
  • 11
    • 84876899238 scopus 로고    scopus 로고
    • Active- and placebo-controlled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus
    • 10.1016/j.jdiacomp.2012.11.005
    • V. Fonseca, E. Ferrannini, J. Wilding, W. Wilpshaar, P. Dhanjal, and G. Ball Active- and placebo-controlled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus J Diabetes Complications 2012 10.1016/j.jdiacomp.2012. 11.005
    • (2012) J Diabetes Complications
    • Fonseca, V.1    Ferrannini, E.2    Wilding, J.3    Wilpshaar, W.4    Dhanjal, P.5    Ball, G.6
  • 12
    • 84877919808 scopus 로고    scopus 로고
    • FDA briefing document NDA 202293
    • Food and Drug Adminstration
    • Food and Drug Adminstration FDA briefing document NDA 202293 Dapagliflozin tablets 5 and 10 mg 2011
    • (2011) Dapagliflozin Tablets 5 and 10 Mg
  • 13
    • 52649083832 scopus 로고    scopus 로고
    • Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
    • Y. Fujimori, K. Katsuno, I. Nakashima, Y. Ishikawa-Takemura, H. Fujikura, and M. Isaji Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models J Pharmacol Exp Ther 327 2008 268 276
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 268-276
    • Fujimori, Y.1    Katsuno, K.2    Nakashima, I.3    Ishikawa-Takemura, Y.4    Fujikura, H.5    Isaji, M.6
  • 14
    • 73349138902 scopus 로고    scopus 로고
    • Future perspectives for insulinotropic agents in the treatment of type 2 diabetes-DPP-4 inhibitors and sulphonylureas
    • B. Gallwitz, and H.U. Haering Future perspectives for insulinotropic agents in the treatment of type 2 diabetes-DPP-4 inhibitors and sulphonylureas Diabetes Obes Metab 12 2010 1 11
    • (2010) Diabetes Obes Metab , vol.12 , pp. 1-11
    • Gallwitz, B.1    Haering, H.U.2
  • 15
    • 33749821010 scopus 로고    scopus 로고
    • Diabetic microvascular complications: Can patients at risk be identified? A review
    • A. Girach, D. Manner, and M. Porta Diabetic microvascular complications: Can patients at risk be identified? A review Int J Clin Pract 60 2006 1471 1483
    • (2006) Int J Clin Pract , vol.60 , pp. 1471-1483
    • Girach, A.1    Manner, D.2    Porta, M.3
  • 17
    • 83655184724 scopus 로고    scopus 로고
    • Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: Characterisation and comparison with other SGLT-2 inhibitors
    • R. Grempler, L. Thomas, M. Eckhardt, F. Himmelsbach, A. Sauer, and D.E. Sharp Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: Characterisation and comparison with other SGLT-2 inhibitors Diabetes Obes Metab 14 2012 83 90
    • (2012) Diabetes Obes Metab , vol.14 , pp. 83-90
    • Grempler, R.1    Thomas, L.2    Eckhardt, M.3    Himmelsbach, F.4    Sauer, A.5    Sharp, D.E.6
  • 18
    • 48249146624 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
    • S. Han, D.L. Hagan, J.R. Taylor, L. Xin, W. Meng, and S.A. Biller Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats Diabetes 57 2008 1723 1729
    • (2008) Diabetes , vol.57 , pp. 1723-1729
    • Han, S.1    Hagan, D.L.2    Taylor, J.R.3    Xin, L.4    Meng, W.5    Biller, S.A.6
  • 19
    • 78650686769 scopus 로고    scopus 로고
    • Serum uric acid as a new player in the development of diabetic nephropathy
    • P. Hovind, P. Rossing, R.J. Johnson, and H.H. Parving Serum uric acid as a new player in the development of diabetic nephropathy J Ren Nutr 21 2011 124 127
    • (2011) J Ren Nutr , vol.21 , pp. 124-127
    • Hovind, P.1    Rossing, P.2    Johnson, R.J.3    Parving, H.H.4
  • 20
    • 84860492610 scopus 로고    scopus 로고
    • Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus
    • M. Imamura, K. Nakanishi, T. Suzuki, K. Ikegai, R. Shiraki, and T. Ogiyama Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus Bioorg Med Chem 20 2012 3263 3279
    • (2012) Bioorg Med Chem , vol.20 , pp. 3263-3279
    • Imamura, M.1    Nakanishi, K.2    Suzuki, T.3    Ikegai, K.4    Shiraki, R.5    Ogiyama, T.6
  • 21
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • S.E. Inzucchi, R.M. Bergenstal, J.B. Buse, M. Diamant, E. Ferrannini, and M. Nauck Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetes Care 35 2012 1364 1379
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6
  • 22
    • 79958255267 scopus 로고    scopus 로고
    • SGLT2 inhibitors: Molecular design and potential differences in effect
    • M. Isaji SGLT2 inhibitors: Molecular design and potential differences in effect Kidney Int Suppl 2011 S14 S19
    • (2011) Kidney Int Suppl
    • Isaji, M.1
  • 24
    • 80052189619 scopus 로고    scopus 로고
    • Diabetes field cautiously upbeat despite possible setback for leading SGLT2 inhibitor
    • D. Jones Diabetes field cautiously upbeat despite possible setback for leading SGLT2 inhibitor Nat Rev Drug Discov 10 2011 645 646
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 645-646
    • Jones, D.1
  • 25
    • 84864615705 scopus 로고    scopus 로고
    • Ipragliflozin (ASP1941), a selective sodium-dependent glucose cotransporter 2 inhibitor, safely stimulates urinary glucose excretion without inducing hypoglycemia in healthy Japanese subjects
    • T. Kadokura, M. Saito, A. Utsuno, K. Kazuta, S. Yoshida, and S. Kawasaki Ipragliflozin (ASP1941), a selective sodium-dependent glucose cotransporter 2 inhibitor, safely stimulates urinary glucose excretion without inducing hypoglycemia in healthy Japanese subjects Diabetol Int 2 2011 172 182
    • (2011) Diabetol Int , vol.2 , pp. 172-182
    • Kadokura, T.1    Saito, M.2    Utsuno, A.3    Kazuta, K.4    Yoshida, S.5    Kawasaki, S.6
  • 27
    • 0026033325 scopus 로고
    • Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression
    • B.B. Kahn, G.I. Shulman, R.A. DeFronzo, S.W. Cushman, and L. Rossetti Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression J Clin Invest 87 1991 561 570
    • (1991) J Clin Invest , vol.87 , pp. 561-570
    • Kahn, B.B.1    Shulman, G.I.2    Defronzo, R.A.3    Cushman, S.W.4    Rossetti, L.5
  • 28
    • 77951143723 scopus 로고    scopus 로고
    • (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl] -1-thio-d-glucito l (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment
    • H. Kakinuma, T. Oi, Y. Hashimoto-Tsuchiya, M. Arai, Y. Kawakita, and Y. Fukasawa (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1- thio-d-glucito l (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment J Med Chem 53 2010 3247 3261
    • (2010) J Med Chem , vol.53 , pp. 3247-3261
    • Kakinuma, H.1    Oi, T.2    Hashimoto-Tsuchiya, Y.3    Arai, M.4    Kawakita, Y.5    Fukasawa, Y.6
  • 29
    • 0028044629 scopus 로고
    • The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose
    • Y. Kanai, W.S. Lee, G. You, D. Brown, and M.A. Hediger The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose J Clin Invest 93 1994 397 404
    • (1994) J Clin Invest , vol.93 , pp. 397-404
    • Kanai, Y.1    Lee, W.S.2    You, G.3    Brown, D.4    Hediger, M.A.5
  • 33
    • 33845873376 scopus 로고    scopus 로고
    • Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level
    • K. Katsuno, Y. Fujimori, Y. Takemura, M. Hiratochi, F. Itoh, and Y. Komatsu Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level J Pharmacol Exp Ther 320 2007 323 330
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 323-330
    • Katsuno, K.1    Fujimori, Y.2    Takemura, Y.3    Hiratochi, M.4    Itoh, F.5    Komatsu, Y.6
  • 34
    • 79955635827 scopus 로고    scopus 로고
    • SGLT inhibitors as new therapeutic tools in the treatment of diabetes
    • R.K. Kinne, and F. Castaneda SGLT inhibitors as new therapeutic tools in the treatment of diabetes Handb Exp Pharmacol 105-126 2011
    • (2011) Handb Exp Pharmacol , vol.105-126
    • Kinne, R.K.1    Castaneda, F.2
  • 35
    • 0018486448 scopus 로고
    • Effects of intraluminal d-glucose and probenecid on urate absorption in the rat proximal tubule
    • T.F. Knight, H.O. Senekjian, S. Sansom, and E.J. Weinman Effects of intraluminal d-glucose and probenecid on urate absorption in the rat proximal tubule Am J Physiol 236 1979 F526 F529
    • (1979) Am J Physiol , vol.236
    • Knight, T.F.1    Senekjian, H.O.2    Sansom, S.3    Weinman, E.J.4
  • 37
    • 67349275999 scopus 로고    scopus 로고
    • Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
    • B. Komoroski, N. Vachharajani, Y. Feng, L. Li, D. Kornhauser, and M. Pfister Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus Clin Pharmacol Ther 85 2009 513 519
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 513-519
    • Komoroski, B.1    Vachharajani, N.2    Feng, Y.3    Li, L.4    Kornhauser, D.5    Pfister, M.6
  • 40
    • 0028234548 scopus 로고
    • +/glucose cotransporter. Re-evaluation of function and distribution of expression
    • +/glucose cotransporter. Re-evaluation of function and distribution of expression J Biol Chem 269 1994 12032 12039
    • (1994) J Biol Chem , vol.269 , pp. 12032-12039
    • Lee, W.S.1    Kanai, Y.2    Wells, R.G.3    Hediger, M.A.4
  • 41
    • 35348891586 scopus 로고    scopus 로고
    • Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells
    • Y.J. Lee, Y.J. Lee, and H.J. Han Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells Kidney Int Suppl S27-35 2007
    • (2007) Kidney Int Suppl
    • Lee, Y.J.1    Lee, Y.J.2    Han, H.J.3
  • 42
    • 84857099986 scopus 로고    scopus 로고
    • Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • Y. Liang, K. Arakawa, K. Ueta, Y. Matsushita, C. Kuriyama, and T. Martin Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models PLoS One 7 2012 e30555
    • (2012) PLoS One , vol.7 , pp. 30555
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3    Matsushita, Y.4    Kuriyama, C.5    Martin, T.6
  • 43
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • J.F. List, V. Woo, E. Morales, W. Tang, and F.T. Fiedorek Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes Diabetes Care 32 2009 650 657
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.T.5
  • 44
    • 84865479822 scopus 로고    scopus 로고
    • Why do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?
    • J.J. Liu, T. Lee, and R.A. DeFronzo Why do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans? Diabetes 61 2012 2199 2204
    • (2012) Diabetes , vol.61 , pp. 2199-2204
    • Liu, J.J.1    Lee, T.2    Defronzo, R.A.3
  • 45
    • 84861886161 scopus 로고    scopus 로고
    • Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin- induced diabetic rats, a model of type 1 diabetes mellitus
    • G. Luippold, T. Klein, M. Mark, and R. Grempler Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats, a model of type 1 diabetes mellitus Diabetes Obes Metab 14 2012 601 607
    • (2012) Diabetes Obes Metab , vol.14 , pp. 601-607
    • Luippold, G.1    Klein, T.2    Mark, M.3    Grempler, R.4
  • 46
    • 77957254503 scopus 로고    scopus 로고
    • The novel sodium glucose transporter 2 inhibitor dapagliflozin sustains pancreatic function and preserves islet morphology in obese, diabetic rats
    • F.R. Macdonald, J.E. Peel, H.B. Jones, R.M. Mayers, L. Westgate, and J.M. Whaley The novel sodium glucose transporter 2 inhibitor dapagliflozin sustains pancreatic function and preserves islet morphology in obese, diabetic rats Diabetes Obes Metab 12 2010 1004 1012
    • (2010) Diabetes Obes Metab , vol.12 , pp. 1004-1012
    • MacDonald, F.R.1    Peel, J.E.2    Jones, H.B.3    Mayers, R.M.4    Westgate, L.5    Whaley, J.M.6
  • 47
    • 41649087328 scopus 로고    scopus 로고
    • Discovery of dapagliflozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes
    • W. Meng, B.A. Ellsworth, A.A. Nirschl, P.J. McCann, M. Patel, and R.N. Girotra Discovery of dapagliflozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes J Med Chem 51 2008 1145 1149
    • (2008) J Med Chem , vol.51 , pp. 1145-1149
    • Meng, W.1    Ellsworth, B.A.2    Nirschl, A.A.3    McCann, P.J.4    Patel, M.5    Girotra, R.N.6
  • 48
    • 84860391886 scopus 로고    scopus 로고
    • Kidney: Its impact on glucose homeostasis and hormonal regulation
    • A. Mitrakou Kidney: Its impact on glucose homeostasis and hormonal regulation Diabetes Res Clin Pract 93 Suppl. 1 2011 S66 S72
    • (2011) Diabetes Res Clin Pract , vol.93 , Issue.SUPPL. 1
    • Mitrakou, A.1
  • 49
    • 0015122757 scopus 로고
    • Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects
    • C.E. Mogensen Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects Scand J Clin Lab Invest 28 1971 101 109
    • (1971) Scand J Clin Lab Invest , vol.28 , pp. 101-109
    • Mogensen, C.E.1
  • 50
    • 84868095962 scopus 로고    scopus 로고
    • Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2, improves serum glucose profiles in type 1 diabetes
    • S. Mudaliar, D.A. Armstrong, A.A. Mavian, R. O'Connor-Semmes, P.K. Mydlow, and J. Ye Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2, improves serum glucose profiles in type 1 diabetes Diabetes Care 35 2012 2198 2200
    • (2012) Diabetes Care , vol.35 , pp. 2198-2200
    • Mudaliar, S.1    Armstrong, D.A.2    Mavian, A.A.3    O'Connor-Semmes, R.4    Mydlow, P.K.5    Ye, J.6
  • 52
    • 77956319973 scopus 로고    scopus 로고
    • Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus
    • S. Nomura, S. Sakamaki, M. Hongu, E. Kawanishi, Y. Koga, and T. Sakamoto Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus J Med Chem 53 2010 6355 6360
    • (2010) J Med Chem , vol.53 , pp. 6355-6360
    • Nomura, S.1    Sakamaki, S.2    Hongu, M.3    Kawanishi, E.4    Koga, Y.5    Sakamoto, T.6
  • 53
    • 84866336965 scopus 로고    scopus 로고
    • Discovery of tofogliflozin, a novel C-Arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes
    • Y. Ohtake, T. Sato, T. Kobayashi, M. Nishimoto, N. Taka, and K. Takano Discovery of tofogliflozin, a novel C-Arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes J Med Chem 55 2012 7828 7840
    • (2012) J Med Chem , vol.55 , pp. 7828-7840
    • Ohtake, Y.1    Sato, T.2    Kobayashi, T.3    Nishimoto, M.4    Taka, N.5    Takano, K.6
  • 55
    • 39149145482 scopus 로고    scopus 로고
    • Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004
    • K.L. Ong, B.M. Cheung, L.Y. Wong, N.M. Wat, K.C. Tan, and K.S. Lam Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004 Ann Epidemiol 18 2008 222 229
    • (2008) Ann Epidemiol , vol.18 , pp. 222-229
    • Ong, K.L.1    Cheung, B.M.2    Wong, L.Y.3    Wat, N.M.4    Tan, K.C.5    Lam, K.S.6
  • 56
    • 33847016066 scopus 로고    scopus 로고
    • Human obesity and insulin resistance: Lessons from experiments of nature
    • S. O'Rahilly Human obesity and insulin resistance: Lessons from experiments of nature Biochem Soc Trans 35 2007 33 36
    • (2007) Biochem Soc Trans , vol.35 , pp. 33-36
    • O'Rahilly, S.1
  • 58
    • 79960995107 scopus 로고    scopus 로고
    • Macrovascular effects and safety issues of therapies for type 2 diabetes
    • J. Plutzky Macrovascular effects and safety issues of therapies for type 2 diabetes Am J Cardiol 108 2011 25B 32B
    • (2011) Am J Cardiol , vol.108
    • Plutzky, J.1
  • 61
    • 33644688031 scopus 로고    scopus 로고
    • Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
    • H. Rahmoune, P.W. Thompson, J.M. Ward, C.D. Smith, G. Hong, and J. Brown Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes Diabetes 54 2005 3427 3434
    • (2005) Diabetes , vol.54 , pp. 3427-3434
    • Rahmoune, H.1    Thompson, P.W.2    Ward, J.M.3    Smith, C.D.4    Hong, G.5    Brown, J.6
  • 62
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    • J. Rosenstock, N. Aggarwal, D. Polidori, Y. Zhao, D. Arbit, and K. Usiskin Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes Diabetes Care 35 2012 1232 1238
    • (2012) Diabetes Care , vol.35 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3    Zhao, Y.4    Arbit, D.5    Usiskin, K.6
  • 63
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • J. Rosenstock, M. Vico, L. Wei, A. Salsali, and J.F. List Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy Diabetes Care 35 2012 1473 1478
    • (2012) Diabetes Care , vol.35 , pp. 1473-1478
    • Rosenstock, J.1    Vico, M.2    Wei, L.3    Salsali, A.4    List, J.F.5
  • 65
    • 0023571397 scopus 로고
    • Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
    • L. Rossetti, G.I. Shulman, W. Zawalich, and R.A. DeFronzo Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats J Clin Invest 80 1987 1037 1044
    • (1987) J Clin Invest , vol.80 , pp. 1037-1044
    • Rossetti, L.1    Shulman, G.I.2    Zawalich, W.3    Defronzo, R.A.4
  • 66
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
    • L. Rossetti, D. Smith, G.I. Shulman, D. Papachristou, and R.A. DeFronzo Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats J Clin Invest 79 1987 1510 1515
    • (1987) J Clin Invest , vol.79 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.I.3    Papachristou, D.4    Defronzo, R.A.5
  • 68
    • 82455213037 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus
    • S.L. Schwartz, B. Akinlade, S. Klasen, D. Kowalski, W. Zhang, and W. Wilpshaar Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus Diabetes Technol Ther 13 2011 1219 1227
    • (2011) Diabetes Technol Ther , vol.13 , pp. 1219-1227
    • Schwartz, S.L.1    Akinlade, B.2    Klasen, S.3    Kowalski, D.4    Zhang, W.5    Wilpshaar, W.6
  • 70
    • 79956331954 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    • S. Sha, D. Devineni, A. Ghosh, D. Polidori, S. Chien, and D. Wexler Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects Diabetes Obes Metab 13 2011 669 672
    • (2011) Diabetes Obes Metab , vol.13 , pp. 669-672
    • Sha, S.1    Devineni, D.2    Ghosh, A.3    Polidori, D.4    Chien, S.5    Wexler, D.6
  • 71
    • 77649144555 scopus 로고    scopus 로고
    • Pioglitazone: Side effect and safety profile
    • P. Shah, and S. Mudaliar Pioglitazone: Side effect and safety profile Expert Opin Drug Saf 9 2010 347 354
    • (2010) Expert Opin Drug Saf , vol.9 , pp. 347-354
    • Shah, P.1    Mudaliar, S.2
  • 72
    • 0014864211 scopus 로고
    • Effect of phloridzin on uric acid excretion in man
    • M.D. Skeith, L.A. Healey, and R.E. Cutler Effect of phloridzin on uric acid excretion in man Am J Physiol 219 1970 1080 1082
    • (1970) Am J Physiol , vol.219 , pp. 1080-1082
    • Skeith, M.D.1    Healey, L.A.2    Cutler, R.E.3
  • 73
    • 79960847840 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and diabetes mellitus: Pathogenesis and treatment
    • B.W. Smith, and L.A. Adams Nonalcoholic fatty liver disease and diabetes mellitus: Pathogenesis and treatment Nat Rev Endocrinol 7 2011 456 465
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 456-465
    • Smith, B.W.1    Adams, L.A.2
  • 74
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial
    • K. Strojek, K.H. Yoon, V. Hruba, M. Elze, A.M. Langkilde, and S. Parikh Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial Diabetes Obes Metab 13 2011 928 938
    • (2011) Diabetes Obes Metab , vol.13 , pp. 928-938
    • Strojek, K.1    Yoon, K.H.2    Hruba, V.3    Elze, M.4    Langkilde, A.M.5    Parikh, S.6
  • 75
    • 84861536065 scopus 로고    scopus 로고
    • Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice
    • M. Suzuki, K. Honda, M. Fukazawa, K. Ozawa, H. Hagita, and T. Kawai Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice J Pharmacol Exp Ther 341 2012 692 701
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 692-701
    • Suzuki, M.1    Honda, K.2    Fukazawa, M.3    Ozawa, K.4    Hagita, H.5    Kawai, T.6
  • 81
    • 83655167071 scopus 로고    scopus 로고
    • Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats
    • L. Thomas, R. Grempler, M. Eckhardt, F. Himmelsbach, A. Sauer, and T. Klein Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats Diabetes Obes Metab 14 2012 94 96
    • (2012) Diabetes Obes Metab , vol.14 , pp. 94-96
    • Thomas, L.1    Grempler, R.2    Eckhardt, M.3    Himmelsbach, F.4    Sauer, A.5    Klein, T.6
  • 84
    • 15544383811 scopus 로고    scopus 로고
    • +-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki rats
    • +-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki rats Life Sci 76 2005 2655 2668
    • (2005) Life Sci , vol.76 , pp. 2655-2668
    • Ueta, K.1    Ishihara, T.2    Matsumoto, Y.3    Oku, A.4    Nawano, M.5    Fujita, T.6
  • 86
    • 84857248030 scopus 로고    scopus 로고
    • Renal function in diabetic disease models: The tubular system in the pathophysiology of the diabetic kidney
    • V. Vallon, and S.C. Thomson Renal function in diabetic disease models: The tubular system in the pathophysiology of the diabetic kidney Annu Rev Physiol 74 2012 351 375
    • (2012) Annu Rev Physiol , vol.74 , pp. 351-375
    • Vallon, V.1    Thomson, S.C.2
  • 88
    • 80155181454 scopus 로고    scopus 로고
    • Effect of Ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects
    • S.A. Veltkamp, T. Kadokura, W.J. Krauwinkel, and R.A. Smulders Effect of Ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects Clin Drug Investig 31 2011 839 851
    • (2011) Clin Drug Investig , vol.31 , pp. 839-851
    • Veltkamp, S.A.1    Kadokura, T.2    Krauwinkel, W.J.3    Smulders, R.A.4
  • 89
    • 74949093195 scopus 로고    scopus 로고
    • Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents
    • W.N. Washburn Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents Expert Opin Ther Pat 19 2009 1485 1499
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 1485-1499
    • Washburn, W.N.1
  • 90
    • 84876344111 scopus 로고    scopus 로고
    • Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: A dose-finding study
    • 10.1111/dom.12038
    • J.P. Wilding, E. Ferrannini, V.A. Fonseca, W. Wilpshaar, P. Dhanjal, and A. Houzer Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: A dose-finding study Diabetes Obes Metab 2012 10.1111/dom.12038
    • (2012) Diabetes Obes Metab
    • Wilding, J.P.1    Ferrannini, E.2    Fonseca, V.A.3    Wilpshaar, W.4    Dhanjal, P.5    Houzer, A.6
  • 92
  • 93
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • E.M. Wright, D.D. Loo, and B.A. Hirayama Biology of human sodium glucose transporters Physiol Rev 91 2011 733 794
    • (2011) Physiol Rev , vol.91 , pp. 733-794
    • Wright, E.M.1    Loo, D.D.2    Hirayama, B.A.3
  • 94
    • 0036368517 scopus 로고    scopus 로고
    • Molecular basis for glucose-galactose malabsorption
    • E.M. Wright, E. Turk, and M.G. Martin Molecular basis for glucose-galactose malabsorption Cell Biochem Biophys 36 2002 115 121
    • (2002) Cell Biochem Biophys , vol.36 , pp. 115-121
    • Wright, E.M.1    Turk, E.2    Martin, M.G.3
  • 95
    • 79961228970 scopus 로고    scopus 로고
    • TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity
    • K. Yamamoto, S. Uchida, K. Kitano, N. Fukuhara, L. Okumura-Kitajima, and E. Gunji TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity Br J Pharmacol 164 2011 181 191
    • (2011) Br J Pharmacol , vol.164 , pp. 181-191
    • Yamamoto, K.1    Uchida, S.2    Kitano, K.3    Fukuhara, N.4    Okumura-Kitajima, L.5    Gunji, E.6


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