Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 302, Issue 1, 2012, Pages

  Thomson, Scott C ^a   Rieg, Timo ^a   Miracle, Cynthia ^a   Mansoury, Hadi ^a   Whaley, Jean ^b   Vallon, Volker ^a   Singh, Prabhleen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Dapagliflozin; Hyperfiltration

Indexed keywords

DAPAGLIFLOZIN; SODIUM GLUCOSE COTRANSPORTER 2;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEEDBACK SYSTEM; GLOMERULUS; GLOMERULUS FILTRATION RATE; HENLE LOOP; KIDNEY CLEARANCE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE FUNCTION; KIDNEY TUBULOGLOMERULAR FEEDBACK; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE NEPHRON GLOMERULAR FILTRATION RATE; STREPTOZOCIN DIABETES; URINARY EXCRETION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; FEEDBACK, PHYSIOLOGICAL; GLOMERULAR FILTRATION RATE; GLUCOSIDES; HOMEOSTASIS; KIDNEY GLOMERULUS; KIDNEY TUBULES; MALE; RATS; RATS, WISTAR; SODIUM-GLUCOSE TRANSPORTER 2; STREPTOZOCIN;

EID: 84255185190     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00357.2011     Document Type: Article

References (28)

1. Bonventre JF, Zuk A. Ischemic acute renal failure: An inflammatory disease? Kidney Int 66: 480-485, 2004.
2. Brown R, Ollerstam A, Johansson B, Skott O, Gebre-Medhin S, Fredholm B, Persson AE. Abolished tubuloglomerular feedback, and increased plasma renin in adenosine A1 receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol 281: R1362-R1367, 2001.
3. Deng A, Hammes JS, Thomson SC. Hemodynamics of early tubuloglomerular feedback resetting during reduced proximal reabsorption. Kidney Int 62: 2136-2143, 2001.
4. Goldwasser P, Fotino S. Acute renal failure following massive mannitol infusion. Appropriate response of tubuloglomerular feedback? Arch Intern Med 144: 2214-2116, 1984.
5. Guyton AC, Coleman TG, Cowley AW, Manning RD, Norman RA, Ferguson JD. Brief reviews: a systems analysis approach to understanding long-range arterial blood pressure control and hypertension. Circ Res 35: 159-176, 1974.
6. Hashimoto S, Huang YG, Castrop H, Hansen PB, Mizel D, Briggs J, Schnermann J. Effect of carbonic anhydrase inhibition on GFR and renal hemodynamics in adenosine-1 receptor-deficient mice. Pflügers Arch 448: 621-628, 2004.
7. List JF, Whaley JM. Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans. Kidney Int 79, Suppl 120: S20-S27, 2001.
8. Magee GM, Bilous RW, Cardwell CR, Hunter SJ, Kee F, Fogarty DG. Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis. Diabetologia 52: 691-697, 2009.
9. Miracle CM, Rieg T, Blantz RC, Vallon V, Thomson SC. Combined effects of carbonic anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular function in the kidney. Kidney Blood Press Res 30: 388-399, 2007.
10. Ramsey J, Brown Grogham P R. Electrometric titration of chloride in small volumes. J Exp Biol 32: 822-829, 1955.
11. Schrier RW, Wang W, Poole B, Mitra A. Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J Clin Invest 114: 5-14, 2004.
12. Shannon JA, Smith HW. The excretion of inulin, xylose, and urea by normal and phlorizinized man. J Clin Invest 14: 393-401, 1935.
13. Singh P, Deng A, Blantz RC, Thomson SC. Unexpected effect of angiotensin AT1 receptor blockade on tubuloglomerular feedback in early subtotal nephrectomy. Am J Physiol Renal Physiol 296: F1158-F1165, 2009.
14. Singh P, Thomson SC. Renal homeostasis and tubuloglomerular feedback. Curr Opin Nephrol Hypertens 19: 59-64, 2010.
15. Slomowitz LA, Deng A, Hammes JS, Gabbai F, Thomson SC. Glomerulotubular balance, dietary protein, and the renal response to glycine in diabetic rats. Am J Physiol Regul Integr Comp Physiol 282: R1096-R1103, 2002.
16. Sun D, Samuelson LC, Yang T, Huang Y, Paliege A, Saunders T, Briggs J, Schnermann J. Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors. Proc Natl Acad Sci USA 98: 9983-9988, 2001.
17. Thomson SC, Blantz RC. Homeostatic efficiency of tubuloglomerular feedback in hydropenia, euvolemia, and acute volume expansion. Am J Physiol Renal Fluid Electrolyte Physiol 264: F930-F936, 1993.
18. Thomson SC, Blantz RC, Vallon V. Increased tubular flow induces resetting of tubuloglomerular feedback in euvolemic rats. Am J Physiol Renal Fluid Electrolyte Physiol 270: F461-F468, 1996.
19. Thomson Deng A SC, Bao D, Satriano J, Blantz RC, Vallon V. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. J Clin Invest 107: 217-224, 2001.
20. Thomson SC, Vallon V, Blantz RC. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am J Physiol Renal Physiol 286: F8-F15, 2004.
21. Thomson SC, Vallon V, Blantz RC. Reduced proximal reabsorption resets tubuloglomerular feedback in euvolemic rats. Am J Physiol Regul Integr Comp Physiol 273: R1414-R1420, 1997.
22. Thurau K, Boylan JW. Acute renal success: The unexpected logic of oliguria in acute renal failure. Am J Med 61: 308-315, 1976.
23. Vallon V, Blantz RC, Thomson S. Homeostatic efficiency of tubuloglomerular feedback is reduced in established diabetes mellitus in rats. Am J Physiol Renal Fluid Electrolyte Physiol 269: F876-F883, 1995.
24. Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T. SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol 22: 104-112, 2011.
25. Vallon V, Richter K, Blantz RC, Thomson S, Osswald H. Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption. J Am Soc Nephrol 10: 2569-2576, 1999.
26. Vallon V, Richter K, Huang DY, Rieg T, Schnermann J. Functional consequences at the single-nephron level of the lack of adenosine A1 receptors and tubuloglomerular feedback in mice. Pflügers Arch 448: 214-21, 2004.
27. Wright EM, Martin MG, Turk E. Familial glucose-galactose malabsorption and hereditary renal glycosuria. In: Metabolic Basis of Inherited Disease (8th ed.), edited by Scriver CR, Beaudet AL, Sly WS, and Valle D. New York: McGraw-Hill, 2001, p. 4891-4980.
28. Windhager E, Giebisch G. Micropuncture study of renal tubular transfer of sodium chloride in the rat. Am J Physiol 200: 581-590, 1961.