Effect of phlorizin on SGLT2 expression in the kidney of diabetic rats

Journal of Nephrology

Volumn 23, Issue 5, 2010, Pages 541-546

  Osorio, Horacio ^a,b   Bautista, Rocío ^b   Rios, Amelia ^c   Franco, Martha ^b   Arellano, Abraham ^b   Vargas Robles, Hilda ^a   Romo, Eunice ^a   Escalante, Bruno ^a,c  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b National Cardiology Institute Ignacio Chávez   (Mexico)

^c DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Diabetes; Hypertension; Phlorizin; SGLT2

Indexed keywords

PHLORIZIN; SODIUM GLUCOSE COTRANSPORTER 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DIURESIS; DRUG EFFECT; GLUCOSURIA; HYPERGLYCEMIA; HYPERTENSION; KIDNEY CORTEX; KIDNEY TUBULE EPITHELIUM; MALE; NATRIURESIS; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; SYSTOLIC BLOOD PRESSURE;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; KIDNEY; MALE; MICROVILLI; PHLORHIZIN; RATS; RATS, WISTAR; SODIUM-GLUCOSE TRANSPORTER 2; STREPTOZOCIN;

EID: 78049422043     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Ritz E, Hasslacher C, Tschope W, Koch M, Mann JFE. Hypertension in diabetes mellitus. Contrib Nephrol. 1987;54:77-85.
2. O'Hare JA, Ferris JB, Brady D, Twomey B, O'Sullivan DJ. Exchangeable sodium and renin in hypertensive diabetic patients with and without nephropathy. Hypertension. 1985;7(Suppl II):43-48. (Pubitemid 16183009)
3. Hannedouche TP, Delgado AG, Gnoinsahe DA, Boitard C, Gruenfeld JP. Renal hemodinamics and segmental tubular sodium reabsorption in early type 1 diabetes. Kidney Int. 1990;37:1126-1133.
4. Bank N, Aynedjian HS. Progressive increases in luminal glucose stimulate proximal sodium absorption in normal and diabetic rats. J Clin Invest. 1990;86:309-316.
5. Vallon V, Ritcher K, Blantz RC, Thomson S, Osswald HN. Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption. J Am Soc Nephrol. 1999;10:2569-2576.
6. Asano T, Anai M, Sakoda H, et al. SGLT as therapeutic target. Drugs Future. 2004;29:461-466.
7. Handlon AL. Sodium glucose co-transporter 2 (SGLT2) inhibitors as potential antidiabetic agents. Expert Opin Ther Pat. 2005;15:1531-1540.
8. Janssen SW, Martens GJ, Sweep CG, Span PN, Verhofstad AA, Hermus AR. Phlorizin treatment prevents the decrease in plasma insulin levels but not the progressive histopathological changes in the pancreatic islets during aging of Zucker diabetic fatty rats. J Endocrinol Invest. 2003;26:508-515.
9. Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes. 2005;54:3427-3434.
10. Vestri S, Okamoto MM, de Freitas HS, et al. Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rats. J Membr Biol. 2001;182:105-112.
11. Bautista R, Manning R, Martínez F, et al. Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension. Am J Physiol Renal Physiol. 2004;286:F127-F133. (Pubitemid 38045050)
12. Lombardi D, Gordon KL, Polisnky P, Suga S, Schwartz SM, Johnson RJ. Salt-sensitive hypertension develops after short-term exposure to angiotensin II. Hypertension. 1999;33:1013-1019. (Pubitemid 29186401)
13. de Cavanagh EMV, Inserra F, Toblli J, Stella I, Fraga GC, Ferder L. Enalapril attenuates oxidative stress in diabetic rats. Hypertension. 2001;38:1130-1136.
14. Rossetti L, Smith D, Shulman G, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest. 1987;79:1510-1515.
15. Vazquez E, Coronel I, Bautista R, et al. Angiotensin II-dependent induction of AT2 receptor expression after renal ablation. Am J Physiol Renal Physiol. 2005;288:F207-F213.
16. Martínez F, Manganel M, Montrose-Rafizadeh C, Werner D, Roch-Ramel F. Transport of urate and p-aminohippurate in rabbit renal brush-border membranes. Am J Physiol Renal Physiol. 1990;258:F1145-F1153. (Pubitemid 20185247)
17. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-265.
18. Turner RJ, Moran A. Heterogeneity of sodium dependent D-Glucose transport sites along the proximal tubule: evidence from vesicle studies. Am J Physiol Renal Physiol. 1982;242:F406-F414.
19. Brands MW, Hopkins TE. Poor glycemic control induces hypertension in diabetes mellitus. Hypertension. 1996;27:735-739.
20. Anderson S, Renke HG, García DL, Brenner BM. Short and long term effects of antihypertensive therapy in the diabetic rat. Kidney Int. 1989;36:526-536.
21. Malatiali S, Francis I, Barac-Nieto M. Phlorizin prevents glomerular hyperfiltration but not hypertrophy in diabetic rats. Exp Diabetes Res. 2008; 2008: 305403.
22. Freitas HS, Anhe GF, Melo KFS, et al. Na+-Glucose transporter- 2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: Involvement of hepatocyte nuclear factor-1 expression and activity. Endocrinology. 2008;149:717-724.
23. Wright EM. Renal Na+-glucose cotransporters. Am J Physiol Renal Physiol. 2001;280:F10-F18.
24. Adachi T, Yasuda K, Okamoto Y, et al. T-1095 an inhibitor of renal Na+-glucose transporter inhibitor, improves hyperglicemia in streptozotocin-induced diabetic rats. Metabolism. 2000;49:990-995.
25. Oku A, Ueta K, Arakawa K, et al. T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes. 1999;48:1794-1800.
26. Arakawa K, Ishihara T, Oku A, et al. Improved diabetic síndrome in C57BL/KsJ-db/db mice by oral administration of the Na+-glucose cotransporters inhibitor T-1095. Br J Pharmacol. 2001;132:578-586.