Renal gluconeogenesis: Its importance in human glucose homeostasis

Diabetes Care

Volumn 24, Issue 2, 2001, Pages 382-391

  Gerich, John E ^a,c,d   Woerle, Hans J ^a   Meyer, Christian ^a   Stumvoll, Michael ^b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF ROCHESTER   (United States)

^d Cadmus Journal Services Reprints   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; GLUCOSE;

ACIDOSIS; CARBOHYDRATE METABOLISM; DIET RESTRICTION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; HORMONAL REGULATION; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; POSTPRANDIAL STATE; REVIEW;

EID: 0035146344     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.24.2.382     Document Type: Review

References (86)

1. Control of glycaemia
2. Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period
3. Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans: A stable isotope study
4. 2O for estimating rates of gluconeogenesis: Application to the fasted state
5. Quantifying gluconeogenesis during fasting
6. A non-invasive assessment of hepatic glycogen kinetics and postabsorptive gluconeogenesis in man
7. Role of the human kidney in glucose homeostasis
8. Hypoglycemia
9. Splanchnic glucose and amino acid metabolism in obesity
10. Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus
11. Substrate turnover during prolonged exercise in man: Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids
12. Gut exchange of glucose and lactate in basal state and after oral glucose ingestion in postoperative patients
13. Renal glucose production compensates for the liver during the anhepatic phase of liver transplantation
14. Non-hepatic glucose production in humans
15. The relationship of kidney function to the glucose utilization of the extra abdominal tissues
16. The kidney as a source of glucose in the eviscerated rat
17. Formation of glucose by the kidney
18. Studies on carbohydrate metabolism in rat kidney slices. II. Effects of alloxan diabetes and insulin administration on glucose uptake and formation
19. Gluconeogenesis and pyruvate metabolism in rat kidney in vitro
20. Renal gluconeogenesis. IV. Gluconeogenesis from substrate combinations
21. Renal gluconeogenesis. II. The gluconeogenic capacity of the kidney cortex of various species
22. Renal gluconeogenesis: The effect of diet on the gluconeogenic capacity of rat kidney cortex slices
23. Renal gluconeogenesis
24. Acceleration of renal gluconeogenesis by ketone bodies and fatty acids
25. Gluconeogenesis
26. Gluconeogenesis by the human kidney
27. Liver and kidney metabolism during prolonged starvation
28. The contrasting responses of splanchnic and renal glucose output to gluconeogenic substrates and to hypoglucagonemia in 60-h-fasted humans
29. Renal gluconeogenesis
30. Renal substrate metabolism
31. Enzyme distribution along the nephron
32. Starvation in man
33. Renal glucose production and utilization: New aspects in humans
34. Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting
35. Role of the human kidney in glucose counterregulalion
36. A rapid method for the determination of para-aminohippuric acid in kidney function tests
37. Use of the splanchnic/hepatic balance technique in the study of glucose metabolism
38. Regulation of splanchnic and renal substrate supply by insulin in humans
39. The estimation of hepatic blood flow in man
40. Inference with respect to means and variances
41. Lilly Lecture 1987: The triumvirate: β-cell, muscle, liver: A collusion responsible for NIDDM
42. Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM
43. Amino acid extraction and ammonia metabolism by the human kidney during the prolonged administration of ammonium chloride
44. Substrate utilization of the human kidney
45. Renal substrate exchange in human diabetes mellitus
46. Effects of chronic renal insufficiency and metabolic acidosis on glutamine metabolism in man
47. Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency
48. Hepatic, gut, and renal substrate flux rates in patients with hepatic cirrhosis
49. Splanchnic and renal vasoconstrictor and metabolic responses to neuropeptide Y in resting and exercising man
50. Renal oxygen consumption, thermogenesis, and amino acid utilization during IV infusion of amino acids in man
51. Human kidney substrate utilization and gluconeogenesis
52. Human kidney and liver gluconeogenesis: Evidence for organ substrate selectivity
53. Insulin regulation of renal glucose metabolism in humans
54. Insulin regulation of renal glucose metabolism in conscious dogs
55. Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog
56. Effects of physiological hyperinsulinemia on systemic, renal and hepatic substrate metabolism
57. Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans
58. Uptake and release of glucose by the human kidney: Postabsorptive rates and responses to epinephrine
59. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production
60. Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
61. Demonstration of critical role for FFA in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in man
62. Fasting blood sugar in hepatic disease with reference to infrequency of hypoglycemia
63. Lilly Lecture 1988: Glucose counterregulation and its impact on diabetes mellitus
64. Renal glucose production during insulin-induced hypoglycemia in humans
65. Hypoglycemia associated with renal failure
66. Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load
67. Role of liver, kidney and skeletal muscle in the disposition of an oral glucose load
68. Increased plasma norepinephrine concentrations and metabolic rates following glucose ingestion in man
69. Renal enzymes during experimental diabetes mellitus in the rat: Role of insulin, carbohydrate metabolism, and ketoacidosis
70. Regulation of gluconeogenesis and glycolysis: Studies of mechanisms controlling enzyme activity
71. Glucose-6-phosphatase mRNA and activity are increased to the same extent in kidney and liver of diabetic rats
72. Hepatic glucose output and hepatic insulin sensitivity in diabetes mellitus
73. Arterio-hepatic venous differences of free fatty acids and amino acids
74. Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion
75. Insulin production rate, hepatic insulin retention and splanchnic metabolism after oral glucose ingestion in hyperinsulinaemic type 2 (non-insulin-dependent) diabetes mellitus
76. Increased renal glucose production in insulin dependent diabetes (IDDM): Contribution to systemic glucose appearance and effect of insulin repletion
77. Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus
78. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
79. Gluconeogenesis
80. Interactions in vivo between oxidation of non-esterified fatty adds and gluconeogenesis in the newborn rat
81. Ultrastructural observations on renal glycogen in normal and pathologic human kidneys
82. Le metabolisme du rein humain
83. Role of the kidney in the metabolism of fructose in 60-hour fasted humans
84. Splanchnic and renal exchange of infused fructose in insulin-defident type I diabetic patients and healthy controls
85. Assessment of postabsorptive renal glucose metabolism in humans with multiple glucose tracers
86. Human kidney free fatty acid and glucose uptake: Evidence for a renal glucose-fatty acid cycle