메뉴 건너뛰기




Volumn 74, Issue 7, 2014, Pages 807-824

Canagliflozin: A review of its use in patients with type 2 diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

BIGUANIDE DERIVATIVE; CANAGLIFLOZIN; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DAPAGLIFLOZIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; ELECTROLYTE; EMPAGLIFLOZIN; GLIMEPIRIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; METFORMIN PLUS PIOGLITAZONE; ORAL ANTIDIABETIC AGENT; PLACEBO; SITAGLIPTIN; SULFONYLUREA; ANTIDIABETIC AGENT; GLUCOSIDE; SLC5A2 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2; THIOPHENE DERIVATIVE;

EID: 84901830673     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-014-0225-5     Document Type: Review
Times cited : (53)

References (67)
  • 1
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • 1:CAS:528:DC%2BC38Xps1Kitb4%3D 3357214 10.2337/dc12-0413 22517736
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35(6):1364-79.
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 2
    • 84892659350 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association 10.2337/dc14-S081
    • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37(suppl 1):S81-90.
    • (2014) Diabetes Care , vol.37 , Issue.SUPPL. 1
  • 3
    • 84892649479 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2014
    • American Diabetes Association 10.2337/dc14-S014
    • American Diabetes Association. Standards of medical care in diabetes - 2014. Diabetes Care. 2014;37(suppl 1):S14-80.
    • (2014) Diabetes Care. , vol.37 , Issue.SUPPL. 1
  • 4
    • 84865957851 scopus 로고    scopus 로고
    • International Diabetes Federation Accessed 24 January 2014
    • International Diabetes Federation. IDF diabetes atlas, 2013. (2013). http://www.idf.org/diabetesatlas. Accessed 24 January 2014.
    • (2013) IDF Diabetes Atlas, 2013
  • 5
    • 84857823823 scopus 로고    scopus 로고
    • International Diabetes Federation Accessed 24 January 2014
    • International Diabetes Federation. Global diabetes plan 2011-2021. (2011). http://www.idf.org/sites/default/files/Global-Diabetes-Plan-Final.pdf. Accessed 24 January 2014.
    • (2011) Global Diabetes Plan 2011-2021
  • 6
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
    • 1:STN:280:DC%2BD3cvisFWnsg%3D%3D 27454 10.1136/bmj.321.7258.405 10938048
    • Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405-12.
    • (2000) BMJ , vol.321 , Issue.7258 , pp. 405-412
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3
  • 7
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    • 1:CAS:528:DyaK1MXjvFOls7g%3D 10.1001/jama.281.21.2005 10359389
    • Turner RC, Cull CA, Frighi V, et al. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA. 1999;281(21):2005-12.
    • (1999) JAMA , vol.281 , Issue.21 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3
  • 9
  • 10
    • 77956319973 scopus 로고    scopus 로고
    • Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC3cXpvVartbk%3D 10.1021/jm100332n 20690635
    • Nomura S, Sakamaki S, Hongu M, et al. Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J Med Chem. 2010;53(17):6355-60.
    • (2010) J Med Chem. , vol.53 , Issue.17 , pp. 6355-6360
    • Nomura, S.1    Sakamaki, S.2    Hongu, M.3
  • 11
    • 77949287535 scopus 로고    scopus 로고
    • Sodium-glucose co-transport inhibitors: Progress and therapeutic potential in type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC3cXls1Sltbw%3D 10.2165/11318680-000000000-00000 20205482
    • Neumiller JJ, White JR, Campbell RK. Sodium-glucose co-transport inhibitors: progress and therapeutic potential in type 2 diabetes mellitus. Drugs. 2010;70(4):377-85.
    • (2010) Drugs. , vol.70 , Issue.4 , pp. 377-385
    • Neumiller, J.J.1    White, J.R.2    Campbell, R.K.3
  • 12
    • 75149196250 scopus 로고    scopus 로고
    • Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus
    • 1:CAS:528:DC%2BC3cXhtVGhsr0%3D 10.1210/jc.2009-0473 19892839
    • Nair S, Wilding JP. Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus. J Clin Endocrinol Metab. 2010;95(1):34-42.
    • (2010) J Clin Endocrinol Metab. , vol.95 , Issue.1 , pp. 34-42
    • Nair, S.1    Wilding, J.P.2
  • 13
    • 67349189212 scopus 로고    scopus 로고
    • Renal sodium-glucose transport: Role in diabetes mellitus and potential clinical implications
    • 1:CAS:528:DC%2BD1MXms12jsbo%3D 10.1038/ki.2009.87 19357717
    • Bakris GL, Fonseca VA, Sharma K, et al. Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Kidney Int. 2009;75(12):1272-7.
    • (2009) Kidney Int. , vol.75 , Issue.12 , pp. 1272-1277
    • Bakris, G.L.1    Fonseca, V.A.2    Sharma, K.3
  • 14
    • 84857099986 scopus 로고    scopus 로고
    • Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • 1:CAS:528:DC%2BC38XjtFWitr0%3D 10.1371/journal.pone.0030555
    • Liang Y, Arakawa K, Ueta K, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One (electronic resource). 2012;7(2):e30555.
    • (2012) PLoS One (Electronic Resource). , vol.7 , Issue.2 , pp. 30555
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3
  • 16
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • 3593184 10.1111/dom.12054 23279307
    • Stenlöf K, Cefalu WT, Kim KA, et al. Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab. 2013;15(4):372-82.
    • (2013) Diabetes Obes Metab. , vol.15 , Issue.4 , pp. 372-382
    • Stenlöf, K.1    Cefalu, W.T.2    Kim, K.A.3
  • 17
    • 84887997289 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: A randomised trial
    • 3825495 10.1007/s00125-013-3039-1 24026211
    • Lavalle-González FJ, Januszewicz A, Davidson J, et al. Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial. Diabetologia. 2013;56(12):2582-92.
    • (2013) Diabetologia. , vol.56 , Issue.12 , pp. 2582-2592
    • Lavalle-González, F.J.1    Januszewicz, A.2    Davidson, J.3
  • 18
    • 84877865378 scopus 로고    scopus 로고
    • Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: Results of a randomized, placebo-controlled study
    • 1:CAS:528:DC%2BC3sXhtlOrsrfN 10.2337/dc12-2391 23412078
    • Polidori D, Sha S, Mudaliar S, et al. Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study. Diabetes Care. 2013;36(8):2154-61.
    • (2013) Diabetes Care. , vol.36 , Issue.8 , pp. 2154-2161
    • Polidori, D.1    Sha, S.2    Mudaliar, S.3
  • 19
    • 84880320337 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus
    • 10.1002/jcph.88 23670707
    • Devineni D, Curtin CR, Polidori D, et al. Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus. J Clin Pharmacol. 2013;53(6):601-10.
    • (2013) J Clin Pharmacol. , vol.53 , Issue.6 , pp. 601-610
    • Devineni, D.1    Curtin, C.R.2    Polidori, D.3
  • 20
    • 79956331954 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    • 1:CAS:528:DC%2BC3MXoslaju7o%3D 10.1111/j.1463-1326.2011.01406.x 21457428
    • Sha S, Devineni D, Ghosh A, et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab. 2011;13(7):669-72.
    • (2011) Diabetes Obes Metab. , vol.13 , Issue.7 , pp. 669-672
    • Sha, S.1    Devineni, D.2    Ghosh, A.3
  • 21
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    • 1:CAS:528:DC%2BC38Xps1Kit7k%3D 3357223 10.2337/dc11-1926 22492586
    • Rosenstock J, Aggarwal N, Polidori D, et al. Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care. 2012;35(6):1232-8.
    • (2012) Diabetes Care. , vol.35 , Issue.6 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3
  • 22
    • 84891784200 scopus 로고    scopus 로고
    • Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: A 52-week randomized trial
    • 10.2337/dc12-2491 23564919
    • Schernthaner G, Gross JL, Rosenstock J, et al. Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial. Diabetes Care. 2013;36(9):2508-15.
    • (2013) Diabetes Care. , vol.36 , Issue.9 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3
  • 23
    • 84888059660 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: A randomised trial
    • 1:CAS:528:DC%2BC3sXhvVajtLnK 10.1111/ijcp.12322 24118688
    • Wilding JP, Charpentier G, Hollander P, et al. Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: a randomised trial. Int J Clin Pract. 2013;67(12):1267-82.
    • (2013) Int J Clin Pract. , vol.67 , Issue.12 , pp. 1267-1282
    • Wilding, J.P.1    Charpentier, G.2    Hollander, P.3
  • 24
    • 84898600889 scopus 로고    scopus 로고
    • Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes
    • 1:CAS:528:DC%2BC2cXjsVWqtbw%3D 3980039 10.1007/s00125-014-3196-x 24585202
    • Polidori D, Mari A, Ferrannini E. Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes. Diabetologia. 2014;57(5):891-901.
    • (2014) Diabetologia. , vol.57 , Issue.5 , pp. 891-901
    • Polidori, D.1    Mari, A.2    Ferrannini, E.3
  • 25
    • 70350330155 scopus 로고    scopus 로고
    • Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes
    • 1:CAS:528:DC%2BD1MXhsVOlsbzK 10.1111/j.1463-1326.2009.01113.x 19817791
    • Weir GC, Marselli L, Marchetti P, et al. Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes Obes Metab. 2009;11(Suppl 4):82-90.
    • (2009) Diabetes Obes Metab. , vol.11 , Issue.SUPPL. 4 , pp. 82-90
    • Weir, G.C.1    Marselli, L.2    Marchetti, P.3
  • 26
    • 84876484626 scopus 로고    scopus 로고
    • MiRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models
    • 1:CAS:528:DC%2BC3sXjslehsr8%3D 10.1007/s00125-012-2812-x 23338554
    • Kim JW, You YH, Jung S, et al. miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models. Diabetologia. 2013;56(4):847-55.
    • (2013) Diabetologia. , vol.56 , Issue.4 , pp. 847-855
    • Kim, J.W.1    You, Y.H.2    Jung, S.3
  • 27
    • 84898821701 scopus 로고    scopus 로고
    • Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans
    • 10.1124/dmd.113.056440 24568888
    • Mamidi RN, Cuyckens F, Chen J, et al. Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans. Drug Metab Dispos. 2014;42(5):903-16.
    • (2014) Drug Metab Dispos. , vol.42 , Issue.5 , pp. 903-916
    • Mamidi, R.N.1    Cuyckens, F.2    Chen, J.3
  • 28
    • 84898898964 scopus 로고    scopus 로고
    • Drug-drug interactions with sodium-glucose cotransporters type 2 (SGLT2) inhibitors, new oral glucose-lowering agents for the management of type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC2cXltFensLs%3D 10.1007/s40262-013-0128-8 24420910
    • Scheen AJ. Drug-drug interactions with sodium-glucose cotransporters type 2 (SGLT2) inhibitors, new oral glucose-lowering agents for the management of type 2 diabetes mellitus. Clin Pharmacokinet. 2014;53(4):295-304.
    • (2014) Clin Pharmacokinet. , vol.53 , Issue.4 , pp. 295-304
    • Scheen, A.J.1
  • 29
    • 84893299467 scopus 로고    scopus 로고
    • Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: Findings from the 52-week CANTATA-M study
    • 10.1185/03007995.2013.850066 24073995
    • Stenlöf K, Cefalu WT, Kim KA, et al. Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study. Curr Med Res Opin. 2014;30(2):163-75.
    • (2014) Curr Med Res Opin. , vol.30 , Issue.2 , pp. 163-175
    • Stenlöf, K.1    Cefalu, W.T.2    Kim, K.A.3
  • 30
    • 84884167643 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • 1:CAS:528:DC%2BC3sXhtFSls7fO 10.1016/S0140-6736(13)60683-2 23850055
    • Cefalu WT, Leiter LA, Yoon K-H, et al. Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet. 2013;382(9896):941-50.
    • (2013) Lancet. , vol.382 , Issue.9896 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.-H.3
  • 31
    • 85081470568 scopus 로고    scopus 로고
    • Canagliflozin demonstrates durable glycaemic improvements over 104 weeks compared with glimepiride in subjects with type 2 diabetes mellitus on metformin (abstract no. 182)
    • Barcelona, 23-27 September
    • Langslet G, Cefalu WT, Leiter LA, et al. Canagliflozin demonstrates durable glycaemic improvements over 104 weeks compared with glimepiride in subjects with type 2 diabetes mellitus on metformin (abstract no. 182). In: 49th annual meeting of the European Association for the Study of Diabetes, Barcelona, 23-27 September 2013.
    • (2013) 49th Annual Meeting of the European Association for the Study of Diabetes
    • Langslet, G.1    Cefalu, W.T.2    Leiter, L.A.3
  • 32
    • 84898791440 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone
    • 1:CAS:528:DC%2BC2cXmsFWrtL0%3D 10.1111/dom.12273 24528605
    • Forst T, Guthrie R, Goldenberg R, et al. Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone. Diabetes Obes Metab. 2014;16(5):467-77.
    • (2014) Diabetes Obes Metab. , vol.16 , Issue.5 , pp. 467-477
    • Forst, T.1    Guthrie, R.2    Goldenberg, R.3
  • 33
    • 84880924263 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of the canagliflozin cardiovascular assessment study (CANVAS) - A randomized placebo-controlled trial
    • 10.1016/j.ahj.2013.05.007
    • Neal B, Perkovic V, de Zeeuw D, et al. Rationale, design, and baseline characteristics of the canagliflozin cardiovascular assessment study (CANVAS) - a randomized placebo-controlled trial. Am Heart J. 2013;166(2):217.e11-223.e11.
    • (2013) Am Heart J. , vol.166 , Issue.2
    • Neal, B.1    Perkovic, V.2    De Zeeuw, D.3
  • 34
    • 85081465615 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin (CANA), an inhibitor of sodium glucose co-transporter 2 (SGLT2), added-on to insulin therapy +/- oral agents in type 2 diabetes (abstract no. 764)
    • Berlin, 1-5 October
    • Matthews DR, Fulcher G, Perkovic V, et al. Efficacy and safety of canagliflozin (CANA), an inhibitor of sodium glucose co-transporter 2 (SGLT2), added-on to insulin therapy +/- oral agents in type 2 diabetes (abstract no. 764). In: 48th annual meeting of the European Association for the Study of Diabetes, Berlin, 1-5 October 2012.
    • (2012) 48th Annual Meeting of the European Association for the Study of Diabetes
    • Matthews, D.R.1    Fulcher, G.2    Perkovic, V.3
  • 35
    • 85081472770 scopus 로고    scopus 로고
    • Canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM) inadequately controlled on sulfonylurea (SU) monotherapy: A CANVAS substudy (abstract no. 1124-P)
    • Chicago, 21-25 June
    • Fulcher G, Matthews DR, Perkovic V, et al. Canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM) inadequately controlled on sulfonylurea (SU) monotherapy: a CANVAS substudy (abstract no. 1124-P). In: 73rd annual scientific sessions of the American Diabetes Association, Chicago, 21-25 June 2013.
    • (2013) 73rd Annual Scientific Sessions of the American Diabetes Association
    • Fulcher, G.1    Matthews, D.R.2    Perkovic, V.3
  • 36
    • 85081469572 scopus 로고    scopus 로고
    • Canagliflozin (CANA) added on to dipeptidyl peptidase-4 inhibitors (DPP-4i) or glucagon-like peptide-1 (GLP-1) agonists with or without other antihyperglycemic agents (AHAs) in type 2 diabetes mellitus (T2DM) (abstract no. 1080-P)
    • Chicago, 21-25 June
    • Wysham C, Woo VC, Mathieu C, et al. Canagliflozin (CANA) added on to dipeptidyl peptidase-4 inhibitors (DPP-4i) or glucagon-like peptide-1 (GLP-1) agonists with or without other antihyperglycemic agents (AHAs) in type 2 diabetes mellitus (T2DM) (abstract no. 1080-P). In: 73rd annual scientific sessions of the American Diabetes Association, Chicago, 21-25 June 2013.
    • (2013) 73rd Annual Scientific Sessions of the American Diabetes Association
    • Wysham, C.1    Woo, V.C.2    Mathieu, C.3
  • 37
    • 84880543926 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: A randomized trial
    • 10.3810/hp.2013.04.1020
    • Bode B, Stenlöf K, Sullivan D, et al. Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: a randomized trial. Hosp Pract (Minneap). 2013;41(2):72-84.
    • (2013) Hosp Pract (Minneap). , vol.41 , Issue.2 , pp. 72-84
    • Bode, B.1    Stenlöf, K.2    Sullivan, D.3
  • 38
    • 84899960517 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: A pooled analysis of clinical studies
    • 4021426 10.1186/1472-6823-14-37 24742013
    • Sinclair A, Bode B, Harris S, et al. Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. BMC Endocr Disord. 2014;14(1):37.
    • (2014) BMC Endocr Disord. , vol.14 , Issue.1 , pp. 37
    • Sinclair, A.1    Bode, B.2    Harris, S.3
  • 39
    • 84876311251 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
    • 1:CAS:528:DC%2BC3sXlvVenu7c%3D 3654568 10.1111/dom.12090 23464594
    • Yale JF, Bakris G, Cariou B, et al. Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab. 2013;15(5):463-73.
    • (2013) Diabetes Obes Metab. , vol.15 , Issue.5 , pp. 463-473
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3
  • 40
    • 84901849176 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) over 52 weeks (abstract no. 71)
    • Yale JF, Bakris G, Cariou B, et al. Efficacy and safety of canagliflozin (CANA) in subjects with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) over 52 weeks (abstract no. 71). Can J Diabetes. 2013;37(suppl):S27.
    • (2013) Can J Diabetes. , vol.37 , Issue.SUPPL. , pp. 27
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3
  • 41
    • 85081474568 scopus 로고    scopus 로고
    • Canagliflozin (CANA) is effective and generally well tolerated in subjects with type 2 diabetes mellitus (T2DM) and stage 3 chronic kidney disease (CKD) (abstract no. 73-LB)
    • Chicago, 21-25 June
    • Woo V, Davies M, De Zeeuw D, et al. Canagliflozin (CANA) is effective and generally well tolerated in subjects with type 2 diabetes mellitus (T2DM) and stage 3 chronic kidney disease (CKD) (abstract no. 73-LB). In: 73rd annual scientific sessions of the American Diabetes Association, Chicago, 21-25 June 2013.
    • (2013) 73rd Annual Scientific Sessions of the American Diabetes Association
    • Woo, V.1    Davies, M.2    De Zeeuw, D.3
  • 42
    • 84887147788 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in Japanese patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, 12-week study
    • 1:CAS:528:DC%2BC3sXhslCrs7%2FO 3906835 10.1111/dom.12149 23782594
    • Inagaki N, Kondo K, Yoshinari T, et al. Efficacy and safety of canagliflozin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, 12-week study. Diabetes Obes Metab. 2013;15(12):1136-45.
    • (2013) Diabetes Obes Metab. , vol.15 , Issue.12 , pp. 1136-1145
    • Inagaki, N.1    Kondo, K.2    Yoshinari, T.3
  • 44
    • 84901842720 scopus 로고    scopus 로고
    • Janssen Research & Development LLC (ClinicalTrials.gov identifier NCT02065791). US National Institutes of Health, ClinicalTrials.gov Accessed 10 April 2014
    • Janssen Research & Development LLC. Evaluation of the effects of canagliflozin on renal and cardiovascular outcomes in participants with diabetic nephropathy (CREDENCE) (ClinicalTrials.gov identifier NCT02065791). US National Institutes of Health, ClinicalTrials.gov. (2014). http://clinicaltrials.gov/ ct2/show/study/NCT02065791. Accessed 10 April 2014.
    • (2014) Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants with Diabetic Nephropathy (CREDENCE)
  • 45
    • 84901849274 scopus 로고    scopus 로고
    • Combating the dual burden: Therapeutic targeting of common pathways in obesity and type 2 diabetes
    • 10.1016/S2213-8587(14)70004-X
    • Scheen AJ, Van Gaal LF. Combating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes. Lancet Diabetes Endocrinol. 2014. doi: 10.1016/S2213-8587(14)70004-X.
    • (2014) Lancet Diabetes Endocrinol.
    • Scheen, A.J.1    Van Gaal, L.F.2
  • 46
    • 84891526739 scopus 로고    scopus 로고
    • Impact of sodium glucose cotransporter 2 inhibitors on weight in patients with type 2 diabetes mellitus
    • 10.3810/pgm.2013.09.2698 24113667
    • Barnett AH. Impact of sodium glucose cotransporter 2 inhibitors on weight in patients with type 2 diabetes mellitus. Postgrad Med. 2013;125(5):92-100.
    • (2013) Postgrad Med. , vol.125 , Issue.5 , pp. 92-100
    • Barnett, A.H.1
  • 47
    • 84897447957 scopus 로고    scopus 로고
    • Canagliflozin: Effects in overweight and obese subjects without diabetes mellitus
    • 1:CAS:528:DC%2BC2cXkslCmtrs%3D 10.1002/oby.20663 24227660
    • Bays HE, Weinstein R, Law G, et al. Canagliflozin: effects in overweight and obese subjects without diabetes mellitus. Obesity. 2014;22(4):1042-9.
    • (2014) Obesity. , vol.22 , Issue.4 , pp. 1042-1049
    • Bays, H.E.1    Weinstein, R.2    Law, G.3
  • 48
    • 84888073572 scopus 로고    scopus 로고
    • Canagliflozin, a sodium glucose co-transporter 2 inhibitor, reduces body weight mainly through loss of fat mass in subjects with type 2 diabetes (abstract no. 762)
    • Toubro S, Cefalu WT, Xie J, et al. Canagliflozin, a sodium glucose co-transporter 2 inhibitor, reduces body weight mainly through loss of fat mass in subjects with type 2 diabetes (abstract no. 762). Diabetologia. 2012;55:S313-4.
    • (2012) Diabetologia , vol.55
    • Toubro, S.1    Cefalu, W.T.2    Xie, J.3
  • 49
    • 84864371186 scopus 로고    scopus 로고
    • Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats
    • 1:CAS:528:DC%2BC38XhtFWntL3I 10.1038/oby.2012.59 22402735
    • Devenny JJ, Godonis HE, Harvey SJ, et al. Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats. Obesity. 2012;20(8):1645-52.
    • (2012) Obesity. , vol.20 , Issue.8 , pp. 1645-1652
    • Devenny, J.J.1    Godonis, H.E.2    Harvey, S.J.3
  • 50
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • 1:CAS:528:DC%2BC2cXis1ers7c%3D 3904627 10.1172/JCI72227 24463454
    • Ferrannini E, Muscelli E, Frascerra S, et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest. 2014;124:499-508.
    • (2014) J Clin Invest. , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3
  • 51
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • 1:CAS:528:DC%2BC2cXis1ersL0%3D 3904617 10.1172/JCI70704 24463448
    • Merovci A, Solis-Herrera C, Daniele G, et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest. 2014;124:509-14.
    • (2014) J Clin Invest. , vol.124 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3
  • 52
    • 84869998632 scopus 로고    scopus 로고
    • Dapagliflozin: A review of its use in type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC3sXovVChsg%3D%3D 10.2165/11209910-000000000-00000 23170914
    • Plosker GL. Dapagliflozin: a review of its use in type 2 diabetes mellitus. Drugs. 2012;72(17):2289-312.
    • (2012) Drugs. , vol.72 , Issue.17 , pp. 2289-2312
    • Plosker, G.L.1
  • 54
    • 84863617006 scopus 로고    scopus 로고
    • Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor
    • 1:CAS:528:DC%2BC38XhtVWjs7jN 10.1185/03007995.2012.697053 22632452
    • Nyirjesy P, Zhao Y, Ways K, et al. Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor. Curr Med Res Opin. 2012;28(7):1173-8.
    • (2012) Curr Med Res Opin. , vol.28 , Issue.7 , pp. 1173-1178
    • Nyirjesy, P.1    Zhao, Y.2    Ways, K.3
  • 55
    • 84900823374 scopus 로고    scopus 로고
    • Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: A pooled analysis of clinical studies
    • 10.1185/03007995.2014.890925 24517339
    • Nyirjesy P, Sobel JD, Fung A, et al. Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. Curr Med Res Opin. 2014. doi: 10.1185/03007995.2014.890925.
    • (2014) Curr Med Res Opin.
    • Nyirjesy, P.1    Sobel, J.D.2    Fung, A.3
  • 56
    • 84897019959 scopus 로고    scopus 로고
    • Urinary tract infection in randomized phase III studies of canagliflozin, a sodium glucose co-transporter 2 inhibitor
    • 10.3810/pgm.2014.01.2720 24393747
    • Nicolle LE, Capuano G, Fung A, et al. Urinary tract infection in randomized phase III studies of canagliflozin, a sodium glucose co-transporter 2 inhibitor. Postgrad Med. 2014;126(1):7-17.
    • (2014) Postgrad Med. , vol.126 , Issue.1 , pp. 7-17
    • Nicolle, L.E.1    Capuano, G.2    Fung, A.3
  • 57
    • 84908503059 scopus 로고    scopus 로고
    • Sodium-glucose linked transporter-2 inhibitors: Potential for renoprotection beyond blood glucose lowering
    • 10.1038/ki.2013.451 24257692
    • Gilbert RE. Sodium-glucose linked transporter-2 inhibitors: potential for renoprotection beyond blood glucose lowering. Kidney Int. 2013. doi: 10.1038/ki.2013.451.
    • (2013) Kidney Int.
    • Gilbert, R.E.1
  • 58
    • 84898854471 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: A systematic review and meta-analysis
    • 10.1016/j.jash.2014.01.007 24602971
    • Baker WL, Smyth LR, Riche DM, et al. Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis. J Am Soc Hypertens. 2014. doi: 10.1016/j.jash.2014.01.007.
    • (2014) J Am Soc Hypertens.
    • Baker, W.L.1    Smyth, L.R.2    Riche, D.M.3
  • 59
    • 84879489428 scopus 로고    scopus 로고
    • Study of electrocardiogram intervals in healthy adults receiving single oral doses of canagliflozin (abstract no. 2177-PO)
    • Orlando, 21-25 June
    • Wexler D, Vandebosch A, Usiskin K. Study of electrocardiogram intervals in healthy adults receiving single oral doses of canagliflozin (abstract no. 2177-PO). In: 70th annual scientific sessions of the American Diabetes Association, Orlando, 21-25 June 2010.
    • (2010) 70th Annual Scientific Sessions of the American Diabetes Association
    • Wexler, D.1    Vandebosch, A.2    Usiskin, K.3
  • 61
    • 85081465474 scopus 로고    scopus 로고
    • Accessed 1 May 2014
    • Europe approves J&J diabetes combo Vokanamet. (2014). http://www.pharmatimes.com/article/14-04-27/Europe-approves-J-J-diabetes-combo- Vokanamet.aspx. Accessed 1 May 2014.
    • (2014) Europe Approves J&J Diabetes Combo Vokanamet
  • 63
    • 84874187571 scopus 로고    scopus 로고
    • Cardiovascular effects of GLP-1 and GLP-1-based therapies: Implications for the cardiovascular continuum in diabetes?
    • 1:CAS:528:DC%2BC3sXmsVCrtrc%3D 10.1111/j.1464-5491.2012.03746.x 22804451
    • Burgmaier M, Heinrich C, Marx N. Cardiovascular effects of GLP-1 and GLP-1-based therapies: implications for the cardiovascular continuum in diabetes? Diabet Med. 2013;30(3):289-99.
    • (2013) Diabet Med. , vol.30 , Issue.3 , pp. 289-299
    • Burgmaier, M.1    Heinrich, C.2    Marx, N.3
  • 64
    • 74349113610 scopus 로고    scopus 로고
    • Patient and treatment perspectives: Revisiting the link between type 2 diabetes, weight gain, and cardiovascular risk
    • 10.3949/ccjm.76.s5.04 19952300
    • Peters AL. Patient and treatment perspectives: revisiting the link between type 2 diabetes, weight gain, and cardiovascular risk. Cleve Clin J Med. 2009;76(suppl 5):S20-7.
    • (2009) Cleve Clin J Med. , vol.76 , Issue.SUPPL. 5
    • Peters, A.L.1
  • 65
    • 79960262492 scopus 로고    scopus 로고
    • Management of type 2 diabetes: New and future developments in treatment
    • 1:CAS:528:DC%2BC3MXos1GrsLk%3D 10.1016/S0140-6736(11)60207-9 21705062
    • Tahrani AA, Bailey CJ, Del Prato S, et al. Management of type 2 diabetes: new and future developments in treatment. Lancet. 2011;378(9786):182-97.
    • (2011) Lancet. , vol.378 , Issue.9786 , pp. 182-197
    • Tahrani, A.A.1    Bailey, C.J.2    Del Prato, S.3
  • 66
    • 84895736410 scopus 로고    scopus 로고
    • Sitagliptin: A review of its use in patients with type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC2cXitVyjsrk%3D 10.1007/s40265-013-0169-1 24407560
    • Plosker GL. Sitagliptin: a review of its use in patients with type 2 diabetes mellitus. Drugs. 2014;74(2):223-42.
    • (2014) Drugs. , vol.74 , Issue.2 , pp. 223-242
    • Plosker, G.L.1
  • 67
    • 85081474247 scopus 로고    scopus 로고
    • A health economic analysis of the long-term benefits and associated cost offsets of canagliflozin monotherapy in the United States (abstract no. 1232-P)
    • Chicago, 21-25 June
    • Neslusan C, Johansen P, Willis M, et al. A health economic analysis of the long-term benefits and associated cost offsets of canagliflozin monotherapy in the United States (abstract no. 1232-P). In: 73rd annual scientific session of the American Diabetes Association, Chicago, 21-25 June 2013.
    • (2013) 73rd Annual Scientific Session of the American Diabetes Association
    • Neslusan, C.1    Johansen, P.2    Willis, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.