-
1
-
-
77952557918
-
Missing heritability and strategies for finding the underlying causes of complex disease
-
Eichler EE, Flint J, Gibson G, et al. Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet 2010;11:446–450.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 446-450
-
-
Eichler, E.E.1
Flint, J.2
Gibson, G.3
-
2
-
-
77649289047
-
What role for genetics in the prediction of multiple sclerosis?
-
Sawcer S, Ban M, Wason J, Dudbridge F. What role for genetics in the prediction of multiple sclerosis? Ann Neurol 2010;67:3–10.
-
(2010)
Ann Neurol
, vol.67
, pp. 3-10
-
-
Sawcer, S.1
Ban, M.2
Wason, J.3
Dudbridge, F.4
-
3
-
-
66249086434
-
Risk alleles for multiple sclerosis in multiplex families
-
D'Netto MJ, Ward H, Morrison KM, et al. Risk alleles for multiple sclerosis in multiplex families. Neurology 2009;72:1984–1988.
-
(2009)
Neurology
, vol.72
, pp. 1984-1988
-
-
D'Netto, M.J.1
Ward, H.2
Morrison, K.M.3
-
4
-
-
79551484517
-
Aggregation of multiple sclerosis genetic risk variants in multiple sclerosis and single case families
-
Gourraud PA, McElroy JP, Caillier SJ, et al. Aggregation of multiple sclerosis genetic risk variants in multiple sclerosis and single case families. Ann Neurol 2010;69:65–74.
-
(2010)
Ann Neurol
, vol.69
, pp. 65-74
-
-
Gourraud, P.A.1
McElroy, J.P.2
Caillier, S.J.3
-
5
-
-
79551494636
-
Dissecting the familial risk of multiple sclerosis
-
Hardy J, Thompson AJ. Dissecting the familial risk of multiple sclerosis. Ann Neurol 2010;69:11–12.
-
(2010)
Ann Neurol
, vol.69
, pp. 11-12
-
-
Hardy, J.1
Thompson, A.J.2
-
6
-
-
84855925920
-
Rare and common variants: twenty arguments
-
Gibson G. Rare and common variants: twenty arguments. Nat Rev Genet 2012;13:135–145.
-
(2012)
Nat Rev Genet
, vol.13
, pp. 135-145
-
-
Gibson, G.1
-
7
-
-
84856405512
-
The mystery of missing heritability: genetic interactions create phantom heritability
-
Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci USA 2012;109:1193–1198.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 1193-1198
-
-
Zuk, O.1
Hechter, E.2
Sunyaev, S.R.3
Lander, E.S.4
-
8
-
-
84868212192
-
Risk in complex genetics: “All models are wrong but some are useful
-
Sawcer S, Wason J. Risk in complex genetics: “All models are wrong but some are useful”. Ann Neurol 2012;72:502–509.
-
(2012)
Ann Neurol
, vol.72
, pp. 502-509
-
-
Sawcer, S.1
Wason, J.2
-
9
-
-
84863556835
-
Evolution and functional impact of rare coding variation from deep sequencing of human exomes
-
Tennessen JA, Bigham AW, O'Connor TD, et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 2012;337:64–69.
-
(2012)
Science
, vol.337
, pp. 64-69
-
-
Tennessen, J.A.1
Bigham, A.W.2
O'Connor, T.D.3
-
10
-
-
84878994629
-
Negligible impact of rare autoimmune-locus coding- region variants on missing heritability
-
Hunt KA, Mistry V, Bockett NA, et al. Negligible impact of rare autoimmune-locus coding- region variants on missing heritability. Nature 2013;498:232–237.
-
(2013)
Nature
, vol.498
, pp. 232-237
-
-
Hunt, K.A.1
Mistry, V.2
Bockett, N.A.3
-
11
-
-
80053583731
-
The major cause of multiple sclerosis is environmental: genetics has a minor role-yes
-
Taylor BV. The major cause of multiple sclerosis is environmental: genetics has a minor role-yes. Mult Scler 2011;17:1171–1173.
-
(2011)
Mult Scler
, vol.17
, pp. 1171-1173
-
-
Taylor, B.V.1
-
12
-
-
80053588676
-
The major cause of multiple sclerosis is environmental: genetics has a minor role- no
-
Sawcer S. The major cause of multiple sclerosis is environmental: genetics has a minor role- no. Mult Scler 2011;17:1174–1175.
-
(2011)
Mult Scler
, vol.17
, pp. 1174-1175
-
-
Sawcer, S.1
-
13
-
-
80053613974
-
The major cause of multiple sclerosis is environmental: genetics has a minor role-commentary
-
Hutchinson M. The major cause of multiple sclerosis is environmental: genetics has a minor role-commentary. Mult Scler 2011;17:1176.
-
(2011)
Mult Scler
, vol.17
, pp. 1176
-
-
Hutchinson, M.1
-
14
-
-
84881514998
-
Contribution of genome-wide association studies to scientific research: a pragmatic approach to evaluate their impact
-
Ricigliano VAG, Umeton R, Germinario L, et al. Contribution of genome-wide association studies to scientific research: a pragmatic approach to evaluate their impact. PLoS One 2013;8:e71198.
-
(2013)
PLoS One
, vol.8
-
-
Ricigliano, V.A.G.1
Umeton, R.2
Germinario, L.3
-
15
-
-
25844457409
-
A twin consensus in MS
-
Ebers GC. A twin consensus in MS. Mult Scler 2005;11:497–499.
-
(2005)
Mult Scler
, vol.11
, pp. 497-499
-
-
Ebers, G.C.1
-
17
-
-
0019353363
-
On stochastic perturbation and long-term climate behaviour
-
Sutera A. On stochastic perturbation and long-term climate behaviour. Q J R Meteorol Soc 1981;107:137–151.
-
(1981)
Q J R Meteorol Soc
, vol.107
, pp. 137-151
-
-
Sutera, A.1
-
19
-
-
0034225278
-
Stochastic perturbation in meteorology
-
Bordi I, Sutera A. Stochastic perturbation in meteorology. Wave Random Media 2000;10:1–30.
-
(2000)
Wave Random Media
, vol.10
, pp. 1-30
-
-
Bordi, I.1
Sutera, A.2
-
20
-
-
84879966712
-
A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection
-
Brandes M, Klauschen F, Kuchen S, Germain RN. A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection. Cell 2013;154:197–212.
-
(2013)
Cell
, vol.154
, pp. 197-212
-
-
Brandes, M.1
Klauschen, F.2
Kuchen, S.3
Germain, R.N.4
-
23
-
-
84877798701
-
A “candidate-interactome” aggregate analysis of genome-wide association data in multiple sclerosis
-
Mechelli R, Umeton R, Policano C, et al. A “candidate-interactome” aggregate analysis of genome-wide association data in multiple sclerosis. PLoS One 2013;8:e63300.
-
(2013)
PLoS One
, vol.8
-
-
Mechelli, R.1
Umeton, R.2
Policano, C.3
-
24
-
-
53549123008
-
Nature, nurture or chance: stochastic gene expression and its consequences
-
Raj A, van Oudenaarden A. Nature, nurture or chance: stochastic gene expression and its consequences. Cell 2008;135:216–226.
-
(2008)
Cell
, vol.135
, pp. 216-226
-
-
Raj, A.1
van Oudenaarden, A.2
-
25
-
-
77956520011
-
Functional role for noise in genetic circuits
-
Eldar A, Elowitz MB. Functional role for noise in genetic circuits. Nature 2010;467:167–173.
-
(2010)
Nature
, vol.467
, pp. 167-173
-
-
Eldar, A.1
Elowitz, M.B.2
-
26
-
-
84857399077
-
Asymmetric stochastic switching driven by intrinsic molecular noise
-
Frigola D, Casanellas L, Sanch JM, Ibañes M. Asymmetric stochastic switching driven by intrinsic molecular noise. PLoS One 2012;7:e31487.
-
(2012)
PLoS One
, vol.7
-
-
Frigola, D.1
Casanellas, L.2
Sanch, J.M.3
Ibañes, M.4
-
27
-
-
84901884319
-
Stochastic stabilization of phenotypic states: the genetic bistable switch as a case study
-
Weber M, Buceta J. Stochastic stabilization of phenotypic states: the genetic bistable switch as a case study. PLoS One 2013;8:e73487.
-
(2013)
PLoS One
, vol.8
-
-
Weber, M.1
Buceta, J.2
-
28
-
-
84857437687
-
Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae
-
Stewart-Ornstein J, Weissman JS, El-Samad H. Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol Cell 2012;45:483–493.
-
(2012)
Mol Cell
, vol.45
, pp. 483-493
-
-
Stewart-Ornstein, J.1
Weissman, J.S.2
El-Samad, H.3
-
29
-
-
33845257870
-
Variability and memory of protein levels in human cells
-
Sigal A, Milo R, Cohen A, et al. Variability and memory of protein levels in human cells. Nature 2006;444:643–646.
-
(2006)
Nature
, vol.444
, pp. 643-646
-
-
Sigal, A.1
Milo, R.2
Cohen, A.3
-
30
-
-
77958102017
-
Missing heritability and stochastic genome alterations
-
Heng HH. Missing heritability and stochastic genome alterations. Nat Rev Genet 2010;11:813.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 813
-
-
Heng, H.H.1
-
31
-
-
0001389945
-
Enzyme production as an all-or-none phenomenon
-
Novick A, Weiner M. Enzyme production as an all-or-none phenomenon. Proc Natl Acad Sci USA 1957;43:553–566.
-
(1957)
Proc Natl Acad Sci USA
, vol.43
, pp. 553-566
-
-
Novick, A.1
Weiner, M.2
-
32
-
-
0031029852
-
Stochastic mechanisms in gene expression
-
McAdams HH, Arkin A. Stochastic mechanisms in gene expression. Proc Natl Acad Sci USA 1997;94:814–819.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 814-819
-
-
McAdams, H.H.1
Arkin, A.2
-
33
-
-
84865059896
-
Genetic, environmental and stochastic factors in monozygotic twins discordance with a focus on epigenetic differences
-
Czyz W, Morahan JM, Ebers GC, Ramagopalan SV. Genetic, environmental and stochastic factors in monozygotic twins discordance with a focus on epigenetic differences. BMC Med 2012;10:93.
-
(2012)
BMC Med
, vol.10
, pp. 93
-
-
Czyz, W.1
Morahan, J.M.2
Ebers, G.C.3
Ramagopalan, S.V.4
-
34
-
-
34447098797
-
Multistep pathogenesis of autoimmune disease
-
Goodnow CC. Multistep pathogenesis of autoimmune disease. Cell 2007;130:25–35.
-
(2007)
Cell
, vol.130
, pp. 25-35
-
-
Goodnow, C.C.1
-
35
-
-
80054928002
-
Genomics and the multifactorial nature of human autoimmune disease
-
Cho JH, Gregersen PK. Genomics and the multifactorial nature of human autoimmune disease. N Engl J Med 2011;365:1612–1623.
-
(2011)
N Engl J Med
, vol.365
, pp. 1612-1623
-
-
Cho, J.H.1
Gregersen, P.K.2
-
36
-
-
67650505036
-
Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential: follow-up of 70 patients
-
Lebrun C, Bensa C, Debouverie M, et al. Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential: follow-up of 70 patients. Arch Neurol 2009;66:841–846.
-
(2009)
Arch Neurol
, vol.66
, pp. 841-846
-
-
Lebrun, C.1
Bensa, C.2
Debouverie, M.3
-
37
-
-
78751550042
-
MRI only conversion to multiple sclerosis following a clinically isolated syndrome
-
Chard DT, Dalton CM, Swanton J, et al. MRI only conversion to multiple sclerosis following a clinically isolated syndrome. J Neurol Neurosurg Psychiatry 2011;82:176–179.
-
(2011)
J Neurol Neurosurg Psychiatry
, vol.82
, pp. 176-179
-
-
Chard, D.T.1
Dalton, C.M.2
Swanton, J.3
-
38
-
-
54149084585
-
Multiple sclerosis
-
Compston A, Coles A. Multiple sclerosis. Lancet 2008;372:1502–1517.
-
(2008)
Lancet
, vol.372
, pp. 1502-1517
-
-
Compston, A.1
Coles, A.2
-
39
-
-
79959857905
-
Migration and multiple sclerosis in immigrants to Australia from United Kingdom and Ireland: a reassessment. I. Risk of MS by age at immigration
-
McLeod JG, Hammond SR, Kurtzke JF. Migration and multiple sclerosis in immigrants to Australia from United Kingdom and Ireland: a reassessment. I. Risk of MS by age at immigration. J Neurol 2011;258:1140–1149.
-
(2011)
J Neurol
, vol.258
, pp. 1140-1149
-
-
McLeod, J.G.1
Hammond, S.R.2
Kurtzke, J.F.3
-
41
-
-
84879399880
-
A mechanistic, stochastic model helps understand multiple sclerosis course and pathogenesis
-
Bordi I, Umeton R, Ricigliano VAG, et al. A mechanistic, stochastic model helps understand multiple sclerosis course and pathogenesis. Int J Genomics 2013;2013:910321.
-
(2013)
Int J Genomics
, vol.2013
, pp. 910321
-
-
Bordi, I.1
Umeton, R.2
Ricigliano, V.A.G.3
-
42
-
-
84859641038
-
Using gene expression noise to understand gene regulation
-
Munski B, Nevert G, van Oudenaarden A. Using gene expression noise to understand gene regulation. Science 2012;336:183–187.
-
(2012)
Science
, vol.336
, pp. 183-187
-
-
Munski, B.1
Nevert, G.2
van Oudenaarden, A.3
-
43
-
-
33748994704
-
Stochastic mRNA synthesis in mammalian cells
-
Raj A, Peskin CS, Tranchina D, et al. Stochastic mRNA synthesis in mammalian cells. PLoS Biol 2006;4:e309.
-
(2006)
PLoS Biol
, vol.4
-
-
Raj, A.1
Peskin, C.S.2
Tranchina, D.3
-
44
-
-
77249114260
-
Variability in gene expression underlies incomplete penetrance
-
Raj A, Rifkin SA, Andersen E, van Oudenaarden A. Variability in gene expression underlies incomplete penetrance. Nature 2010;463:913–918.
-
(2010)
Nature
, vol.463
, pp. 913-918
-
-
Raj, A.1
Rifkin, S.A.2
Andersen, E.3
van Oudenaarden, A.4
-
45
-
-
83255177150
-
Single-cell dissection of transcriptional heterogeneity in human colon tumors
-
Dalerba P, Kalisky T, Sahoo D, et al. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol 2011;29:1120–1127.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 1120-1127
-
-
Dalerba, P.1
Kalisky, T.2
Sahoo, D.3
-
46
-
-
84355162740
-
Single-molecule transcript counting of stem-cell markers in the mouse intestine
-
Itzkovitz S, Lyubimova A, Blat IC, et al. Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol 2012;14:106–115.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 106-115
-
-
Itzkovitz, S.1
Lyubimova, A.2
Blat, I.C.3
-
47
-
-
84883447620
-
Allele-specific detection of single mRNA molecules in situ
-
Hansen CH, van Oudenaarden A. Allele-specific detection of single mRNA molecules in situ. Nat Methods 2013;10:869–871.
-
(2013)
Nat Methods
, vol.10
, pp. 869-871
-
-
Hansen, C.H.1
van Oudenaarden, A.2
-
48
-
-
84878997106
-
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
-
Shalek AK, Satija R, Adiconis X, et al. Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature 2013;498:236–240.
-
(2013)
Nature
, vol.498
, pp. 236-240
-
-
Shalek, A.K.1
Satija, R.2
Adiconis, X.3
-
49
-
-
84882582801
-
Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments
-
Wills QF, Livak KJ, Tipping AJ, et al. Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments. Nat Biotechnol 2013;31:748–752.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 748-752
-
-
Wills, Q.F.1
Livak, K.J.2
Tipping, A.J.3
-
51
-
-
84866369892
-
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and late hierarchic phase
-
Buganim Y, Faddah DA, Cheng AW, et al. Single-cell expression analyses during cellular reprogramming reveal an early stochastic and late hierarchic phase. Cell 2012;150:1209–1222.
-
(2012)
Cell
, vol.150
, pp. 1209-1222
-
-
Buganim, Y.1
Faddah, D.A.2
Cheng, A.W.3
-
52
-
-
84864251757
-
Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions
-
Bhatt DM, Pandya-Jones A, Tong AJ, et al. Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell 2012;150:279–290.
-
(2012)
Cell
, vol.150
, pp. 279-290
-
-
Bhatt, D.M.1
Pandya-Jones, A.2
Tong, A.J.3
-
53
-
-
79960278355
-
Shifting patterns: merging molecules, morphogens, motility and methodology
-
Little SC, Wieschaus EF. Shifting patterns: merging molecules, morphogens, motility and methodology. Dev Cell 2011;21:2–4.
-
(2011)
Dev Cell
, vol.21
, pp. 2-4
-
-
Little, S.C.1
Wieschaus, E.F.2
-
54
-
-
84860852665
-
Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli
-
Sawarkar R, Sievers C, Paro R. Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli. Cell 2012;149:807–818.
-
(2012)
Cell
, vol.149
, pp. 807-818
-
-
Sawarkar, R.1
Sievers, C.2
Paro, R.3
-
55
-
-
84877783519
-
Ultrasensitive response motifs: basic amplifiers in molecular signalling networks
-
Zhang Q, Bhattacharya S, Andersen ME. Ultrasensitive response motifs: basic amplifiers in molecular signalling networks. Open Biol 2013;3:130031.
-
(2013)
Open Biol
, vol.3
, pp. 130031
-
-
Zhang, Q.1
Bhattacharya, S.2
Andersen, M.E.3
-
56
-
-
0036297539
-
Stochastic patterns in globin gene expression are established prior to transcriptional activation and are clonally inherited
-
de Krom M, von Lindem M, Grosveld F, Strouboulis J. Stochastic patterns in globin gene expression are established prior to transcriptional activation and are clonally inherited. Mol Cell 2002;9:1319–1326.
-
(2002)
Mol Cell
, vol.9
, pp. 1319-1326
-
-
de Krom, M.1
von Lindem, M.2
Grosveld, F.3
Strouboulis, J.4
-
57
-
-
84862662420
-
Dynamics and memory of heterochromatin in living cells
-
Hathaway NA, Bell O, Hodges C, et al. Dynamics and memory of heterochromatin in living cells. Cell 2012;149:1447–1460.
-
(2012)
Cell
, vol.149
, pp. 1447-1460
-
-
Hathaway, N.A.1
Bell, O.2
Hodges, C.3
-
58
-
-
84873310426
-
Genome-wide chromatin state transitions associated with developmental and environmental clues
-
Zhu J, Adli M, Zou JY, et al. Genome-wide chromatin state transitions associated with developmental and environmental clues. Cell 2013;152:642–654.
-
(2013)
Cell
, vol.152
, pp. 642-654
-
-
Zhu, J.1
Adli, M.2
Zou, J.Y.3
-
59
-
-
84857744447
-
Genomic regions associated with multiple sclerosis are active in B cells
-
Disanto G, Sandve GK, Berlanga-Taylor AJ, et al. Genomic regions associated with multiple sclerosis are active in B cells. PLoS One 2012;7:e3228.
-
(2012)
PLoS One
, vol.7
-
-
Disanto, G.1
Sandve, G.K.2
Berlanga-Taylor, A.J.3
-
60
-
-
84865822182
-
Systematic localization of common disease- associated variation in regulatory DNA
-
Maurano MT, Humbert R, Rynes E, et al. Systematic localization of common disease- associated variation in regulatory DNA. Science 2012;337:1190–1195.
-
(2012)
Science
, vol.337
, pp. 1190-1195
-
-
Maurano, M.T.1
Humbert, R.2
Rynes, E.3
-
61
-
-
84878777552
-
An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome
-
De Jager PL, Bennett DA. An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome. JAMA Neurol 2013;70:719–726.
-
(2013)
JAMA Neurol
, vol.70
, pp. 719-726
-
-
De Jager, P.L.1
Bennett, D.A.2
-
62
-
-
84858749570
-
Gender-based blood transcritptomes and interactomes in multiple sclerosis: involvement of SP1 dependent gene transcription
-
Menon R, Di Dario M, Cordiglieri C, et al. Gender-based blood transcritptomes and interactomes in multiple sclerosis: involvement of SP1 dependent gene transcription. J Autoimmun 2011;38:144–155.
-
(2011)
J Autoimmun
, vol.38
, pp. 144-155
-
-
Menon, R.1
Di Dario, M.2
Cordiglieri, C.3
-
63
-
-
84865068203
-
Vitamin D receptor binding, chromatin states and association with multiple sclerosis
-
Disanto G, Sandve GK, Berlanga-Taylor AJ, et al. Vitamin D receptor binding, chromatin states and association with multiple sclerosis. Hum Mol Genet 2012;21:3575–3586.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 3575-3586
-
-
Disanto, G.1
Sandve, G.K.2
Berlanga-Taylor, A.J.3
-
64
-
-
84886769508
-
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
-
Ho Y-C, Shan L, Hosmane NN, et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 2013;155:540–551.
-
(2013)
Cell
, vol.155
, pp. 540-551
-
-
Ho, Y.-C.1
Shan, L.2
Hosmane, N.N.3
-
65
-
-
84865137988
-
An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions
-
Arvey A, Tempera I, Tsai K, et al. An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. Cell Host Microbe 2012;12:233–245.
-
(2012)
Cell Host Microbe
, vol.12
, pp. 233-245
-
-
Arvey, A.1
Tempera, I.2
Tsai, K.3
-
66
-
-
84875948453
-
Interpreting the Epstein-Barr virus (EBV) epigenome using high-throughput data
-
Arvey A, Tempera I, Lieberman PM. Interpreting the Epstein-Barr virus (EBV) epigenome using high-throughput data. Viruses 2013;5:1042–1054.
-
(2013)
Viruses
, vol.5
, pp. 1042-1054
-
-
Arvey, A.1
Tempera, I.2
Lieberman, P.M.3
-
67
-
-
84871537798
-
An endogenous accelerator of viral gene expression confers a fitness advantage
-
Teng MW, Bolovan-Fritts C, Dar RD, et al. An endogenous accelerator of viral gene expression confers a fitness advantage. Cell 2012;151:1569–1580.
-
(2012)
Cell
, vol.151
, pp. 1569-1580
-
-
Teng, M.W.1
Bolovan-Fritts, C.2
Dar, R.D.3
-
68
-
-
84876222028
-
Selective inhibition of tumor oncogenes by disruption of super-enhancers
-
Lovén J, Hoke HA, Lin CY, et al. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 2013;153:320–334.
-
(2013)
Cell
, vol.153
, pp. 320-334
-
-
Lovén, J.1
Hoke, H.A.2
Lin, C.Y.3
-
69
-
-
77952300025
-
Interaction of Epstein-Barr virus (EBV) with human B- lymphocytes
-
Klein G, Klein E, Kashuba E. Interaction of Epstein-Barr virus (EBV) with human B- lymphocytes. Biochem Biophys Res Commun 2010;396:67–73.
-
(2010)
Biochem Biophys Res Commun
, vol.396
, pp. 67-73
-
-
Klein, G.1
Klein, E.2
Kashuba, E.3
-
70
-
-
84867021989
-
Transcriptional amplification in tumor cells with elevated c-Myc
-
Lin CY, Lovén J, Rahl PB, et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 2012;151:56–67.
-
(2012)
Cell
, vol.151
, pp. 56-67
-
-
Lin, C.Y.1
Lovén, J.2
Rahl, P.B.3
-
71
-
-
84867010006
-
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
-
Nie Z, Hu G, Wei G, et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 2012;151:68–79.
-
(2012)
Cell
, vol.151
, pp. 68-79
-
-
Nie, Z.1
Hu, G.2
Wei, G.3
-
72
-
-
0345257150
-
Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold
-
Faroudi M, Utzny C, Salio M, et al. Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold. Proc Natl Acad Sci USA 2003;100:14145–14150.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 14145-14150
-
-
Faroudi, M.1
Utzny, C.2
Salio, M.3
-
73
-
-
84880953116
-
Stochastic cytokine expression induces mixed T helper cell states
-
Fang M, Xie H, Dougan SK, et al. Stochastic cytokine expression induces mixed T helper cell states. PLoS Biol 2013;11:e1001618.
-
(2013)
PLoS Biol
, vol.11
-
-
Fang, M.1
Xie, H.2
Dougan, S.K.3
-
74
-
-
0034097576
-
Compositional bias and mimicry toward the nonself proteome in immunodominant T cell epitopes of self and nonself antigens
-
Ristori G, Salvetti M, Pesole G, et al. Compositional bias and mimicry toward the nonself proteome in immunodominant T cell epitopes of self and nonself antigens. FASEB J 2000;14:431–438.
-
(2000)
FASEB J
, vol.14
, pp. 431-438
-
-
Ristori, G.1
Salvetti, M.2
Pesole, G.3
-
75
-
-
84867156668
-
Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface
-
Di Zenzo G, Di Lullo G, Corti D, et al. Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface. J Clin Invest 2012;122:3781–3790.
-
(2012)
J Clin Invest
, vol.122
, pp. 3781-3790
-
-
Di Zenzo, G.1
Di Lullo, G.2
Corti, D.3
-
76
-
-
0032589596
-
Use of Bacille Calmette Guèrin (BCG) in multiple sclerosis
-
Ristori G, Buzzi MG, Sabatini U, et al. Use of Bacille Calmette Guèrin (BCG) in multiple sclerosis. Neurology 1999;53:1588–1589.
-
(1999)
Neurology
, vol.53
, pp. 1588-1589
-
-
Ristori, G.1
Buzzi, M.G.2
Sabatini, U.3
-
77
-
-
84892183623
-
Effects of Bacille Calmette-Guèrin after the first demyelinating event in the CNS
-
Ristori G, Romano S, Cannoni S, et al. Effects of Bacille Calmette-Guèrin after the first demyelinating event in the CNS. Neurology 2014;82:41–48.
-
(2014)
Neurology
, vol.82
, pp. 41-48
-
-
Ristori, G.1
Romano, S.2
Cannoni, S.3
-
78
-
-
84876787121
-
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
-
Kleinewietfeld M, Manzel A, Titze J, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013;496:518–522.
-
(2013)
Nature
, vol.496
, pp. 518-522
-
-
Kleinewietfeld, M.1
Manzel, A.2
Titze, J.3
-
79
-
-
84879970347
-
Sodium accumulation is associated with disability and a progressive course in multiple sclerosis
-
Paling D, Solanky BS, Riemer F, et al. Sodium accumulation is associated with disability and a progressive course in multiple sclerosis. Brain 2013;136:2305–2317.
-
(2013)
Brain
, vol.136
, pp. 2305-2317
-
-
Paling, D.1
Solanky, B.S.2
Riemer, F.3
-
80
-
-
79960290509
-
Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance
-
Maccarrone M, Bernardi G, Agrò AF, Centonze D. Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance. Br J Pharmacol 2011;163:1379–1390.
-
(2011)
Br J Pharmacol
, vol.163
, pp. 1379-1390
-
-
Maccarrone, M.1
Bernardi, G.2
Agrò, A.F.3
Centonze, D.4
-
81
-
-
71849098862
-
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score
-
De Jager PL, Chibnik LB, Cui J, et al. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol 2009;8:1111–1119.
-
(2009)
Lancet Neurol
, vol.8
, pp. 1111-1119
-
-
De Jager, P.L.1
Chibnik, L.B.2
Cui, J.3
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