Compositional bias and mimicry toward the nonself proteome in immunodominant T cell epitopes of self and nonself antigens

FASEB Journal

Volumn 14, Issue 3, 2000, Pages 431-438

  Ristori, Giovanni ^a   Salvetti, Marco ^a   Pesole, Graziano ^b,e   Attimonelli, Marcella ^c   Buttinelli, Carla ^a   Martin, Roland ^d   Riccio, Paolo ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF BASILICATA   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

Molecular mimicry immunogenicity; T lymphocytes; Tolerance; Vaccine design

Indexed keywords

AUTOANTIGEN; EPITOPE; PROTEOME;

AMINO ACID SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; CROSS REACTION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOGENICITY; MOLECULAR MIMICRY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0034097576     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.3.431     Document Type: Article

References (48)

1. Burnet, F. M. (1959) The Clonal Selection Theory of Acquired Immunity, Cambridge University Press, Cambridge, U.K.
2. Cohen, I. R. (1992) The cognitive principle challenges clonal selection. Immunol. Today 13, 441-444
3. Nanda, N. K., Arzoo, K. K., Geysen, H. M., Sette, A., and Sercarz, E. E. (1995) Recognition of multiple peptide cores by a single T-cell receptor. J. Exp. Med. 182, 531-539
4. Wucherpfennig, K. W., and Strominger, J. L. (1995) Molecular mimicry in T-cell mediated autoimmunity. Cell 80, 695-705
5. Hemmer, B., Fleckenstein B. T., Vergelli, M., Jung, G., McFarland, H., Martin, R., and Wiesmuller, K. H. (1997) Identification of high potency microbial self ligands for a human autoreactive class-II restricted T-cell clone. J. Exp. Med. 185, 1651-1660
6. Hemmer, B., Vergelli, M., Pinilla, C., Houghten, R., and Martin, R. (1998) Probing degeneracy in T-cell recognition using peptide combinatorial libraries. Immunol. Today 19, 163-168
7. Mason, D. (1998) A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19, 395-404
8. Oldstone, M. B. A. (1998) Molecular mimicry and immunemediated diseases. FASEB J. 12, 1255-1265
9. Fujinami, R. S., and Oldstone, M. B. A. (1985) Amino acid omology between the encephalitogenic site of myelin basic protein and virus. Mechanism for autoimmunity. Science 230, 1043-1045
10. Barnett, L. A., and Fujinami, R. S. (1992) Molecular mimicry: a mechanism for autoimmune injury. FASEB J. 6, 840-844
11. Medzhitov, R., and Janeway, C. A. (1997) Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295-298
12. Fearon, D. T., and Locksley, R. M. (1996) The instructive role of innate immunity in the acquired immune response. Science 272, 50-53
13. Schwartz, R. H. (1992) Costimulation of T-lymphocytes: the role of CD28, CTIA4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71, 1065-1068
14. Evavold, B. D., Sloan-Lancaster, J., Wilson, K. J., Rothbard, J. B., and Allen, P. M. (1995) Specific T-cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity 2, 655-705
15. Barnaba, V. (1996) Viruses, hidden self epitopes and autoimmunitry. Immunol. Rev. 152, 46-66
16. Ota, K., Matsui, M., Milford, E. L., Mackin, G. A., Weiner, H.L., and Hafler, D. A. (1990) T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature (London) 346, 183-187
17. Meinl, E., Weber, F., Drexler, K., Morelle, C., Ott, M., Saruhan-Direskeneli, G., Goebels, N., Ertl, B., Jechart, G., Giegerich, G., Schonbeck, S., Bannwarth, W., Wekerle, H., and Hohlfeld, R. (1993) Myelin basic protein-specific T-lymphocyte response in multiple sclerosis. J. Clin. Invest. 92, 2633-2643
18. Valli, A., Sette, A., Kappos, L., Oseroff, C., Sidney, J., Miescher, G., Hochberg, M., Albert, E.D., and Adorini, L. (1993) Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T-cells from multiple sclerosis patients. J. Clin. Invest. 91, 616-628
19. Salvetti, M., Ristori, G., D'Amato, M., Buttinelli, C., Falcone, M., Fieschi, C., Wekerle, H., and Pozzilli, C. (1993) Predominant and stable response to regions of myelin basic protein can be detected in individual patients with multiple sclerosis. Eur. J. Immunol. 23, 1232-1239
20. Pesole, G., Attimonelli, M., and Saccone, C. (1994) Linguistic approaches to the analysis of sequence information. Trends Biotechnol. 12, 401-408
21. Gouy, M., Gautier, C., Attimonelli, M., Lanave, C., and Di Paola, G. (1985) ACNUC-a portable retrieval system for nucleic acid sequence databases: logical and physical designs and usage. Comput. Appl. Biosci. 1, 167-172
22. Grillo, G., Attimonelli, M., Liuni, S., and Pesole, G. (1996) CLEAN-UP: a fast computer program for removing redundancies from nucleotide sequence databases. Comput. Appl. Biosci. 12, 1-8
23. Martin, R., Utz, U., Coligan, J. E., Richert, J. R., Flerlage, M., Robinson, E., Stone, R., Biddison, W. E., McFarlin, D. E., and McFarland, H. F. (1992) Diversity in fine specificity and T-cell receptor usage of the human CD4+ cytotoxic T-cell response specific for the immunodominant myelin basic protein peptide 87-106. J. Immunol. 148, 1359-1366
24. Jung, G., and Beck-Sickinger, A. G. (1992) Multiple peptide synthesis methods and their applications. Angew. Chem. Int. Ed. Engl. 31, 367-383
25. Schwartz, R. H. (1985) T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu. Rev. Immunol. 3, 237-261
26. Baumhuter, S., Wallace, C. J. A., Proudfoot, E. I., Bron, C., and Corradin, G. (1987) Multiple T-cell antigenic determinants identified within a limited region of the horse cytochrome c molecule. Eur. J. Immunol. 17, 651-656
27. Mamula, M. J., Lin, R.-H., Janeway, C. A., and Hardin, J. A. (1992) Breaking T-cell tolerance with foreign and self coimmunogens: a study of autoimmune B and T-cell epitopes of cytochrome c. J. Immunol. 149, 789-795
28. Huffman, R. M., Diepolder, H. M., Zachoval, R., Zwiebel, F. M., Jung, M. C., Scholz, S.. Nitschko, H; Rietmuller, G., and Pape, G. R. (1995) Mapping of immunodominant CD4+ T-lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection. Hepatology 21, 632-638
29. Lechmann, M., Ihlenfeldt, H. G., Braunschweiger, I., Giers, G., Jung, G., Matz, B., Kaiser, R., Sauerbruch, T., and Spengler, U. (1996) T- and B-cell response to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus positive blood donors without viremia. Hepatology 24, 790-795
30. Carballido, J. M., Carbadillo-Perig, N., Kagi, M. K., Meloen, R. H., Wuthrich, B., Heusser, C. H., and Blaser, K. (1993) T-cell epitope specificity in human allergic and nonallergic subjects to bee venom phospholipase A2. J. Immunol. 150, 3582-3591
31. Margalit, H., Spouge, J. L., Cornette, J. L., Cease, K. B., Delisi, C., and Berzofsky, J. A. (1987) Prediction of immunodominant helper T-cell antigenic sites from the primary sequence. J. Immunol. 138, 2213-2229
32. Rothbard, J. B., and Taylor, W. R. (1988) A sequence pattern common to T-cell epitopes. EMBO J. 7, 93-100
33. Sette, A., Buus, S., Appella, E., Smith, J. A., Chesnut, R., Miles, C., Colon, S. M., and Grey, H. M. (1989) Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis. Proc. Natl. Acad. Sci. USA 86, 3296-3300
34. Reyes, V. E., Phillips, L., Humphreys, R. E., and Lew, R. A. (1989) Prediction of protein helices with a derivative of the strip-of-helix hydrophobicity algorithm. J. Biol. Chem. 264, 12854-1258
35. Reyes, V. E., Fowlie, E. J., Lu, S., Phillips, L., Chin, L. T., Humphreys, R. E., and Lew, R. A. (1990) Comparison of three related methods to select T-cell-presented sequences of protein antigens. Mol. Immunol. 27, 1021-1027
36. Kolaskar, A .S., Tongaonkar, P. C. (1990) A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett. 276, 172-174
37. Steinman, R. M., Pack, M., and Inaba, K. (1997) Dendritic cells in the T cell areas of lymphoid organs. Immunol. Rev. 156, 25-37
38. Viret, C., Wong, F. S., and Janeway, C.A. (1999) Designing and maintaining the mature TCR repertoire: the continuum self-peptide:self-MHC complex recognition. Immunity 10, 559-568
39. Matzinger, P. (1994) Memories are made of this. Nature (London) 369, 605-606
40. Nakano, N., Rooke, R., Benoist, C., and Mathis, D. (1997) Positive selection of T-cells induced by viral delivery of neopeptitles to the thymus. Science 275, 678-683
41. Williams, O., Tanaka, Y., Tarazona, R., and Kioussis, D. (1997) The agonist-antagonist balance in positive selection. Immunol. Today 18, 121-126
42. Bevan, M. J. (1997) In thymic selection, peptide diversity gives and takes away. Immunity 7, 175-178
43. k peptide combination. J. Exp. Med. 186, 1441-1450
44. Sant'Angelo, D. B., Waterbury, P. G., Cohen, B. E., Martin, W. D., Van Kaer, L., Hayday, A. C., and Janeway, C. A., Jr. (1997) The imprint of intrathymic self peptides on the mature T-cell receptor repertoire. Immunity 7, 517-524
45. Barton, G. M., and Rudensky, A. Y. (1999) Requirement for diverse, low-abundance peptides in positive selection of T-cells. Science 283, 67-70
46. Lucas, B., Stefanova, I., Yatsumoto, K., Dautigny, N., and Germain, R. N. (1999) Divergent changes in the sensitivity of maturing T-cell to structurally related ligands underlies formation of a useful T-cell repertoire. Immunity 10, 367-376
47. Moudgil, K. D., Sekiguchi, D., Kim, S. Y., and Sercarz, E. E. (1997) Immunodominance is independent of structural constraints. J. Immunol. 159, 2574-2579
48. Landry, S. J. (1997) Local protein instability predictive of helper T-cell epitopes. Immunol. Today 18, 527-532