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Volumn 38, Issue 2-3, 2012, Pages

Gender-based blood transcriptomes and interactomes in multiple sclerosis: Involvement of SP1 dependent gene transcription

Author keywords

Gender; Multiple sclerosis; SP1 transcription factor; Systems biology; Transcriptomics

Indexed keywords

3',3' N XYLENYLBIS(DAUNORUBICIN); ANDROGEN RECEPTOR; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERACTOME; RNA; TRANSCRIPTION FACTOR SP1; TRANSCRIPTOME; UNCLASSIFIED DRUG;

EID: 84858749570     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.11.004     Document Type: Article
Times cited : (41)

References (54)
  • 2
    • 65249142200 scopus 로고    scopus 로고
    • The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?
    • Weiner H.L. The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?. Ann Neurol 2009, 65:239-248.
    • (2009) Ann Neurol , vol.65 , pp. 239-248
    • Weiner, H.L.1
  • 3
    • 67349277156 scopus 로고    scopus 로고
    • UBC Neurologists. Natural history comparisons of primary and secondary progressive multiple sclerosis reveals differences and similarities
    • Tremlett H., Zhao Y., Devonshire V. UBC Neurologists. Natural history comparisons of primary and secondary progressive multiple sclerosis reveals differences and similarities. J Neurol 2009, 256:374-381.
    • (2009) J Neurol , vol.256 , pp. 374-381
    • Tremlett, H.1    Zhao, Y.2    Devonshire, V.3
  • 4
    • 3142556134 scopus 로고    scopus 로고
    • Development of biomarkers in multiple sclerosis
    • Bielekova B., Martin R. Development of biomarkers in multiple sclerosis. Brain 2004, 127:1463-1478.
    • (2004) Brain , vol.127 , pp. 1463-1478
    • Bielekova, B.1    Martin, R.2
  • 5
    • 34347248415 scopus 로고    scopus 로고
    • Genomics in multiple sclerosis-current state and future directions
    • Comabella M., Martin R. Genomics in multiple sclerosis-current state and future directions. J Neuroimmunol 2007, 187:1-8.
    • (2007) J Neuroimmunol , vol.187 , pp. 1-8
    • Comabella, M.1    Martin, R.2
  • 7
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • International Multiple Sclerosis Genetics Consortium
    • International Multiple Sclerosis Genetics Consortium, Hafler D.A., Compston A., Sawcer S., Lander E.S., Daly M.J., et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007, 357:851-862.
    • (2007) N Engl J Med , vol.357 , pp. 851-862
    • Hafler, D.A.1    Compston, A.2    Sawcer, S.3    Lander, E.S.4    Daly, M.J.5
  • 8
    • 64049119359 scopus 로고    scopus 로고
    • Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes
    • Wiendl H., Hohlfeld R. Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes. Neurology 2009, 72:1008-1015.
    • (2009) Neurology , vol.72 , pp. 1008-1015
    • Wiendl, H.1    Hohlfeld, R.2
  • 9
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis
    • McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001, 50:121-127.
    • (2001) Ann Neurol , vol.50 , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3    Goodkin, D.4    Hartung, H.P.5    Lublin, F.D.6
  • 11
    • 0035793042 scopus 로고    scopus 로고
    • Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
    • Li C., Wong W.H. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 2001, 98:31-36.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 31-36
    • Li, C.1    Wong, W.H.2
  • 12
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher V.G., Tibshirani R., Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001, 98:5116-5121.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 13
    • 46049099698 scopus 로고    scopus 로고
    • Bayesian analysis of comparative microarray experiments by model averaging
    • Sebastiani P., Xie H., Ramoni M.F. Bayesian analysis of comparative microarray experiments by model averaging. Bayesian Anal 2006, 1:707-732.
    • (2006) Bayesian Anal , vol.1 , pp. 707-732
    • Sebastiani, P.1    Xie, H.2    Ramoni, M.F.3
  • 15
    • 45949092783 scopus 로고    scopus 로고
    • VisANT: an integrative framework for networks in systems biology
    • Hu Z., Snitkin E.S., DeLisi C. VisANT: an integrative framework for networks in systems biology. Brief Bioinform 2008, 9:317-325.
    • (2008) Brief Bioinform , vol.9 , pp. 317-325
    • Hu, Z.1    Snitkin, E.S.2    DeLisi, C.3
  • 16
    • 0035363488 scopus 로고    scopus 로고
    • In vivo gene expression revealed by cDNA arrays: the pattern in relapsing-remitting multiple sclerosis patients compared with normal subjects
    • Ramanathan M., Weinstock-Guttman B., Nguyen L.T., Badgett D., Miller C., Patrick K., et al. In vivo gene expression revealed by cDNA arrays: the pattern in relapsing-remitting multiple sclerosis patients compared with normal subjects. J Neuroimmunol 2001, 116:213-219.
    • (2001) J Neuroimmunol , vol.116 , pp. 213-219
    • Ramanathan, M.1    Weinstock-Guttman, B.2    Nguyen, L.T.3    Badgett, D.4    Miller, C.5    Patrick, K.6
  • 17
    • 10744231299 scopus 로고    scopus 로고
    • Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease
    • Bomprezzi R., Ringner M., Kim S., Bittner M.L., Khan J., Chen Y., et al. Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum Mol Genet 2003, 12:2191-2199.
    • (2003) Hum Mol Genet , vol.12 , pp. 2191-2199
    • Bomprezzi, R.1    Ringner, M.2    Kim, S.3    Bittner, M.L.4    Khan, J.5    Chen, Y.6
  • 18
    • 1442304886 scopus 로고    scopus 로고
    • Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity
    • Achiron A., Gurevich M., Friedman N., Kaminski N., Mandel M. Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity. Ann Neurol 2004, 55:410-417.
    • (2004) Ann Neurol , vol.55 , pp. 410-417
    • Achiron, A.1    Gurevich, M.2    Friedman, N.3    Kaminski, N.4    Mandel, M.5
  • 19
    • 1842687455 scopus 로고    scopus 로고
    • Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells
    • Iglesias A.H., Camelo S., Hwang D., Villanueva R., Stephanopoulos G., Dangond F. Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells. J Neuroimmunol 2004, 150:163-177.
    • (2004) J Neuroimmunol , vol.150 , pp. 163-177
    • Iglesias, A.H.1    Camelo, S.2    Hwang, D.3    Villanueva, R.4    Stephanopoulos, G.5    Dangond, F.6
  • 20
    • 26044433609 scopus 로고    scopus 로고
    • Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis
    • Booth D.R., Arthur A.T., Teutsch S.M., Bye C., Rubio J., Armati P.J., et al. Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. J Mol Med 2005, 83:822-830.
    • (2005) J Mol Med , vol.83 , pp. 822-830
    • Booth, D.R.1    Arthur, A.T.2    Teutsch, S.M.3    Bye, C.4    Rubio, J.5    Armati, P.J.6
  • 21
    • 34447341975 scopus 로고    scopus 로고
    • Zinc-ion binding and cytokine activity regulation pathways predicts outcome in relapsing-remitting multiple sclerosis
    • Achiron A., Gurevich M., Snir Y., Segal E., Mandel M. Zinc-ion binding and cytokine activity regulation pathways predicts outcome in relapsing-remitting multiple sclerosis. Clin Exp Immunol 2007, 149:235-242.
    • (2007) Clin Exp Immunol , vol.149 , pp. 235-242
    • Achiron, A.1    Gurevich, M.2    Snir, Y.3    Segal, E.4    Mandel, M.5
  • 22
    • 69049102091 scopus 로고    scopus 로고
    • Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells
    • Gurevich M., Tuller T., Rubinstein U., Or-Bach R., Achiron A. Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells. BMC Med Genomics 2009, 2:46.
    • (2009) BMC Med Genomics , vol.2 , pp. 46
    • Gurevich, M.1    Tuller, T.2    Rubinstein, U.3    Or-Bach, R.4    Achiron, A.5
  • 23
    • 77953524192 scopus 로고    scopus 로고
    • The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis
    • Gandhi K.S., McKay F.C., Cox M., Riveros C., Armstrong N., Heard R.N., et al. The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Hum Mol Genet 2010, 19:2134-2143.
    • (2010) Hum Mol Genet , vol.19 , pp. 2134-2143
    • Gandhi, K.S.1    McKay, F.C.2    Cox, M.3    Riveros, C.4    Armstrong, N.5    Heard, R.N.6
  • 24
    • 70349781720 scopus 로고    scopus 로고
    • Gender effects in relapsing-remitting multiple sclerosis: correlation between clinical variables and gene expression molecular pathways
    • Achiron A., Gurevich M. Gender effects in relapsing-remitting multiple sclerosis: correlation between clinical variables and gene expression molecular pathways. J Neurol Sci 2009, 286:47-53.
    • (2009) J Neurol Sci , vol.286 , pp. 47-53
    • Achiron, A.1    Gurevich, M.2
  • 26
    • 77749309959 scopus 로고    scopus 로고
    • Evidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson disease
    • Simunovic F., Yi M., Wang Y., Stephens R., Sonntag K.C. Evidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson disease. PLoS One 2010, 5:e8856.
    • (2010) PLoS One , vol.5
    • Simunovic, F.1    Yi, M.2    Wang, Y.3    Stephens, R.4    Sonntag, K.C.5
  • 27
    • 35148814074 scopus 로고    scopus 로고
    • Transcriptional profiling of Alzheimer blood mononuclear cells by microarray
    • Maes O.C., Xu S., Yu B., Chertkow H.M., Wang E., Schipper H.M. Transcriptional profiling of Alzheimer blood mononuclear cells by microarray. Neurobiol Aging 2007, 28:1795-1809.
    • (2007) Neurobiol Aging , vol.28 , pp. 1795-1809
    • Maes, O.C.1    Xu, S.2    Yu, B.3    Chertkow, H.M.4    Wang, E.5    Schipper, H.M.6
  • 30
    • 70349772045 scopus 로고    scopus 로고
    • Sex hormones, brain damage and clinical course of multiple sclerosis
    • Tomassini V., Pozzilli C. Sex hormones, brain damage and clinical course of multiple sclerosis. J Neurol Sci 2009, 286:35-39.
    • (2009) J Neurol Sci , vol.286 , pp. 35-39
    • Tomassini, V.1    Pozzilli, C.2
  • 31
    • 67349236051 scopus 로고    scopus 로고
    • The genetics and epigenetics of autoimmune diseases
    • Hewagama A., Richardson B. The genetics and epigenetics of autoimmune diseases. J Autoimmun 2009, 33:3-11.
    • (2009) J Autoimmun , vol.33 , pp. 3-11
    • Hewagama, A.1    Richardson, B.2
  • 32
    • 70449725209 scopus 로고    scopus 로고
    • Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies
    • Urdinguio R.G., Sanchez-Mut J.V., Esteller M. Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol 2009, 8:1056-1072.
    • (2009) Lancet Neurol , vol.8 , pp. 1056-1072
    • Urdinguio, R.G.1    Sanchez-Mut, J.V.2    Esteller, M.3
  • 33
    • 0142247170 scopus 로고    scopus 로고
    • Stealth technology: how Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detection
    • Tao Q., Robertson K.D. Stealth technology: how Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detection. Clin Immunol 2003, 109:53-63.
    • (2003) Clin Immunol , vol.109 , pp. 53-63
    • Tao, Q.1    Robertson, K.D.2
  • 34
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li Q., Verma I.M. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002, 2:725-734.
    • (2002) Nat Rev Immunol , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 35
    • 54949147176 scopus 로고    scopus 로고
    • New regulators of NF-kappaB in inflammation
    • Ghosh S., Hayden M.S. New regulators of NF-kappaB in inflammation. Nat Rev Immunol 2008, 8:837-848.
    • (2008) Nat Rev Immunol , vol.8 , pp. 837-848
    • Ghosh, S.1    Hayden, M.S.2
  • 36
    • 70350011787 scopus 로고    scopus 로고
    • NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis
    • Yan J., Greer J.M. NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis. CNS Neurol Disord Drug Targets 2008, 7:536-557.
    • (2008) CNS Neurol Disord Drug Targets , vol.7 , pp. 536-557
    • Yan, J.1    Greer, J.M.2
  • 37
    • 20444446595 scopus 로고    scopus 로고
    • Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis
    • Camelo S., Iglesias A.H., Hwang D., Due B., Ryu H., Smith K., et al. Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol 2005, 164:10-21.
    • (2005) J Neuroimmunol , vol.164 , pp. 10-21
    • Camelo, S.1    Iglesias, A.H.2    Hwang, D.3    Due, B.4    Ryu, H.5    Smith, K.6
  • 38
    • 0035979737 scopus 로고    scopus 로고
    • Duration of nuclear NF-kappaB action regulated by reversible acetylation
    • Chen L., Fischle W., Verdin E., Greene W.C. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 2001, 293:1653-1657.
    • (2001) Science , vol.293 , pp. 1653-1657
    • Chen, L.1    Fischle, W.2    Verdin, E.3    Greene, W.C.4
  • 39
    • 33645125545 scopus 로고    scopus 로고
    • Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells
    • Rokhlin O.W., Glover R.B., Guseva N.V., Taghiyev A.F., Kohlgraf K.G., Cohen M.B. Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. Mol Cancer Res 2006, 4:113-123.
    • (2006) Mol Cancer Res , vol.4 , pp. 113-123
    • Rokhlin, O.W.1    Glover, R.B.2    Guseva, N.V.3    Taghiyev, A.F.4    Kohlgraf, K.G.5    Cohen, M.B.6
  • 40
    • 64749088085 scopus 로고    scopus 로고
    • Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells
    • Altuwaijri S., Chuang K.H., Lai K.P., Lai J.J., Lin H.Y., Young F.M., et al. Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells. Mol Endocrinol 2009, 23:444-453.
    • (2009) Mol Endocrinol , vol.23 , pp. 444-453
    • Altuwaijri, S.1    Chuang, K.H.2    Lai, K.P.3    Lai, J.J.4    Lin, H.Y.5    Young, F.M.6
  • 43
    • 78649928621 scopus 로고    scopus 로고
    • A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis
    • Riveros C., Mellor D., Gandhi K.S., McKay F.C., Cox M.B., Berretta R., et al. A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis. PLoS One 2010, 5:e14176.
    • (2010) PLoS One , vol.5
    • Riveros, C.1    Mellor, D.2    Gandhi, K.S.3    McKay, F.C.4    Cox, M.B.5    Berretta, R.6
  • 44
    • 15244358503 scopus 로고    scopus 로고
    • Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
    • Xie X., Lu J., Kulbokas E.J., Golub T.R., Mootha V., Lindblad-Toh K., et al. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature 2005, 434:338-345.
    • (2005) Nature , vol.434 , pp. 338-345
    • Xie, X.1    Lu, J.2    Kulbokas, E.J.3    Golub, T.R.4    Mootha, V.5    Lindblad-Toh, K.6
  • 45
    • 0035399598 scopus 로고    scopus 로고
    • A NF-kappa B/Sp1 region is essential for chromatin remodeling and correct transcription of a human granulocyte-macrophage colony-stimulating factor transgene
    • Cakouros D., Cockerill P.N., Bert A.G., Mital R., Roberts D.C., Shannon M.F. A NF-kappa B/Sp1 region is essential for chromatin remodeling and correct transcription of a human granulocyte-macrophage colony-stimulating factor transgene. J Immunol 2001, 167:302-310.
    • (2001) J Immunol , vol.167 , pp. 302-310
    • Cakouros, D.1    Cockerill, P.N.2    Bert, A.G.3    Mital, R.4    Roberts, D.C.5    Shannon, M.F.6
  • 46
    • 0034464787 scopus 로고    scopus 로고
    • Androgen induction of cyclin-dependent kinase inhibitor p21 gene: role of androgen receptor and transcription factor Sp1 complex
    • Lu S., Jenster G., Epner D.E. Androgen induction of cyclin-dependent kinase inhibitor p21 gene: role of androgen receptor and transcription factor Sp1 complex. Mol Endocrinol 2000, 14:753-760.
    • (2000) Mol Endocrinol , vol.14 , pp. 753-760
    • Lu, S.1    Jenster, G.2    Epner, D.E.3
  • 47
    • 77950480186 scopus 로고    scopus 로고
    • Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia
    • Liu S., Wu L.C., Pang J., Santhanam R., Schwind S., Wu Y.Z., et al. Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell 2010, 17:333-347.
    • (2010) Cancer Cell , vol.17 , pp. 333-347
    • Liu, S.1    Wu, L.C.2    Pang, J.3    Santhanam, R.4    Schwind, S.5    Wu, Y.Z.6
  • 48
    • 33751384465 scopus 로고    scopus 로고
    • GATHER: a systems approach to interpreting genomic signatures
    • Chang J.T., Nevins J.R. GATHER: a systems approach to interpreting genomic signatures. Bioinformatics 2006, 22:2926-2933.
    • (2006) Bioinformatics , vol.22 , pp. 2926-2933
    • Chang, J.T.1    Nevins, J.R.2
  • 49
    • 0032478124 scopus 로고    scopus 로고
    • A comparison of DNA-binding drugs as inhibitors of E2F1- and Sp1-DNA complexes and associated gene expression
    • Chiang S.Y., Azizkhan J.C., Beerman T.A. A comparison of DNA-binding drugs as inhibitors of E2F1- and Sp1-DNA complexes and associated gene expression. Biochemistry 1998, 37:3109-3115.
    • (1998) Biochemistry , vol.37 , pp. 3109-3115
    • Chiang, S.Y.1    Azizkhan, J.C.2    Beerman, T.A.3
  • 50
    • 0033199286 scopus 로고    scopus 로고
    • Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro
    • Martin B., Vaquero A., Priebe W., Portugal J. Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro. Nucleic Acids Res 1999, 27:3402-3409.
    • (1999) Nucleic Acids Res , vol.27 , pp. 3402-3409
    • Martin, B.1    Vaquero, A.2    Priebe, W.3    Portugal, J.4
  • 51
    • 45849085448 scopus 로고    scopus 로고
    • Sp1 transcription factor as a target for anthracyclines: effects on gene transcription
    • Mansilla S., Portugal J. Sp1 transcription factor as a target for anthracyclines: effects on gene transcription. Biochimie 2008, 90:976-987.
    • (2008) Biochimie , vol.90 , pp. 976-987
    • Mansilla, S.1    Portugal, J.2
  • 53
    • 0032539641 scopus 로고    scopus 로고
    • Ultratight DNA binding of a new bisintercalating anthracycline antibiotic
    • Leng F., Priebe W., Chaires J.B. Ultratight DNA binding of a new bisintercalating anthracycline antibiotic. Biochemistry 1998, 37:1743-1753.
    • (1998) Biochemistry , vol.37 , pp. 1743-1753
    • Leng, F.1    Priebe, W.2    Chaires, J.B.3


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