Stochastic patterns in globin gene expression are established prior to transcriptional activation and are clonally inherited

Molecular Cell

Volumn 9, Issue 6, 2002, Pages 1319-1326

  De Krom, Mariken ^a   Van de Corput, Mariette ^a   Von Lindern, Marieke ^a   Grosveld, Frank ^a   Strouboulis, John ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLOBIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ERYTHROID CELL; GENE ACTIVATION; GENE EXPRESSION; GENE LOCUS; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; STOCHASTIC MODEL; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0036297539     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00558-0     Document Type: Article

References (26)

1. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells
2. Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells
3. Expansion of the allelic exclusion principle?
4. Allelic inactivation regulates olfactory receptor gene expression
5. Regulation of X-chromosome inactivation in development in mice and humans
6. Chromatin interaction mechanism of transcriptional control in vivo
7. Activation by locus control regions?
8. Mono-allelic Ly49 NK cell receptor expression
9. Understanding αglobin gene expression: A step towards effective gene therapy
10. Monoallelic expression of the interleukin-2 locus
11. A stochastic model for gene induction
12. Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect
13. Cellular selection in the genesis of multicellular organization
14. Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription
15. Protein dynamics: Implications for nuclear architecture and gene expression
16. Receptor selection in B and T lymphocytes
17. Regulation of IL-4 expression by activation of individual alleles
18. Hypothesis: Genes which function in a stochastic lineage commitment process are subject to monoallelic expression
19. Mechanisms of developmental control of transcription in the murine α- and β-globin loci
20. Optimizing the detection of nascent transcripts by RNA fluorescence in situ hybridization
21. Fluorescence in situ hybridization analysis of transcript dynamics in cells
22. Beyond the nucleosome: Epigenetic aspects of position-effect variegation in Drosophila
23. Position effect variegation in Drosophila is associated with an altered chromatin structure
24. Transcription complex stability and chromatin dynamics in vivo
25. The role of EKLF in human β-globin gene competition