-
1
-
-
68249108329
-
Prediction and interaction in complex disease genetics: Experience in type 1 diabetes
-
Clayton DG,. Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet 2009; 5: e1000540.
-
(2009)
PLoS Genet
, vol.5
-
-
Clayton, D.G.1
-
2
-
-
84971185409
-
The correlation between relatives on the supposition of Mendelian inheritance
-
Fisher RA,. The correlation between relatives on the supposition of Mendelian inheritance. Philos Trans R Soc Edinb 1918; 52: 399-433.
-
(1918)
Philos Trans R Soc Edinb
, vol.52
, pp. 399-433
-
-
Fisher, R.A.1
-
3
-
-
45949085378
-
Polygenes, risk prediction, and targeted prevention of breast cancer
-
Pharoah PD, Antoniou AC, Easton DF, Ponder BA,. Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med 2008; 358: 2796-2803.
-
(2008)
N Engl J Med
, vol.358
, pp. 2796-2803
-
-
Pharoah, P.D.1
Antoniou, A.C.2
Easton, D.F.3
Ponder, B.A.4
-
4
-
-
79952847282
-
Strengthening the reporting of genetic risk prediction studies: The GRIPS Statement
-
Janssens AC, Ioannidis JP, van Duijn CM, et al. Strengthening the reporting of genetic risk prediction studies: the GRIPS Statement. Ann Intern Med 2011; 154: 421-425.
-
(2011)
Ann Intern Med
, vol.154
, pp. 421-425
-
-
Janssens, A.C.1
Ioannidis, J.P.2
Van Duijn, C.M.3
-
5
-
-
80051684615
-
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
-
International Multiple Sclerosis Genetics Consortium (IMSGC) and Wellcome Trust Case Control Consortium,2 (WTCCC2).
-
International Multiple Sclerosis Genetics Consortium (IMSGC) and Wellcome Trust Case Control Consortium,2 (WTCCC2). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011; 476: 214-219.
-
(2011)
Nature
, vol.476
, pp. 214-219
-
-
-
6
-
-
0029874022
-
Age-adjusted recurrence risks for relatives of patients with multiple sclerosis
-
Robertson NP, Fraser M, Deans J, et al. Age-adjusted recurrence risks for relatives of patients with multiple sclerosis. Brain 1996; 119 (pt 2): 449-455.
-
(1996)
Brain
, vol.119
, Issue.PART 2
, pp. 449-455
-
-
Robertson, N.P.1
Fraser, M.2
Deans, J.3
-
7
-
-
77649289047
-
What role for genetics in the prediction of multiple sclerosis?
-
Sawcer S, Ban M, Wason J, Dudbridge F,. What role for genetics in the prediction of multiple sclerosis? Ann Neurol 2010; 67: 3-10.
-
(2010)
Ann Neurol
, vol.67
, pp. 3-10
-
-
Sawcer, S.1
Ban, M.2
Wason, J.3
Dudbridge, F.4
-
8
-
-
0030992685
-
Offspring recurrence rates and clinical characteristics of conjugal multiple sclerosis
-
Robertson NP, O'Riordan JI, Chataway J, et al. Offspring recurrence rates and clinical characteristics of conjugal multiple sclerosis. Lancet 1997; 349: 1587-1590.
-
(1997)
Lancet
, vol.349
, pp. 1587-1590
-
-
Robertson, N.P.1
O'Riordan, J.I.2
Chataway, J.3
-
9
-
-
0028128084
-
The British Isles survey of multiple sclerosis in twins
-
Mumford CJ, Wood NW, Kellar-Wood H, et al. The British Isles survey of multiple sclerosis in twins. Neurology 1994; 44: 11-15.
-
(1994)
Neurology
, vol.44
, pp. 11-15
-
-
Mumford, C.J.1
Wood, N.W.2
Kellar-Wood, H.3
-
10
-
-
79952138032
-
Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis
-
Hedstrom AK, Sundqvist E, Baarnhielm M, et al. Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis. Brain 2011; 134: 653-664.
-
(2011)
Brain
, vol.134
, pp. 653-664
-
-
Hedstrom, A.K.1
Sundqvist, E.2
Baarnhielm, M.3
-
11
-
-
62549098116
-
Beyond odds ratios-communicating disease risk based on genetic profiles
-
Kraft P, Wacholder S, Cornelis MC, et al. Beyond odds ratios-communicating disease risk based on genetic profiles. Nat Rev Genet 2009; 10: 264-269.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 264-269
-
-
Kraft, P.1
Wacholder, S.2
Cornelis, M.C.3
-
12
-
-
79952489475
-
Estimating missing heritability for disease from genome-wide association studies
-
Lee SH, Wray NR, Goddard ME, Visscher PM,. Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 2011; 88: 294-305.
-
(2011)
Am J Hum Genet
, vol.88
, pp. 294-305
-
-
Lee, S.H.1
Wray, N.R.2
Goddard, M.E.3
Visscher, P.M.4
-
13
-
-
18944373385
-
Temporal relationship between elevation of Epstein-Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis
-
Levin LI, Munger KL, Rubertone MV, et al. Temporal relationship between elevation of Epstein-Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis. JAMA 2005; 293: 2496-2500.
-
(2005)
JAMA
, vol.293
, pp. 2496-2500
-
-
Levin, L.I.1
Munger, K.L.2
Rubertone, M.V.3
-
14
-
-
33845720114
-
Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
-
Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006; 296: 2832-2838.
-
(2006)
JAMA
, vol.296
, pp. 2832-2838
-
-
Munger, K.L.1
Levin, L.I.2
Hollis, B.W.3
-
15
-
-
34250672398
-
Smoking is a risk factor for multiple sclerosis: A metanalysis
-
Hawkes CH,. Smoking is a risk factor for multiple sclerosis: a metanalysis. Mult Scler 2007; 13: 610-615.
-
(2007)
Mult Scler
, vol.13
, pp. 610-615
-
-
Hawkes, C.H.1
-
16
-
-
0008376153
-
Smoking and carcinoma of the lung; Preliminary report
-
Doll R, Hill AB,. Smoking and carcinoma of the lung; preliminary report. Br Med J 1950; 2: 739-748.
-
(1950)
Br Med J
, vol.2
, pp. 739-748
-
-
Doll, R.1
Hill, A.B.2
-
17
-
-
79960899377
-
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
-
Australo-Anglo-American Spondyloarthritis Consortium (tasc) And Wellcome Trust Case Control C. 2 (WTCCC2).
-
Australo-Anglo-American Spondyloarthritis Consortium (TASC) and Wellcome Trust Case Control Consortium,2 (WTCCC2). Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet 2011; 43: 761-767.
-
(2011)
Nat Genet
, vol.43
, pp. 761-767
-
-
-
18
-
-
80054832080
-
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
-
Dejesus-Hernandez M, Mackenzie IR, Boeve BF, et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 2011; 72: 245-256.
-
(2011)
Neuron
, vol.72
, pp. 245-256
-
-
Dejesus-Hernandez, M.1
MacKenzie, I.R.2
Boeve, B.F.3
-
19
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch N, Merikangas K,. The future of genetic studies of complex human diseases. Science 1996; 273: 1516-1517.
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
20
-
-
23944499790
-
A high-density screen for linkage in multiple sclerosis
-
International Multiple Sclerosis Genetics Consortium (.
-
International Multiple Sclerosis Genetics Consortium (IMSGC),. A high-density screen for linkage in multiple sclerosis. Am J Hum Genet 2005; 77: 454-467.
-
(2005)
Am J Hum Genet
, vol.77
, pp. 454-467
-
-
-
21
-
-
42349112088
-
Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
-
McCarthy MI, Abecasis GR, Cardon LR, et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008; 9: 356-369.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 356-369
-
-
McCarthy, M.I.1
Abecasis, G.R.2
Cardon, L.R.3
-
22
-
-
65249131713
-
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
-
Nejentsev S, Walker N, Riches D, et al. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009; 324: 387-389.
-
(2009)
Science
, vol.324
, pp. 387-389
-
-
Nejentsev, S.1
Walker, N.2
Riches, D.3
-
23
-
-
84255175933
-
Rare variants in the CYP27B1 gene associated with multiple sclerosis
-
Ramagopalan SV, Dyment D, Cader MZ, et al. Rare variants in the CYP27B1 gene associated with multiple sclerosis. Ann Neurol 2011; 70: 881-886.
-
(2011)
Ann Neurol
, vol.70
, pp. 881-886
-
-
Ramagopalan, S.V.1
Dyment, D.2
Cader, M.Z.3
-
24
-
-
79851468862
-
Synthetic associations are unlikely to account for many common disease genome-wide association signals
-
Anderson CA, Soranzo N, Zeggini E, Barrett JC,. Synthetic associations are unlikely to account for many common disease genome-wide association signals. PLoS Biol 2011; 9: e1000580.
-
(2011)
PLoS Biol
, vol.9
-
-
Anderson, C.A.1
Soranzo, N.2
Zeggini, E.3
Barrett, J.C.4
-
25
-
-
77249134594
-
Rare variants create synthetic genome-wide associations
-
Dickson SP, Wang K, Krantz I, et al. Rare variants create synthetic genome-wide associations. PLoS Biol 2010; 8: e1000294.
-
(2010)
PLoS Biol
, vol.8
-
-
Dickson, S.P.1
Wang, K.2
Krantz, I.3
-
26
-
-
84856405512
-
The mystery of missing heritability: Genetic interactions create phantom heritability
-
Zuk O, Hechter E, Sunyaev SR, Lander ES,. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci U S A 2012; 109: 1193-1198.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 1193-1198
-
-
Zuk, O.1
Hechter, E.2
Sunyaev, S.R.3
Lander, E.S.4
-
27
-
-
66149186884
-
Twin studies and the heritability of MS: A conclusion
-
Hawkes CH, Macgregor AJ,. Twin studies and the heritability of MS: a conclusion. Mult Scler 2009; 15: 661-667.
-
(2009)
Mult Scler
, vol.15
, pp. 661-667
-
-
Hawkes, C.H.1
MacGregor, A.J.2
-
28
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature 2009; 461: 747-753.
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
Collins, F.S.2
Cox, N.J.3
-
29
-
-
0036578764
-
Polygenic susceptibility to breast cancer and implications for prevention
-
Pharoah PD, Antoniou A, Bobrow M, et al. Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet 2002; 31: 33-36.
-
(2002)
Nat Genet
, vol.31
, pp. 33-36
-
-
Pharoah, P.D.1
Antoniou, A.2
Bobrow, M.3
-
30
-
-
58649108766
-
Risk for multiple sclerosis in relatives and spouses of patients diagnosed with autoimmune and related conditions
-
Hemminki K, Li X, Sundquist J, et al. Risk for multiple sclerosis in relatives and spouses of patients diagnosed with autoimmune and related conditions. Neurogenetics 2009; 10: 5-11.
-
(2009)
Neurogenetics
, vol.10
, pp. 5-11
-
-
Hemminki, K.1
Li, X.2
Sundquist, J.3
-
31
-
-
79551484517
-
Aggregation of multiple sclerosis genetic risk variants in multiple and single case families
-
Gourraud PA, McElroy JP, Caillier SJ, et al. Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann Neurol 2011; 69: 65-74.
-
(2011)
Ann Neurol
, vol.69
, pp. 65-74
-
-
Gourraud, P.A.1
McElroy, J.P.2
Caillier, S.J.3
-
32
-
-
25844457409
-
A twin consensus in MS
-
Ebers GC,. A twin consensus in MS. Mult Scler 2005; 11: 497-499.
-
(2005)
Mult Scler
, vol.11
, pp. 497-499
-
-
Ebers, G.C.1
-
34
-
-
0021983786
-
Sick individuals and sick populations
-
Rose G,. Sick individuals and sick populations. Int J Epidemiol 1985; 14: 32-38.
-
(1985)
Int J Epidemiol
, vol.14
, pp. 32-38
-
-
Rose, G.1
|