Risk alleles for multiple sclerosis in multiplex families

Neurology

Volumn 72, Issue 23, 2009, Pages 1984-1988

  D'Netto, M J ^a   Ward, H ^a   Morrison, K M ^a   Ramagopalan, S V ^a   Dyment, D A ^a   Deluca, G C ^a   Handunnetthi, L ^a   Sadovnick, A D ^b   Ebers, G C ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; PEDIGREE; PRIORITY JOURNAL;

EID: 66249086434     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181a92c25     Document Type: Article

References (30)

1. Ebers GC. Environmental factors and multiple sclerosis. Lancet Neurol 2008;7:268-277.
2. Dyment DA, Ebers GC, Sadovnick AD. Genetics of multiple sclerosis. Lancet Neurol 2004;3:104-110.
3. Ramagopalan SV, Morris AP, Dyment DA, et al. The inheritance of resistance alleles in multiple sclerosis. PLoS Genet 2007;3:1607-1613.
4. Gregory SG, Schmidt S, Seth P, et al. Interleukin 7 receptor - chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 2007;39:1083-1091.
5. Herrera BM, Cader MZ, Dyment DA, et al. Follow-up investigation of 12 proposed linkage regions in multiple sclerosis. Genes Immun 2006;7:366-371.
6. Herrera BM, Ramagopalan SV, Orton S, et al. Parental transmission of MS in a population-based Canadian cohort. Neurology 2007;69:1202-1203.
7. Sawcer S, Ban M, Maranian M, et al. A high-density screen for linkage in multiple sclerosis. Am J Hum Genet 2005; 77:454-467.
8. Hafler DA, Compston A, Sawcer S, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007;357:851-862.
9. Rubio J, Stankovich J, Field J, et al. Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. Genes Immun 2008;9: 624-630.
10. Weber F, Fontaine B, Cournu-Rebeix I, et al. IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. Genes Immun 2008;9:259-263.
11. Matesanz F, Caro-Maldonado A, Fedetz M, et al. IL2RA/ CD25 polymorphisms contribute to multiple sclerosis susceptibility. J Neurol 2007;254:682-684.
12. International Multiple Sclerosis Genetics Consortium. Refining genetic associations in multiple sclerosis. Lancet Neurol 2008;7:567-569.
13. Ramagopalan SV, Anderson C, Sadovnick AD, Ebers GC. Genomewide study of multiple sclerosis. N Engl J Med 2007;357:2199-200.
14. Booth DR, Arthur AT, Teutsch SM, et al. Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. J Mol Med 2005;83:822-830.
15. Zhang Z, Duvefelt K, Svensson F, et al. Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. Genes Immun 2005; 6:145-152.
16. Lundmark F, Duvefelt K, Iacobaeus E, et al. Variation in interleukin 7 receptor - chain (IL7R) influences risk of multiple sclerosis. Nat Genet 2007;39:1108-1113.
17. Hoppenbrouwers IA, Aulchenko YS, Ebers GC, et al. EVI5 is a risk gene for multiple sclerosis. Genes Immun 2008;9:334-337.
18. Zoledziewska M, Costa G, Pitzalis M, et al. Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia. Genes Immun 2009;10:15-17.
19. International Multiple Sclerosis Genetics Consortium. The expanding genetic overlap between multiple sclerosis and type 1 diabetes. Genes Immun 2009;10:11-14.
20. Sadovnock AD, Risch NJ, Ebers GC. Canadian collaborative project on genetic susceptibility to MS, phase 2: rationale and method. Canadian Collaborative Study Group. Can J Neurol Sci 1998;25:216-221.
21. Ebers GC, Koopman WJ, Hader W, et al. The natural history of multiple sclerosis: a geographically based study, 8: familial multiple sclerosis. Brain 2000;123:641-649.
22. Willer CJ, Dyment DA, Cherny S, et al. A genome-wide scan in forty large pedigrees with multiple sclerosis. J Hum Genet 2007;52:955-962.
23. Dyment DA, Cader MZ, Herrera BM, et al. A genome scan in a single pedigree with a high prevalence of multiple sclerosis. J Neurol Neurosurg Psychiatry 2008;79:158-162.
24. Martin ER, Monks SA, Warren LL, Kaplan NL. A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am J Hum Genet 2000;67:146-154.
25. Dudbridge F. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Heredity 2008;66:87-98.
26. Martin ER, Bass MP, Kaplan NL. Correcting for a potential bias in the pedigree disequilibrium test. Am J Hum Genet 2001;68:1065-1067.
27. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a toolset for whole-genome association and population-based linkage analysis. Am J Hum Genet 2007;81:559-575.
28. Lowe CE, Cooper JD, Brusko T, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 2007;39:1074-1082.
29. Maier LM, Lowe E, Cooper J, et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 2009;5:e1000322.
30. Ramagopalan SV, Dyment DA, Valdar W, et al. Autoimmune disease in families with multiple sclerosis: a population-based study. Lancet Neurol 2007;6:604-610.