메뉴 건너뛰기




Volumn 35, Issue 5, 2013, Pages 1821-1834

Coenzyme Q10 supplementation reverses age-related impairments in spatial learning and lowers protein oxidation

Author keywords

Aging; C57BL 6J; CoenzymeQ10; Mitochondria; Oxidative damage; Ubidecarenone; Ubiquinone

Indexed keywords

CARBONYL DERIVATIVE; UBIDECARENONE;

EID: 84892614039     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-012-9484-9     Document Type: Article
Times cited : (43)

References (71)
  • 1
    • 0014252133 scopus 로고
    • Changes in ultrastructure and respiratory control in mitochondria of rat heart hypertrophied by exercise
    • Arcos JC, Sohal RS et al (1968) Changes in ultrastructure and respiratory control in mitochondria of rat heart hypertrophied by exercise. Exp Mol Pathol 8:49-65
    • (1968) Exp Mol Pathol , vol.8 , pp. 49-65
    • Arcos, J.C.1    Sohal, R.S.2
  • 2
    • 0027326051 scopus 로고
    • Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure (interim analysis). The CoQ10 drug surveillance investigators
    • Baggio E, Gandini R et al (1993) Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure (interim analysis). The CoQ10 Drug Surveillance Investigators. Clin Investig 71(8 Suppl): S145-149
    • (1993) Clin Investig , vol.71 , Issue.8 SUPPL.
    • Baggio, E.1    Gandini, R.2
  • 3
    • 0025449680 scopus 로고
    • Natural distribution and occurrence of coenzyme Q homologues
    • Battino M, Ferri E et al (1990) Natural distribution and occurrence of coenzyme Q homologues. Membr Biochem 9 (3):179-190
    • (1990) Membr Biochem , vol.9 , Issue.3 , pp. 179-190
    • Battino, M.1    Ferri, E.2
  • 4
    • 0032588769 scopus 로고    scopus 로고
    • Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases
    • Beal MF (1999) Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases. Biofactors 9 (2-4):261-266
    • (1999) Biofactors , vol.9 , Issue.2-4 , pp. 261-266
    • Beal, M.F.1
  • 5
    • 0028173480 scopus 로고
    • Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate
    • Beal MF, Henshaw DR et al (1994) Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Ann Neurol 36(6):882-888
    • (1994) Ann Neurol , vol.36 , Issue.6 , pp. 882-888
    • Beal, M.F.1    Henshaw, D.R.2
  • 6
    • 0034595888 scopus 로고    scopus 로고
    • Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
    • Bickford PC, Gould T et al (2000) Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Res 866:211-217
    • (2000) Brain Res , vol.866 , pp. 211-217
    • Bickford, P.C.1    Gould, T.2
  • 7
    • 0025673969 scopus 로고
    • Ubidecarenone in the treatment of mitochondrial myopathies: A multi-center double-blind trial
    • Bresolin N, Doriguzzi C et al (1990) Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial. J Neurol Sci 100(1-2):70-78
    • (1990) J Neurol Sci , vol.100 , Issue.1-2 , pp. 70-78
    • Bresolin, N.1    Doriguzzi, C.2
  • 8
    • 29244439038 scopus 로고    scopus 로고
    • Neural plasticity in the ageing brain
    • Burke SN, Barnes CA (2006) Neural plasticity in the ageing brain. Nat Rev Neurosci 7(1):30-40
    • (2006) Nat Rev Neurosci , vol.7 , Issue.1 , pp. 30-40
    • Burke, S.N.1    Barnes, C.A.2
  • 9
    • 34848841548 scopus 로고    scopus 로고
    • Coenzyme Q 10 and cardiovascular risk factors in idiopathic sudden sensorineural hearing loss patients
    • Cadoni G, Scipione S et al (2007) Coenzyme Q 10 and cardiovascular risk factors in idiopathic sudden sensorineural hearing loss patients. Otol Neurotol 28(7):878-883
    • (2007) Otol Neurotol , vol.28 , Issue.7 , pp. 878-883
    • Cadoni, G.1    Scipione, S.2
  • 10
    • 0035667921 scopus 로고    scopus 로고
    • Biochemical functions of coenzyme Q10
    • Crane FL (2001) Biochemical functions of coenzyme Q10. J Am Coll Nutr 20(6):591-598
    • (2001) J Am Coll Nutr , vol.20 , Issue.6 , pp. 591-598
    • Crane, F.L.1
  • 11
    • 33845891619 scopus 로고    scopus 로고
    • Spatial learning and psychomotor performance of C57BL/6 mice: Age sensitivity and reliability of individual differences
    • de Fiebre NC, Sumien N et al (2006) Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences. AGE 28 (3):235-253
    • (2006) AGE , vol.28 , Issue.3 , pp. 235-253
    • De Fiebre, N.C.1    Sumien, N.2
  • 12
    • 0029042393 scopus 로고
    • Biochemical, physiological and medical aspects of ubiquinone function
    • Ernster L, Dallner G (1995) Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1271(1):195-204
    • (1995) Biochim Biophys Acta , vol.1271 , Issue.1 , pp. 195-204
    • Ernster, L.1    Dallner, G.2
  • 13
    • 0027392717 scopus 로고
    • Genetics of age-related hearing loss in mice: I Inbred and F1 hybrid strains
    • Erway LC, Willot JF et al (1993) Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains. Hear Res 65:125-132
    • (1993) Hear Res , vol.65 , pp. 125-132
    • Erway, L.C.1    Willot, J.F.2
  • 14
    • 0036523110 scopus 로고    scopus 로고
    • Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease
    • Ferrante RJ, Andreassen OA et al (2002) Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci 22(5):1592-1599
    • (2002) J Neurosci , vol.22 , Issue.5 , pp. 1592-1599
    • Ferrante, R.J.1    Andreassen, O.A.2
  • 15
    • 33645068499 scopus 로고    scopus 로고
    • Tolerance of high-dose (3, 000 mg/day) coenzyme Q10 in ALS
    • Ferrante KL, Shefner J et al (2005) Tolerance of high-dose (3, 000 mg/day) coenzyme Q10 in ALS. Neurology 65 (11):1834-1836
    • (2005) Neurology , vol.65 , Issue.11 , pp. 1834-1836
    • Ferrante, K.L.1    Shefner, J.2
  • 16
    • 63349103959 scopus 로고    scopus 로고
    • Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL)
    • Fetoni AR, Piacentini R et al (2009) Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL). Brain Res 1257:108-116
    • (2009) Brain Res , vol.1257 , pp. 108-116
    • Fetoni, A.R.1    Piacentini, R.2
  • 17
    • 0032524667 scopus 로고    scopus 로고
    • Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain complex
    • Fontaine E, Eriksson O et al (1998) Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain complex. J Biol Chem 273(20):12662-12668
    • (1998) J Biol Chem , vol.273 , Issue.20 , pp. 12662-12668
    • Fontaine, E.1    Eriksson, O.2
  • 18
    • 0028839391 scopus 로고
    • Endogenous ubiquinol prevents protein modification accompanying lipid peroxidation in beef heart submitochondrial membranes
    • Forsmark-Andree P, Dallner G et al (1995) Endogenous ubiquinol prevents protein modification accompanying lipid peroxidation in beef heart submitochondrial membranes. Free Radic Biol Med 19:749-757
    • (1995) Free Radic Biol Med , vol.19 , pp. 749-757
    • Forsmark-Andree, P.1    Dallner, G.2
  • 19
    • 0026181672 scopus 로고
    • Neurobehavioral biomarkers of aging: Influence of genotype and dietary restriction
    • Forster MJ, Lal H (1991) Neurobehavioral biomarkers of aging: influence of genotype and dietary restriction. Biomed Environ Sci 4(1-2):144-165
    • (1991) Biomed Environ Sci , vol.4 , Issue.1-2 , pp. 144-165
    • Forster, M.J.1    Lal, H.2
  • 20
    • 0026707506 scopus 로고
    • Within-subject behavioral analysis of recent memory in aging mice
    • Forster MJ, Lal H (1992) Within-subject behavioral analysis of recent memory in aging mice. Behav Pharmacol 3(4):337-349
    • (1992) Behav Pharmacol , vol.3 , Issue.4 , pp. 337-349
    • Forster, M.J.1    Lal, H.2
  • 21
    • 0032877156 scopus 로고    scopus 로고
    • Estimating age-related changes in psychomotor function: Influence of practice and of level of caloric intake in different genotypes
    • Forster MJ, Lal H (1999) Estimating age-related changes in psychomotor function: influence of practice and of level of caloric intake in different genotypes. Neurobiol Aging 20(2):167-176
    • (1999) Neurobiol Aging , vol.20 , Issue.2 , pp. 167-176
    • Forster, M.J.1    Lal, H.2
  • 22
    • 0029978498 scopus 로고    scopus 로고
    • Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain
    • Forster MJ, Dubey A et al (1996) Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc Natl Acad Sci U S A 93(10):4765-4769
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.10 , pp. 4765-4769
    • Forster, M.J.1    Dubey, A.2
  • 23
    • 0034545209 scopus 로고    scopus 로고
    • Reversible effects of longterm caloric restriction on protein oxidative damage
    • Forster MJ, Sohal BH et al (2000) Reversible effects of longterm caloric restriction on protein oxidative damage. J Gerontol A Biol Sci Med Sci 55(11):B522-B529
    • (2000) J Gerontol A Biol Sci Med Sci , vol.55 , Issue.11
    • Forster, M.J.1    Sohal, B.H.2
  • 24
    • 0032806666 scopus 로고    scopus 로고
    • Age-related psychomotor and spatial learning deficits in 129/SvJ mice
    • Hengemihle JM, Long JM et al (1999) Age-related psychomotor and spatial learning deficits in 129/SvJ mice. Neurobiology of Aging 20(1):9-18
    • (1999) Neurobiology of Aging , vol.20 , Issue.1 , pp. 9-18
    • Hengemihle, J.M.1    Long, J.M.2
  • 25
    • 0029257854 scopus 로고
    • Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure
    • The Q10 Study Group
    • Hofman-Bang C, Rehnqvist N et al (1995) Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group. J Card Fail 1(2):101-107
    • (1995) J Card Fail , vol.1 , Issue.2 , pp. 101-107
    • Hofman-Bang, C.1    Rehnqvist, N.2
  • 26
    • 77956802394 scopus 로고    scopus 로고
    • Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects
    • Hyson HC, Kieburtz K et al (2010) Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects. Mov Disord 25(12):1924-1928
    • (2010) Mov Disord , vol.25 , Issue.12 , pp. 1924-1928
    • Hyson, H.C.1    Kieburtz, K.2
  • 27
    • 0032249646 scopus 로고    scopus 로고
    • Role of coenzyme Q and superoxide in vitamin e cycling
    • Kagan VE, Tyurina YY et al (1998) Role of coenzyme Q and superoxide in vitamin E cycling. Subcell Biochem 30:491-507
    • (1998) Subcell Biochem , vol.30 , pp. 491-507
    • Kagan, V.E.1    Tyurina, Y.Y.2
  • 28
    • 0037221433 scopus 로고    scopus 로고
    • Hydrogen peroxide modulation of synaptic plasticity
    • Kamsler A, Segal M (2003) Hydrogen peroxide modulation of synaptic plasticity. J Neurosci 23(1):269-276
    • (2003) J Neurosci , vol.23 , Issue.1 , pp. 269-276
    • Kamsler, A.1    Segal, M.2
  • 29
    • 0141639911 scopus 로고    scopus 로고
    • Coenzyme Q intake elevates the mitochondrial and tissue levels of Coenzyme Q and alpha-tocopherol in young mice
    • Kamzalov S, Sumien N et al (2003) Coenzyme Q intake elevates the mitochondrial and tissue levels of Coenzyme Q and alpha-tocopherol in young mice. J Nutr 133(10):3175-3180
    • (2003) J Nutr , vol.133 , Issue.10 , pp. 3175-3180
    • Kamzalov, S.1    Sumien, N.2
  • 30
    • 33846241298 scopus 로고    scopus 로고
    • Sources and targets of reactive oxygen species in synaptic plasticity and memory
    • Kishida KT, Klann E (2007) Sources and targets of reactive oxygen species in synaptic plasticity and memory. Antioxid Redox Signal 9(2):233-244
    • (2007) Antioxid Redox Signal , vol.9 , Issue.2 , pp. 233-244
    • Kishida, K.T.1    Klann, E.2
  • 31
    • 0031044805 scopus 로고    scopus 로고
    • Energy metabolism defects in Huntington's disease and effects of coenzyme Q10
    • Koroshetz WJ, Jenkins BG et al (1997) Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Ann Neurol 41(2):160-165
    • (1997) Ann Neurol , vol.41 , Issue.2 , pp. 160-165
    • Koroshetz, W.J.1    Jenkins, B.G.2
  • 32
    • 0002675717 scopus 로고
    • Mitochondrial isolation from liver and kidney: Strategy, techniques, and criteria for purity
    • Lash LH, Jones DP (eds). Academic, San Diego
    • Lash LH, Sall JM (1993) Mitochondrial isolation from liver and kidney: strategy, techniques, and criteria for purity. In: Lash LH, Jones DP (eds) Methods in toxicology: mitochondrial dysfunction, vol. 2. Academic, San Diego, pp 8-12
    • (1993) Methods in Toxicology: Mitochondrial Dysfunction , vol.2 , pp. 8-12
    • Lash, L.H.1    Sall, J.M.2
  • 33
    • 0032522304 scopus 로고    scopus 로고
    • Electron transport-linked ubiquinonedependent recycling of alpha-tocopherol inhibits autooxidation of mitochondrial membranes
    • Lass A, Sohal RS (1998) Electron transport-linked ubiquinonedependent recycling of alpha-tocopherol inhibits autooxidation of mitochondrial membranes. Arch Biochem Biophys 352(2):229-236
    • (1998) Arch Biochem Biophys , vol.352 , Issue.2 , pp. 229-236
    • Lass, A.1    Sohal, R.S.2
  • 34
    • 0032587816 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 and alpha-tocopherol administration on their tissue levels in the mouse: Elevation of mitochondrial alpha-tocopherol by coenzyme Q10
    • Lass A, Forster MJ et al (1999a) Effects of coenzyme Q10 and alpha-tocopherol administration on their tissue levels in the mouse: elevation of mitochondrial alpha-tocopherol by coenzyme Q10. Free Radic Biol Med 26(11-12):1375-1382
    • (1999) Free Radic Biol Med , vol.26 , Issue.11-12 , pp. 1375-1382
    • Lass, A.1    Forster, M.J.2
  • 35
    • 0033025991 scopus 로고    scopus 로고
    • Mitochondrial coenzyme Q content and aging
    • Lass A, Kwong LK, Sohal RS (1999b) Mitochondrial coenzyme Q content and aging. Biofactors 9:199-205
    • (1999) Biofactors , vol.9 , pp. 199-205
    • Lass, A.1    Kwong, L.K.2    Sohal, R.S.3
  • 36
    • 0028287088 scopus 로고
    • Spatial learning deficits in the aged rat: Neuroanatomical and neurochemical correlates
    • Lee JM, Ross ER et al (1994) Spatial learning deficits in the aged rat: neuroanatomical and neurochemical correlates. Brain Res Bull 33(5):489-500
    • (1994) Brain Res Bull , vol.33 , Issue.5 , pp. 489-500
    • Lee, J.M.1    Ross, E.R.2
  • 37
    • 0033000255 scopus 로고    scopus 로고
    • Localization and mobility of coenzyme Q in lipid bilayers and membranes
    • Lenaz G, Fato R et al (1999) Localization and mobility of coenzyme Q in lipid bilayers and membranes. Biofactors 9:87-93
    • (1999) Biofactors , vol.9 , pp. 87-93
    • Lenaz, G.1    Fato, R.2
  • 38
    • 0028291974 scopus 로고
    • Carbonyl assays for determination of oxidatively modified proteins
    • Levine RL, Williams JA et al (1994) Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol 233:346-357
    • (1994) Methods Enzymol , vol.233 , pp. 346-357
    • Levine, R.L.1    Williams, J.A.2
  • 39
    • 34249826635 scopus 로고    scopus 로고
    • The role of coenzyme Q10 in statin-associated myopathy: A systematic review
    • Marcoff L, Thompson PD (2007) The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol 49(23):2231-2237
    • (2007) J Am Coll Cardiol , vol.49 , Issue.23 , pp. 2231-2237
    • Marcoff, L.1    Thompson, P.D.2
  • 40
    • 0032555066 scopus 로고    scopus 로고
    • Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
    • Matthews RT, Yang L et al (1998) "Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects." Proc Natl Acad Sci USA 95(15):8892-8897.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.15 , pp. 8892-8897
    • Matthews, R.T.1    Yang, L.2
  • 41
    • 13844298846 scopus 로고    scopus 로고
    • Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice
    • McDonald SR, Sohal RS et al (2005) Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice. Free Radic Biol Med 38(6):729-736
    • (2005) Free Radic Biol Med , vol.38 , Issue.6 , pp. 729-736
    • McDonald, S.R.1    Sohal, R.S.2
  • 42
    • 0027471273 scopus 로고
    • The neuropharmacological and neurochemical basis of place learning in the Morris water maze
    • McNamara RK, Skelton RW (1993) The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain Res Brain Res Rev 18(1):33-49
    • (1993) Brain Res Brain Res Rev , vol.18 , Issue.1 , pp. 33-49
    • McNamara, R.K.1    Skelton, R.W.2
  • 43
    • 80053380604 scopus 로고    scopus 로고
    • Both the doral hippocampus and the dorsolateral striatum are needed for rat navigation in the Morris water maze
    • Miyoshi E, Wietzikoski E et al (2012) Both the doral hippocampus and the dorsolateral striatum are needed for rat navigation in the Morris water maze. Behav Brain Res 226(1):171-178
    • (2012) Behav Brain Res , vol.226 , Issue.1 , pp. 171-178
    • Miyoshi, E.1    Wietzikoski, E.2
  • 44
    • 0027293550 scopus 로고
    • Effect of coenzyme Q10 therapy in patients with congestive heart failure: A longterm multicenter randomized study
    • Morisco C, Trimarco B et al (1993) Effect of coenzyme Q10 therapy in patients with congestive heart failure: a longterm multicenter randomized study. Clin Investig 71(8 Suppl):S134-S136
    • (1993) Clin Investig , vol.71 , Issue.8 SUPPL.
    • Morisco, C.1    Trimarco, B.2
  • 45
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11 (1):47-60
    • (1984) J Neurosci Methods , vol.11 , Issue.1 , pp. 47-60
    • Morris, R.1
  • 46
    • 0030698871 scopus 로고    scopus 로고
    • Life and death of neurons in the aging brain
    • Morrison JH, Hof PR (1997) Life and death of neurons in the aging brain. Science 278:412-419
    • (1997) Science , vol.278 , pp. 412-419
    • Morrison, J.H.1    Hof, P.R.2
  • 47
    • 0025358550 scopus 로고
    • Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution
    • Mukai K, Kikuchi S et al (1990) Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution. Biochim Biophys Acta 1035(1):77-82
    • (1990) Biochim Biophys Acta , vol.1035 , Issue.1 , pp. 77-82
    • Mukai, K.1    Kikuchi, S.2
  • 48
    • 0035940815 scopus 로고    scopus 로고
    • Signatures of hippocampal oxidative stress in aged spatial learning-imparied rodents
    • Nicolle MM, Gonzalez J et al (2001) Signatures of hippocampal oxidative stress in aged spatial learning-imparied rodents. Neuroscience 107:415-431
    • (2001) Neuroscience , vol.107 , pp. 415-431
    • Nicolle, M.M.1    Gonzalez, J.2
  • 49
    • 0348049913 scopus 로고    scopus 로고
    • The biomolecule ubiquinone exerts a variety of biological functions
    • Nohl H, Staniek K et al (2003) The biomolecule ubiquinone exerts a variety of biological functions. Biofactors 18:23-31
    • (2003) Biofactors , vol.18 , pp. 23-31
    • Nohl, H.1    Staniek, K.2
  • 50
    • 0141790274 scopus 로고    scopus 로고
    • The functional age of hearing loss in a mouse model of presbycusis I. Behavioral assessments
    • Prosen CA, Dore DJ et al (2003) The functional age of hearing loss in a mouse model of presbycusis. I. Behavioral assessments. Hear Res 183(1-2):44-56
    • (2003) Hear Res , vol.183 , Issue.1-2 , pp. 44-56
    • Prosen, C.A.1    Dore, D.J.2
  • 51
    • 0842348226 scopus 로고    scopus 로고
    • Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet
    • Quiles JL, Ochoa JJ et al (2004) Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet. Exp Gerontol 39:189-194
    • (2004) Exp Gerontol , vol.39 , pp. 189-194
    • Quiles, J.L.1    Ochoa, J.J.2
  • 52
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S, Nihal M et al (2008) Dose translation from animal to human studies revisited. FASEB J 22(3):659-661
    • (2008) FASEB J , vol.22 , Issue.3 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2
  • 53
    • 0348049914 scopus 로고    scopus 로고
    • Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure
    • Rosenfeldt F, Hilton D et al (2003) Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors 18(1-4):91-100
    • (2003) Biofactors , vol.18 , Issue.1-4 , pp. 91-100
    • Rosenfeldt, F.1    Hilton, D.2
  • 54
    • 33947423399 scopus 로고    scopus 로고
    • Coenzyme Q10 in the treatment of hypertension: A meta-analysis of the clinical trials
    • Rosenfeldt FL, Haas SJ et al (2007) Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens 21(4):297-306
    • (2007) J Hum Hypertens , vol.21 , Issue.4 , pp. 297-306
    • Rosenfeldt, F.L.1    Haas, S.J.2
  • 55
    • 8444227821 scopus 로고    scopus 로고
    • Reactive oxygen species and synaptic plasticity in the aging hippocampus
    • Serrano F, Klann E (2004) Reactive oxygen species and synaptic plasticity in the aging hippocampus. Ageing Res Rev 3 (4):431-443
    • (2004) Ageing Res Rev , vol.3 , Issue.4 , pp. 431-443
    • Serrano, F.1    Klann, E.2
  • 56
    • 32944454490 scopus 로고    scopus 로고
    • Effects of Concord grape juice on cognitive and motor deficits in aging
    • Shukitt-Hale B, Carey A et al (2006) Effects of Concord grape juice on cognitive and motor deficits in aging. Nutrition 22 (3):295-302
    • (2006) Nutrition , vol.22 , Issue.3 , pp. 295-302
    • Shukitt-Hale, B.1    Carey, A.2
  • 57
    • 33746048422 scopus 로고    scopus 로고
    • Clinical trials of coenzyme Q10 in neurological disorders
    • Shults CW, Haas R (2005) Clinical trials of coenzyme Q10 in neurological disorders. Biofactors 25(1-4):117-126
    • (2005) Biofactors , vol.25 , Issue.1-4 , pp. 117-126
    • Shults, C.W.1    Haas, R.2
  • 59
    • 31344439942 scopus 로고    scopus 로고
    • Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice
    • Sohal RS, Kamzalov S et al (2006) Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice. Free Radic Biol Med 40(3):480-487
    • (2006) Free Radic Biol Med , vol.40 , Issue.3 , pp. 480-487
    • Sohal, R.S.1    Kamzalov, S.2
  • 60
    • 77956181829 scopus 로고    scopus 로고
    • Mitochondrial oxidative damage and apoptosis in age-related hearing loss
    • Someya S, Prolla TA (2010) Mitochondrial oxidative damage and apoptosis in age-related hearing loss. Mech Ageing Dev 131(7-8):480-486
    • (2010) Mech Ageing Dev , vol.131 , Issue.7-8 , pp. 480-486
    • Someya, S.1    Prolla, T.A.2
  • 61
    • 36049039540 scopus 로고    scopus 로고
    • Genes encoding mitochondrial respiratory chain components are profoundly downregulated with aging in the cochlea of DBA/2 J mice
    • Someya S, Yamasoba T et al (2007) Genes encoding mitochondrial respiratory chain components are profoundly downregulated with aging in the cochlea of DBA/2 J mice. Brain Res 1182:26-33
    • (2007) Brain Res , vol.1182 , pp. 26-33
    • Someya, S.1    Yamasoba, T.2
  • 62
    • 77953776205 scopus 로고    scopus 로고
    • Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys
    • Someya S, Tanokura M et al (2010) Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys. Curr Aging Sci 3(1):20-25
    • (2010) Curr Aging Sci , vol.3 , Issue.1 , pp. 20-25
    • Someya, S.1    Tanokura, M.2
  • 63
    • 2342588705 scopus 로고    scopus 로고
    • Short-term vitamin e intake fails to improve cognitive or psychomotor performance of aged mice
    • Sumien N, Heinrich KR et al (2004) Short-term vitamin E intake fails to improve cognitive or psychomotor performance of aged mice. Free Radic Biol Med 36(11):1424-1433
    • (2004) Free Radic Biol Med , vol.36 , Issue.11 , pp. 1424-1433
    • Sumien, N.1    Heinrich, K.R.2
  • 64
    • 33845864190 scopus 로고    scopus 로고
    • Profiling psychomotor and cognitive aging in four-way cross mice
    • Sumien N, Sims MN et al (2006) Profiling psychomotor and cognitive aging in four-way cross mice. AGE 28:265-282
    • (2006) AGE , vol.28 , pp. 265-282
    • Sumien, N.1    Sims, M.N.2
  • 65
    • 70349330674 scopus 로고    scopus 로고
    • Prolonged intake of coenzyme Q10 impairs cognitive functions in mice
    • Sumien N, Heinrich KR et al (2009) Prolonged intake of coenzyme Q10 impairs cognitive functions in mice. J Nutr 139 (10):1926-1932
    • (2009) J Nutr , vol.139 , Issue.10 , pp. 1926-1932
    • Sumien, N.1    Heinrich, K.R.2
  • 66
    • 0024580556 scopus 로고
    • Decline in skeletal muscle mitochrondrial respiratory chain functions: Possible factor in aging
    • Trounce I, Byrne E et al (1989) Decline in skeletal muscle mitochrondrial respiratory chain functions: possible factor in aging. Lancet 25:637-639
    • (1989) Lancet , vol.25 , pp. 637-639
    • Trounce, I.1    Byrne, E.2
  • 67
    • 0021996572 scopus 로고
    • Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
    • Turrens JF, Alexandre A et al (1985) Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch Biochem Biophys 237:408-414
    • (1985) Arch Biochem Biophys , vol.237 , pp. 408-414
    • Turrens, J.F.1    Alexandre, A.2
  • 68
    • 1642287689 scopus 로고    scopus 로고
    • Metabolism and function of coenzyme Q
    • Turunen M, Olsson J et al (2004) Metabolism and function of coenzyme Q. Biochem Biophys Acta 1660:171-199
    • (2004) Biochem Biophys Acta , vol.1660 , pp. 171-199
    • Turunen, M.1    Olsson, J.2
  • 69
    • 33750604229 scopus 로고    scopus 로고
    • Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes
    • Watson JB, Arnold MM et al (2006) Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes. J Neurosci Res 84(7):1564-1574
    • (2006) J Neurosci Res , vol.84 , Issue.7 , pp. 1564-1574
    • Watson, J.B.1    Arnold, M.M.2
  • 70
    • 0021685732 scopus 로고
    • The acoustic startle response in DBA/2 and C57BL/6 mice: Relationship to auditory neuronal response properties and hearing impairment
    • Willott JF, Kulig J et al (1984) The acoustic startle response in DBA/2 and C57BL/6 mice: relationship to auditory neuronal response properties and hearing impairment. Hear Res 16(2):161-167
    • (1984) Hear Res , vol.16 , Issue.2 , pp. 161-167
    • Willott, J.F.1    Kulig, J.2
  • 71
    • 84892571004 scopus 로고
    • Hippocampal and prefrontal cortex contributions to learning and memory: Analysis of lesion and aging effects on maze learning in rats
    • Winocur G, Moscovitch M (1990) Hippocampal and prefrontal cortex contributions to learning and memory: analysis of lesion and aging effects on maze learning in rats. Behav Neurosci 97:13-27
    • (1990) Behav Neurosci , vol.97 , pp. 13-27
    • Winocur, G.1    Moscovitch, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.