Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia

Metabolic Brain Disease

Volumn 30, Issue 5, 2015, Pages 1139-1150

  Sarkaki, Alireza ^a   Farbood, Yaghoob ^a   Badavi, Mohammad ^a   Khalaj, Leila ^b   Khodagholi, Fariba ^c   Ashabi, Ghorbangol ^a  

^a AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ALBORZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

AMPK; Anxiety; Autophagy; Compound c; Forebrain ischemia; Metformin

Indexed keywords

AUTOPHAGY PROTEIN 10; AUTOPHAGY PROTEIN 11; AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 6; AUTOPHAGY PROTEIN 7; AUTOPHAGY PROTEIN 8; AUTOPHAGY PROTEIN 9; BECLIN 1; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIGHT CHAIN 3B PROTEIN; METFORMIN; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG;

ADULT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; AUTOPHAGY; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFICACY; ELEVATED PLUS MAZE TEST; EXPLORATORY BEHAVIOR; GLUCOSE BLOOD LEVEL; HIPPOCAMPUS; IMMUNOFLUORESCENCE TEST; LOCOMOTION; MALE; NEUROPROTECTION; NONHUMAN; OPEN FIELD TEST; PSYCHOPHARMACOLOGY; PSYCHOPHARMACOTHERAPY; RAT; REGULATORY MECHANISM; REPERFUSION INJURY; SENSORIMOTOR FUNCTION; SIGNAL TRANSDUCTION; TRANQUILIZING ACTIVITY; TRANSIENT ISCHEMIC ATTACK; WESTERN BLOTTING; ANIMAL; ANXIETY; BRAIN ISCHEMIA; DRUG EFFECTS; FOREBRAIN; METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY; PSYCHOLOGY; WISTAR RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANXIETY; AUTOPHAGY; BRAIN ISCHEMIA; MALE; METFORMIN; MOTOR ACTIVITY; PROSENCEPHALON; RATS; RATS, WISTAR;

EID: 84941178413     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-015-9677-x     Document Type: Article

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