Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a Dose-dependent manner

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Wessels, Bart ^a   Ciapaite, Jolita ^b   Van Den Broek, Nicole M A ^a   Nicolay, Klaas ^a   Prompers, Jeanine J ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; METFORMIN; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); WATER; INSULIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; EX VIVO STUDY; GENOTYPE; IN VIVO STUDY; LEAN BODY WEIGHT; MALE; MITOCHONDRIAL RESPIRATION; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; MUSCLE OXIDATIVE CAPACITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; RAT; RESPIROMETRY; TREATMENT DURATION; ZUCKER DIABETIC FATTY RAT; ANIMAL; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; HUMAN; METABOLISM; MITOCHONDRION; OBESITY; OXIDATION REDUCTION REACTION; PATHOLOGY; SKELETAL MUSCLE; ZUCKER RAT;

ANIMALS; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; MALE; METFORMIN; MITOCHONDRIA; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OBESITY; OXIDATION-REDUCTION; RATS; RATS, ZUCKER;

EID: 84903397393     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100525     Document Type: Article

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