Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats

Free Radical Biology and Medicine

Volumn 49, Issue 6, 2010, Pages 1082-1087

  Kane, Daniel A ^a   Anderson, Ethan J ^a,b   Price, Jesse W ^a   Woodlief, Tracey L ^a   Lin, Chien Te ^a   Bikman, Benjamin T ^a   Cortright, Ronald N ^a,b   Neufer, P Darrell ^a,b  

^a EAST CAROLINA UNIVERSITY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Diabetes; Free radicals; Metformin; Mitochondria; Reactive oxygen species; Respiration; Skeletal muscle

Indexed keywords

HYDROGEN PEROXIDE; METFORMIN; OXYGEN; PALMITOYLCARNITINE; SAPONIN; SUCCINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ELECTRON TRANSPORT; EX VIVO STUDY; GLYCEMIC CONTROL; IN VIVO STUDY; INSULIN RESISTANCE; MALE; MEMBRANE PERMEABILITY; MITOCHONDRION; MUSCLE CELL; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; ZUCKER RAT;

RATTUS;

EID: 77955509269     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.06.022     Document Type: Article

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