Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

Genome Research

Volumn 24, Issue 1, 2014, Pages 1-13

  Corradin, Olivia ^a   Saiakhova, Alina ^a   Akhtar Zaidi, Batool ^a   Myeroff, Lois ^b   Willis, Joseph ^a,b   Cowper Sallari, Richard ^c   Lupien, Mathieu ^c   Markowitz, Sanford ^a,b   Scacheri, Peter C ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN;

ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOBLAST; CELIAC DISEASE; CELL TYPE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CROHN DISEASE; ENHANCER REGION; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENE TARGETING; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC VARIABILITY; HAPLOTYPE MAP; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RNA SEQUENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; ULCERATIVE COLITIS;

ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; CELIAC DISEASE; COLITIS, ULCERATIVE; CROHN DISEASE; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

EID: 84891697734     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.164079.113     Document Type: Article

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