Type 2 diabetes-associated K+ channel TALK-1 modulates β-cell electrical excitability, second-phase insulin secretion, and glucose homeostasis

Diabetes

Volumn 64, Issue 11, 2015, Pages 3818-3828

  Vierra, Nicholas C ^a   Dadi, Prasanna K ^a   Jeong, Imju ^a   Dickerson, Matthew ^a   Powell, David R ^b   Jacobson, David A ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GLUCOSE; GLUTAMIC ACID; INSULIN; POTASSIUM CHANNEL; TWIK RELATED ALKALINE PH ACTIVATED K2P 1 CHANNEL POTASSIUM CHANNEL; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; KCNK16 PROTEIN, HUMAN; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOTINYLATION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ADHESION; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; EMBRYO; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LIPID DIET; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; POINT MUTATION; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; GENETICS; HOMEOSTASIS; MALE; MEMBRANE POTENTIAL; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; HOMEOSTASIS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MEMBRANE POTENTIALS; MICE; POTASSIUM CHANNELS, TANDEM PORE DOMAIN;

EID: 84961966439     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0280     Document Type: Article

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