Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

Cell Stem Cell

Volumn 18, Issue 6, 2016, Pages 755-768

  Zhu, Zengrong ^a   Li, Qing V ^a   Lee, Kihyun ^a,b   Rosen, Bess P ^b   González, Federico ^a   Soh, Chew Li ^a   Huangfu, Danwei ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CRISPR ASSOCIATED PROTEIN; NEUROGENIN 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARX; TRANSCRIPTION FACTOR GLIS3; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR MNX1; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR PTF1A; TRANSCRIPTION FACTOR RFX6; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; GLUCOSE; HOMEODOMAIN PROTEIN; NERVE PROTEIN; NEUROG3 PROTEIN, HUMAN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTOR; RFX6 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DIABETES MELLITUS; GENE FUNCTION; GENETIC CONSERVATION; GENOME; HUMAN; HUMAN CELL; IN VITRO STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORGANOGENESIS; PANCREAS; PANCREAS ISLET BETA CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RNA EDITING; CELL LINE; CYTOLOGY; DRUG EFFECTS; EMBRYOLOGY; GENE EDITING; GENE INACTIVATION; GENETICS; HAPLOINSUFFICIENCY; HUMAN EMBRYONIC STEM CELL; HUMAN GENOME; METABOLISM; MUTATION; NEWBORN; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHENOTYPE; TIME FACTOR;

BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CRISPR-CAS SYSTEMS; DIABETES MELLITUS; GENE EDITING; GENE KNOCKOUT TECHNIQUES; GENOME, HUMAN; GLUCOSE; HAPLOINSUFFICIENCY; HOMEODOMAIN PROTEINS; HUMAN EMBRYONIC STEM CELLS; HUMANS; INFANT, NEWBORN; INSULIN-SECRETING CELLS; MUTATION; NERVE TISSUE PROTEINS; PANCREAS; PHENOTYPE; PLURIPOTENT STEM CELLS; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TIME FACTORS; TRANS-ACTIVATORS;

EID: 84964576014     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.03.015     Document Type: Article

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