-
1
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet, P. & Jain, R. K. Angiogenesis in cancer and other diseases. Nature 407, 249-257 (2000).
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
2
-
-
84863691378
-
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
-
Singh, M. & Ferrara, N. Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Nat. Biotechnol. 30, 648-657 (2012).
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 648-657
-
-
Singh, M.1
Ferrara, N.2
-
3
-
-
84859575611
-
Anti-angiogenesis therapy in cancer: Current challenges and future perspectives
-
Shojaei, F. Anti-angiogenesis therapy in cancer: current challenges and future perspectives. Cancer Lett. 320, 130-137 (2012).
-
(2012)
Cancer Lett.
, vol.320
, pp. 130-137
-
-
Shojaei, F.1
-
4
-
-
33845433384
-
Angiogenesis inhibition with bevacizumab and the surgical management of colorectal cancer
-
Thornton, A. D., Ravn, P., Winslet, M. & Chester, K. Angiogenesis inhibition with bevacizumab and the surgical management of colorectal cancer. Br. J. Surg. 93, 1456-1463 (2006).
-
(2006)
Br. J. Surg.
, vol.93
, pp. 1456-1463
-
-
Thornton, A.D.1
Ravn, P.2
Winslet, M.3
Chester, K.4
-
5
-
-
70350482135
-
Gastrointestinal oncological surgery in patients with metastatic cancer treated with angiogenesis inhibitors: Safe or not? ANZ J
-
Chua, T. C. Gastrointestinal oncological surgery in patients with metastatic cancer treated with angiogenesis inhibitors: safe or not? ANZ J. Surg. 79, 672-673 (2009).
-
(2009)
Surg.
, vol.79
, pp. 672-673
-
-
Chua, T.C.1
-
6
-
-
84987608654
-
Current challenges in peptide-based drug discovery
-
Otvos, L. Jr. & Wade, J. D. Current challenges in peptide-based drug discovery. Front. Chem. 2, 62 (2014).
-
(2014)
Front. Chem.
, vol.2
, pp. 62
-
-
Otvos, L.1
Wade, J.D.2
-
7
-
-
84871394690
-
The future of peptide-based drugs
-
Craik, D. J., Fairlie, D. P., Liras, S. & Price, D. The future of peptide-based drugs. Chem. Biol. Drug Des. 81, 136-147 (2013).
-
(2013)
Chem. Biol. Drug Des.
, vol.81
, pp. 136-147
-
-
Craik, D.J.1
Fairlie, D.P.2
Liras, S.3
Price, D.4
-
8
-
-
64149106522
-
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
-
Reynolds, A. R. et al. Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat. Med. 15, 392-400 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 392-400
-
-
Reynolds, A.R.1
-
9
-
-
0033579483
-
Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif
-
Craik, D. J., Daly, N. L., Bond, T. & Waine, C. Plant cyclotides: a unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. J. Mol. Biol. 294, 1327-1336 (1999).
-
(1999)
J. Mol. Biol.
, vol.294
, pp. 1327-1336
-
-
Craik, D.J.1
Daly, N.L.2
Bond, T.3
Waine, C.4
-
10
-
-
0034674028
-
Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure
-
Hernandez, J. F. et al. Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure. Biochemistry 39, 5722-5730 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 5722-5730
-
-
Hernandez, J.F.1
-
11
-
-
0344655676
-
High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds
-
Luckett, S. et al. High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds. J. Mol. Biol. 290, 525-533 (1999).
-
(1999)
J. Mol. Biol.
, vol.290
, pp. 525-533
-
-
Luckett, S.1
-
12
-
-
84879023057
-
Joseph Rudinger memorial lecture: Discovery and applications of cyclotides
-
Craik, D. J. Joseph Rudinger memorial lecture: discovery and applications of cyclotides. J. Pept. Sci. 19, 393-407 (2013).
-
(2013)
J. Pept. Sci.
, vol.19
, pp. 393-407
-
-
Craik, D.J.1
-
13
-
-
0028927655
-
Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1
-
Saether, O. et al. Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1. Biochemistry 34, 4147-4158 (1995).
-
(1995)
Biochemistry
, vol.34
, pp. 4147-4158
-
-
Saether, O.1
-
14
-
-
32944465547
-
Structural plasticity of the cyclic-cystine-knot framework: Implications for biological activity and drug design
-
Clark, R. J., Daly, N. L. & Craik, D. J. Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design. Biochem. J. 394, 85-93 (2006).
-
(2006)
Biochem. J.
, vol.394
, pp. 85-93
-
-
Clark, R.J.1
Daly, N.L.2
Craik, D.J.3
-
15
-
-
84879017232
-
Cyclotides as grafting frameworks for protein engineering and drug design applications
-
Poth, A. G., Chan, L. Y. & Craik, D. J. Cyclotides as grafting frameworks for protein engineering and drug design applications. Biopolymers 100, 480-491 (2013).
-
(2013)
Biopolymers
, vol.100
, pp. 480-491
-
-
Poth, A.G.1
Chan, L.Y.2
Craik, D.J.3
-
16
-
-
84896512272
-
Disulfide-rich macrocyclic peptides as templates in drug design
-
Northfield, S. E. et al. Disulfide-rich macrocyclic peptides as templates in drug design. Eur. J. Med. Chem. 77, 248-257 (2014).
-
(2014)
Eur. J. Med. Chem.
, vol.77
, pp. 248-257
-
-
Northfield, S.E.1
-
17
-
-
84861615565
-
Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
-
Wong, C. T. et al. Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment. Angew. Chem. Int. Ed. Engl. 51, 5620-5624 (2012).
-
(2012)
Angew. Chem. Int. Ed. Engl.
, vol.51
, pp. 5620-5624
-
-
Wong, C.T.1
-
18
-
-
84055177578
-
Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds
-
Chan, L. Y. et al. Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. Blood 118, 6709-6717 (2011).
-
(2011)
Blood
, vol.118
, pp. 6709-6717
-
-
Chan, L.Y.1
-
19
-
-
84881250938
-
In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide
-
Ji, Y. et al. In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide. J. Am. Chem. Soc. 135, 11623-11633 (2013).
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 11623-11633
-
-
Ji, Y.1
-
20
-
-
58149089532
-
Engineering stabilized vascular endothelial growth factor-A antagonists: Synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides
-
Gunasekera, S. et al. Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides. J. Med. Chem. 51, 7697-7704 (2008).
-
(2008)
J. Med. Chem.
, vol.51
, pp. 7697-7704
-
-
Gunasekera, S.1
-
21
-
-
84881232071
-
Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
-
Welti, J., Loges, S., Dimmeler, S. & Carmeliet, P. Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J. Clin. Invest. 123, 3190-3200 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 3190-3200
-
-
Welti, J.1
Loges, S.2
Dimmeler, S.3
Carmeliet, P.4
-
22
-
-
0033876426
-
Template-constrained cyclic peptide analogues of somatostatin: Subtype-selective binding to somatostatin receptors and antiangiogenic activity
-
Suich, D. J. et al. Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity. Bioorg. Med. Chem. 8, 2229-2241 (2000).
-
(2000)
Bioorg. Med. Chem.
, vol.8
, pp. 2229-2241
-
-
Suich, D.J.1
-
23
-
-
0028861262
-
Binding epitope of somatostatin defined by phage-displayed peptide libraries
-
Wright, R. M. et al. Binding epitope of somatostatin defined by phage-displayed peptide libraries. Biotechnology 13, 165-169 (1995).
-
(1995)
Biotechnology
, vol.13
, pp. 165-169
-
-
Wright, R.M.1
-
24
-
-
76049107574
-
Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasis
-
Abe, R. et al. Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasis. J. Dermatol. Sci. 57, 183-191 (2010).
-
(2010)
J. Dermatol. Sci.
, vol.57
, pp. 183-191
-
-
Abe, R.1
-
25
-
-
0033538517
-
Pigment epithelium-derived factor: A potent inhibitor of angiogenesis
-
Dawson, D. W. et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285, 245-248 (1999).
-
(1999)
Science
, vol.285
, pp. 245-248
-
-
Dawson, D.W.1
-
26
-
-
33645524125
-
Variable phosphorylation states of pigment-epithelium-derived factor differentially regulate its function
-
Maik-Rachline, G. & Seger, R. Variable phosphorylation states of pigment-epithelium-derived factor differentially regulate its function. Blood 107, 2745-2752 (2006).
-
(2006)
Blood
, vol.107
, pp. 2745-2752
-
-
Maik-Rachline, G.1
Seger, R.2
-
27
-
-
0034607797
-
Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis
-
Bae, D. G., Gho, Y. S., Yoon, W. H. & Chae, C. B. Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis. J. Biol. Chem. 275, 13588-13596 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 13588-13596
-
-
Bae, D.G.1
Gho, Y.S.2
Yoon, W.H.3
Chae, C.B.4
-
28
-
-
17844372767
-
Arginine-rich anti-vascular endothelial growth factor (anti-VEGF) hexapeptide inhibits collagen-induced arthritis and VEGF-stimulated productions of TNF-alpha and IL-6 by human monocytes
-
Yoo, S. A. et al. Arginine-rich anti-vascular endothelial growth factor (anti-VEGF) hexapeptide inhibits collagen-induced arthritis and VEGF-stimulated productions of TNF-alpha and IL-6 by human monocytes. J. Immunol. 174, 5846-5855 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 5846-5855
-
-
Yoo, S.A.1
-
29
-
-
13544255403
-
The pathophysiologic role of VEGF in hematologic malignancies: Therapeutic implications
-
Podar, K. & Anderson, K. C. The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications. Blood 105, 1383-1395 (2005).
-
(2005)
Blood
, vol.105
, pp. 1383-1395
-
-
Podar, K.1
Anderson, K.C.2
-
31
-
-
18944381675
-
Somatostatin receptors 2 and 5 are preferentially expressed in proliferating endothelium
-
Adams, R. L., Adams, I. P., Lindow, S. W., Zhong, W. & Atkin, S. L. Somatostatin receptors 2 and 5 are preferentially expressed in proliferating endothelium. Br. J. Cancer 92, 1493-1498 (2005).
-
(2005)
Br. J. Cancer
, vol.92
, pp. 1493-1498
-
-
Adams, R.L.1
Adams, I.P.2
Lindow, S.W.3
Zhong, W.4
Atkin, S.L.5
-
32
-
-
33645473155
-
Sunitinib maleate
-
Atkins, M., Jones, C. A. & Kirkpatrick, P. Sunitinib maleate. Nat. Rev. Drug Discov. 5, 279-280 (2006).
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 279-280
-
-
Atkins, M.1
Jones, C.A.2
Kirkpatrick, P.3
-
33
-
-
84921442644
-
Peptide therapeutics: Current status and future directions
-
Fosgerau, K. & Hoffmann, T. Peptide therapeutics: current status and future directions. Drug Discov. Today 20, 122-128 (2015).
-
(2015)
Drug Discov. Today
, vol.20
, pp. 122-128
-
-
Fosgerau, K.1
Hoffmann, T.2
-
34
-
-
77953717986
-
Improvement of drug-like properties of peptides: The somatostatin paradigm
-
Ovadia, O. et al. Improvement of drug-like properties of peptides: the somatostatin paradigm. Expert Opin. Drug Discov. 5, 655-671 (2010).
-
(2010)
Expert Opin. Drug Discov.
, vol.5
, pp. 655-671
-
-
Ovadia, O.1
-
35
-
-
84898955500
-
Triazine-based tool box for developing peptidic PET imaging probes: Syntheses, microfluidic radiolabeling, and structure-activity evaluation
-
Li, H. et al. Triazine-based tool box for developing peptidic PET imaging probes: syntheses, microfluidic radiolabeling, and structure-activity evaluation. Bioconjug. Chem. 25, 761-772 (2014).
-
(2014)
Bioconjug. Chem.
, vol.25
, pp. 761-772
-
-
Li, H.1
-
36
-
-
84906914073
-
HER 1-2 punch: Dual EGFR targeting deals resistance a deadly blow
-
Gibbons, D. L. & Byers, L. A. A. HER 1-2 punch: dual EGFR targeting deals resistance a deadly blow. Cancer Discov. 4, 991-994 (2014).
-
(2014)
Cancer Discov.
, vol.4
, pp. 991-994
-
-
Gibbons, D.L.1
Byers, L.A.A.2
-
37
-
-
84895074402
-
The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif
-
Conibear, A. C. et al. The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem 15, 451-459 (2014).
-
(2014)
ChemBioChem
, vol.15
, pp. 451-459
-
-
Conibear, A.C.1
-
38
-
-
84939213771
-
Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold
-
Huang, Y. H. et al. Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Sci. Rep. 5, 12974 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 12974
-
-
Huang, Y.H.1
-
39
-
-
78650884323
-
Somatostatin receptor-targeted anti-cancer therapy
-
Sun, L. C. & Coy, D. H. Somatostatin receptor-targeted anti-cancer therapy. Curr. Drug Deliv. 8, 2-10 (2011).
-
(2011)
Curr. Drug Deliv.
, vol.8
, pp. 2-10
-
-
Sun, L.C.1
Coy, D.H.2
-
40
-
-
84879354864
-
The many facets of PEDF in drug discovery and disease: A diamond in the rough or split personality disorder? Expert Opin
-
Craword, S. E., Fitchev, P., Veliceasa, D. & Volpert, O. V. The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder? Expert Opin. Drug Discov. 8, 769-792 (2013).
-
(2013)
Drug Discov.
, vol.8
, pp. 769-792
-
-
Craword, S.E.1
Fitchev, P.2
Veliceasa, D.3
Volpert, O.V.4
-
41
-
-
84933677744
-
Therapeutic uses of somatostatin and its analogues: Current view and potential applications
-
Rai, U., Thrimawithana, T. R., Valery, C. & Young, S. A. Therapeutic uses of somatostatin and its analogues: current view and potential applications. Pharmacol. Ther. 152, 98-110 (2015).
-
(2015)
Pharmacol. Ther.
, vol.152
, pp. 98-110
-
-
Rai, U.1
Thrimawithana, T.R.2
Valery, C.3
Young, S.A.4
-
42
-
-
84875463812
-
The effects of PEDF on cancer biology: Mechanisms of action and therapeutic potential
-
Becerra, S. P. & Notario, V. The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential. Nat. Rev. Cancer 13, 258-271 (2013).
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 258-271
-
-
Becerra, S.P.1
Notario, V.2
-
43
-
-
84863225073
-
Ophthalmic drug discovery: Novel targets and mechanisms for retinal diseases and glaucoma
-
Zhang, K., Zhang, L. & Weinreb, R. N. Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma. Nat. Rev. Drug Discov. 11, 541-559 (2012).
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 541-559
-
-
Zhang, K.1
Zhang, L.2
Weinreb, R.N.3
-
44
-
-
69949150993
-
Isolation and characterization of peptides from Momordica cochinchinensis seeds
-
Chan, L. Y. et al. Isolation and characterization of peptides from Momordica cochinchinensis seeds. J. Nat. Prod. 72, 1453-1458 (2009).
-
(2009)
J. Nat. Prod.
, vol.72
, pp. 1453-1458
-
-
Chan, L.Y.1
-
45
-
-
84956889439
-
Cyclic thrombospondin-1 mimetics: Grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration
-
Chan, L. Y., Craik, D. J. & Daly, N. L. Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration. Biosci. Rep. 35, e00270 (2015).
-
(2015)
Biosci. Rep.
, vol.35
, pp. e00270
-
-
Chan, L.Y.1
Craik, D.J.2
Daly, N.L.3
-
46
-
-
19444382397
-
The CCPN data model for NMR spectroscopy: Development of a software pipeline
-
Vranken, W. F. et al. The CCPN data model for NMR spectroscopy: development of a software pipeline. Proteins 59, 687-696 (2005).
-
(2005)
Proteins
, vol.59
, pp. 687-696
-
-
Vranken, W.F.1
-
48
-
-
0029364052
-
1H, 13C and 15N chemical shift referencing in biomolecular NMR
-
Wishart, D. S. et al. 1H, 13C and 15N chemical shift referencing in biomolecular NMR. J. Biomol. NMR 6, 135-140 (1995).
-
(1995)
J. Biomol. NMR
, vol.6
, pp. 135-140
-
-
Wishart, D.S.1
-
49
-
-
0029881007
-
MOLMOL: A program for display and analysis of macromolecular structures
-
Koradi, R., Billeter, M. & Wuthrich, K. MOLMOL: a program for display and analysis of macromolecular structures. J. Mol. Graph. 14, 51-55, 29-32 (1996).
-
(1996)
J. Mol. Graph.
, vol.14
, Issue.51-55
, pp. 29-32
-
-
Koradi, R.1
Billeter, M.2
Wuthrich, K.3
|