Engineered Cystine Knot Miniproteins as Potent Inhibitors of Human Mast Cell Tryptase β

Journal of Molecular Biology

Volumn 395, Issue 1, 2010, Pages 167-175

  Sommerhoff, Christian P ^a   Avrutina, Olga ^b   Schmoldt, Hans Ulrich ^b   Gabrijelcic Geiger, Dusica ^a   Diederichsen, Ulf ^c   Kolmar, Harald ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

cystine knot miniproteins; human mast cell tryptase; knottins; macrocyclic peptides; protein inhibitor

Indexed keywords

CYSTEINE; TRYPTASE; TRYPTASE BETA; TRYPTASE BETA INHIBITOR; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYSTINE KNOT MOTIF; DRUG DESIGN; DRUG ISOLATION; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; MAST CELL; MOMORDICA; NONHUMAN; PLANT SEED; PRIORITY JOURNAL; PROTEIN TARGETING;

MOMORDICA COCHINCHINENSIS;

EID: 70450224855     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.10.028     Document Type: Article

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