Head-to-tail cyclized cystine-knot peptides by a combined recombinant and chemical route of synthesis

ChemBioChem

Volumn 9, Issue 1, 2008, Pages 33-37

  Avrutina, Olga ^a   Schmoldt, Hans Ulrich ^a,e   Gabrijelcic Geiger, Dusica ^c   Wentzel, Alexander ^d   Frauendorf, Holm ^b   Sommerhoff, Christian P ^c   Diederichsen, Ulf ^b   Kolmar, Harald ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d Selecore GmbH   (Germany)

^e NascaCell Technologies AG   (Germany)

Author keywords

Cyclic peptides; Cystine knot miniproteins; Hydrazones; Inhibitors; Macrocyclization; Protein modifications

Indexed keywords

CONOTOXIN; CYCLOPEPTIDE; CYCLOTIDE; CYSTEINE; GAMMA LACTONE DERIVATIVE; HYBRID PROTEIN; HYDRAZONE DERIVATIVE; ION CHANNEL; METHIONINE; PEPTIDE DERIVATIVE; PERIODATE SODIUM; RECOMBINANT PROTEIN; SPIDER VENOM; TRYPTASE;

AMINO ACID SEQUENCE; ARTICLE; CYCLIZATION; GENE CONSTRUCT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID OXIDATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEINASE INHIBITION;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIZATION; CYSTINE KNOT MOTIFS; DISULFIDES; GRANZYMES; HUMANS; HYDRAZONES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PEPTIDES, CYCLIC; PERIODIC ACID; PROTEIN FOLDING; RECOMBINANT FUSION PROTEINS; RIBONUCLEASES;

EID: 38149082114     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700452     Document Type: Article

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