Potent inhibitors of β-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

Journal of Medicinal Chemistry

Volumn 52, Issue 20, 2009, Pages 6197-6200

  Thongyoo, Panumart ^a   Bonomelli, Camille ^b   Leatherbarrow, Robin J ^a   Tate, Edward W ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITÉ DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TYRPTASE; CYCLOPEPTIDE; CYCLOTIDE; CYSTINE; LEUKOCYTE ELASTASE; PROTEIN MCOTI II; PROTEINASE INHIBITOR; SCAFFOLD PROTEIN; SERINE PROTEINASE; TRYPTASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; ELECTRICITY; ENZYME INHIBITION; HUMAN; INFLAMMATORY DISEASE; NUCLEAR MAGNETIC RESONANCE; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; CYCLOTIDES; DRUG DESIGN; HUMANS; LEUKOCYTE ELASTASE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TRYPTASES;

EID: 70350059832     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm901233u     Document Type: Article

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