High-affinity cyclic peptide matriptase inhibitors

Journal of Biological Chemistry

Volumn 288, Issue 19, 2013, Pages 13885-13896

  Quimbar, Pedro ^a   Malik, Uru ^b   Sommerhoff, Christian P ^c   Kaas, Quentin ^b   Chan, Lai Y ^b   Huang, Yen Hua ^b   Grundhuber, Maresa ^c   Dunse, Kerry ^a   Craik, David J ^b   Anderson, Marilyn A ^a   Daly, Norelle L ^b,d  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d JAMES COOK UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC PEPTIDES; INHIBITORY ACTIVITY; PEPTIDE INHIBITORS; POTENT INHIBITOR; PROTEASE INHIBITOR; STRUCTURE ACTIVITY RELATIONSHIPS; SUNFLOWER TRYPSIN INHIBITOR-1; THERAPEUTIC POTENTIALS;

PEPTIDES;

ENZYME INHIBITION;

CYCLOPEPTIDE; MATRIPTASE; TRYPSIN INHIBITOR;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MODIFICATION; MOLECULAR MODEL; MOMORDICA COCHINCHINENSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

MOLECULAR MODELING; NUCLEAR MAGNETIC RESONANCE; PEPTIDE CONFORMATION; PEPTIDES; PROTEASE INHIBITOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; HELIANTHUS; HUMANS; HYDROGEN BONDING; KINETICS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MOMORDICA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; PLANT PROTEINS; PROTEIN BINDING; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 84877717427     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.460030     Document Type: Article

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