Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 52, 2013, Pages 21183-21188

  Koehbach, Johannes ^a   O'Brien, Margaret ^b   Muttenthaler, Markus ^c   Miazzo, Marion ^a   Akcan, Muharrem ^d   Elliott, Alysha G ^d   Daly, Norelle L ^d,e   Harvey, Peta J ^d   Arrowsmith, Sarah ^f   Gunasekera, Sunithi ^g   Smith, Terry J ^b   Wray, Susan ^f   Göransson, Ulf ^g   Dawson, Philip E ^c   Craik, David J ^d   Freissmuth, Michael ^a   Gruber, Christian W ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e JAMES COOK UNIVERSITY   (Australia)

^f UNIVERSITY OF LIVERPOOL   (United Kingdom)

^g UPPSALA UNIVERSITY   (Sweden)

Author keywords

Chemical pharmacology; Circular plant peptide; Peptide drugs; Peptide ligand design; Uterotonic

Indexed keywords

CYCLOTIDE; CYSTYLTYROSYLTHREONYLGLYCYLCYSTEINE; G PROTEIN COUPLED RECEPTOR; NONAPEPTIDE; OXYTOCIC AGENT; OXYTOCIN; RADIOLIGAND; UNCLASSIFIED DRUG; VASOPRESSIN V1A RECEPTOR;

ARTICLE; ASSAY; CONTROLLED STUDY; DRUG DESIGN; HUMAN; HUMAN CELL; MYOMETRIUM; PLANT; PRIORITY JOURNAL; SECOND MESSENGER BASED REPORTER ASSAY; SMOOTH MUSCLE CONTRACTILITY;

EID: 84891348136     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1311183110     Document Type: Article

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