메뉴 건너뛰기




Volumn 21, Issue 11, 2011, Pages 1657-1672

Cyclotides: A patent review

Author keywords

Circular proteins; Cyclic peptides; Cyclotides; Cystine knot; Drug design; Kalata B1

Indexed keywords

CYCLOTIDE; CYSTINE; KNOTTIN; POLYPEPTIDE; THROMBOPOIETIN; TRYPTASE INHIBITOR;

EID: 80054912450     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2011.620606     Document Type: Article
Times cited : (21)

References (118)
  • 1
    • 0033579483 scopus 로고    scopus 로고
    • Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif
    • DOI 10.1006/jmbi.1999.3383
    • Craik DJ, Daly NL, Bond T, Waine C. Plant cyclotides: a unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. J Mol Biol 1999;294:1327-36 (Pubitemid 30008803)
    • (1999) Journal of Molecular Biology , vol.294 , Issue.5 , pp. 1327-1336
    • Craik, D.J.1    Daly, N.L.2    Bond, T.3    Waine, C.4
  • 2
    • 0035239222 scopus 로고    scopus 로고
    • The cystine knot motif in toxins and implications for drug design
    • Craik DJ, Daly NL, Waine C. The cystine knot motif in toxins and implications for drug design. Toxicon 2001;39:43-60
    • (2001) Toxicon , vol.39 , pp. 43-60
    • Craik, D.J.1    Daly, N.L.2    Waine, C.3
  • 3
    • 0000014794 scopus 로고
    • An oxytocic principle found in Oldenlandia affinis DC
    • Gran L, An oxytocic principle found in Oldenlandia affinis DC. Medd Nor Farm Selsk. 1970;12:173-80
    • (1970) Medd Nor Farm Selsk. , vol.12 , pp. 173-80
    • Gran, L.1
  • 4
    • 0015858263 scopus 로고
    • Isolation of oxytocic peptides from Oldenlandia affinis by solvent extraction of tetraphenylborate complexes and chromatography on sephadex LH-20
    • Gran L. Isolation of oxytocic peptides from Oldenlandia affinis by solvent extraction of tetraphenylborate complexes and chromatography on sephadex LH-20. Lloydia 1973;36:207-8
    • (1973) Lloydia , vol.36 , pp. 207-8
    • Gran, L.1
  • 5
    • 0003064562 scopus 로고
    • Some molecular properties of kalatapeptide B-1. A uterotonic polypeptide isolated from Oldenlandia affinis DC
    • Sletten K, Gran L. Some molecular properties of kalatapeptide B-1. A uterotonic polypeptide isolated from Oldenlandia affinis DC. Medd Nor Farm Selsk 1973;7-8:69-82
    • (1973) Medd Nor Farm Selsk , vol.7-8 , pp. 69-82
    • Sletten, K.1    Gran, L.2
  • 6
    • 0028927655 scopus 로고
    • Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1
    • Saether O, Craik DJ, Campbell ID, et al. Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1. Biochemistry (Mosc) 1995;34:4147-58
    • (1995) Biochemistry (Mosc) , vol.34 , pp. 4147-58
    • Saether, O.1    Craik, D.J.2    Campbell, I.D.3
  • 7
    • 2442715239 scopus 로고    scopus 로고
    • Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: The importance of the cyclic cystine knot
    • DOI 10.1021/bi049711q
    • Colgrave ML, Craik DJ. Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot. Biochemistry (Mosc) 2004;43:5965-75 (Pubitemid 38669464)
    • (2004) Biochemistry , vol.43 , Issue.20 , pp. 5965-5975
    • Colgrave, M.L.1    Craik, D.J.2
  • 8
    • 0028036769 scopus 로고
    • Circulins A and B: Novel HIV-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia
    • Gustafson KR, Sowder RCI, Henderson LE, et al. Circulins A and B: novel HIV-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia. J Am Chem Soc 1994;116:9337-8
    • (1994) J Am Chem Soc , vol.116 , pp. 9337-8
    • Gustafson, K.R.1    Rci, S.2    Henderson, L.E.3
  • 9
    • 0028598525 scopus 로고
    • Cyclopsychotride A, A biologically active, 31-residue cyclic peptide isolated from Psychotria longipes
    • Witherup KM, Bogusky MJ, Anderson PS, et al. Cyclopsychotride A, A biologically active, 31-residue cyclic peptide isolated from Psychotria longipes. J Nat Prod 1994;57:1619-25
    • (1994) J Nat Prod , vol.57 , pp. 1619-25
    • Witherup, K.M.1    Bogusky, M.J.2    Anderson, P.S.3
  • 11
    • 38549134937 scopus 로고    scopus 로고
    • CyBase: A database of cyclic protein sequences and structures, with applications in protein discovery and engineering
    • DOI 10.1093/nar/gkm953
    • Wang CK, Kaas Q, Chiche L, Craik DJ. CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering. Nucleic Acids Res 2008;36:D206-10 (Pubitemid 351149723)
    • (2008) Nucleic Acids Research , vol.36 , Issue.SUPPL. 1
    • Wang, C.K.L.1    Kaas, Q.2    Chiche, L.3    Craik, D.J.4
  • 13
    • 79959864353 scopus 로고    scopus 로고
    • Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family
    • Nguyen GK, Zhang S, Nguyen NT, et al. Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. J Biol Chem 2011;286:24275-87
    • (2011) J Biol Chem , Issue.286 , pp. 24275-87
    • Nguyen, G.K.1    Zhang, S.2    Nguyen, N.T.3
  • 14
    • 79959965754 scopus 로고    scopus 로고
    • Discovery of an unusual biosynthetic origin for circular proteins in legumes
    • Poth AG, Colgrave ML, Lyons RE, et al. Discovery of an unusual biosynthetic origin for circular proteins in legumes. Proc Natl Acad Sci USA 2011;108:10127-32
    • (2011) Proc Natl Acad Sci USA , Issue.108 , pp. 10127-32
    • Poth, A.G.1    Colgrave, M.L.2    Lyons, R.E.3
  • 15
    • 79954569541 scopus 로고    scopus 로고
    • Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins
    • Poth AG, Colgrave ML, Philip R, et al. Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chem Biol 2011;6:345-55
    • (2011) ACS Chem Biol , Issue.6 , pp. 345-55
    • Poth, A.G.1    Colgrave, M.L.2    Philip, R.3
  • 17
    • 33646248365 scopus 로고    scopus 로고
    • The cyclotide family of circular miniproteins: Nature's combinatorial peptide template
    • Craik DJ, Cemazar M, Wang CK, Daly NL. The cyclotide family of circular miniproteins: nature's combinatorial peptide template. Biopolymers 2006;84:250-66
    • (2006) Biopolymers , vol.84 , pp. 250-66
    • Craik, D.J.1    Cemazar, M.2    Wang, C.K.3    Daly, N.L.4
  • 18
    • 0015723952 scopus 로고
    • On the effect of a polypeptide isolated from "kalata-Kalata" (Oldenlandia affinis DC) on the oestrogen dominated uterus
    • Gran L. On the effect of a polypeptide isolated from "Kalata- Kalata" (Oldenlandia affinis DC) on the oestrogen dominated uterus. Acta Pharmacol Toxicol 1973;33:400-8
    • (1973) Acta Pharmacol Toxicol , vol.33 , pp. 400-8
    • Gran, L.1
  • 19
  • 20
    • 39149141320 scopus 로고    scopus 로고
    • The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity
    • Herrmann A, Burman R, Mylne J, et al. The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity. Phytochemistry 2008;69:939-52
    • (2008) Phytochemistry , vol.69 , pp. 939-52
    • Herrmann, A.1    Burman, R.2    Mylne, J.3
  • 23
    • 80052650140 scopus 로고    scopus 로고
    • Evaluation of toxicity and anti-tumour activity of cycloviolacin O2 in mice
    • Burman R, Svedlund E, Felth J, et al. Evaluation of toxicity and anti-tumour activity of cycloviolacin O2 in mice. Biopolymers Pept Sci 2010;94:626-34
    • (2010) Biopolymers Pept Sci , vol.94 , pp. 626-34
    • Burman, R.1    Svedlund, E.2    Felth, J.3
  • 24
    • 79955567660 scopus 로고    scopus 로고
    • Anticancer and chemosensitizing abilities of cycloviolacin O2 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa
    • Gerlach SL, Rathinakumar R, Chakravarty G, et al. Anticancer and chemosensitizing abilities of cycloviolacin O2 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa. Biopolymers 2010;94:617-25
    • (2010) Biopolymers , vol.94 , pp. 617-25
    • Gerlach, S.L.1    Rathinakumar, R.2    Chakravarty, G.3
  • 25
    • 66649136413 scopus 로고    scopus 로고
    • Circling the enemy: Cyclic proteins in plant defence
    • Craik DJ. Circling the enemy: cyclic proteins in plant defence. Trends Plant Sci 2009;14:328-35
    • (2009) Trends Plant Sci , vol.14 , pp. 328-35
    • Craik, D.J.1
  • 26
    • 33847385325 scopus 로고    scopus 로고
    • Insecticidal plant cyclotides and related cystine knot toxins
    • DOI 10.1016/j.toxicon.2006.11.018, PII S004101010600434X
    • Gruber CW, Cemazar M, Anderson MA, Craik DJ. Insecticidal plant cyclotides and related cystine knot toxins. Toxicon 2007;49:561-75 (Pubitemid 46341392)
    • (2007) Toxicon , vol.49 , Issue.4 , pp. 561-575
    • Gruber, C.W.1    Cemazar, M.2    Anderson, M.A.3    Craik, D.J.4
  • 28
    • 54349090107 scopus 로고    scopus 로고
    • The anthelmintic activity of the cyclotides: Natural variants with enhanced activity
    • Colgrave ML, Kotze AC, Ireland DC, et al. The anthelmintic activity of the cyclotides: natural variants with enhanced activity. ChemBioChem 2008;9:1939-45
    • (2008) ChemBioChem , vol.9 , pp. 1939-45
    • Colgrave, M.L.1    Kotze, A.C.2    Ireland, D.C.3
  • 29
    • 57849088141 scopus 로고    scopus 로고
    • Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms
    • Colgrave ML, Kotze AC, Kopp S, et al. Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms. Acta Trop 2009;109:163-6
    • (2009) Acta Trop , vol.109 , pp. 163-6
    • Colgrave, M.L.1    Kotze, A.C.2    Kopp, S.3
  • 30
    • 47849105966 scopus 로고    scopus 로고
    • Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculate (golden apple snail)
    • DOI 10.1021/jf800302f
    • Plan MR, Saska I, Cagauan AG, Craik DJ. Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail). J Agric Food Chem 2008;56:5237-41 (Pubitemid 352039129)
    • (2008) Journal of Agricultural and Food Chemistry , vol.56 , Issue.13 , pp. 5237-5241
    • Plan, M.R.R.1    Saska, I.2    Cagauan, A.G.3    Craik, D.J.4
  • 32
    • 0036257686 scopus 로고    scopus 로고
    • Converting a peptide into a drug: Strategies to improve stability and bioavailability
    • Adessi C, Soto C. Converting a peptide into a drug: strategies to improve stability and bioavailability. Curr Med Chem 2002;9:963-78 (Pubitemid 34498572)
    • (2002) Current Medicinal Chemistry , vol.9 , Issue.9 , pp. 963-978
    • Adessi, C.1    Soto, C.2
  • 33
    • 0031822610 scopus 로고    scopus 로고
    • A biomimetic strategy in the synthesis and fragmentation of cyclic protein
    • Tam JP, Lu Y-A. A biomimetic strategy in the synthesis and fragmentation of cyclic protein. Protein Sci 1998;7:1583-92 (Pubitemid 28331278)
    • (1998) Protein Science , vol.7 , Issue.7 , pp. 1583-1592
    • Tam, J.P.1    Lu, Y.I.-A.N.2
  • 34
    • 0033543137 scopus 로고    scopus 로고
    • Chemical synthesis and folding pathways of large cyclic polypeptides: Studies of the cystine knot polypeptide kalata B1
    • Daly NL, Love S, Alewood PF, Craik DJ. Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1. Biochemistry (Mosc) 1999;38:10606-14
    • (1999) Biochemistry (Mosc) , vol.38 , pp. 10606-14
    • Daly, N.L.1    Love, S.2    Alewood, P.F.3    Craik, D.J.4
  • 36
    • 0027944205 scopus 로고
    • Synthesis of proteins by native chemical ligation
    • Dawson PE, Muir TW, Clark-Lewis I, Kent SB. Synthesis of proteins by native chemical ligation. Science 1994;266:776-9 (Pubitemid 24359280)
    • (1994) Science , vol.266 , Issue.5186 , pp. 776-779
    • Dawson, P.E.1    Muir, T.W.2    Clark-Lewis, I.3    Kent, S.B.H.4
  • 38
    • 0037458652 scopus 로고    scopus 로고
    • Disulfide folding pathways of cystine knot proteins: Tying the knot within the circular backbone of the cyclotides
    • DOI 10.1074/jbc.M210492200
    • Daly NL, Clark RJ, Craik DJ. Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides. J Biol Chem 2003;278:6314-22 (Pubitemid 36800889)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.8 , pp. 6314-6322
    • Daly, N.L.1    Clark, R.J.2    Craik, D.J.3
  • 39
    • 0346220263 scopus 로고    scopus 로고
    • Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cyclic cystine knot motif
    • DOI 10.1074/jbc.M308771200
    • Goransson U, Craik DJ. Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cyclic cystine knot motif. J Biol Chem 2003;278:48188-96 (Pubitemid 37523272)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.48 , pp. 48188-48196
    • Goransson, U.1    Craik, D.J.2
  • 40
    • 33749128301 scopus 로고    scopus 로고
    • Chemical synthesis and biosynthesis of the cyclotide family of circular proteins
    • DOI 10.1080/15216540600889532, PII KP287U827L852077
    • Gunasekera S, Daly NL, Anderson MA, Craik DJ. Chemical synthesis and biosynthesis of the cyclotide family of circular proteins. IUBMB Life 2006;58:515-24 (Pubitemid 44470237)
    • (2006) IUBMB Life , vol.58 , Issue.9 , pp. 515-524
    • Gunasekera, S.1    Daly, N.L.2    Anderson, M.A.3    Craik, D.J.4
  • 41
    • 14844315799 scopus 로고    scopus 로고
    • Oxidative folding of the cystine knot motif in cyclotide proteins
    • DOI 10.2174/0929866053005863
    • Craik DJ, Daly NL. Oxidative folding of the cystine knot motif in cyclotide proteins. Protein Pept Lett 2005;12:147-52 (Pubitemid 40335666)
    • (2005) Protein and Peptide Letters , vol.12 , Issue.2 , pp. 147-152
    • Craik, D.J.1    Daly, N.L.2
  • 43
    • 65949100618 scopus 로고    scopus 로고
    • Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides
    • Trabi M, Mylne JS, Sando L, Craik DJ. Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides. Org Biomol Chem 2009;7:2378-88
    • (2009) Org Biomol Chem , vol.7 , pp. 2378-88
    • Trabi, M.1    Mylne, J.S.2    Sando, L.3    Craik, D.J.4
  • 44
    • 58149291681 scopus 로고    scopus 로고
    • Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: CDNA sequence variation, alternative RNA splicing and potential cyclotide diversity
    • Zhang J, Liao B, Craik DJ, et al. Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity. Gene 2009;431:23-32
    • (2009) Gene , vol.431 , pp. 23-32
    • Zhang, J.1    Liao, B.2    Craik, D.J.3
  • 45
    • 45849122826 scopus 로고    scopus 로고
    • Plant cell culture technology-harnessing a biological approach for competitive cyclotides production
    • Dornenburg H. Plant cell culture technology-harnessing a biological approach for competitive cyclotides production. Biotechnol Lett 2008;30:1311-21
    • (2008) Biotechnol Lett , vol.30 , pp. 1311-21
    • Dornenburg, H.1
  • 46
    • 68049092854 scopus 로고    scopus 로고
    • Progress in kalata peptide production via plant cell bioprocessing
    • Dornenburg H. Progress in kalata peptide production via plant cell bioprocessing. Biotechnol J 2009;4:632-45
    • (2009) Biotechnol J , vol.4 , pp. 632-45
    • Dornenburg, H.1
  • 47
    • 80054879031 scopus 로고    scopus 로고
    • Cyclotide synthesis and supply: From plant to bioprocess
    • Dornenburg H. Cyclotide synthesis and supply: from plant to bioprocess. Biopolymers 2010;94:602-10
    • (2010) Biopolymers , Issue.94 , pp. 602-10
    • Dornenburg, H.1
  • 48
    • 43049115684 scopus 로고    scopus 로고
    • Plant cell-based processes for cyclotides production
    • Dornenburg H, Frickinger P, Seydel P. Plant cell-based processes for cyclotides production. J Biotechnol 2008;135:123-6
    • (2008) J Biotechnol , vol.135 , pp. 123-6
    • Dornenburg, H.1    Frickinger, P.2    Seydel, P.3
  • 49
    • 33744953723 scopus 로고    scopus 로고
    • Establishment of in vitro plants, cell and tissue cultures from Oldenlandia affinis for the production of cyclic peptides
    • DOI 10.1007/s11240-005-9056-0
    • Seydel P, Dornenburg H. Establishment of in vitro plants, cell and tissue cultures from Oldenlandia affinis for the production of cyclic peptides. Plant Cell Tissue Org Cult 2006;85:247-55 (Pubitemid 43854269)
    • (2006) Plant Cell, Tissue and Organ Culture , vol.85 , Issue.3 , pp. 247-255
    • Seydel, P.1    Dornenburg, H.2
  • 50
    • 35649012780 scopus 로고    scopus 로고
    • Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures
    • DOI 10.1007/s00253-007-1159-6
    • Seydel P, Gruber CW, Craik DJ, Dornenburg H. Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures. Appl Microbiol Biotechnol 2007;77:275-84 (Pubitemid 350029441)
    • (2007) Applied Microbiology and Biotechnology , vol.77 , Issue.2 , pp. 275-284
    • Seydel, P.1    Gruber, C.W.2    Craik, D.J.3    Dornenburg, H.4
  • 51
    • 52949116910 scopus 로고    scopus 로고
    • Biosynthesis of the cyclotide kalata B1 by using protein splicing
    • Kimura RH, Tran A-T, Camarero JA. Biosynthesis of the cyclotide kalata B1 by using protein splicing. Angew Chem Int Ed 2006;118:987-90
    • (2006) Angew Chem Int Ed , vol.118 , pp. 987-90
    • Kimura, R.H.1    Tran, A.-T.2    Camarero, J.A.3
  • 52
    • 34548127744 scopus 로고    scopus 로고
    • Biosynthesis of a fully functional cyclotide inside living bacterial cells
    • DOI 10.1002/cbic.200700183
    • Camarero JA, Kimura RH, Woo Y-H, et al. Biosynthesis of a fully functional cyclotide inside living bacterial cells. ChemBioChem 2007;8:1363-6 (Pubitemid 47300326)
    • (2007) ChemBioChem , vol.8 , Issue.12 , pp. 1363-1366
    • Camarero, J.A.1    Kimura, R.H.2    Woo, Y.-H.3    Shekhtman, A.4    Cantor, J.5
  • 53
    • 78649987052 scopus 로고    scopus 로고
    • Cyclotides, a promising molecular scaffold for peptide-based therapeutics
    • Jagadish K, Camarero JA. Cyclotides, a promising molecular scaffold for peptide-based therapeutics. Biopolymers 2010;94:611-16
    • (2010) Biopolymers , Issue.94 , pp. 611-16
    • Jagadish, K.1    Camarero, J.A.2
  • 54
    • 0038498076 scopus 로고    scopus 로고
    • Enzymatic cyclization of a potent bowman-birk protease inhibitor, sunflower trypsin inhibitor-1, and solution structure of an acyclic precursor peptide
    • DOI 10.1074/jbc.M212996200
    • Marx UC, Korsinczky ML, Schirra HJ, et al. Enzymatic cyclization of a potent Bowman-Birk protease inhibitor, sunflower trypsin inhibitor-1, and solution structure of an acyclic precursor peptide. J Biol Chem 2003;278:21782-9 (Pubitemid 36792582)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.24 , pp. 21782-21789
    • Marx, U.C.1    Korsinczky, M.L.J.2    Schirra, H.J.3    Jones, A.4    Condie, B.5    Otvos Jr., L.6    Craik, D.J.7
  • 55
    • 34547566772 scopus 로고    scopus 로고
    • Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins
    • DOI 10.1002/cbic.200700187
    • Thongyoo P, Jaulent AM, Tate EW, Leatherbarrow RJ. Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins. ChemBioChem 2007;8:1107-9 (Pubitemid 47194814)
    • (2007) ChemBioChem , vol.8 , Issue.10 , pp. 1107-1109
    • Thongyoo, P.1    Jaulent, A.M.2    Tate, E.W.3    Leatherbarrow, R.J.4
  • 56
    • 4444359659 scopus 로고    scopus 로고
    • Novel strategies for isolation and characterization of cyclotides: The discovery of bioactive macrocyclic plant polypeptides in the Violaceae
    • DOI 10.2174/1389203043379495
    • Goransson U, Svangard E, Claeson P, Bohlin L. Novel strategies for isolation and characterization of cyclotides: the discovery of bioactive macrocyclic plant polypeptides in the Violaceae. Curr Protein Pept Sci 2004;5:317-29 (Pubitemid 39200162)
    • (2004) Current Protein and Peptide Science , vol.5 , Issue.5 , pp. 317-329
    • Goransson, U.1    Svangard, E.2    Claeson, P.3    Bohlin, L.4
  • 57
    • 77957236219 scopus 로고    scopus 로고
    • Isolation, sequencing, and structure-activity relationships of cyclotides
    • Ireland DC, Clark RJ, Daly NL, Craik DJ. Isolation, sequencing, and structure-activity relationships of cyclotides. J Nat Prod 2010;73:1610-22
    • (2010) J Nat Prod , Issue.73 , pp. 1610-22
    • Ireland, D.C.1    Clark, R.J.2    Daly, N.L.3    Craik, D.J.4
  • 58
    • 79958826757 scopus 로고    scopus 로고
    • The chemistry of cyclotides
    • Craik DJ, Conibear AC. The chemistry of cyclotides. J Org Chem 2011;76:4805-17
    • (2011) J Org Chem , Issue.76 , pp. 4805-17
    • Craik, D.J.1    Conibear, A.C.2
  • 59
    • 33947359890 scopus 로고    scopus 로고
    • NMR as a tool for elucidating the structures of circular and knotted proteins
    • DOI 10.1039/b616856f
    • Craik DJ, Daly NL. NMR as a tool for elucidating the structures of circular and knotted proteins. Mol Biosyst 2007;3:257-65 (Pubitemid 46456310)
    • (2007) Molecular BioSystems , vol.3 , Issue.4 , pp. 257-265
    • Craik, D.J.1    Daly, N.L.2
  • 62
    • 73749087526 scopus 로고    scopus 로고
    • Cyclotides as templates in drug design
    • Henriques ST, Craik DJ. Cyclotides as templates in drug design. Drug Discov Today 2010;15:57-64
    • (2010) Drug Discov Today , Issue.15 , pp. 57-64
    • Henriques, S.T.1    Craik, D.J.2
  • 63
    • 78650009505 scopus 로고    scopus 로고
    • Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics
    • Garcia AE, Camarero JA. Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics. Curr Mol Pharmacol 2010;3:153-63
    • (2010) Curr Mol Pharmacol , Issue.3 , pp. 153-63
    • Garcia, A.E.1    Camarero, J.A.2
  • 64
    • 80054907283 scopus 로고    scopus 로고
    • The University of Queensland. Cystine knot molecules. US7960340; 2000
    • The University of Queensland. Cystine knot molecules. US7960340; 2000
  • 65
    • 80054907507 scopus 로고    scopus 로고
    • The University of Queensland and Hexima Ltd. Novel nucleic acid molecules. WO0134829; 2000
    • The University of Queensland and Hexima Ltd. Novel nucleic acid molecules. WO0134829; 2000
  • 66
    • 80054911943 scopus 로고    scopus 로고
    • Viogard AB. On-growth inhibiting compounds. WO0004055; 2000
    • Viogard AB. On-growth inhibiting compounds. WO0004055; 2000
  • 68
    • 80054947347 scopus 로고    scopus 로고
    • E.I. Du Pont De Nemours & Co. Nucleic acid molecules encoding cyclotide polypeptides and methods of use. US7232939; 2005
    • E.I. Du Pont De Nemours & Co. Nucleic acid molecules encoding cyclotide polypeptides and methods of use. US7232939; 2005
  • 69
    • 80054955832 scopus 로고    scopus 로고
    • NascaCell Technologies. Use of microproteins as tryptase inhibitors. WO06032436; 2005
    • NascaCell Technologies. Use of microproteins as tryptase inhibitors. WO06032436; 2005
  • 70
    • 80054956575 scopus 로고    scopus 로고
    • E.I. Du Pont De Nemours & Co. Insecticidal plant cyclotide with activity against homopteran insects. US7211658; 2005
    • E.I. Du Pont De Nemours & Co. Insecticidal plant cyclotide with activity against homopteran insects. US7211658; 2005
  • 71
    • 80054894624 scopus 로고    scopus 로고
    • Pioneer Hi Breed International, Inc. and E.I. Du Pont De Nemours & Co. Maize cyclo1 gene and promoter. WO06076189; 2006
    • Pioneer Hi Breed International, Inc. and E.I. Du Pont De Nemours & Co. Maize cyclo1 gene and promoter. WO06076189; 2006
  • 74
    • 80054939338 scopus 로고    scopus 로고
    • Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof. WO2007038619; 2006
    • Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof. WO2007038619; 2006
  • 75
    • 80054881502 scopus 로고    scopus 로고
    • Singapore Polytechnic. Novel polypeptides for anti-viral treatment. WO2007149052; 2007
    • Singapore Polytechnic. Novel polypeptides for anti-viral treatment. WO2007149052; 2007
  • 77
    • 73749087228 scopus 로고    scopus 로고
    • Cyclotides: Macrocyclic peptides with applications in drug design and agriculture
    • Craik DJ, Mylne JS, Daly NL. Cyclotides: macrocyclic peptides with applications in drug design and agriculture. Cell Mol Life Sci 2010;67:9-16
    • (2010) Cell Mol Life Sci , Issue.67 , pp. 9-16
    • Craik, D.J.1    Mylne, J.S.2    Daly, N.L.3
  • 78
    • 32944465547 scopus 로고    scopus 로고
    • Structural plasticity of the cyclic-cystine-knot framework: Implications for biological activity and drug design
    • DOI 10.1042/BJ20051691
    • Clark RJ, Daly NL, Craik DJ. Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design. Biochem J 2006;394:85-93 (Pubitemid 43259658)
    • (2006) Biochemical Journal , vol.394 , Issue.1 , pp. 85-93
    • Clark, R.J.1    Daly, N.L.2    Craik, D.J.3
  • 79
    • 58149089532 scopus 로고    scopus 로고
    • Engineering stabilized vascular endothelial growth factor-A antagonists: Synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides
    • Gunasekera S, Foley FM, Clark RJ, et al. Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides. J Med Chem 2008;51:7697-704
    • (2008) J Med Chem , vol.51 , pp. 7697-704
    • Gunasekera, S.1    Foley, F.M.2    Clark, R.J.3
  • 81
    • 33645329115 scopus 로고    scopus 로고
    • Plant cyclopeptides
    • Tan N-H, Zhou J. Plant cyclopeptides. Chem Rev 2006;106:840-95
    • (2006) Chem Rev , vol.106 , pp. 840-95
    • Tan, N.-H.1    Zhou, J.2
  • 82
    • 43949110597 scopus 로고    scopus 로고
    • Cyclotides: Natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep
    • DOI 10.1021/bi800223y
    • Colgrave ML, Kotze AC, Huang YH, et al. Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep. Biochemistry 2008;47:5581-9 (Pubitemid 351705169)
    • (2008) Biochemistry , vol.47 , Issue.20 , pp. 5581-5589
    • Colgrave, M.L.1    Kotze, A.C.2    Huang, Y.-H.3    O'Grady, J.4    Simonsen, S.M.5    Craik, D.J.6
  • 84
    • 0033549108 scopus 로고    scopus 로고
    • Thia zip reaction for synthesis of large cyclic peptides: Mechanisms and applications
    • Tam JP, Lu Y-A, Yu Q. Thia zip reaction for synthesis of large cyclic peptides: mechanisms and applications. J Am Chem Soc 1999;121:4316-24
    • (1999) J Am Chem Soc , vol.121 , pp. 4316-24
    • Tam, J.P.1    Lu, Y.-A.2    Yu, Q.3
  • 87
    • 31544481160 scopus 로고    scopus 로고
    • Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif
    • DOI 10.1042/BJ20051371
    • Daly NL, Clark RJ, Plan MR, Craik DJ. Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Biochem J 2006;393:619-26 (Pubitemid 43163802)
    • (2006) Biochemical Journal , vol.393 , Issue.3 , pp. 619-626
    • Daly, N.L.1    Clark, R.J.2    Plan, M.R.3    Craik, D.J.4
  • 88
    • 0034705410 scopus 로고    scopus 로고
    • Acyclic permutants of naturally occurring cyclic proteins: Characterization of cystine knot and β-sheet formation in the macrocyclic polypeptide kalata B1
    • DOI 10.1074/jbc.M000450200
    • Daly NL, Craik DJ. Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta -sheet formation in the macrocyclic polypeptide kalata B1. J Biol Chem 2000;275:19068-75 (Pubitemid 30422874)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.25 , pp. 19068-19075
    • Daly, N.L.1    Craik, D.J.2
  • 89
    • 0038322581 scopus 로고    scopus 로고
    • Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity
    • DOI 10.1021/bi027323n
    • Barry DG, Daly NL, Clark RJ, et al. Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity. Biochemistry 2003;42:6688-95 (Pubitemid 36666109)
    • (2003) Biochemistry , vol.42 , Issue.22 , pp. 6688-6695
    • Barry, D.G.1    Daly, N.L.2    Clark, R.J.3    Sando, L.4    Craik, D.J.5
  • 90
    • 43949138210 scopus 로고    scopus 로고
    • Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity
    • Simonsen SM, Sando L, Rosengren KJ, et al. Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. J Biol Chem 2008;283:9805-13
    • (2008) J Biol Chem , vol.283 , pp. 9805-13
    • Simonsen, S.M.1    Sando, L.2    Rosengren, K.J.3
  • 91
    • 0032724231 scopus 로고    scopus 로고
    • Inhibitors of human mast cell serine proteases and potential therapeutic applications
    • DOI 10.1517/13543776.9.11.1537
    • Rice K, Spencer J. Inhibitors of human mast cell serine proteases and potential therapeutic applications. Expert Opin Ther Pat 1999;9:1537-55 (Pubitemid 29515558)
    • (1999) Expert Opinion on Therapeutic Patents , vol.9 , Issue.11 , pp. 1537-1555
    • Rice, K.1    Spencer, J.2
  • 92
    • 70349414437 scopus 로고    scopus 로고
    • Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins
    • Kolmar H. Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins. Curr Opin Pharmacol 2009;9:608-14
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 608-14
    • Kolmar, H.1
  • 93
    • 63149084613 scopus 로고    scopus 로고
    • Knottin cyclization: Impact on structure and dynamics
    • Heitz A, Avrutina O, Le-Nguyen D, et al. Knottin cyclization: impact on structure and dynamics. BMC Struct Biol 2008;8:54
    • (2008) BMC Struct Biol , vol.8 , pp. 54
    • Heitz, A.1    Avrutina, O.2    Le-Nguyen, D.3
  • 94
    • 33846876110 scopus 로고    scopus 로고
    • Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration
    • DOI 10.1016/j.ijpharm.2006.09.028, PII S0378517306007794
    • Werle M, Kafedjiiski K, Kolmar H, Bernkop-Schnurch A. Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration. Int J Pharm 2007;332:72-9 (Pubitemid 46227767)
    • (2007) International Journal of Pharmaceutics , vol.332 , Issue.1-2 , pp. 72-79
    • Werle, M.1    Kafedjiiski, K.2    Kolmar, H.3    Bernkop-Schnurch, A.4
  • 95
    • 33745098362 scopus 로고    scopus 로고
    • The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery
    • DOI 10.1080/10611860600648254, PII X554137175732
    • Werle M, Schmitz T, Huang HL, et al. The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery. J Drug Target 2006;14:137-46 (Pubitemid 43878822)
    • (2006) Journal of Drug Targeting , vol.14 , Issue.3 , pp. 137-146
    • Werle, M.1    Schmitz, T.2    Huang, H.-L.3    Wentzel, A.4    Kolmar, H.5    Bernkop-Schnurch, A.6
  • 96
    • 85047682496 scopus 로고    scopus 로고
    • Minireview: Receptor dimerization in GH and erythropoietin action - It takes two to Tango, but how?
    • DOI 10.1210/en.143.1.2
    • Frank SJ. Receptor dimerization in GH and erythropoietin action-it takes two to tango, but how? Endocrinology 2002;143:2-10 (Pubitemid 34056396)
    • (2002) Endocrinology , vol.143 , Issue.1 , pp. 2-10
    • Frank, S.J.1
  • 97
    • 0037064537 scopus 로고    scopus 로고
    • Molecular mechanisms of cytokine receptor activation
    • DOI 10.1016/S0167-4889(02)00316-6, PII S0167488902003166
    • Grotzinger J. Molecular mechanisms of cytokine receptor activation. Biochim Biophys Acta 2002;1592:215-23 (Pubitemid 35284880)
    • (2002) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1592 , Issue.3 , pp. 215-223
    • Grotzinger, J.1
  • 99
    • 0028109434 scopus 로고
    • The structure, biology and potential therapeutic applications of recombinant thrombopoietin
    • Lok S, Foster DC. The structure, biology and potential therapeutic applications of recombinant thrombopoietin. Stem Cells 1994;12:586-98 (Pubitemid 24361708)
    • (1994) Stem Cells , vol.12 , Issue.6 , pp. 586-598
    • Lok, S.1    Foster, D.C.2
  • 100
    • 0028809982 scopus 로고
    • The physiologic role and therapeutic potential of the Mpl-ligand in thrombopoiesis
    • Hunt P. The physiologic role and therapeutic potential of the Mpl-ligand in thrombopoiesis. Stem Cells 1995;13:579-87
    • (1995) Stem Cells , vol.13 , pp. 579-87
    • Hunt, P.1
  • 101
    • 0029035985 scopus 로고
    • Thrombopoietin: The primary regulator of platelet production
    • Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood 1995;86:419-31
    • (1995) Blood , vol.86 , pp. 419-31
    • Kaushansky, K.1
  • 102
    • 66749122752 scopus 로고    scopus 로고
    • Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia
    • Kuter DJ. Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia. Annu Rev Med 2009;60:193-206
    • (2009) Annu Rev Med , vol.60 , pp. 193-206
    • Kuter, D.J.1
  • 103
    • 70349439112 scopus 로고    scopus 로고
    • "Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides
    • Sancheti H, Camarero JA. "Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides. Adv Drug Deliv Rev 2009;61:908-17
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 908-17
    • Sancheti, H.1    Camarero, J.A.2
  • 104
    • 0033575092 scopus 로고    scopus 로고
    • Biosynthesis of a head-to-tail cyclized protein with improved biological activity
    • DOI 10.1021/ja990929n
    • Camarero JA, Muir TW. Biosynthesis of a head-to-tail cyclized protein with improved biological activity. J Am Chem Soc 1999;121:5597-8 (Pubitemid 29292991)
    • (1999) Journal of the American Chemical Society , vol.121 , Issue.23 , pp. 5597-5598
    • Camarero, J.A.1    Muir, T.W.2
  • 105
    • 0034828385 scopus 로고    scopus 로고
    • Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain
    • DOI 10.1016/S0968-0896(01)00217-6, PII S0968089601002176
    • Camarero JA, Fushman D, Cowburn D, Muir TW. Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain. Bioorg Med Chem 2001;9:2479-84 (Pubitemid 32834634)
    • (2001) Bioorganic and Medicinal Chemistry , vol.9 , Issue.9 , pp. 2479-2484
    • Camarero, J.A.1    Fushman, D.2    Cowburn, D.3    Muir, T.W.4
  • 106
    • 71049186869 scopus 로고    scopus 로고
    • Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I
    • Austin J, Wang W, Puttamadappa S, et al. Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I. ChemBioChem 2009;10:2663-70
    • (2009) ChemBioChem , vol.10 , pp. 2663-70
    • Austin, J.1    Wang, W.2    Puttamadappa, S.3
  • 107
    • 77955881150 scopus 로고    scopus 로고
    • In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1
    • Austin J, Kimura RH, Woo YH, Camarero JA. In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1. Amino Acids 2010;38:1313-22
    • (2010) Amino Acids , vol.38 , pp. 1313-22
    • Austin, J.1    Kimura, R.H.2    Woo, Y.H.3    Camarero, J.A.4
  • 110
    • 33645077862 scopus 로고    scopus 로고
    • Seamless Proteins tie up their loose ends
    • Craik DJ. Seamless Proteins tie up their loose ends. Science 2006;311:1563-4
    • (2006) Science , vol.311 , pp. 1563-4
    • Craik, D.J.1
  • 113
    • 4444341077 scopus 로고    scopus 로고
    • Theta-defensins: Cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins
    • DOI 10.2174/1389203043379459
    • Selsted ME. Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins. Curr Protein Pept Sci 2004;5:365-71 (Pubitemid 39200166)
    • (2004) Current Protein and Peptide Science , vol.5 , Issue.5 , pp. 365-371
    • Selsted, M.E.1
  • 114
    • 0036495674 scopus 로고    scopus 로고
    • Circular proteins - No end in sight
    • DOI 10.1016/S0968-0004(02)02057-1, PII S0968000402020571
    • Trabi M, Craik DJ. Circular proteins - no end in sight. Trends Biochem Sci 2002;27:132-8 (Pubitemid 34219323)
    • (2002) Trends in Biochemical Sciences , vol.27 , Issue.3 , pp. 132-138
    • Trabi, M.1    Craik, D.J.2
  • 115
    • 79955058492 scopus 로고    scopus 로고
    • Albumins and their processing machinery are hijacked for cyclic peptides in sunflower
    • Mylne JS, Colgrave ML, Daly NL, et al. Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nat Chem Biol 2011;7:257-9
    • (2011) Nat Chem Biol , vol.7 , pp. 257-9
    • Mylne, J.S.1    Colgrave, M.L.2    Daly, N.L.3
  • 116
    • 0029881007 scopus 로고    scopus 로고
    • MOLMOL: A program for display and analysis of macromolecular structures
    • Koradi R, Billeter M, Wuthrich K. MOLMOL: a program for display and analysis of macromolecular structures. J Mol Graph 1996;14:29-32
    • (1996) J Mol Graph , vol.14 , pp. 29-32
    • Koradi, R.1    Billeter, M.2    Wuthrich, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.