Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function

Science Signaling

Volumn 10, Issue 466, 2017, Pages

  Nihira, Naoe T ^a   Ogura, Kohei ^a,b   Shimizu, Kouhei ^a,c   North, Brian J ^a   Zhang, Jinfang ^a   Gao, Daming ^a,d   Inuzuka, Hiroyuki ^a   Wei, Wenyi ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; DEUBIQUITINASE; ETOPOSIDE; LYSINE; PROTEIN MDM2; PROTEIN P53; SIRTUIN 1; UBIQUITIN PROTEIN LIGASE E3; HISTONE ACETYLTRANSFERASE PCAF; P300-CBP-ASSOCIATED FACTOR; PROTEIN BINDING; SIRT1 PROTEIN, HUMAN; UBIQUITIN CARBOXYL TERMINAL HYDROLASE 7;

APOPTOSIS; ARTICLE; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; DEACETYLATION; DRUG EXPOSURE; EMBRYO; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE FUNCTION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEAR LOCALIZATION SIGNAL; ONCOGENE; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STABILITY; RING FINGER MOTIF; UBIQUITINATION; A-549 CELL LINE; ACETYLATION; CELL TRANSFORMATION; GENETICS; HCT 116 CELL LINE; HEK293 CELL LINE; IMMUNOBLOTTING; MCF-7 CELL LINE; METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE;

A549 CELLS; ACETYLATION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; HCT116 CELLS; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; LYSINE; MCF-7 CELLS; ONCOGENES; P300-CBP TRANSCRIPTION FACTORS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; RNA INTERFERENCE; SIRTUIN 1; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-SPECIFIC PEPTIDASE 7; UBIQUITINATION;

EID: 85013442794     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aai8026     Document Type: Article

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