ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage

Journal of Biological Chemistry

Volumn 285, Issue 7, 2010, Pages 4909-4919

  Taira, Naoe ^a   Yamamoto, Hiroyuki ^a   Yamaguchi, Tomoko ^a   Miki, Yoshio ^a   Yoshida, Kiyotsugu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOTIC CELL DEATH; APOPTOTIC RESPONSE; ATM PHOSPHORYLATES; CELL CYCLE; DNA DAMAGES; DNA REPAIR; GENOTOXIC STRESS; INTRACELLULAR CONTROL; KINASE ACTIVITY; N-TERMINAL DOMAINS; NORMAL CONDITION; NUCLEAR LOCALIZATION SIGNAL; PRO-APOPTOTIC FUNCTION; PROTEASOME INHIBITORS; STABLE COMPLEXES; TUMOR SUPPRESSORS;

ASYNCHRONOUS TRANSFER MODE; AUTOMATIC TELLER MACHINES; CELL DEATH; DEGRADATION; DNA; INTERNET PROTOCOLS; PHOSPHORYLATION; TRANSCRIPTION FACTORS;

GENES;

ATM PROTEIN; DNA; DUAL SPECIFICITY TYROSINE REGULATED KINASE 2; PROTEIN DYRK2; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; PROTEIN TYROSINE KINASE; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CELL FRACTIONATION; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; INHIBITION KINETICS; NUCLEAR LOCALIZATION SIGNAL; PLASMID; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; STRESS;

APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CYSTEINE PROTEINASE INHIBITORS; DNA DAMAGE; DNA-BINDING PROTEINS; DOXORUBICIN; ETOPOSIDE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; LEUPEPTINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UBIQUITINATION;

EID: 77951182462     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.042341     Document Type: Article

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