-
1
-
-
0024094917
-
The effects of variations in the number and sequence of targeting signals on nuclear uptake
-
Dworetzky SI, Lanford RE, Feldherr CM: The effects of variations in the number and sequence of targeting signals on nuclear uptake. J Cell Biol, 1988, 107:1279-1287.
-
(1988)
J Cell Biol
, vol.107
, pp. 1279-1287
-
-
Dworetzky, S.I.1
Lanford, R.E.2
Feldherr, C.M.3
-
2
-
-
0025949412
-
Nuclear targeting sequences - A consensus?
-
Dingwall C, Laskey RA: Nuclear targeting sequences - a consensus? Trends Biochem Sci 1991, 16:478-481.
-
(1991)
Trends Biochem Sci
, vol.16
, pp. 478-481
-
-
Dingwall, C.1
Laskey, R.A.2
-
3
-
-
0028845313
-
A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway
-
Michael WM, Choi M, Dreyfuss G: A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell 1995, 83:415-422.
-
(1995)
Cell
, vol.83
, pp. 415-422
-
-
Michael, W.M.1
Choi, M.2
Dreyfuss, G.3
-
4
-
-
0030595342
-
A novel receptor mediated nuclear protein import pathway
-
Pollard VW, Michael WM, Naldalny B, Slomi MC, Wang P, Dreyfuss G: A novel receptor mediated nuclear protein import pathway. Cell 1996, 88:985-994. The import signal of hnRNPA1 is the M9 domain. This paper shows that the M9-mediated import pathway is distinct from the import of 'classical' NLS substrates. Transportin is identified as the import receptor for the M9 substrate. Transportin is 24% identical to importin β. In contrast to the import of NLS-containing proteins, no equivalent of importin a is involved in M9 import. Rather, the M9 domain binds directly to transportin.
-
(1996)
Cell
, vol.88
, pp. 985-994
-
-
Pollard, V.W.1
Michael, W.M.2
Naldalny, B.3
Slomi, M.C.4
Wang, P.5
Dreyfuss, G.6
-
5
-
-
0025873549
-
Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport
-
Fischer U, Darzynkiewicz E, Tahara SM, Dathan NA, Lührmann R, Mattaj IW: Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport J Cell Biol 1991, 113:705-714.
-
(1991)
J Cell Biol
, vol.113
, pp. 705-714
-
-
Fischer, U.1
Darzynkiewicz, E.2
Tahara, S.M.3
Dathan, N.A.4
Lührmann, R.5
Mattaj, I.W.6
-
6
-
-
0026025536
-
Multiple pathways in nuclear transport: The import of U2 snRNP occurs by a novel kinetic pathway
-
Michaud N, Goldfarb DS: Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway. J Cell Biol 1991, 112:215-223.
-
(1991)
J Cell Biol
, vol.112
, pp. 215-223
-
-
Michaud, N.1
Goldfarb, D.S.2
-
7
-
-
0022516246
-
Synthetic peptides as nuclear localization signals
-
Goldfarb DS, Gariepy J, Schoolnik G, Kornberg RD: Synthetic peptides as nuclear localization signals. Nature 1986, 322:641-644.
-
(1986)
Nature
, vol.322
, pp. 641-644
-
-
Goldfarb, D.S.1
Gariepy, J.2
Schoolnik, G.3
Kornberg, R.D.4
-
8
-
-
0025083331
-
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
-
Adam SA, Sterne-Marr R, Gerace L: Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J Cell Biol 1990, 111:807-816.
-
(1990)
J Cell Biol
, vol.111
, pp. 807-816
-
-
Adam, S.A.1
Sterne-Marr, R.2
Gerace, L.3
-
9
-
-
0028217405
-
Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope
-
Adam EJH, Adam SA : Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope. J Cell Biol 1994, 125:547-555.
-
(1994)
J Cell Biol
, vol.125
, pp. 547-555
-
-
Adam, E.J.H.1
Adam, S.A.2
-
10
-
-
0029115837
-
Sequence and characterization of cytoplasmic nuclear import factor p97
-
Chi NC, Adam EJH, Adam SA: Sequence and characterization of cytoplasmic nuclear import factor p97. J Cell Biol 1995, 130:265-274.
-
(1995)
J Cell Biol
, vol.130
, pp. 265-274
-
-
Chi, N.C.1
Adam, E.J.H.2
Adam, S.A.3
-
11
-
-
0027937653
-
Isolation of a protein that is essential for the first step of nuclear protein import
-
Görlich D, Prehn S, Laskey RA , Hartmann E: Isolation of a protein that is essential for the first step of nuclear protein import. Cell 1994, 79:767-778.
-
(1994)
Cell
, vol.79
, pp. 767-778
-
-
Görlich, D.1
Prehn, S.2
Laskey, R.A.3
Hartmann, E.4
-
12
-
-
0029278621
-
Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope
-
Görlich D, Kostka S, Kraft R, Dingwall C, Laskey RA, Hartmann E, Prehn S: Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr Biol 1995, 5:383-392.
-
(1995)
Curr Biol
, vol.5
, pp. 383-392
-
-
Görlich, D.1
Kostka, S.2
Kraft, R.3
Dingwall, C.4
Laskey, R.A.5
Hartmann, E.6
Prehn, S.7
-
13
-
-
0029093824
-
In vivo evidence for involvement of a 58 kDa component of nuclear pore targeting complex in nuclear protein import
-
Imamoto N, Shimamoto T, Takao T, Tachibana T, Kose S, Matsubae M, Sekimoto T, Shimonishi Y, Yoneda Y: In vivo evidence for involvement of a 58 kDa component of nuclear pore targeting complex in nuclear protein import. EMBO J 1995, 14:3617-3626.
-
(1995)
EMBO J
, vol.14
, pp. 3617-3626
-
-
Imamoto, N.1
Shimamoto, T.2
Takao, T.3
Tachibana, T.4
Kose, S.5
Matsubae, M.6
Sekimoto, T.7
Shimonishi, Y.8
Yoneda, Y.9
-
14
-
-
0027376308
-
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
-
Moore MS, Blobel G: The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 1993, 365:661-663.
-
(1993)
Nature
, vol.365
, pp. 661-663
-
-
Moore, M.S.1
Blobel, G.2
-
15
-
-
0028170744
-
Purification of a Ran-interacting protein that is required for protein import into the nucleus
-
Moore MS, Blobel G: Purification of a Ran-interacting protein that is required for protein import into the nucleus. Proc Natl Acad Sci USA 1994, 91:10212-10216.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10212-10216
-
-
Moore, M.S.1
Blobel, G.2
-
16
-
-
0027714921
-
Inhibition of nuclear protein import by nonhydrolyzable analogs of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor
-
Melchior F, Paschal B, Evans E, Gerace L: Inhibition of nuclear protein import by nonhydrolyzable analogs of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J Cell Biol 1993, 123:1649-1659.
-
(1993)
J Cell Biol
, vol.123
, pp. 1649-1659
-
-
Melchior, F.1
Paschal, B.2
Evans, E.3
Gerace, L.4
-
17
-
-
0029027836
-
Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore protein p62
-
Paschal BM, Gerace L: Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore protein p62. J Cell Biol 1995, 129:925-937.
-
(1995)
J Cell Biol
, vol.129
, pp. 925-937
-
-
Paschal, B.M.1
Gerace, L.2
-
18
-
-
0028950991
-
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins
-
Radu A, Blobel G, Moore MS: Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Natl Acad Sci USA 1995, 92:1769-1773.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1769-1773
-
-
Radu, A.1
Blobel, G.2
Moore, M.S.3
-
19
-
-
0029984570
-
Nucleocytoplasmic transport
-
Görlich D, Mattaj IW: Nucleocytoplasmic transport. Science 1996, 271:1513-1518.
-
(1996)
Science
, vol.271
, pp. 1513-1518
-
-
Görlich, D.1
Mattaj, I.W.2
-
20
-
-
0028970112
-
A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore binding
-
Imamoto N, Tachibana T, Matsubae M, Yoneda Y: A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore binding. J Biol Chem 1995, 270:8559-8565.
-
(1995)
J Biol Chem
, vol.270
, pp. 8559-8565
-
-
Imamoto, N.1
Tachibana, T.2
Matsubae, M.3
Yoneda, Y.4
-
21
-
-
0028988731
-
Identification of hSRP1 α as a functional receptor for nuclear localization sequences
-
Weis K, Mattaj IW, Lamond AI: Identification of hSRP1 α as a functional receptor for nuclear localization sequences. Science 1995, 268:1049-1053.
-
(1995)
Science
, vol.268
, pp. 1049-1053
-
-
Weis, K.1
Mattaj, I.W.2
Lamond, A.I.3
-
22
-
-
0026042170
-
Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import
-
Adam A, Gerace L: Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import. Cell 1991, 66:837-847.
-
(1991)
Cell
, vol.66
, pp. 837-847
-
-
Adam, A.1
Gerace, L.2
-
23
-
-
0029059548
-
Distinct functions for the two importin subunits in nuclear protein import
-
Görlich D, Vogel F, Mills AD, Hartmann E, Laskey RA: Distinct functions for the two importin subunits in nuclear protein import Nature 1995, 377:246-248.
-
(1995)
Nature
, vol.377
, pp. 246-248
-
-
Görlich, D.1
Vogel, F.2
Mills, A.D.3
Hartmann, E.4
Laskey, R.A.5
-
24
-
-
0028983494
-
Mammalian karyopherin α1b and α2b heterodimers: α1 or α2 subunit binds nuclear localization sequence and βsubunit interacts with peptide repeat containing nucleoporins
-
Moroianu J, Hijikata M, Blobel G, Radu A: Mammalian karyopherin α1b and α2b heterodimers: α1 or α2 subunit binds nuclear localization sequence and βsubunit interacts with peptide repeat containing nucleoporins. Proc Natl Acad Sci USA 1995, 92:6532-6536.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 6532-6536
-
-
Moroianu, J.1
Hijikata, M.2
Blobel, G.3
Radu, A.4
-
25
-
-
0029921174
-
A 41 amino acid motif in importin alpha confers binding to importin beta and hence transit into the nucleus
-
Görlich D, Henklein P, Laskey RA, Hartmann E: A 41 amino acid motif in importin alpha confers binding to importin beta and hence transit into the nucleus. EMBO J 1996, 15:1810-1817. This study identifies the IBB domain in importin α. A fusion of the IBB domain and a heterologous reporter is efficiently imported into the nucleus, bypassing the requirement for importin a and entering in the way as does importin α. However, whereas importin α is rapidly returned to the cytoplasm, the IBB fusion lacks the domain responsible for re-export. These different requirements for entry and exit suggest that the return of importin a to the cytoplasm is not the reversal of its import.
-
(1996)
EMBO J
, vol.15
, pp. 1810-1817
-
-
Görlich, D.1
Henklein, P.2
Laskey, R.A.3
Hartmann, E.4
-
26
-
-
0030010107
-
The conserved amino terminal domain of hSRP1a is essential for nuclear protein import
-
Weis K, Ryder U, Lamond AI: The conserved amino terminal domain of hSRP1a is essential for nuclear protein import EMBO J 1996, 15:1818-1825. This study shows that importin a consists of two functional domains, an amino-terminal IBB domain and an NLS-binding site. The IBB domain is sufficient to target a heterologous reporter into the nucleus, but it is not an export signal. Furthermore, it is shown that titrating of importin β with an isolated IBB domain competes with the import of an NLS-reporter protein.
-
(1996)
EMBO J
, vol.15
, pp. 1818-1825
-
-
Weis, K.1
Ryder, U.2
Lamond, A.I.3
-
27
-
-
0029853631
-
Identification of different roles for RanGDP and RanGTP in nuclear protein import
-
Görlich D, Panté N, Kutay U, Aebi U, Bischoff FR: Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J 1996, 15:5584-5594. This study shows that cytoplasmic Ran supports import in only its GDP-bound form and it is suggested that translocation involves nucleotide exchange and GTP hydrolysis on NPC-bound Ran. The interaction between Ran-GTP and importin β is shown to be required for termination of import, but not for the actual translocation through the NPC.
-
(1996)
EMBO J
, vol.15
, pp. 5584-5594
-
-
Görlich, D.1
Panté, N.2
Kutay, U.3
Aebi, U.4
Bischoff, F.R.5
-
28
-
-
0030960586
-
Dominant-negative mutants of importin-β block multiple pathways of import and export through the nuclear pore complex
-
Kutay U, Izaurralde E, Bischoff FR, Mattaj IW, Görlich D: Dominant-negative mutants of importin-β block multiple pathways of import and export through the nuclear pore complex EMBO J 1997, 16:1153-1163.
-
(1997)
EMBO J
, vol.16
, pp. 1153-1163
-
-
Kutay, U.1
Izaurralde, E.2
Bischoff, F.R.3
Mattaj, I.W.4
Görlich, D.5
-
29
-
-
0029847386
-
RanBP1 stabilises the interaction of Ran with p97 in nuclear protein import
-
Chi NC, Adam EJH, Visser GD, Adam SA: RanBP1 stabilises the interaction of Ran with p97 in nuclear protein import. J Cell Biol 1996, 135:559-569. This study analyzes multiple interactions between Ran, RanBP1 and importin β. It shows that RanBP1 can stimulate nuclear protein import in vitro.
-
(1996)
J Cell Biol
, vol.135
, pp. 559-569
-
-
Chi, N.C.1
Adam, E.J.H.2
Visser, G.D.3
Adam, S.A.4
-
30
-
-
0029920934
-
The nuclear transport factor karyopherin β binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein
-
Floer M, Blobel G: The nuclear transport factor karyopherin β binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein. J Biol Chem 1996, 271:5313-5316.
-
(1996)
J Biol Chem
, vol.271
, pp. 5313-5316
-
-
Floer, M.1
Blobel, G.2
-
31
-
-
0029798506
-
Nucleotide-specific interaction of Ran/TC4 with nuclear transport factor NTF2 and p97
-
Paschal BM, Delphin C, Gerace L: Nucleotide-specific interaction of Ran/TC4 with nuclear transport factor NTF2 and p97. Proc Natl Acad USA 1996, 93:7679-7683.
-
(1996)
Proc Natl Acad USA
, vol.93
, pp. 7679-7683
-
-
Paschal, B.M.1
Delphin, C.2
Gerace, L.3
-
32
-
-
0028834428
-
Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
-
Rexach M, Blobel G: Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 1995, 83:683-692.
-
(1995)
Cell
, vol.83
, pp. 683-692
-
-
Rexach, M.1
Blobel, G.2
-
33
-
-
0030454052
-
Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities
-
Weis K, Dingwall C, Lamond AI: Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J 1996, 15:7120-7128. Aspartic acid 125 from Ran's conserved GTP-binding site was mutated to asparagine. The resulting D125N Ran mutant utilizes XTP instead of GTP. NLS-dependent nuclear import with wild-type Ran requires free GTP and can be blocked with GTP analogues but not with analogues of ATP. Import with D125N Ran is XTP-dependent and resistant to inhibition by either GTP or ATP analogues. This suggests that the rate-limiting steps of import are driven by nucleotide hydrolysis by Ran and by no other NTPase.
-
(1996)
EMBO J
, vol.15
, pp. 7120-7128
-
-
Weis, K.1
Dingwall, C.2
Lamond, A.I.3
-
34
-
-
0026419320
-
Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
-
Bischoff FR, Ponstingl H: Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 1991, 354:80-82.
-
(1991)
Nature
, vol.354
, pp. 80-82
-
-
Bischoff, F.R.1
Ponstingl, H.2
-
35
-
-
0028934834
-
Human RanGTPase activating protein RanGAP1 is a homolog of yeast RNA1p involved in messenger RNA processing and transport
-
Bischoff FR, Krebber H, Kempf T, Hermes I, Ponstingl H: Human RanGTPase activating protein RanGAP1 is a homolog of yeast RNA1p involved in messenger RNA processing and transport Proc Natl Acad Sci USA 1995, 92:1749-1753.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1749-1753
-
-
Bischoff, F.R.1
Krebber, H.2
Kempf, T.3
Hermes, I.4
Ponstingl, H.5
-
36
-
-
0028937195
-
Coactivation of RanGTPase and inhibition of GTP dissociation by Ran GTP binding protein RanBP1
-
Bischoff FR, Krebber H, Smirnova E, Dong WH, Ponstingl H: Coactivation of RanGTPase and inhibition of GTP dissociation by Ran GTP binding protein RanBP1. EMBO J 1995, 14:705-715.
-
(1995)
EMBO J
, vol.14
, pp. 705-715
-
-
Bischoff, F.R.1
Krebber, H.2
Smirnova, E.3
Dong, W.H.4
Ponstingl, H.5
-
37
-
-
0027732054
-
Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4
-
Coutavas E, Ren M, Oppenheim JD, D'Eustachio P, Rush MG: Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. Nature 1993, 366:585-587.
-
(1993)
Nature
, vol.366
, pp. 585-587
-
-
Coutavas, E.1
Ren, M.2
Oppenheim, J.D.3
D'Eustachio, P.4
Rush, M.G.5
-
38
-
-
0029026774
-
The C terminus of the nuclear Ran/TC4 GTPase stabilises the GDP bound state and mediates interactions with RCC1, Ran-GAP and HTF9A/RanBP1
-
Richards SA, Lounsbury KM, Macara IG: The C terminus of the nuclear Ran/TC4 GTPase stabilises the GDP bound state and mediates interactions with RCC1, Ran-GAP and HTF9A/RanBP1. J Biol Chem 1995, 270:14405-14411.
-
(1995)
J Biol Chem
, vol.270
, pp. 14405-14411
-
-
Richards, S.A.1
Lounsbury, K.M.2
Macara, I.G.3
-
39
-
-
0027518572
-
Nuclear PRP20 protein is required for mRNA export
-
Amberg DC, Fleischmann M, Stagljar I, Cole CN, Aebi M: Nuclear PRP20 protein is required for mRNA export. EMBO J 1993, 12:233-241.
-
(1993)
EMBO J
, vol.12
, pp. 233-241
-
-
Amberg, D.C.1
Fleischmann, M.2
Stagljar, I.3
Cole, C.N.4
Aebi, M.5
-
40
-
-
0021911104
-
Characterization of an essential Saccharomyces cerevisiae gene related to RNA processing: Cloning of RNA1 and generation of a new allele with a novel phenotype
-
Atkinson NS, Dunst RW, Hopper AK: Characterization of an essential Saccharomyces cerevisiae gene related to RNA processing: cloning of RNA1 and generation of a new allele with a novel phenotype. Mol Cell Biol 1985, 5:907-915.
-
(1985)
Mol Cell Biol
, vol.5
, pp. 907-915
-
-
Atkinson, N.S.1
Dunst, R.W.2
Hopper, A.K.3
-
41
-
-
0028926274
-
Diverse effects of the guanine nucleotide exchange factor RCC1 on RNA transport
-
Cheng Y, Dahlberg JE, Lund E: Diverse effects of the guanine nucleotide exchange factor RCC1 on RNA transport. Science 1995, 267:1807-1810.
-
(1995)
Science
, vol.267
, pp. 1807-1810
-
-
Cheng, Y.1
Dahlberg, J.E.2
Lund, E.3
-
42
-
-
0029899120
-
Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the RanTC4 GTPase mediates an essential function independent of nuclear protein import
-
Carey KL, Richards SA, Lounsbury KM, Macara IG: Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the RanTC4 GTPase mediates an essential function independent of nuclear protein import. J Cell Biol 1996, 133:985-996. An in vivo study showing dominant-negative effects of three Ran mutants on nuclear protein import. These mutants were Ran Gly19→Val (stabilized in the GTP-bound form), Thr24→Asn (stabilized in the GDP-bound form) and a carboxy-terminal deletion mutant with a reduced affinity for RanBP1.
-
(1996)
J Cell Biol
, vol.133
, pp. 985-996
-
-
Carey, K.L.1
Richards, S.A.2
Lounsbury, K.M.3
Macara, I.G.4
-
43
-
-
0029150288
-
Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import
-
Corbett AH, Koepp DM, Schlenstedt G, Lee MS, Hopper AK, Silver PA: Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import. J Cell Biol 1995, 130:1017-1026.
-
(1995)
J Cell Biol
, vol.130
, pp. 1017-1026
-
-
Corbett, A.H.1
Koepp, D.M.2
Schlenstedt, G.3
Lee, M.S.4
Hopper, A.K.5
Silver, P.A.6
-
44
-
-
0026726128
-
Defects in mRNA 3′-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: Possible coupling of mRNA processing and chromatin structure
-
Forrester W, Stutz F, Rosbash M, Wickens M: Defects in mRNA 3′-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure. Genes Dev 1992, 6:1914-1926.
-
(1992)
Genes Dev
, vol.6
, pp. 1914-1926
-
-
Forrester, W.1
Stutz, F.2
Rosbash, M.3
Wickens, M.4
-
45
-
-
0029944335
-
Ran/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus
-
Palacios I, Weis K, Klebe C, Dingwall C: Ran/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. J Cell Biol 1996, 133:485-494. This study shows that dominant-negative mutants of Ran block not only import of proteins with a classical NLS, but also nuclear import of U snRNP. This suggests that U snRNP import is also Ran-dependent.
-
(1996)
J Cell Biol
, vol.133
, pp. 485-494
-
-
Palacios, I.1
Weis, K.2
Klebe, C.3
Dingwall, C.4
-
47
-
-
0028784164
-
Mutants in a yeast Ran binding protein are defective in nuclear transport
-
Schlenstedt G, Wong DH, Koepp DM, Silver PA: Mutants in a yeast Ran binding protein are defective in nuclear transport EMBO J 1995, 14:5367-5378.
-
(1995)
EMBO J
, vol.14
, pp. 5367-5378
-
-
Schlenstedt, G.1
Wong, D.H.2
Koepp, D.M.3
Silver, P.A.4
-
48
-
-
0026506656
-
mtr1, a conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm
-
Kadowaki T, Zhao Y, Tartakoff A: mtr1, a conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm. Proc Natl Acad Sci USA 1992, 89:2312-2316.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 2312-2316
-
-
Kadowaki, T.1
Zhao, Y.2
Tartakoff, A.3
-
49
-
-
0025836659
-
Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
-
Bischoff FR, Ponstingl H: Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proc Natl Acad Sci USA 1991, 88:10830-10834.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10830-10834
-
-
Bischoff, F.R.1
Ponstingl, H.2
-
50
-
-
0028832520
-
GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import
-
Melchior F, Guan T, Yokoyama N, Nishimoto T, Gerace L: GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import. J Cell Biol 1995, 131:571-581.
-
(1995)
J Cell Biol
, vol.131
, pp. 571-581
-
-
Melchior, F.1
Guan, T.2
Yokoyama, N.3
Nishimoto, T.4
Gerace, L.5
-
51
-
-
0024445582
-
The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA
-
Ohtsubo M, Okazaki H, Nishimoto T: The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA. J Cell Biol 1989, 109:1389-1397.
-
(1989)
J Cell Biol
, vol.109
, pp. 1389-1397
-
-
Ohtsubo, M.1
Okazaki, H.2
Nishimoto, T.3
-
52
-
-
0025375307
-
The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus
-
Hopper AK, Traglia HM, Dunst RW: The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus. J Cell Biol 1990, 111:309-321.
-
(1990)
J Cell Biol
, vol.111
, pp. 309-321
-
-
Hopper, A.K.1
Traglia, H.M.2
Dunst, R.W.3
-
53
-
-
0029738481
-
A nuclear export signal is essential for the cytosolic localisation of the Ran binding protein, RanBP1
-
Richards SA, Lounsbury KM, Carey KL, Macara IG: A nuclear export signal is essential for the cytosolic localisation of the Ran binding protein, RanBP1. J Cell Biol 1996, 134:1157-1168. This study shows that RanBP1 has two functional domains, namely, the well known Ran-binding domain and a carboxy-terminal domain that localizes RanBP1 to the cytoplasm. Cytoplasmic localization is achieved by a nuclear export signal and by cytoplasmic retention. RanBP1 lacking the carboxy-terminal domain accumulates in the nucleus and blocks nuclear protein import in a dominant way. This suggests that the exclusively cytoplasmic localization of RanBP1 is crucial for its function.
-
(1996)
J Cell Biol
, vol.134
, pp. 1157-1168
-
-
Richards, S.A.1
Lounsbury, K.M.2
Carey, K.L.3
Macara, I.G.4
-
54
-
-
0030932134
-
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
-
Mahajan R, Delphin C, Guan T, Gerace L, Melchior F: A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell 1997, 88:97-107. A proportion of RanGAP1 was found to be covalently modified by a ubiquitin-related polypeptide termed SUMO-1. The RanGAP1-SUMO-1 conjugate localizes to the cytoplasmic periphery of the NPC and associates specifically with RanBP2/Nup358. In contrast, the unmodified RanGAP1 is soluble and cytoplasmic.
-
(1997)
Cell
, vol.88
, pp. 97-107
-
-
Mahajan, R.1
Delphin, C.2
Guan, T.3
Gerace, L.4
Melchior, F.5
-
55
-
-
0030455748
-
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein between cytosol and nuclear pore complex
-
Matunis MJ, Coutavas E, Blobel G: A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein between cytosol and nuclear pore complex. J Cell Biol 1997, 135:1457-1470. Two populations of RanGAP1 are reported. These are a 70 kDa unmodified, cytoplasmic form and a 90 kDa form which is modified with ubiquitin-like polypeptide and which localizes predominantly to the cytoplasmic fibres of the NPC.
-
(1997)
J Cell Biol
, vol.135
, pp. 1457-1470
-
-
Matunis, M.J.1
Coutavas, E.2
Blobel, G.3
-
56
-
-
0029070074
-
Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region
-
Wu J, Matunis MJ, Kraemer D, Blobel G, Coutavas E: Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J Biol Chem 1995, 270:14209-14213.
-
(1995)
J Biol Chem
, vol.270
, pp. 14209-14213
-
-
Wu, J.1
Matunis, M.J.2
Kraemer, D.3
Blobel, G.4
Coutavas, E.5
-
57
-
-
0029032954
-
A giant nucleopore protein that binds Ran/TC4
-
Yokoyama N, Hayashi N, Seki T, Panté N, Ohba T, Nishii K, Kuma K, Hayashida T, Miyata T, Aebi U et al.: A giant nucleopore protein that binds Ran/TC4. Nature 1995, 376:184-188.
-
(1995)
Nature
, vol.376
, pp. 184-188
-
-
Yokoyama, N.1
Hayashi, N.2
Seki, T.3
Panté, N.4
Ohba, T.5
Nishii, K.6
Kuma, K.7
Hayashida, T.8
Miyata, T.9
Aebi, U.10
-
58
-
-
0028206481
-
A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation
-
Lounsbury KM, Beddow AL, Macara IG: A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation. J Biol Chem 1994, 269:11285-11290.
-
(1994)
J Biol Chem
, vol.269
, pp. 11285-11290
-
-
Lounsbury, K.M.1
Beddow, A.L.2
Macara, I.G.3
-
59
-
-
0028102739
-
Loss of RCC1 leads to suppression of nuclear protein import in living cells
-
Tachibana T, Imamoto N, Seino H, Nishimoto T, Yoneda Y: Loss of RCC1 leads to suppression of nuclear protein import in living cells. J Biol Chem 1994, 269:24542-24545.
-
(1994)
J Biol Chem
, vol.269
, pp. 24542-24545
-
-
Tachibana, T.1
Imamoto, N.2
Seino, H.3
Nishimoto, T.4
Yoneda, Y.5
-
60
-
-
0030570091
-
Role of the nuclear transport factor p10 in nuclear import
-
Nehrbass U, Blobel G: Role of the nuclear transport factor p10 in nuclear import. Science 1996, 272:120-122. This study shows, by in vitro binding assays, that p10 (NTF2) can interact with importin β, nucleoporins, and Ran-GDP. A model for protein translocation into the nucleus is proposed.
-
(1996)
Science
, vol.272
, pp. 120-122
-
-
Nehrbass, U.1
Blobel, G.2
-
61
-
-
0029744973
-
The NTF2 gene encodes an essential, highly conserved proteins that functions in nuclear transport in vivo
-
Corbett AH, Silver PA: The NTF2 gene encodes an essential, highly conserved proteins that functions in nuclear transport in vivo. J Biol Chem 1996, 271:18477-18484. Describes the identification of yeast NTF2 in a screen for temperature-sensitive mutants that are defective in nuclear protein import.
-
(1996)
J Biol Chem
, vol.271
, pp. 18477-18484
-
-
Corbett, A.H.1
Silver, P.A.2
-
62
-
-
0030593377
-
The 1.6 Å resolution crystal structure of nuclear transport factor 2 (NTF2)
-
Bulock TL, Clarkson DW, Kent HM, Stewart M: The 1.6 Å resolution crystal structure of nuclear transport factor 2 (NTF2). J Mol Biol 1996, 260:422-431.
-
(1996)
J Mol Biol
, vol.260
, pp. 422-431
-
-
Bulock, T.L.1
Clarkson, D.W.2
Kent, H.M.3
Stewart, M.4
-
63
-
-
0021717131
-
Movement of a karyophilic protein through the nuclear pores of oocytes
-
Feldherr CM, Kallenbach E, Schultz N: Movement of a karyophilic protein through the nuclear pores of oocytes. J Cell Biol 1984, 99:2216-2222.
-
(1984)
J Cell Biol
, vol.99
, pp. 2216-2222
-
-
Feldherr, C.M.1
Kallenbach, E.2
Schultz, N.3
-
64
-
-
0029797940
-
Sequential binding of import ligands to distinct nucleopore regions during their nuclear import
-
Pantè N, Aebi U: Sequential binding of import ligands to distinct nucleopore regions during their nuclear import. Science 1996, 273:1729-1732. The nuclear pore passage of nucleoplasmin-gold was studied in Xenopus oocytes. Binding of the gold particles was observed at two distinct positions of the NPC, first at the distal part of the cytoplasmic filaments of the NPC, and second at the cytoplasmic entry of the central gated channel of the NPC. A model is proposed in which the substrate is transferred by bending of the filaments from the first to the second intermediate.
-
(1996)
Science
, vol.273
, pp. 1729-1732
-
-
Pantè, N.1
Aebi, U.2
-
65
-
-
0023852444
-
Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores
-
Richardson WD, Mills AD, Dilworth SM, Laskey RA, Dingwall C: Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores. Cell 1988, 52:655-664.
-
(1988)
Cell
, vol.52
, pp. 655-664
-
-
Richardson, W.D.1
Mills, A.D.2
Dilworth, S.M.3
Laskey, R.A.4
Dingwall, C.5
-
66
-
-
0031016658
-
Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin β and reduces GTPase-activating protein (RanGAP) inhibition by karyopherin β
-
Lounsbury KM, Macara IG: Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin β and reduces GTPase-activating protein (RanGAP) inhibition by karyopherin β. J Biol Chem 1997, 272:551-555.
-
(1997)
J Biol Chem
, vol.272
, pp. 551-555
-
-
Lounsbury, K.M.1
Macara, I.G.2
-
67
-
-
0029845118
-
Kap104: A karyopherin involved in the nuclear transport of messenger RNA binding proteins
-
••]). It is shown to interact with nuclear pore complexes and to be required for nuclear import of Nab2p and Hrp1p, two factors related to human hnRNP proteins.
-
(1996)
Science
, vol.274
, pp. 624-627
-
-
Aitchison, J.D.1
Blobel, G.2
Rout, M.P.3
-
68
-
-
0026339487
-
Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins
-
Piñol-Roma S, Dreyfuss G: Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins. Science 1991, 253:312-314.
-
(1991)
Science
, vol.253
, pp. 312-314
-
-
Piñol-Roma, S.1
Dreyfuss, G.2
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