-
1
-
-
84930754135
-
Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors
-
Juchum, M.; Gunther, M.; Laufer, S.A. Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors. Drug Resist. Update 2015, 20, 12-28.
-
(2015)
Drug Resist. Update
, vol.20
, pp. 12-28
-
-
Juchum, M.1
Gunther, M.2
Laufer, S.A.3
-
2
-
-
0036176510
-
Mechanisms of cancer drug resistance
-
Gottesman, M.M. Mechanisms of cancer drug resistance. Ann. Rev. Med. 2002, 53, 615-627.
-
(2002)
Ann. Rev. Med.
, vol.53
, pp. 615-627
-
-
Gottesman, M.M.1
-
3
-
-
0035400270
-
Mechanisms of resistance to cisplatin
-
Kartalou, M.; Essigmann, J.M. Mechanisms of resistance to cisplatin. Mutat. Res. 2001, 478, 23-43.
-
(2001)
Mutat. Res.
, vol.478
, pp. 23-43
-
-
Kartalou, M.1
Essigmann, J.M.2
-
4
-
-
0029553183
-
An overview of epithelio-mesenchymal transformation
-
Hay, E.D. An overview of epithelio-mesenchymal transformation. Acta Anat. 1995, 154, 8-20.
-
(1995)
Acta Anat.
, vol.154
, pp. 8-20
-
-
Hay, E.D.1
-
5
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
Kalluri, R.; Weinberg, R.A. The basics of epithelial-mesenchymal transition. J. Clin. Investig. 2009, 119, 1420-1428.
-
(2009)
J. Clin. Investig
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
6
-
-
0344845003
-
Epithelial-mesenchymal transitions in development and pathologies
-
Thiery, J.P. Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell Biol. 2003, 15, 740-746.
-
(2003)
Curr. Opin. Cell Biol.
, vol.15
, pp. 740-746
-
-
Thiery, J.P.1
-
7
-
-
84894593599
-
Molecular mechanisms of epithelial-mesenchymal transition
-
Lamouille, S.; Xu, J.; Derynck, R. Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. 2014, 15, 178-196.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 178-196
-
-
Lamouille, S.1
Xu, J.2
Derynck, R.3
-
8
-
-
84907501988
-
Signaling mechanisms of the epithelial-mesenchymal transition
-
Gonzalez, D.M.; Medici, D. Signaling mechanisms of the epithelial-mesenchymal transition. Sci. Signal 2014, 7.
-
(2014)
Sci. Signal
, vol.7
-
-
Gonzalez, D.M.1
Medici, D.2
-
9
-
-
34547599359
-
Transforming growth factor-beta 1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
-
Kaimori, A.; Potter, J.; Kaimori, J.Y.; Wang, C.; Mezey, E.; Koteish, A. Transforming growth factor-beta 1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J. Biol. Chem. 2007, 282, 22089-22101.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 22089-22101
-
-
Kaimori, A.1
Potter, J.2
Kaimori, J.Y.3
Wang, C.4
Mezey, E.5
Koteish, A.6
-
10
-
-
15744374449
-
Wnt-dependent regulation of the E-cadherin repressor snail
-
Yook, J.I.; Li, X.Y.; Ota, I.; Fearon, E.R.; Weiss, S.J. Wnt-dependent regulation of the E-cadherin repressor snail. J. Biol. Chem. 2005, 280, 11740-11748.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11740-11748
-
-
Yook, J.I.1
Li, X.Y.2
Ota, I.3
Fearon, E.R.4
Weiss, S.J.5
-
11
-
-
9144246932
-
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
-
Timmerman, L.A.; Grego-Bessa, J.; Raya, A.; Bertran, E.; Perez-Pomares, J.M.; Diez, J.; Aranda, S.; Palomo, S.; McCormick, F.; Izpisua-Belmonte, J.C.; et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 2004, 18, 99-115.
-
(2004)
Genes Dev.
, vol.18
, pp. 99-115
-
-
Timmerman, L.A.1
Grego-Bessa, J.2
Raya, A.3
Bertran, E.4
Perez-Pomares, J.M.5
Diez, J.6
Aranda, S.7
Palomo, S.8
McCormick, F.9
Izpisua-Belmonte, J.C.10
-
12
-
-
81155126047
-
Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer
-
Yoo, Y.A.; Kang, M.H.; Lee, H.J.; Kim, B.H.; Park, J.K.; Kim, H.K.; Kim, J.S.; Oh, S.C. Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. Cancer Res. 2011, 71, 7061-7070.
-
(2011)
Cancer Res.
, vol.71
, pp. 7061-7070
-
-
Yoo, Y.A.1
Kang, M.H.2
Lee, H.J.3
Kim, B.H.4
Park, J.K.5
Kim, H.K.6
Kim, J.S.7
Oh, S.C.8
-
13
-
-
84897561550
-
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
-
Rokavec, M.; Oner, M.G.; Li, H.; Jackstadt, R.; Jiang, L.; Lodygin, D.; Kaller, M.; Horst, D.; Ziegler, P.K.; Schwitalla, S.; et al. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J. Clin. Investig. 2014, 124, 1853-1867.
-
(2014)
J. Clin. Investig
, vol.124
, pp. 1853-1867
-
-
Rokavec, M.1
Oner, M.G.2
Li, H.3
Jackstadt, R.4
Jiang, L.5
Lodygin, D.6
Kaller, M.7
Horst, D.8
Ziegler, P.K.9
Schwitalla, S.10
-
14
-
-
24944497786
-
Non-Smad TGF-beta signals
-
Moustakas, A.; Heldin, C.H. Non-Smad TGF-beta signals. J. Cell Sci. 2005, 118, 3573-3584.
-
(2005)
J. Cell Sci.
, vol.118
, pp. 3573-3584
-
-
Moustakas, A.1
Heldin, C.H.2
-
15
-
-
84861448736
-
TGF-beta-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
-
Lamouille, S.; Connolly, E.; Smyth, J.W.; Akhurst, R.J.; Derynck, R. TGF-beta-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J. Cell Sci. 2012, 125, 1259-1273.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 1259-1273
-
-
Lamouille, S.1
Connolly, E.2
Smyth, J.W.3
Akhurst, R.J.4
Derynck, R.5
-
16
-
-
33747625686
-
Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
-
Grotegut, S.; von Schweinitz, D.; Christofori, G.; Lehembre, F. Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail. EMBO J. 2006, 25, 3534-3545.
-
(2006)
EMBO J
, vol.25
, pp. 3534-3545
-
-
Grotegut, S.1
Von Schweinitz, D.2
Christofori, G.3
Lehembre, F.4
-
17
-
-
34147193818
-
Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappa B and snail
-
Kim, H.J.; Litzenburger, B.C.; Cui, X.J.; Delgado, D.A.; Grabiner, B.C.; Lin, X.; Lewis, M.T.; Gottardis, M.M.; Wong, T.W.; Attar, R.M.; et al. Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappa B and snail. Mol. Cell. Biol. 2007, 27, 3165-3175.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3165-3175
-
-
Kim, H.J.1
Litzenburger, B.C.2
Cui, X.J.3
Delgado, D.A.4
Grabiner, B.C.5
Lin, X.6
Lewis, M.T.7
Gottardis, M.M.8
Wong, T.W.9
Attar, R.M.10
-
18
-
-
0033789680
-
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
-
Batlle, E.; Sancho, E.; Franci, C.; Dominguez, D.; Monfar, M.; Baulida, J.; de Herreros, A.G. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol. 2000, 2, 84-89.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 84-89
-
-
Batlle, E.1
Sancho, E.2
Franci, C.3
Dominguez, D.4
Monfar, M.5
Baulida, J.6
De Herreros, A.G.7
-
19
-
-
0034964418
-
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
-
Comijn, J.; Berx, G.; Vermassen, P.; Verschueren, K.; van Grunsven, L.; Bruyneel, E.; Mareel, M.; Huylebroeck, D.; van Roy, F. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell 2001, 7, 1267-1278.
-
(2001)
Mol. Cell
, vol.7
, pp. 1267-1278
-
-
Comijn, J.1
Berx, G.2
Vermassen, P.3
Verschueren, K.4
Van Grunsven, L.5
Bruyneel, E.6
Mareel, M.7
Huylebroeck, D.8
Van Roy, F.9
-
20
-
-
0035920152
-
A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions
-
Perez-Moreno, M.A.; Locascio, A.; Rodrigo, I.; Dhondt, G.; Portillo, F.; Nieto, M.A.; Cano, A. A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J. Biol. Chem. 2001, 276, 27424-27431.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27424-27431
-
-
Perez-Moreno, M.A.1
Locascio, A.2
Rodrigo, I.3
Dhondt, G.4
Portillo, F.5
Nieto, M.A.6
Cano, A.7
-
21
-
-
84872200824
-
Early events in cell adhesion and polarity during epithelial-mesenchymal transition
-
Huang, R.Y.J.; Guilford, P.; Thiery, J.P. Early events in cell adhesion and polarity during epithelial-mesenchymal transition. J. Cell Sci. 2012, 125, 4417-4422.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4417-4422
-
-
Huang, R.Y.J.1
Guilford, P.2
Thiery, J.P.3
-
22
-
-
42549107446
-
Cadherin switching
-
Wheelock, M.J.; Shintani, Y.; Maeda, M.; Fukumoto, Y.; Johnson, K.R. Cadherin switching. J. Cell Sci. 2008, 121, 727-735.
-
(2008)
J. Cell Sci.
, vol.121
, pp. 727-735
-
-
Wheelock, M.J.1
Shintani, Y.2
Maeda, M.3
Fukumoto, Y.4
Johnson, K.R.5
-
23
-
-
65349132693
-
EMT, the cytoskeleton, and cancer cell invasion
-
Yilmaz, M.; Christofori, G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 2009, 28, 15-33.
-
(2009)
Cancer Metastasis Rev.
, vol.28
, pp. 15-33
-
-
Yilmaz, M.1
Christofori, G.2
-
24
-
-
0026781976
-
Loss of epithelial markers and acquisition of vimentin expression in adriamycin-resistant and vinblastine-resistant human breast-cancer cell-lines
-
Sommers, C.L.; Heckford, S.E.; Skerker, J.M.; Worland, P.; Torri, J.A.; Thompson, E.W.; Byers, S.W.; Gelmann, E.P. Loss of epithelial markers and acquisition of vimentin expression in adriamycin-resistant and vinblastine-resistant human breast-cancer cell-lines. Cancer Res. 1992, 52, 5190-5197.
-
(1992)
Cancer Res.
, vol.52
, pp. 5190-5197
-
-
Sommers, C.L.1
Heckford, S.E.2
Skerker, J.M.3
Worland, P.4
Torri, J.A.5
Thompson, E.W.6
Byers, S.W.7
Gelmann, E.P.8
-
25
-
-
67650999217
-
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
-
Arumugam, T.; Ramachandran, V.; Fournier, K.F.;Wang, H.M.; Marquis, L.; Abbruzzese, J.L.; Gallick, G.E.; Logsdon, C.D.; McConkey, D.J.; Choi, W. Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res. 2009, 69, 5820-5828.
-
(2009)
Cancer Res.
, vol.69
, pp. 5820-5828
-
-
Arumugam, T.1
Ramachandran, V.2
Fournier, K.F.3
Wang, H.M.4
Marquis, L.5
Abbruzzese, J.L.6
Gallick, G.E.7
Logsdon, C.D.8
McConkey, D.J.9
Choi, W.10
-
26
-
-
76649134077
-
Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
-
McConkey, D.J.; Choi, W.; Marquis, L.; Martin, F.; Williams, M.B.; Shah, J.; Svatek, R.; Das, A.; Adam, L.; Kamat, A.; et al. Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer. Cancer Metastasis Rev. 2009, 28, 335-344.
-
(2009)
Cancer Metastasis Rev.
, vol.28
, pp. 335-344
-
-
McConkey, D.J.1
Choi, W.2
Marquis, L.3
Martin, F.4
Williams, M.B.5
Shah, J.6
Svatek, R.7
Das, A.8
Adam, L.9
Kamat, A.10
-
27
-
-
84938099381
-
Epithelial-mesenchymal transition and drug resistance in breast cancer
-
Huang, J.; Li, H.Z.; Ren, G.S. Epithelial-mesenchymal transition and drug resistance in breast cancer. Int. J. Oncol. 2015, 47, 840-848.
-
(2015)
Int. J. Oncol.
, vol.47
, pp. 840-848
-
-
Huang, J.1
Li, H.Z.2
Ren, G.S.3
-
28
-
-
84948429460
-
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
-
Fischer, K.R.; Durrans, A.; Lee, S.; Sheng, J.T.; Li, F.H.; Wong, S.T.C.; Choi, H.J.; El Rayes, T.; Ryu, S.H.; Troeger, J.; et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature 2015, 527, 472-476.
-
(2015)
Nature
, vol.527
, pp. 472-476
-
-
Fischer, K.R.1
Durrans, A.2
Lee, S.3
Sheng, J.T.4
Li, F.H.5
Wong, S.T.C.6
Choi, H.J.7
El Rayes, T.8
Ryu, S.H.9
Troeger, J.10
-
29
-
-
84948407218
-
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
-
Zheng, X.F.; Carstens, J.L.; Kim, J.; Scheible, M.; Kaye, J.; Sugimoto, H.; Wu, C.C.; LeBleu, V.S.; Kalluri, R. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature 2015, 527, 525-530.
-
(2015)
Nature
, vol.527
, pp. 525-530
-
-
Zheng, X.F.1
Carstens, J.L.2
Kim, J.3
Scheible, M.4
Kaye, J.5
Sugimoto, H.6
Wu, C.C.7
LeBleu, V.S.8
Kalluri, R.9
-
30
-
-
0029873924
-
Transforming growth factor-beta in in vivo resistance
-
Teicher, B.A.; Holden, S.A.; Ara, G.; Chen, G. Transforming growth factor-beta in in vivo resistance. Cancer Chemother. Pharmacol. 1996, 37, 601-609.
-
(1996)
Cancer Chemother. Pharmacol.
, vol.37
, pp. 601-609
-
-
Teicher, B.A.1
Holden, S.A.2
Ara, G.3
Chen, G.4
-
31
-
-
84899735257
-
Animal models and the tumor microenvironment: Studies of tumor-host symbiosis
-
Lindner, D. Animal models and the tumor microenvironment: Studies of tumor-host symbiosis. Semin. Oncol. 2014, 41, 146-155.
-
(2014)
Semin. Oncol.
, vol.41
, pp. 146-155
-
-
Lindner, D.1
-
32
-
-
84926616258
-
Chemoresistance to doxorubicin induces epithelial-mesenchymal transition via upregulation of transforming growth factor signaling in HCT116 colon cancer cells
-
Li, J.P.; Liu, H.; Yu, J.P.; Yu, H.G. Chemoresistance to doxorubicin induces epithelial-mesenchymal transition via upregulation of transforming growth factor signaling in HCT116 colon cancer cells. Mol. Med. Rep. 2015, 12, 192-198.
-
(2015)
Mol. Med. Rep.
, vol.12
, pp. 192-198
-
-
Li, J.P.1
Liu, H.2
Yu, J.P.3
Yu, H.G.4
-
33
-
-
84871392766
-
Expression of Wnt3 activates Wnt/beta-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells
-
Wu, Y.Y.; Ginther, C.; Kim, J.; Mosher, N.; Chung, S.Y.; Slamon, D.; Vadgama, J.V. Expression of Wnt3 activates Wnt/beta-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. Mol. Cancer Res. 2012, 10, 1597-1606.
-
(2012)
Mol. Cancer Res.
, vol.10
, pp. 1597-1606
-
-
Wu, Y.Y.1
Ginther, C.2
Kim, J.3
Mosher, N.4
Chung, S.Y.5
Slamon, D.6
Vadgama, J.V.7
-
34
-
-
84945550963
-
SMO gene amplification and activation of the Hedgehog pathway as novel mechanisms of resistance to anti-epidermal growth factor receptor drugs in human lung cancer
-
Della Corte, C.M.; Bellevicine, C.; Vicidomini, G.; Vitagliano, D.; Malapelle, U.; Accardo, M.; Fabozzi, A.; Fiorelli, A.; Fasano, M.; Papaccio, F.; et al. SMO gene amplification and activation of the Hedgehog pathway as novel mechanisms of resistance to anti-epidermal growth factor receptor drugs in human lung cancer. Clin. Cancer Res. 2015, 21, 4686-4697.
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 4686-4697
-
-
Della Corte, C.M.1
Bellevicine, C.2
Vicidomini, G.3
Vitagliano, D.4
Malapelle, U.5
Accardo, M.6
Fabozzi, A.7
Fiorelli, A.8
Fasano, M.9
Papaccio, F.10
-
35
-
-
84959019701
-
Twist mediates an aggressive phenotype in human colorectal cancer cells
-
Deng, J.J.; Zhang, W.; Xu, X.M.; Zhang, F.; Tao, W.P.; Ye, J.J.; Ge, W. Twist mediates an aggressive phenotype in human colorectal cancer cells. Int. J. Oncol. 2016, 48, 1117-1124.
-
(2016)
Int. J. Oncol.
, vol.48
, pp. 1117-1124
-
-
Deng, J.J.1
Zhang, W.2
Xu, X.M.3
Zhang, F.4
Tao, W.P.5
Ye, J.J.6
Ge, W.7
-
36
-
-
84929278270
-
FOXC2 promotes chemoresistance in nasopharyngeal carcinomas via induction of epithelial mesenchymal transition
-
Zhou, Z.J.; Zhang, L.; Xie, B.W.; Wang, X.P.; Yang, X.H.; Ding, N.H.; Zhang, J.; Liu, Q.Q.; Tan, G.L.; Feng, D.Y.; et al. FOXC2 promotes chemoresistance in nasopharyngeal carcinomas via induction of epithelial mesenchymal transition. Cancer Lett. 2015, 363, 137-145.
-
(2015)
Cancer Lett.
, vol.363
, pp. 137-145
-
-
Zhou, Z.J.1
Zhang, L.2
Xie, B.W.3
Wang, X.P.4
Yang, X.H.5
Ding, N.H.6
Zhang, J.7
Liu, Q.Q.8
Tan, G.L.9
Feng, D.Y.10
-
37
-
-
84923052543
-
FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells
-
Chiu, W.T.; Huang, Y.F.; Tsai, H.Y.; Chen, C.C.; Chang, C.H.; Huang, S.C.; Hsu, K.F.; Chou, C.Y. FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells. Oncotarget 2015, 6, 2349-2365.
-
(2015)
Oncotarget
, vol.6
, pp. 2349-2365
-
-
Chiu, W.T.1
Huang, Y.F.2
Tsai, H.Y.3
Chen, C.C.4
Chang, C.H.5
Huang, S.C.6
Hsu, K.F.7
Chou, C.Y.8
-
38
-
-
84939251769
-
FOXF2 suppresses the FOXC2-mediated epithelial mesenchymal transition and multidrug resistance of basal-like breast cancer
-
Cai, J.; Tian, A.X.;Wang, Q.S.; Kong, P.Z.; Du, X.; Li, X.Q.; Feng, Y.M. FOXF2 suppresses the FOXC2-mediated epithelial mesenchymal transition and multidrug resistance of basal-like breast cancer. Cancer Lett. 2015, 367, 129-137.
-
(2015)
Cancer Lett.
, vol.367
, pp. 129-137
-
-
Cai, J.1
Tian, A.X.2
Wang, Q.S.3
Kong, P.Z.4
Du, X.5
Li, X.Q.6
Feng, Y.M.7
-
39
-
-
84862777088
-
EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer
-
Haslehurst, A.M.; Koti, M.; Dharsee, M.; Nuin, P.; Evans, K.; Geraci, J.; Childs, T.; Chen, J.; Li, J.R.; Weberpals, J.; Davey, S.; et al. EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer. BMC Cancer 2012, 12.
-
(2012)
BMC Cancer
, vol.12
-
-
Haslehurst, A.M.1
Koti, M.2
Dharsee, M.3
Nuin, P.4
Evans, K.5
Geraci, J.6
Childs, T.7
Chen, J.8
Li, J.R.9
Weberpals, J.10
Davey, S.11
-
40
-
-
84881540768
-
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance
-
Siebzehnrubl, F.A.; Silver, D.J.; Tugertimur, B.; Deleyrolle, L.P.; Siebzehnrubl, D.; Sarkisian, M.R.; Devers, K.G.; Yachnis, A.T.; Kupper, M.D.; Neal, D.; et al. The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol. Med. 2013, 5, 1196-1212.
-
(2013)
EMBO Mol. Med.
, vol.5
, pp. 1196-1212
-
-
Siebzehnrubl, F.A.1
Silver, D.J.2
Tugertimur, B.3
Deleyrolle, L.P.4
Siebzehnrubl, D.5
Sarkisian, M.R.6
Devers, K.G.7
Yachnis, A.T.8
Kupper, M.D.9
Neal, D.10
-
41
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh, S.K.; Hawkins, C.; Clarke, I.D.; Squire, J.A.; Bayani, J.; Hide, T.; Henkelman, R.M.; Cusimano, M.D.; Dirks, P.B. Identification of human brain tumour initiating cells. Nature 2004, 432, 396-401.
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
Hawkins, C.2
Clarke, I.D.3
Squire, J.A.4
Bayani, J.5
Hide, T.6
Henkelman, R.M.7
Cusimano, M.D.8
Dirks, P.B.9
-
42
-
-
24644480749
-
Molecular requirements for epithelial-mesenchymal transition during tumor progression
-
Huber, M.A.; Kraut, N.; Beug, H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell. Biol. 2005, 17, 548-558.
-
(2005)
Curr. Opin. Cell. Biol.
, vol.17
, pp. 548-558
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
43
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
Mani, S.A.; Guo, W.; Liao, M.J.; Eaton, E.N.; Ayyanan, A.; Zhou, A.Y.; Brooks, M.; Reinhard, F.; Zhang, C.C.; Shipitsin, M.; et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133, 704-715.
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.J.3
Eaton, E.N.4
Ayyanan, A.5
Zhou, A.Y.6
Brooks, M.7
Reinhard, F.8
Zhang, C.C.9
Shipitsin, M.10
-
44
-
-
77956178360
-
EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
-
Singh, A.; Settleman, J. EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene 2010, 29, 4741-4751.
-
(2010)
Oncogene
, vol.29
, pp. 4741-4751
-
-
Singh, A.1
Settleman, J.2
-
45
-
-
79960936439
-
Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative
-
Biddle, A.; Liang, X.; Gammon, L.; Fazil, B.; Harper, L.J.; Emich, H.; Costea, D.E.; Mackenzie, I.C. Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res. 2011, 71, 5317-5326.
-
(2011)
Cancer Res.
, vol.71
, pp. 5317-5326
-
-
Biddle, A.1
Liang, X.2
Gammon, L.3
Fazil, B.4
Harper, L.J.5
Emich, H.6
Costea, D.E.7
Mackenzie, I.C.8
-
46
-
-
84892619683
-
Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts
-
Liu, S.L.; Cong, Y.; Wang, D.; Sun, Y.; Deng, L.; Liu, Y.J.; Martin-Trevino, R.; Shang, L.; McDermott, S.P.; Landis, M.D.; et al. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Rep. 2014, 2, 78-91.
-
(2014)
Stem Cell Rep.
, vol.2
, pp. 78-91
-
-
Liu, S.L.1
Cong, Y.2
Wang, D.3
Sun, Y.4
Deng, L.5
Liu, Y.J.6
Martin-Trevino, R.7
Shang, L.8
McDermott, S.P.9
Landis, M.D.10
-
47
-
-
84870816403
-
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
-
Ocana, O.H.; Corcoles, R.; Fabra, A.; Moreno-Bueno, G.; Acloque, H.; Vega, S.; Barrallo-Gimeno, A.; Cano, A.; Nieto, M.A. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 2012, 22, 709-724.
-
(2012)
Cancer Cell
, vol.22
, pp. 709-724
-
-
Ocana, O.H.1
Corcoles, R.2
Fabra, A.3
Moreno-Bueno, G.4
Acloque, H.5
Vega, S.6
Barrallo-Gimeno, A.7
Cano, A.8
Nieto, M.A.9
-
48
-
-
0036364467
-
Multidrug resistance in cancer: Role of ATP-dependent transporters
-
Gottesman, M.M.; Fojo, T.; Bates, S.E. Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat. Rev. Cancer 2002, 2, 48-58.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 48-58
-
-
Gottesman, M.M.1
Fojo, T.2
Bates, S.E.3
-
49
-
-
63449139456
-
Structure of P-plycoprotein reveals a molecular basis for poly-specific drug binding
-
Aller, S.G.; Yu, J.; Ward, A.; Weng, Y.; Chittaboina, S.; Zhuo, R.P.; Harrell, P.M.; Trinh, Y.T.; Zhang, Q.H.; Urbatsch, I.L.; et al. Structure of P-plycoprotein reveals a molecular basis for poly-specific drug binding. Science 2009, 323, 1718-1722.
-
(2009)
Science
, vol.323
, pp. 1718-1722
-
-
Aller, S.G.1
Yu, J.2
Ward, A.3
Weng, Y.4
Chittaboina, S.5
Zhuo, R.P.6
Harrell, P.M.7
Trinh, Y.T.8
Zhang, Q.H.9
Urbatsch, I.L.10
-
50
-
-
39749097290
-
Role of the MRP1/ABCC1 multidrug transporter protein in cancer
-
Munoz, M.; Henderson, M.; Haber, M.; Norris, M. Role of the MRP1/ABCC1 multidrug transporter protein in cancer. IUBMB Life 2007, 59, 752-757.
-
(2007)
IUBMB Life
, vol.59
, pp. 752-757
-
-
Munoz, M.1
Henderson, M.2
Haber, M.3
Norris, M.4
-
51
-
-
84858002750
-
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
-
Natarajan, K.; Xie, Y.; Baer, M.R.; Ross, D.D. Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance. Biochem. Pharmacol. 2012, 83, 1084-1103.
-
(2012)
Biochem. Pharmacol.
, vol.83
, pp. 1084-1103
-
-
Natarajan, K.1
Xie, Y.2
Baer, M.R.3
Ross, D.D.4
-
52
-
-
80051495448
-
Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters
-
Saxena, M.; Stephens, M.A.; Pathak, H.; Rangarajan, A. Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters. Cell Death Dis. 2011, 2.
-
(2011)
Cell Death Dis.
, vol.2
-
-
Saxena, M.1
Stephens, M.A.2
Pathak, H.3
Rangarajan, A.4
-
53
-
-
77955819939
-
Epithelial-mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma
-
Uramoto, H.; Iwata, T.; Onitsuka, T.; Shimokawa, H.; Hanagiri, T.; Oyama, T. Epithelial-mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma. Anticancer Res. 2010, 30, 2513-2517.
-
(2010)
Anticancer Res.
, vol.30
, pp. 2513-2517
-
-
Uramoto, H.1
Iwata, T.2
Onitsuka, T.3
Shimokawa, H.4
Hanagiri, T.5
Oyama, T.6
-
54
-
-
84929248179
-
EGFR-TKI resistance in NSCLC patients: Mechanisms and strategies
-
Lin, Y.; Wang, X.; Jin, H. EGFR-TKI resistance in NSCLC patients: Mechanisms and strategies. Am. J. Cancer Res. 2014, 4, 411-435.
-
(2014)
Am. J. Cancer Res.
, vol.4
, pp. 411-435
-
-
Lin, Y.1
Wang, X.2
Jin, H.3
-
55
-
-
31544452076
-
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
-
Witta, S.E.; Gemmill, R.M.; Hirsch, F.R.; Coldren, C.D.; Hedman, K.; Ravdel, L.; Helfrich, B.; Dziadziuszko, R.; Chan, D.C.; Sugita, M.; et al. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res. 2006, 66, 944-950.
-
(2006)
Cancer Res.
, vol.66
, pp. 944-950
-
-
Witta, S.E.1
Gemmill, R.M.2
Hirsch, F.R.3
Coldren, C.D.4
Hedman, K.5
Ravdel, L.6
Helfrich, B.7
Dziadziuszko, R.8
Chan, D.C.9
Sugita, M.10
-
56
-
-
79954596010
-
Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor
-
Chang, T.H.; Tsai, M.F.; Su, K.Y.; Wu, S.G.; Huang, C.P.; Yu, S.L.; Yu, Y.L.; Lan, C.C.; Yang, C.H.; Lin, S.B.; et al. Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor. Am. J. Respir. Crit. Care 2011, 183, 1071-1079.
-
(2011)
Am. J. Respir. Crit. Care
, vol.183
, pp. 1071-1079
-
-
Chang, T.H.1
Tsai, M.F.2
Su, K.Y.3
Wu, S.G.4
Huang, C.P.5
Yu, S.L.6
Yu, Y.L.7
Lan, C.C.8
Yang, C.H.9
Lin, S.B.10
-
57
-
-
84885190908
-
Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo
-
Xie, M.; He, C.S.; Wei, S.H.; Zhang, L. Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo. Eur. J. Cancer 2013, 49, 3559-3572.
-
(2013)
Eur. J. Cancer
, vol.49
, pp. 3559-3572
-
-
Xie, M.1
He, C.S.2
Wei, S.H.3
Zhang, L.4
-
58
-
-
84945537059
-
Intratumoral heterogeneity in EGFR-mutant NSCLC results in divergent resistance mechanisms in response to EGFR tyrosine kinase inhibition
-
Soucheray, M.; Capelletti, M.; Pulido, I.; Kuang, Y.; Paweletz, C.P.; Becker, J.H.; Kikuchi, E.; Xu, C.; Patel, T.B.; Al-Shahrour, F.; et al. Intratumoral heterogeneity in EGFR-mutant NSCLC results in divergent resistance mechanisms in response to EGFR tyrosine kinase inhibition. Cancer Res. 2015, 75, 4372-4383.
-
(2015)
Cancer Res.
, vol.75
, pp. 4372-4383
-
-
Soucheray, M.1
Capelletti, M.2
Pulido, I.3
Kuang, Y.4
Paweletz, C.P.5
Becker, J.H.6
Kikuchi, E.7
Xu, C.8
Patel, T.B.9
Al-Shahrour, F.10
-
59
-
-
84959255800
-
ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer
-
Yoshida, T.; Song, L.; Bai, Y.; Kinose, F.; Li, J.; Ohaegbulam, K.C.; Munoz-Antonia, T.; Qu, X.; Eschrich, S.; Uramoto, H.; et al. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. PLoS ONE 2016, 11, e0147344.
-
(2016)
PLoS ONE
, vol.11
-
-
Yoshida, T.1
Song, L.2
Bai, Y.3
Kinose, F.4
Li, J.5
Ohaegbulam, K.C.6
Munoz-Antonia, T.7
Qu, X.8
Eschrich, S.9
Uramoto, H.10
-
60
-
-
78651073833
-
The role of tumor stroma in cancer progression and prognosis: Emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer
-
Bremnes, R.M.; Donnem, T.; Al-Saad, S.; Al-Shibli, K.; Andersen, S.; Sirera, R.; Camps, C.; Marinez, I.; Busund, L.T. The role of tumor stroma in cancer progression and prognosis: Emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer. J. Thorac. Oncol. 2011, 6, 209-217.
-
(2011)
J. Thorac. Oncol.
, vol.6
, pp. 209-217
-
-
Bremnes, R.M.1
Donnem, T.2
Al-Saad, S.3
Al-Shibli, K.4
Andersen, S.5
Sirera, R.6
Camps, C.7
Marinez, I.8
Busund, L.T.9
-
61
-
-
84893736743
-
Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells
-
Guan, J.; Zhang, H.;Wen, Z.; Gu, Y.M.; Cheng, Y.; Sun, Y.; Zhang, T.T.; Jia, C.W.; Lu, Z.H.; Chen, J. Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells. Cancer Lett. 2014, 345, 132-139.
-
(2014)
Cancer Lett.
, vol.345
, pp. 132-139
-
-
Guan, J.1
Zhang, H.2
Wen, Z.3
Gu, Y.M.4
Cheng, Y.5
Sun, Y.6
Zhang, T.T.7
Jia, C.W.8
Lu, Z.H.9
Chen, J.10
-
62
-
-
84908602903
-
Epithelial-mesenchymal transition and drug resistance: Role, molecular mechanisms, and therapeutic strategies
-
Sui, H.; Zhu, L.; Deng, W.; Li, Q. Epithelial-mesenchymal transition and drug resistance: Role, molecular mechanisms, and therapeutic strategies. Oncol. Res. Treat. 2014, 37, 584-589.
-
(2014)
Oncol. Res. Treat
, vol.37
, pp. 584-589
-
-
Sui, H.1
Zhu, L.2
Deng, W.3
Li, Q.4
-
63
-
-
84855661853
-
Activation of PI3 kinase/Akt/HIF-1 alpha pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma
-
Jiao, M.; Nan, K.J. Activation of PI3 kinase/Akt/HIF-1 alpha pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma. Int. J. Oncol. 2012, 40, 461-468.
-
(2012)
Int. J. Oncol.
, vol.40
, pp. 461-468
-
-
Jiao, M.1
Nan, K.J.2
-
64
-
-
0030001378
-
P-glycoproteins and multidrug resistance
-
Bellamy, W.T. P-glycoproteins and multidrug resistance. Ann. Rev. Pharmacol. 1996, 36, 161-183.
-
(1996)
Ann. Rev. Pharmacol.
, vol.36
, pp. 161-183
-
-
Bellamy, W.T.1
-
65
-
-
0028816350
-
A Phase-III randomized study of oral verapamil as a chemosensitizer to reverse drug-resistance in patients with refractory myeloma - A Southwest Oncology Group study
-
Dalton, W.S.; Crowley, J.J.; Salmon, S.S.; Grogan, T.M.; Laufman, L.R.;Weiss, G.R.; Bonnet, J.D. A Phase-III randomized study of oral verapamil as a chemosensitizer to reverse drug-resistance in patients with refractory myeloma - A Southwest Oncology Group study. Cancer 1995, 75, 815-820.
-
(1995)
Cancer
, vol.75
, pp. 815-820
-
-
Dalton, W.S.1
Crowley, J.J.2
Salmon, S.S.3
Grogan, T.M.4
Laufman, L.R.5
Weiss, G.R.6
Bonnet, J.D.7
-
66
-
-
64349122714
-
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the P-glycoprotein (ABCB1) modulator tariquidar
-
Kuhnle, M.; Egger, M.; Muller, C.; Mahringer, A.; Bernhardt, G.; Fricker, G.; Konig, B.; Buschauer, A. Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the P-glycoprotein (ABCB1) modulator tariquidar. J. Med. Chem. 2009, 52, 1190-1197.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 1190-1197
-
-
Kuhnle, M.1
Egger, M.2
Muller, C.3
Mahringer, A.4
Bernhardt, G.5
Fricker, G.6
Konig, B.7
Buschauer, A.8
-
67
-
-
67349183943
-
A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia
-
Lancet, J.E.; Baer, M.R.; Duran, G.E.; List, A.F.; Fielding, R.; Marcelletti, J.F.; Multani, P.S.; Sikic, B.I. A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia. Leuk. Res. 2009, 33, 1055-1061.
-
(2009)
Leuk. Res.
, vol.33
, pp. 1055-1061
-
-
Lancet, J.E.1
Baer, M.R.2
Duran, G.E.3
List, A.F.4
Fielding, R.5
Marcelletti, J.F.6
Multani, P.S.7
Sikic, B.I.8
-
68
-
-
68749099671
-
Identification of selective inhibitors of cancer stem cells by high-throughput screening
-
Gupta, P.B.; Onder, T.T.; Jiang, G.; Tao, K.; Kuperwasser, C.;Weinberg, R.A.; Lander, E.S. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138, 645-659.
-
(2009)
Cell
, vol.138
, pp. 645-659
-
-
Gupta, P.B.1
Onder, T.T.2
Jiang, G.3
Tao, K.4
Kuperwasser, C.5
Weinberg, R.A.6
Lander, E.S.7
-
69
-
-
84929603385
-
Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the beta-catenin/TCF complex association via FOXO3a activation
-
Zhou, Y.; Liang, C.; Xue, F.; Chen, W.; Zhi, X.; Feng, X.; Bai, X.; Liang, T. Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the beta-catenin/TCF complex association via FOXO3a activation. Oncotarget 2015, 6, 10350-10365.
-
(2015)
Oncotarget
, vol.6
, pp. 10350-10365
-
-
Zhou, Y.1
Liang, C.2
Xue, F.3
Chen, W.4
Zhi, X.5
Feng, X.6
Bai, X.7
Liang, T.8
-
70
-
-
84955494637
-
Consecutive salinomycin treatment reduces doxorubicin resistance of breast tumor cells by diminishing drug efflux pump expression and activity
-
Hermawan, A.; Wagner, E.; Roidl, A. Consecutive salinomycin treatment reduces doxorubicin resistance of breast tumor cells by diminishing drug efflux pump expression and activity. Oncol. Rep. 2016, 35, 1732-1740.
-
(2016)
Oncol. Rep.
, vol.35
, pp. 1732-1740
-
-
Hermawan, A.1
Wagner, E.2
Roidl, A.3
-
71
-
-
84924516677
-
Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer
-
Toden, S.; Okugawa, Y.; Jascur, T.; Wodarz, D.; Komarova, N.L.; Buhrmann, C.; Shakibaei, M.; Boland, C.R.; Goel, A. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis 2015, 36, 355-367.
-
(2015)
Carcinogenesis
, vol.36
, pp. 355-367
-
-
Toden, S.1
Okugawa, Y.2
Jascur, T.3
Wodarz, D.4
Komarova, N.L.5
Buhrmann, C.6
Shakibaei, M.7
Boland, C.R.8
Goel, A.9
-
72
-
-
84930181902
-
ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat
-
Meidhof, S.; Brabletz, S.; Lehmann, W.; Preca, B.T.; Mock, K.; Ruh, M.; Schuler, J.; Berthold, M.;Weber, A.; Burk, U.; et al. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol. Med. 2015, 7, 831-847.
-
(2015)
EMBO Mol. Med.
, vol.7
, pp. 831-847
-
-
Meidhof, S.1
Brabletz, S.2
Lehmann, W.3
Preca, B.T.4
Mock, K.5
Ruh, M.6
Schuler, J.7
Berthold, M.8
Weber, A.9
Burk, U.10
-
73
-
-
84989344362
-
Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3 beta-Snail pathway
-
Namba, T.; Kodama, R.; Moritomo, S.; Hoshino, T.; Mizushima, T. Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3 beta-Snail pathway. Cell Death Dis. 2015, 6.
-
(2015)
Cell Death Dis.
, vol.6
-
-
Namba, T.1
Kodama, R.2
Moritomo, S.3
Hoshino, T.4
Mizushima, T.5
-
74
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans, J.M.; Donnelly, L.A.; Emslie-Smith, A.M.; Alessi, D.R.; Morris, A.D. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005, 330, 1304-1305.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
75
-
-
55449124298
-
Metformin suppresses intestinal polyp growth in ApcMin/+ mice
-
Tomimoto, A.; Endo, H.; Sugiyama, M.; Fujisawa, T.; Hosono, K.; Takahashi, H.; Nakajima, N.; Nagashima, Y.; Wada, K.; Nakagama, H.; et al. Metformin suppresses intestinal polyp growth in ApcMin/+ mice. Cancer Sci. 2008, 99, 2136-2141.
-
(2008)
Cancer Sci.
, vol.99
, pp. 2136-2141
-
-
Tomimoto, A.1
Endo, H.2
Sugiyama, M.3
Fujisawa, T.4
Hosono, K.5
Takahashi, H.6
Nakajima, N.7
Nagashima, Y.8
Wada, K.9
Nakagama, H.10
-
76
-
-
67749144226
-
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
-
Jiralerspong, S.; Palla, S.L.; Giordano, S.H.; Meric-Bernstam, F.; Liedtke, C.; Barnett, C.M.; Hsu, L.; Hung, M.C.; Hortobagyi, G.N.; Gonzalez-Angulo, A.M. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J. Clin. Oncol. 2009, 27, 3297-3302.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3297-3302
-
-
Jiralerspong, S.1
Palla, S.L.2
Giordano, S.H.3
Meric-Bernstam, F.4
Liedtke, C.5
Barnett, C.M.6
Hsu, L.7
Hung, M.C.8
Hortobagyi, G.N.9
Gonzalez-Angulo, A.M.10
-
77
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
Hirsch, H.A.; Iliopoulos, D.; Tsichlis, P.N.; Struhl, K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009, 69, 7507-7511.
-
(2009)
Cancer Res.
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
78
-
-
77957005003
-
Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status
-
Vazquez-Martin, A.; Oliveras-Ferraros, C.; Cufi, S.; Del Barco, S.; Martin-Castillo, B.; Menendez, J.A. Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status. Cell Cycle 2010, 9, 3807-3814.
-
(2010)
Cell Cycle
, vol.9
, pp. 3807-3814
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Cufi, S.3
Del Barco, S.4
Martin-Castillo, B.5
Menendez, J.A.6
-
79
-
-
84899733576
-
Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis
-
Zhao, Z.; Cheng, X.; Wang, Y.; Han, R.; Li, L.; Xiang, T.; He, L.; Long, H.; Zhu, B.; He, Y. Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis. PLoS ONE 2014, 9, e95884.
-
(2014)
PLoS ONE
, vol.9
-
-
Zhao, Z.1
Cheng, X.2
Wang, Y.3
Han, R.4
Li, L.5
Xiang, T.6
He, L.7
Long, H.8
Zhu, B.9
He, Y.10
-
80
-
-
84891532512
-
Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
-
Qu, C.; Zhang, W.; Zheng, G.; Zhang, Z.; Yin, J.; He, Z. Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells. Mol. Cell Biochem. 2014, 386, 63-71.
-
(2014)
Mol. Cell Biochem.
, vol.386
, pp. 63-71
-
-
Qu, C.1
Zhang, W.2
Zheng, G.3
Zhang, Z.4
Yin, J.5
He, Z.6
-
81
-
-
84907048181
-
AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis
-
Chou, C.C.; Lee, K.H.; Lai, I.L.;Wang, D.; Mo, X.; Kulp, S.K.; Shapiro, C.L.; Chen, C.S. AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis. Cancer Res. 2014, 74, 4783-4795.
-
(2014)
Cancer Res.
, vol.74
, pp. 4783-4795
-
-
Chou, C.C.1
Lee, K.H.2
Lai, I.L.3
Wang, D.4
Mo, X.5
Kulp, S.K.6
Shapiro, C.L.7
Chen, C.S.8
-
82
-
-
84941997589
-
Existing drugs and their application in drug discovery targeting cancer stem cells
-
Lv, J.F.; Shim, J.S. Existing drugs and their application in drug discovery targeting cancer stem cells. Arch. Pharm. Res. 2015, 38, 1617-1626.
-
(2015)
Arch. Pharm. Res.
, vol.38
, pp. 1617-1626
-
-
Lv, J.F.1
Shim, J.S.2
-
83
-
-
84863247475
-
A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma
-
Chua, K.N.; Sim, W.J.; Racine, V.; Lee, S.Y.; Goh, B.C.; Thiery, J.P. A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma. PLoS ONE 2012, 7, e33183.
-
(2012)
PLoS ONE
, vol.7
-
-
Chua, K.N.1
Sim, W.J.2
Racine, V.3
Lee, S.Y.4
Goh, B.C.5
Thiery, J.P.6
-
84
-
-
84873309547
-
Screening therapeutic EMT blocking agents in a three-dimensional microenvironment
-
Aref, A.R.; Huang, R.Y.; Yu, W.; Chua, K.N.; Sun, W.; Tu, T.Y.; Bai, J.; Sim, W.J.; Zervantonakis, I.K.; Thiery, J.P.; et al. Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr. Biol. 2013, 5, 381-389.
-
(2013)
Integr. Biol.
, vol.5
, pp. 381-389
-
-
Aref, A.R.1
Huang, R.Y.2
Yu, W.3
Chua, K.N.4
Sun, W.5
Tu, T.Y.6
Bai, J.7
Sim, W.J.8
Zervantonakis, I.K.9
Thiery, J.P.10
-
85
-
-
84946866413
-
Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment
-
Bai, J.; Tu, T.Y.; Kim, C.; Thiery, J.P.; Kamm, R.D. Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment. Oncotarget 2015, 6, 36603-36614.
-
(2015)
Oncotarget
, vol.6
, pp. 36603-36614
-
-
Bai, J.1
Tu, T.Y.2
Kim, C.3
Thiery, J.P.4
Kamm, R.D.5
-
86
-
-
84945374735
-
Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells
-
Wen, Z.; Feng, S.; Wei, L.; Wang, Z.; Hong, D.;Wang, Q. Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells. Int. J. Mol. Med. 2015, 36, 1657-1663.
-
(2015)
Int. J. Mol. Med.
, vol.36
, pp. 1657-1663
-
-
Wen, Z.1
Feng, S.2
Wei, L.3
Wang, Z.4
Hong, D.5
Wang, Q.6
-
87
-
-
84958948834
-
WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells
-
Xu, L.; Zhang, L.; Hu, C.; Liang, S.J.; Fei, X.C.; Yan, N.N.; Zhang, Y.Y.; Zhang, F.C. WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells. Int. J. Oncol. 2016, 48, 1175-1186.
-
(2016)
Int. J. Oncol.
, vol.48
, pp. 1175-1186
-
-
Xu, L.1
Zhang, L.2
Hu, C.3
Liang, S.J.4
Fei, X.C.5
Yan, N.N.6
Zhang, Y.Y.7
Zhang, F.C.8
-
88
-
-
84948581519
-
Moscatilin inhibits epithelial-to-mesenchymal transition and sensitizes anoikis in human lung cancer H460 cells
-
Busaranon, K.; Plaimee, P.; Sritularak, B.; Chanvorachote, P. Moscatilin inhibits epithelial-to-mesenchymal transition and sensitizes anoikis in human lung cancer H460 cells. J. Nat. Med. 2016, 70, 18-27.
-
(2016)
J. Nat. Med.
, vol.70
, pp. 18-27
-
-
Busaranon, K.1
Plaimee, P.2
Sritularak, B.3
Chanvorachote, P.4
-
89
-
-
84952050678
-
Inhibitory effects of metformin at low concentration on epithelial-mesenchymal transition of CD44(+)CD117(+) ovarian cancer stem cells
-
Zhang, R.R.; Zhang, P.;Wang, H.; Hou, D.M.; Li, W.T.; Xiao, G.S.; Li, C.W. Inhibitory effects of metformin at low concentration on epithelial-mesenchymal transition of CD44(+)CD117(+) ovarian cancer stem cells. Stem Cell Res. Ther. 2015, 6.
-
(2015)
Stem Cell Res. Ther.
, vol.6
-
-
Zhang, R.R.1
Zhang, P.2
Wang, H.3
Hou, D.M.4
Li, W.T.5
Xiao, G.S.6
Li, C.W.7
-
90
-
-
84951834982
-
Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway
-
Qin, G.; Xu, F.; Qin, T.; Zheng, Q.F.; Shi, D.B.; Xia, W.; Tian, Y.; Tang, Y.L.; Wang, J.S.; Xiao, X.S.; et al. Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway. Oncotarget 2015, 6, 41794-41808.
-
(2015)
Oncotarget
, vol.6
, pp. 41794-41808
-
-
Qin, G.1
Xu, F.2
Qin, T.3
Zheng, Q.F.4
Shi, D.B.5
Xia, W.6
Tian, Y.7
Tang, Y.L.8
Wang, J.S.9
Xiao, X.S.10
-
91
-
-
84954419881
-
Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1 alpha signalling
-
Xu, B.; Jiang, C.W.; Han, H.X.; Liu, H.; Tang, M.; Liu, L.X.; Ji, W.Y.; Lu, X.C.; Yang, X.L.; Zhang, Y.X.; et al. Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1 alpha signalling. Clin. Exp. Pharmacol. Phys. 2015, 42, 1296-1307.
-
(2015)
Clin. Exp. Pharmacol. Phys.
, vol.42
, pp. 1296-1307
-
-
Xu, B.1
Jiang, C.W.2
Han, H.X.3
Liu, H.4
Tang, M.5
Liu, L.X.6
Ji, W.Y.7
Lu, X.C.8
Yang, X.L.9
Zhang, Y.X.10
-
92
-
-
84951021829
-
Disulfiram inhibits TGF-beta-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-kappa B/Snail pathway
-
Han, D.; Wu, G.; Chang, C.; Zhu, F.; Xiao, Y.; Li, Q.H.; Zhang, T.; Zhang, L.L. Disulfiram inhibits TGF-beta-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-kappa B/Snail pathway. Oncotarget 2015, 6, 40907-40919.
-
(2015)
Oncotarget
, vol.6
, pp. 40907-40919
-
-
Han, D.1
Wu, G.2
Chang, C.3
Zhu, F.4
Xiao, Y.5
Li, Q.H.6
Zhang, T.7
Zhang, L.L.8
-
93
-
-
84942521960
-
Zerumbone attenuates TGF-beta 1-mediated epithelial-mesenchymal transition via upregulated E-cadherin expression and downregulated Smad2 signalling pathways in non-small cell lung cancer (A549) cells
-
Hseu, Y.C.; Huang, Y.C.; Korivi, M.;Wu, J.J.; Way, T.D.; Ou, T.T.; Chiu, L.W.; Lee, C.C.; Lin, M.L.; Yang, H.L. Zerumbone attenuates TGF-beta 1-mediated epithelial-mesenchymal transition via upregulated E-cadherin expression and downregulated Smad2 signalling pathways in non-small cell lung cancer (A549) cells. J. Funct. Foods 2015, 18, 58-72.
-
(2015)
J. Funct. Foods
, vol.18
, pp. 58-72
-
-
Hseu, Y.C.1
Huang, Y.C.2
Korivi, M.3
Wu, J.J.4
Way, T.D.5
Ou, T.T.6
Chiu, L.W.7
Lee, C.C.8
Lin, M.L.9
Yang, H.L.10
-
94
-
-
84938070381
-
Bufalin inhibits TGF-beta-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-beta receptors
-
Zhao, L.; Liu, S.Z.; Che, X.F.; Hou, K.Z.; Ma, Y.J.; Li, C.; Wen, T.; Fan, Y.B.; Hu, X.J.; Liu, Y.P.; et al. Bufalin inhibits TGF-beta-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-beta receptors. Int. J. Mol. Med. 2015, 36, 645-652.
-
(2015)
Int. J. Mol. Med.
, vol.36
, pp. 645-652
-
-
Zhao, L.1
Liu, S.Z.2
Che, X.F.3
Hou, K.Z.4
Ma, Y.J.5
Li, C.6
Wen, T.7
Fan, Y.B.8
Hu, X.J.9
Liu, Y.P.10
-
95
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel, D.P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004, 116, 281-297.
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
96
-
-
4644309196
-
The functions of animal microRNAs
-
Ambros, V. The functions of animal microRNAs. Nature 2004, 431, 350-355.
-
(2004)
Nature
, vol.431
, pp. 350-355
-
-
Ambros, V.1
-
97
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
Bartel, D.P. MicroRNAs: Target recognition and regulatory functions. Cell 2009, 136, 215-233.
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
98
-
-
77953022034
-
Implication of microRNAs in drug resistance for designing novel cancer therapy
-
Sarkar, F.H.; Li, Y.W.; Wang, Z.W.; Kong, D.J.; Ali, S. Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist. Update 2010, 13, 57-66.
-
(2010)
Drug Resist. Update
, vol.13
, pp. 57-66
-
-
Sarkar, F.H.1
Li, Y.W.2
Wang, Z.W.3
Kong, D.J.4
Ali, S.5
-
99
-
-
77957969261
-
Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance
-
Wang, Z.W.; Li, Y.W.; Ahmad, A.; Azmi, A.S.; Kong, D.J.; Banerjee, S.; Sarkar, F.H. Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance. Drug Resist. Update 2010, 13, 109-118.
-
(2010)
Drug Resist. Update
, vol.13
, pp. 109-118
-
-
Wang, Z.W.1
Li, Y.W.2
Ahmad, A.3
Azmi, A.S.4
Kong, D.J.5
Banerjee, S.6
Sarkar, F.H.7
-
100
-
-
43049103824
-
The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
-
Gregory, P.A.; Bert, A.G.; Paterson, E.L.; Barry, S.C.; Tsykin, A.; Farshid, G.; Vadas, M.A.; Khew-Goodall, Y.; Goodall, G.J. The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 2008, 10, 593-601.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 593-601
-
-
Gregory, P.A.1
Bert, A.G.2
Paterson, E.L.3
Barry, S.C.4
Tsykin, A.5
Farshid, G.6
Vadas, M.A.7
Khew-Goodall, Y.8
Goodall, G.J.9
-
101
-
-
41649091906
-
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
-
Park, S.M.; Gaur, A.B.; Lengyel, E.; Peter, M.E. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Gene Dev. 2008, 22, 894-907.
-
(2008)
Gene Dev.
, vol.22
, pp. 894-907
-
-
Park, S.M.1
Gaur, A.B.2
Lengyel, E.3
Peter, M.E.4
-
102
-
-
73049110243
-
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
-
Wellner, U.; Schubert, J.; Burk, U.C.; Schmalhofer, O.; Zhu, F.; Sonntag, A.; Waldvogel, B.; Vannier, C.; Darling, D.; zur Hausen, A.; et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat. Cell Biol. 2009, 11, U1487-U236.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. U1487-U2236
-
-
Wellner, U.1
Schubert, J.2
Burk, U.C.3
Schmalhofer, O.4
Zhu, F.5
Sonntag, A.6
Waldvogel, B.7
Vannier, C.8
Darling, D.9
Zur Hausen, A.10
-
103
-
-
44649163918
-
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
-
Burk, U.; Schubert, J.; Wellner, U.; Schmalhofer, O.; Vincan, E.; Spaderna, S.; Brabletz, T. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008, 9, 582-589.
-
(2008)
EMBO Rep.
, vol.9
, pp. 582-589
-
-
Burk, U.1
Schubert, J.2
Wellner, U.3
Schmalhofer, O.4
Vincan, E.5
Spaderna, S.6
Brabletz, T.7
-
104
-
-
84958980394
-
miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells
-
Nishijima, N.; Seike, M.; Soeno, C.; Chiba, M.; Miyanaga, A.; Noro, R.; Sugano, T.; Matsumoto, M.; Kubota, K.; Gema, A. miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells. Int. J. Oncol. 2016, 48, 937-944.
-
(2016)
Int. J. Oncol.
, vol.48
, pp. 937-944
-
-
Nishijima, N.1
Seike, M.2
Soeno, C.3
Chiba, M.4
Miyanaga, A.5
Noro, R.6
Sugano, T.7
Matsumoto, M.8
Kubota, K.9
Gema, A.10
-
105
-
-
84922714354
-
Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
-
Ma, J.; Fang, B.B.; Zeng, F.P.; Ma, C.; Pang, H.J.; Cheng, L.; Shi, Y.; Wang, H.; Yin, B.; Xia, J.; et al. Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Oncotarget 2015, 6, 1740-1749.
-
(2015)
Oncotarget
, vol.6
, pp. 1740-1749
-
-
Ma, J.1
Fang, B.B.2
Zeng, F.P.3
Ma, C.4
Pang, H.J.5
Cheng, L.6
Shi, Y.7
Wang, H.8
Yin, B.9
Xia, J.10
-
106
-
-
84923296705
-
MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells
-
Yang, Q.L.; Wang, Y.Y.; Lu, X.H.; Zhao, Z.L.; Zhu, L.H.; Chen, S.L.; Wu, Q.; Chen, C.J.; Wang, Z.W. MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells. Oncotarget 2015, 6, 3268-3279.
-
(2015)
Oncotarget
, vol.6
, pp. 3268-3279
-
-
Yang, Q.L.1
Wang, Y.Y.2
Lu, X.H.3
Zhao, Z.L.4
Zhu, L.H.5
Chen, S.L.6
Wu, Q.7
Chen, C.J.8
Wang, Z.W.9
-
107
-
-
84955643085
-
miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin
-
Zhu, X.; Shen, H.; Yin, X.; Long, L.; Xie, C.; Liu, Y.; Hui, L.; Lin, X.; Fang, Y.; Cao, Y.; et al. miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin. Oncogene 2016, 35, 323-332.
-
(2016)
Oncogene
, vol.35
, pp. 323-332
-
-
Zhu, X.1
Shen, H.2
Yin, X.3
Long, L.4
Xie, C.5
Liu, Y.6
Hui, L.7
Lin, X.8
Fang, Y.9
Cao, Y.10
-
108
-
-
84927691071
-
miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells
-
Zhao, Z.; Zhang, L.; Yao, Q.; Tao, Z. miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells. Cancer Gene Ther. 2015, 22, 108-114.
-
(2015)
Cancer Gene Ther.
, vol.22
, pp. 108-114
-
-
Zhao, Z.1
Zhang, L.2
Yao, Q.3
Tao, Z.4
-
109
-
-
84927130210
-
The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells
-
Wang, R.; Li, Y.M.; Hou, Y.Y.; Yang, Q.L.; Chen, S.L.;Wang, X.; Wang, Z.S.; Yang, Y.; Chen, C.J.;Wang, Z.W.; et al. The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells. Oncotarget 2015, 6, 7000-7010.
-
(2015)
Oncotarget
, vol.6
, pp. 7000-7010
-
-
Wang, R.1
Li, Y.M.2
Hou, Y.Y.3
Yang, Q.L.4
Chen, S.L.5
Wang, X.6
Wang, Z.S.7
Yang, Y.8
Chen, C.J.9
Wang, Z.W.10
-
110
-
-
84928726641
-
MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2
-
Liao, H.Z.; Bai, Y.F.; Qiu, S.C.; Zheng, L.; Huang, L.Y.; Liu, T.Z.; Wang, X.; Liu, Y.T.; Xu, N.B.; Yan, X.H.; et al. MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2. Oncotarget 2015, 6, 8914-8928.
-
(2015)
Oncotarget
, vol.6
, pp. 8914-8928
-
-
Liao, H.Z.1
Bai, Y.F.2
Qiu, S.C.3
Zheng, L.4
Huang, L.Y.5
Liu, T.Z.6
Wang, X.7
Liu, Y.T.8
Xu, N.B.9
Yan, X.H.10
-
111
-
-
84874735111
-
Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer
-
Ward, A.; Balwierz, A.; Zhang, J.D.; Kublbeck, M.; Pawitan, Y.; Hielscher, T.; Wiemann, S.; Sahin, O. Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene 2013, 32, 1173-1182.
-
(2013)
Oncogene
, vol.32
, pp. 1173-1182
-
-
Ward, A.1
Balwierz, A.2
Zhang, J.D.3
Kublbeck, M.4
Pawitan, Y.5
Hielscher, T.6
Wiemann, S.7
Sahin, O.8
-
112
-
-
84934901525
-
miR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung adenocarcinoma cells
-
Li, J.P.; Wang, Y.P.; Song, Y.L.; Fu, Z.M.; Yu, W.J. miR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung adenocarcinoma cells. Mol. Cancer 2014, 13.
-
(2014)
Mol. Cancer
, vol.13
-
-
Li, J.P.1
Wang, Y.P.2
Song, Y.L.3
Fu, Z.M.4
Yu, W.J.5
-
113
-
-
84901009729
-
MiR-489 regulates chemoresistance in breast cancer via epithelial mesenchymal transition pathway
-
Jiang, L.; He, D.X.; Yang, D.T.; Chen, Z.; Pan, Q.X.; Mao, A.Q.; Cai, Y.F.; Li, X.Y.; Xing, H.; Shi, M.; et al. MiR-489 regulates chemoresistance in breast cancer via epithelial mesenchymal transition pathway. FEBS Lett. 2014, 588, 2009-2015.
-
(2014)
FEBS Lett.
, vol.588
, pp. 2009-2015
-
-
Jiang, L.1
He, D.X.2
Yang, D.T.3
Chen, Z.4
Pan, Q.X.5
Mao, A.Q.6
Cai, Y.F.7
Li, X.Y.8
Xing, H.9
Shi, M.10
-
114
-
-
84978131506
-
miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer
-
Tan, X.H.; Fu, Y.B.; Chen, L.; Lee, W.; Lai, Y.L.; Rezaei, K.; Tabbara, S.; Latham, P.; Teal, C.B.; Man, Y.G.; et al. miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer. Oncotarget 2016, 7, 293-307.
-
(2016)
Oncotarget
, vol.7
, pp. 293-307
-
-
Tan, X.H.1
Fu, Y.B.2
Chen, L.3
Lee, W.4
Lai, Y.L.5
Rezaei, K.6
Tabbara, S.7
Latham, P.8
Teal, C.B.9
Man, Y.G.10
-
115
-
-
84959144672
-
Cancer stem cells and chemoresistance: The smartest survives the raid
-
Zhao, J.H. Cancer stem cells and chemoresistance: The smartest survives the raid. Pharmacol. Ther. 2016, 160, 145-158.
-
(2016)
Pharmacol. Ther.
, vol.160
, pp. 145-158
-
-
Zhao, J.H.1
-
116
-
-
73449089494
-
Companies waver in efforts to target transforming growth factor beta in cancer
-
Garber, K. Companies waver in efforts to target transforming growth factor beta in cancer. J. Natl. Cancer Inst. 2009, 101, 1664-1666.
-
(2009)
J. Natl. Cancer Inst.
, vol.101
, pp. 1664-1666
-
-
Garber, K.1
-
117
-
-
80053585761
-
Induction of heart valve lesions by small-molecule ALK5 inhibitors
-
Anderton, M.J.; Mellor, H.R.; Bell, A.; Sadler, C.; Pass, M.; Powell, S.; Steele, S.J.; Roberts, R.R.A.; Heier, A. Induction of heart valve lesions by small-molecule ALK5 inhibitors. Toxicol. Pathol. 2011, 39, 916-924.
-
(2011)
Toxicol. Pathol.
, vol.39
, pp. 916-924
-
-
Anderton, M.J.1
Mellor, H.R.2
Bell, A.3
Sadler, C.4
Pass, M.5
Powell, S.6
Steele, S.J.7
Roberts, R.R.A.8
Heier, A.9
-
118
-
-
84939783826
-
Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
-
Herbertz, S.; Sawyer, J.S.; Stauber, A.J.; Gueorguieva, I.; Driscoll, K.E.; Estrem, S.T.; Cleverly, A.L.; Desaiah, D.; Guba, S.C.; Benhadji, K.A.; et al. Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway. Drug Des. Dev. Ther. 2015, 9, 4479-4499.
-
(2015)
Drug Des. Dev. Ther.
, vol.9
, pp. 4479-4499
-
-
Herbertz, S.1
Sawyer, J.S.2
Stauber, A.J.3
Gueorguieva, I.4
Driscoll, K.E.5
Estrem, S.T.6
Cleverly, A.L.7
Desaiah, D.8
Guba, S.C.9
Benhadji, K.A.10
-
119
-
-
84866029510
-
Complexities of TGF-beta targeted cancer therapy
-
Connolly, E.C.; Freimuth, J.; Akhurst, R.J. Complexities of TGF-beta targeted cancer therapy. Int. J. Biol. Sci. 2012, 8, 964-978.
-
(2012)
Int. J. Biol. Sci.
, vol.8
, pp. 964-978
-
-
Connolly, E.C.1
Freimuth, J.2
Akhurst, R.J.3
-
120
-
-
84959297670
-
Probing the fifty shades of EMT in metastasis
-
Li, W.; Kang, Y. Probing the fifty shades of EMT in metastasis. Trends Cancer 2016, 2, 65-67.
-
(2016)
Trends Cancer
, vol.2
, pp. 65-67
-
-
Li, W.1
Kang, Y.2
-
121
-
-
84870845421
-
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
-
Tsai, J.H.; Donaher, J.L.; Murphy, D.A.; Chau, S.; Yang, J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012, 22, 725-736.
-
(2012)
Cancer Cell
, vol.22
, pp. 725-736
-
-
Tsai, J.H.1
Donaher, J.L.2
Murphy, D.A.3
Chau, S.4
Yang, J.5
-
122
-
-
84870806564
-
EMT and MET in metastasis: Where are the cancer stem cells?
-
Brabletz, T. EMT and MET in metastasis: Where are the cancer stem cells? Cancer Cell 2012, 22, 699-701.
-
(2012)
Cancer Cell
, vol.22
, pp. 699-701
-
-
Brabletz, T.1
-
123
-
-
84954271052
-
Phenotypic plasticity determines cancer stem cell therapeutic resistance in oral squamous cell carcinoma
-
Biddle, A.; Gammon, L.; Liang, X.; Costea, D.E.; Mackenzie, I.C. Phenotypic plasticity determines cancer stem cell therapeutic resistance in oral squamous cell carcinoma. EBioMedicine 2016, 4, 138-145.
-
(2016)
EBioMedicine
, vol.4
, pp. 138-145
-
-
Biddle, A.1
Gammon, L.2
Liang, X.3
Costea, D.E.4
Mackenzie, I.C.5
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