Animal models and the tumor microenvironment: Studies of tumor-host symbiosis

Seminars in Oncology

Volumn 41, Issue 2, 2014, Pages 146-155

  Lindner, Daniel ^a  

^a TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; APOLIPOPROTEIN A1; THROMBOSPONDIN 1;

ACIDOSIS; ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER MODEL; CANCER SURVIVAL; CARCINOGENESIS; CELL METABOLISM; CHRONIC INFLAMMATION; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; HYPOXIA; METASTASIS; MURINE MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SYMBIOSIS; TISSUE PRESSURE; TUMOR HOST SYMBIOSIS; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION;

ACIDOSIS; ANGIOGENESIS INHIBITORS; ANIMALS; APOLIPOPROTEIN A-I; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; GENOTYPE; HUMANS; HYDROGEN-ION CONCENTRATION; INFLAMMATION; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; THROMBOSPONDIN 1; TREATMENT OUTCOME; TUMOR MICROENVIRONMENT;

EID: 84899735257     PISSN: 00937754     EISSN: 15328708     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2014.02.004     Document Type: Article

References (78)

1. C.C. Little The inheritance of cancer Science 42 1915 494 495
2. K. Polyak, I. Haviv, and I.G. Campbell Co-evolution of tumor cells and their microenvironment Trends Genet 25 2009 30 38
3. O. Warburg On the origin of cancer cells Science 123 1956 309 314
4. H. Hashizume, P. Baluk, S. Morikawa, J.W. McLean, G. Thurston, and S. Roberge et al. Openings between defective endothelial cells explain tumor vessel leakiness Am J Pathol 156 2000 1363 1380
5. D. Fukumura, and R.K. Jain Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization Microvasc Res 74 2007 72 84
6. O. Tredan, C.M. Galmarini, K. Patel, and I.F. Tannock Drug resistance and the solid tumor microenvironment J Natl Cancer Inst 99 2007 1441 1454
7. D.J. Lindner, and D. Raghavan Intra-tumoral extracellular pH: A useful parameter of response to chemotherapy in syngenic tumor lines Br J Cancer 100 2009 1287 1291
8. L.Q. Chen, C.M. Howison, J.J. Jeffery, I.F. Robey, P.H. Kuo, and M.D. Pagel Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI Magn Reson Med 2013 Nov 26 10.1002/mrm.25053 [Epub ahead of print]
9. K.S. Kim, W. Park, J. Hu, Y.H. Bae, and K. Na A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle Biomaterials 35 2014 337 343
10. R.O. Hynes The extracellular matrix: not just pretty fibrils Science 326 2009 1216 1219
11. K.P. Olive, M.A. Jacobetz, C.J. Davidson, A. Gopinathan, D. McIntyre, and D. Honess et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer Science 324 2009 1457 1461
12. A. Orimo, P.B. Gupta, D.C. Sgroi, F. Arenzana-Seisdedos, T. Delaunay, and R. Naeem et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion Cell 121 2005 335 348
13. I.P. Witz Tumor-microenvironment interactions: dangerous liaisons Adv Cancer Res 100 2008 203 229
14. P. Garin-Chesa, L.J. Old, and W.J. Rettig Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers Proc Natl Acad Sci U S A 87 1990 7235 7239
15. W.N. Brennen, D.M. Rosen, H. Wang, J.T. Isaacs, and S.R. Denmeade Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug J Natl Cancer Inst 104 2012 1320 1334
16. M. Kraman, P.J. Bambrough, J.N. Arnold, E.W. Roberts, L. Magiera, and J.O. Jones et al. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha Science 330 2010 827 830
17. M. Quante, S.P. Tu, H. Tomita, T. Gonda, S.S. Wang, and S. Takashi et al. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth Cancer Cell 19 2011 257 272
18. N.C. Direkze, K. Hodivala-Dilke, R. Jeffery, T. Hunt, R. Poulsom, and D. Oukrif et al. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts Cancer Res 64 2004 8492 8495
19. S. Pathak, M.A. Nemeth, A.S. Multani, G.N. Thalmann, A.C. von Eschenbach, and L.W. Chung Can cancer cells transform normal host cells into malignant cells? Br J Cancer 76 1997 1134 1138
20. S. Vijayakumar, D. Garcia, C.H. Hensel, M. Banerjee, T. Bracht, and R. Xiang et al. The human Y chromosome suppresses the tumorigenicity of PC-3, a human prostate cancer cell line, in athymic nude mice Genes Chromosomes Cancer 44 2005 365 372
21. F. Mbeunkui, and D.J. Johann Jr Cancer and the tumor microenvironment: a review of an essential relationship Cancer Chemother Pharmacol 63 2009 571 582
22. L. Devy, S. Blacher, C. Grignet-Debrus, K. Bajou, V. Masson, and R.D. Gerard et al. The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent FASEB J 16 2002 147 154
23. M.J. Hendrix, E.A. Seftor, A.R. Hess, and R.E. Seftor Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma Nat Rev Cancer 3 2003 411 421
24. Z.A. Khan, E. Boscolo, A. Picard, S. Psutka, J.M. Melero-Martin, and T.C. Bartch et al. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice J Clin Invest 118 2008 2592 2599
25. R.K. Jain Delivery of molecular medicine to solid tumors Science 271 1996 1079 1080
26. R.K. Jain Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy Science 307 2005 58 62
27. K. Hida, and M. Klagsbrun A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities Cancer Res 65 2005 2507 2510
28. R.A.B. Ezekowitz, J.B. Milliken, and J. Folkman Interferon alfa-2a therapy for life-threatening hemangiomas of infancy N Engl J Med 326 1992 1456 1463
29. F. Belardelli, I. Gresser, C. Maury, P. Duvillard, M. Prade, and M.T. Maunoury Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously Int J Cancer 31 1983 649 653
30. Y.A. Sidky, and E.C. Borden Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses Cancer Res 47 1987 5155 5161
31. K.L. Taylor, R.K. Oates, R.W. Grane, D.W. Leaman, E.C. Borden, and D.J. Lindner Interferon-alpha1,8 inhibits tumor-induced angiogenesis in murine angiosarcomas J Interferon Cytokine Res 26 2006 353 361
32. B. Chiavarina, D. Whitaker-Menezes, G. Migneco, U.E. Martinez-Outschoorn, S. Pavlides, and A. Howell et al. HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: autophagy drives compartment-specific oncogenesis Cell Cycle 9 2010 3534 3551
33. D. Lukashev, B. Klebanov, H. Kojima, A. Grinberg, A. Ohta, and L. Berenfeld et al. Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes J Immunol 177 2006 4962 4965
34. M. Thiel, C.C. Caldwell, S. Kreth, S. Kuboki, P. Chen, and P. Smith et al. Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival PLoS One 2 2007 e853
35. C.A. Corzo, T. Condamine, L. Lu, M.J. Cotter, J.I. Youn, and P. Cheng et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment J Exp Med 207 2010 2439 2453
36. A. Mantovani Molecular pathways linking inflammation and cancer Curr Mol Med 10 2010 369 373
37. Y. Ben-Neriah, and M. Karin Inflammation meets cancer, with NF-kappaB as the matchmaker Nature Immunol 12 2011 715 723
38. F. Colotta, P. Allavena, A. Sica, C. Garlanda, and A. Mantovani Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability Carcinogenesis 30 2009 1073 1081
39. K.A. Rye, C.A. Bursill, G. Lambert, F. Tabet, and P.J. Barter The metabolism and anti-atherogenic properties of HDL J Lipid Res 50 Suppl 2009 S195 S200
40. A.V. Khera, M. Cuchel, M. de la Llera-Moya, A. Rodrigues, M.F. Burke, and K. Jafri et al. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis N Engl J Med 364 2011 127 135
41. L. Camont, M.J. Chapman, and A. Kontush Biological activities of HDL subpopulations and their relevance to cardiovascular disease Trends Mol Med 17 2011 594 603
42. S.M. Gordon, S. Hofmann, D.S. Askew, and W.S. Davidson High density lipoprotein: it's not just about lipid transport anymore Trends Endocrinol Metab 22 2011 9 15
43. G.W. Cockerill, K.A. Rye, J.R. Gamble, M.A. Vadas, and P.J. Barter High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules Arterioscler Thromb Vasc Biol 15 1995 1987 1994
44. R.V. Srinivas, Y.V. Venkatachalapathi, Z. Rui, R.J. Owens, K.B. Gupta, and S.K. Srinivas et al. Inhibition of virus-induced cell fusion by apolipoprotein A-I and its amphipathic peptide analogs J Cell Biochem 45 1991 224 237
45. I.P. Singh, A.K. Chopra, D.H. Coppenhaver, G.M. Ananatharamaiah, and S. Baron Lipoproteins account for part of the broad non-specific antiviral activity of human serum Antiviral Res 42 1999 211 218
46. N. Tada, T. Sakamoto, A. Kagami, K. Mochizuki, and K. Kurosaka Antimicrobial activity of lipoprotein particles containing apolipoprotein Al Mol Cell Biochem 119 1993 171 178
47. A.J. Wilhelm, M. Zabalawi, J.S. Owen, D. Shah, J.M. Grayson, and A.S. Major et al. Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-/-, ApoA-I-/- mice J Biol Chem 285 2010 36158 36169
48. D.M. Levine, T.S. Parker, T.M. Donnelly, A. Walsh, and A.L. Rubin In vivo protection against endotoxin by plasma high density lipoprotein Proc Natl Acad Sci U S A 90 1993 12040 12044
49. C. Grunfeld, M. Marshall, J.K. Shigenaga, A.H. Moser, P. Tobias, and K.R. Feingold Lipoproteins inhibit macrophage activation by lipoteichoic acid J Lipid Res 40 1999 245 252
50. M. Zamanian-Daryoush, D.J. Lindner, T.C. Tallant, Z.J.B. Wang, E. Klipfell, and Y. Parker et al. The cardioprotective protein apoA1 promotes potent anti-tumorigenic effects J Biol Chem M113 2013 468967
51. X.Z. West, N.L. Malinin, A.A. Merkulova, M. Tischenko, B.A. Kerr, and E.C. Borden et al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands Nature 467 2010 972 976
52. S. Kim, and M. Karin Role of TLR2-dependent inflammation in metastatic progression Ann N Y Acad Sci 1217 2011 191 206
53. R.L. Silverstein, and M. Febbraio CD36-TSP-HRGP interactions in the regulation of angiogenesis Curr Pharm Des 13 2007 3559 3567
54. Q. Li, N. Ahuja, P.C. Burger, and J.P. Issa Methylation and silencing of the Thrombospondin-1 promoter in human cancer Oncogene 18 1991 3284 3289
55. Q.W. Yang, S. Liu, Y. Tian, H.R. Salwen, A. Chlenski, and J. Weinstein et al. Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma Cancer Res 63 2003 6299 6310
56. S. Lee, K.S. Hwang, H.J. Lee, J.S. Kim, and G.H. Kang Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia Lab Invest 84 2004 884 893
57. H.C. Kim, J.C. Kim, S.A. Roh, C.S. Yu, J.H. Yook, and S.T. Oh et al. Aberrant CpG island methylation in early-onset sporadic gastric carcinoma J Cancer Res Clin Oncol 131 2005 733 740
58. D.J. Lindner, Y. Wu, R.M. Haney, B.S. Jacobs, J.P. Fruehauf, and R. Tuthill et al. Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis Matrix Biol 32 2 2012 123 132
59. F. Rastinejad, P.J. Polverini, and N.P. Bouck Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene Cell 56 1989 345 355
60. G.N. Naumov, E. Bender, D. Zurakowski, S.Y. Kang, D. Sampson, and E. Flynn et al. A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype J Natl Cancer Inst 98 2006 316 325
61. H.F. Dvorak Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing N Engl J Med 315 1986 1650 1659
62. G.S. Ashcroft, X. Yang, A.B. Glick, M. Weinstein, J.L. Letterio, and D.E. Mizel et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response Nat Cell Biol 1 1999 260 266
63. G.S. Ashcroft Bidirectional regulation of macrophage function by TGF-beta Microbes Infect 1 1999 1275 1282
64. F. Werner, M.K. Jain, M.W. Feinberg, N.E. Sibinga, A. Pellacani, and P. Wiesel et al. Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3 J Biol Chem 275 2000 36653 36658
65. Y. Sato, T. Ohshima, and T. Kondo Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing Biochem Biophys Res Commun 265 1999 194 199
66. C.N. Serhan Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators J Periodontol 79 2008 1520 1526
67. D.G. Greenhalgh The role of apoptosis in wound healing Int J Biochem Cell Biol 30 1998 1019 1030
68. G.A. McQuibban, J.H. Gong, E.M. Tam, C.A. McCulloch, I. Clark-Lewis, and C.M. Overall Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3 Science 289 2000 1202 1206
69. M. Spite, J. Claria, and CN. Serhan Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases Cell Metab 19 2014 21 36
70. S. Hong, and Y. Lu Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury Front Immunol 4 2013 13
71. C.N. Serhan, and J. Savill Resolution of inflammation: the beginning programs the end Nat Immunol 6 2005 1191 1197
72. J.E. Jones, E.A. Nelson, and A. Al-Hity Skin grafting for venous leg ulcers Cochrane Database System Rev 1 2013 CD001737
73. D. Blanco, S. Vicent, M.F. Fraga, I. Fernandez-Garcia, J. Freire, and A. Lujambio et al. Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway Neoplasia 9 2007 840 852
74. T. Tanaka Development of an inflammation-associated colorectal cancer model and its application for research on carcinogenesis and chemoprevention Int J Inflamm 2012 658786
75. T. Tanaka, H. Kohno, R. Suzuki, Y. Yamada, S. Sugie, and H. Mori A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate Cancer Sci 94 2003 965 973
76. D.W. Rosenberg, C. Giardina, and T. Tanaka Mouse models for the study of colon carcinogenesis Carcinogenesis 30 2009 183 196
77. T. Tanaka Preclinical cancer chemoprevention studies using animal model of inflammation-associated colorectal carcinogenesis Cancers 4 2012 673 700
78. Y.J. Kim, K.S. Hong, J.W. Chung, J.H. Kim, and K.B. Hahm Prevention of colitis-associated carcinogenesis with infliximab Cancer Prev Res 3 2010 1314 1333