메뉴 건너뛰기




Volumn 37, Issue 10, 2014, Pages 584-589

Epithelial-mesenchymal transition and drug resistance: Role, molecular mechanisms, and therapeutic strategies

Author keywords

Drug resistance; Epithelial mesenchymal transition; Microenvironment; microRNAs; Signal transduction pathway

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; CURCUMIN; ERLOTINIB; GEFITINIB; HYPOXIA INDUCIBLE FACTOR 1; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR PROTEIN;

EID: 84908602903     PISSN: 22965270     EISSN: 22965262     Source Type: Journal    
DOI: 10.1159/000367802     Document Type: Review
Times cited : (77)

References (59)
  • 2
    • 84896056524 scopus 로고    scopus 로고
    • Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition
    • Gros J, Tabin CJ: Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition. Science 2014;343:1253-6.
    • (2014) Science , vol.343 , pp. 1253-1256
    • Gros, J.1    Tabin, C.J.2
  • 3
    • 84888201303 scopus 로고    scopus 로고
    • Role of integrated cancer nanomedicine in overcoming drug resistance
    • Iyer AK, Singh A, Ganta S, Amiji MM: Role of integrated cancer nanomedicine in overcoming drug resistance. Adv Drug Deliv Rev 2013;65:1784-802.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 1784-1802
    • Iyer, A.K.1    Singh, A.2    Ganta, S.3    Amiji, M.M.4
  • 4
    • 0020358296 scopus 로고
    • Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells
    • Greenburg G, Hay ED: Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol 1982;95:333-9.
    • (1982) J Cell Biol , vol.95 , pp. 333-339
    • Greenburg, G.1    Hay, E.D.2
  • 6
    • 0028317081 scopus 로고
    • Modulations of the epithelial phenotype during embryogenesis and cancer progression
    • Savagner P, Boyer B, Valles AM, Jouanneau J, Thiery JP: Modulations of the epithelial phenotype during embryogenesis and cancer progression. Cancer Treat Res 1994;71:229-49.
    • (1994) Cancer Treat Res , vol.71 , pp. 229-249
    • Savagner, P.1    Boyer, B.2    Valles, A.M.3    Jouanneau, J.4    Thiery, J.P.5
  • 7
    • 84880182318 scopus 로고    scopus 로고
    • Osmotic stress transcription factor 1b (Ostf1b) promotes migration properties with the modulation of epithelial mesenchymal transition (EMT) phenotype in human embryonic kidney cell
    • Lai KP, Law AY, Lau MC, Takei Y, Tse WK, Wong CK: Osmotic stress transcription factor 1b (Ostf1b) promotes migration properties with the modulation of epithelial mesenchymal transition (EMT) phenotype in human embryonic kidney cell. Int J Biochem Cell Biol 2013;45:1921-6.
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 1921-1926
    • Lai, K.P.1    Law, A.Y.2    Lau, M.C.3    Takei, Y.4    Tse, W.K.5    Wong, C.K.6
  • 8
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial- mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA: Epithelial- mesenchymal transitions in development and disease. Cell 2009;139:871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 9
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • Kang Y, Massagué J: Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004;118:277-9.
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massagué, J.2
  • 10
    • 84883337584 scopus 로고    scopus 로고
    • Multi-drug-resistant cells enriched from chronic myeloid leukemia cells by doxorubicin possess tumor-initiating-cell properties
    • Xin H, Kong Y, Jiang X, Wang K, Qin X, Miao ZH, Zhu Y, Tan W: Multi-drug-resistant cells enriched from chronic myeloid leukemia cells by doxorubicin possess tumor-initiating-cell properties. J Pharmacol Sci 2013;122:299-304.
    • (2013) J Pharmacol Sci , vol.122 , pp. 299-304
    • Xin, H.1    Kong, Y.2    Jiang, X.3    Wang, K.4    Qin, X.5    Miao, Z.H.6    Zhu, Y.7    Tan, W.8
  • 11
    • 33947528384 scopus 로고    scopus 로고
    • Snail silencing effectively suppresses tumour growth and invasiveness
    • Olmeda D, Jorda M, Peinado H, Fabra A, Cano A: Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene 2007;26:1862-74.
    • (2007) Oncogene , vol.26 , pp. 1862-1874
    • Olmeda, D.1    Jorda, M.2    Peinado, H.3    Fabra, A.4    Cano, A.5
  • 12
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D, Cano A: Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007;7:415-28.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 13
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • Singh A, Settleman J: EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010;29:4741-51.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 14
    • 84892852707 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition. What is the impact on breast cancer stem cells and drug resistance
    • pii:S0305-7372(13)00197-7
    • Mallini P, Lennard T, Kirby J, Meeson A: Epithelial-to-mesenchymal transition. What is the impact on breast cancer stem cells and drug resistance. Cancer Treat Rev 2013;pii:S0305-7372(13)00197-7.
    • (2013) Cancer Treat Rev
    • Mallini, P.1    Lennard, T.2    Kirby, J.3    Meeson, A.4
  • 15
    • 84860480401 scopus 로고    scopus 로고
    • Signal transduction pathways and transcriptional mechanisms of MDR1/Pgpmediated multidrug resistance in human cancer cells
    • Sui H, Fan ZZ Li Q: Signal transduction pathways and transcriptional mechanisms of MDR1/Pgpmediated multidrug resistance in human cancer cells. J Int Med Res 2012;40:426-35.
    • (2012) J Int Med Res , vol.40 , pp. 426-435
    • Sui, H.1    Fan, Z.Z.2    Li, Q.3
  • 16
    • 79955775908 scopus 로고    scopus 로고
    • COX-2 contributes to P-glycoproteinmediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer
    • Sui H, Zhou SF, Wang Y, Liu X, Zhou L, Yin P, Fan Z, Li Q: COX-2 contributes to P-glycoproteinmediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer. Carcinogenesis 2011;32:667-75.
    • (2011) Carcinogenesis , vol.32 , pp. 667-675
    • Sui, H.1    Zhou, S.F.2    Wang, Y.3    Liu, X.4    Zhou, L.5    Yin, P.6    Fan, Z.7    Li, Q.8
  • 17
    • 77958099641 scopus 로고    scopus 로고
    • Multiple drug resistance mechanisms in cancer
    • Baguley BC: Multiple drug resistance mechanisms in cancer. Mol Biotechnol 2010;46:308-16.
    • (2010) Mol Biotechnol , vol.46 , pp. 308-316
    • Baguley, B.C.1
  • 18
    • 27144477683 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
    • Thomson S, Buck E, Petti F, Griffin G, Brown E, Ramnarine N, Iwata KK, Gibson N, Haley JD: Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 2005;65:9455-62.
    • (2005) Cancer Res , vol.65 , pp. 9455-9462
    • Thomson, S.1    Buck, E.2    Petti, F.3    Griffin, G.4    Brown, E.5    Ramnarine, N.6    Iwata, K.K.7    Gibson, N.8    Haley, J.D.9
  • 19
    • 84892839751 scopus 로고    scopus 로고
    • Epithelial- to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance
    • Mallini P, Lennard T, Kirby J, Meeson A: Epithelial- to-mesenchymal transition: what is the impact on breast cancer stem cells and drug resistance. Cancer Treat Rev 2014;40:341-8.
    • (2014) Cancer Treat Rev , vol.40 , pp. 341-348
    • Mallini, P.1    Lennard, T.2    Kirby, J.3    Meeson, A.4
  • 20
    • 84901789420 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: Insights from cancer biology with therapeutic implications for colorectal cancer
    • Findlay VJ, Wang C, Watson DK, Camp ER: Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer. Cancer Gene Ther 2014;21:181-7.
    • (2014) Cancer Gene Ther , vol.21 , pp. 181-187
    • Findlay, V.J.1    Wang, C.2    Watson, D.K.3    Camp, E.R.4
  • 21
    • 84879106039 scopus 로고    scopus 로고
    • Notch3 induces epithelial-mesenchymal transition and attenuates carboplatin-induced apoptosis in ovarian cancer cells
    • Gupta N1, Xu Z, El-Sehemy A, Steed H, Fu Y: Notch3 induces epithelial-mesenchymal transition and attenuates carboplatin-induced apoptosis in ovarian cancer cells. Gynecol Oncol 2013;130:200-6.
    • (2013) Gynecol Oncol , vol.130 , pp. 200-206
    • Gupta, N.1    Xu, Z.2    El-Sehemy, A.3    Steed, H.4    Fu, Y.5
  • 22
    • 85052549631 scopus 로고    scopus 로고
    • Prognostic significance of the epithelial-to-mesenchymal transition markers e-cadherin, vimentin and twist in bladder cancer
    • Zhao J, Dong D, Sun L, Zhang G, Sun L: Prognostic significance of the epithelial-to-mesenchymal transition markers e-cadherin, vimentin and twist in bladder cancer. Int Braz J Urol 2014;40:179-189.
    • (2014) Int Braz J Urol , vol.40 , pp. 179-189
    • Zhao, J.1    Dong, D.2    Sun, L.3    Zhang, G.4    Sun, L.5
  • 24
    • 84892839751 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance
    • Mallini P, Lennard T, Kirby J, Meeson A: Epithelial-to-mesenchymal transition: what is the impact on breast cancer stem cells and drug resistance. Cancer Treat Rev 2014;40:341-8.
    • (2014) Cancer Treat Rev , vol.40 , pp. 341-348
    • Mallini, P.1    Lennard, T.2    Kirby, J.3    Meeson, A.4
  • 25
    • 78649872745 scopus 로고    scopus 로고
    • Metformin against TGFβ- induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis
    • Cufí S, Martin AV, Ferraros CO, Martin-Castillo B, Joven J, Menendez JA: Metformin against TGFβ- induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis. Cell Cycle 2010;9:4461-8.
    • (2010) Cell Cycle , vol.9 , pp. 4461-4468
    • Cufí, S.1    Martin, A.V.2    Ferraros, C.O.3    Martin-Castillo, B.4    Joven, J.5    Menendez, J.A.6
  • 26
    • 64249150262 scopus 로고    scopus 로고
    • MDR1/P-gp and VEGF synergistically enhance the invasion of Hep-2 cells with multidrug resistance induced by taxol
    • Li L, Jiang AC, Dong P, Wang H, Xu W, Xu C: MDR1/P-gp and VEGF synergistically enhance the invasion of Hep-2 cells with multidrug resistance induced by taxol. Ann Surg Oncol 2009;16: 1421-28.
    • (2009) Ann Surg Oncol , vol.16 , pp. 1421-1428
    • Li, L.1    Jiang, A.C.2    Dong, P.3    Wang, H.4    Xu, W.5    Xu, C.6
  • 27
    • 84860529329 scopus 로고    scopus 로고
    • Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
    • Jang JY, Kim MK, Jeon YK, Joung YK, Park KD, Kim CW: Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells. Exp Mol Med 2012;44:251-9.
    • (2012) Exp Mol Med , vol.44 , pp. 251-259
    • Jang, J.Y.1    Kim, M.K.2    Jeon, Y.K.3    Joung, Y.K.4    Park, K.D.5    Kim, C.W.6
  • 28
    • 80051495448 scopus 로고    scopus 로고
    • Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters
    • Saxena M, Stephens MA, Pathak H, Rangarajan A: Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters. Cell Death Dis 2011;2:e179.
    • (2011) Cell Death Dis , vol.2 , pp. e179
    • Saxena, M.1    Stephens, M.A.2    Pathak, H.3    Rangarajan, A.4
  • 29
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • Liotta LA, Kohn EC: The microenvironment of the tumour-host interface. Nature 2001;411:375-9.
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 30
    • 84859715721 scopus 로고    scopus 로고
    • Tumor microenvironment: A main actor in the metastasis process
    • Spano D, Zollo M: Tumor microenvironment: a main actor in the metastasis process. Clin Exp Metastasis 2012;29:381-95.
    • (2012) Clin Exp Metastasis , vol.29 , pp. 381-395
    • Spano, D.1    Zollo, M.2
  • 31
    • 84893736743 scopus 로고    scopus 로고
    • Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells
    • Guan J, Zhang H, Wen Z, Gu Y, Cheng Y, Sun Y, Zhang T, Jia C, Lu Z, Chen J: Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells. Cancer Lett 2014;345:132-9.
    • (2014) Cancer Lett , vol.345 , pp. 132-139
    • Guan, J.1    Zhang, H.2    Wen, Z.3    Gu, Y.4    Cheng, Y.5    Sun, Y.6    Zhang, T.7    Jia, C.8    Lu, Z.9    Chen, J.10
  • 37
    • 61449136971 scopus 로고    scopus 로고
    • Hypoxia-mediated up-regulation of MGr1-Ag/37LRP in gastric cancers occurs via hypoxia-inducible-factor 1-dependent mechanism and contributes to drug resistance
    • Liu L, Sun L, Zhang H, Li Z, Ning X, Shi Y, Guo C, Han S, Wu K, Fan D: Hypoxia-mediated up-regulation of MGr1-Ag/37LRP in gastric cancers occurs via hypoxia-inducible-factor 1-dependent mechanism and contributes to drug resistance. Int J Cancer 2009;124:1707-15.
    • (2009) Int J Cancer , vol.124 , pp. 1707-1715
    • Liu, L.1    Sun, L.2    Zhang, H.3    Li, Z.4    Ning, X.5    Shi, Y.6    Guo, C.7    Han, S.8    Wu, K.9    Fan, D.10
  • 38
    • 84879315192 scopus 로고    scopus 로고
    • Vasculogenic mimicry and aberrant expression of HIF-1α/E-cad are associated with worse prognosis of esophageal squamous cell carcinoma
    • Chai DM, Bao ZQ, Hu JG, Ma L, Feng ZZ, Tao YS: Vasculogenic mimicry and aberrant expression of HIF-1α/E-cad are associated with worse prognosis of esophageal squamous cell carcinoma. J Huazhong Univ Sci Technolog Med Sci 2013;33:385-91.
    • (2013) J Huazhong Univ Sci Technolog Med Sci , vol.33 , pp. 385-391
    • Chai, D.M.1    Bao, Z.Q.2    Hu, J.G.3    Ma, L.4    Feng, Z.Z.5    Tao, Y.S.6
  • 39
    • 84855661853 scopus 로고    scopus 로고
    • Activation of PI3 kinase/Akt/ HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma
    • Jiao M, Nan KJ: Activation of PI3 kinase/Akt/ HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma. Int J Oncol 2012;40:461-8.
    • (2012) Int J Oncol , vol.40 , pp. 461-468
    • Jiao, M.1    Nan, K.J.2
  • 40
    • 47549098136 scopus 로고    scopus 로고
    • The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression
    • Vincan E, Barker N: The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression. Clin Exp Metastasis 2008;25:657-63.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 657-663
    • Vincan, E.1    Barker, N.2
  • 41
    • 77957868981 scopus 로고    scopus 로고
    • ATF3, an adaptiveresponse gene, enhances TGF(beta) signaling and cancer-initiating cell features in breast cancer cells
    • Yin X, Wolford CC, Chang YS, McConoughey SJ, Ramsey SA, Aderem A, Hai T: ATF3, an adaptiveresponse gene, enhances TGF(beta) signaling and cancer-initiating cell features in breast cancer cells. J Cell Sci 2010;123:3558-65.
    • (2010) J Cell Sci , vol.123 , pp. 3558-3565
    • Yin, X.1    Wolford, C.C.2    Chang, Y.S.3    McConoughey, S.J.4    Ramsey, S.A.5    Aderem, A.6    Hai, T.7
  • 42
    • 80052947064 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations
    • Chen X, Lingala S, Khoobyari S, Nolta J, Zern MA, Wu J: Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations. J Hepatol 2011;55:838-45.
    • (2011) J Hepatol , vol.55 , pp. 838-845
    • Chen, X.1    Lingala, S.2    Khoobyari, S.3    Nolta, J.4    Zern, M.A.5    Wu, J.6
  • 43
    • 34347383964 scopus 로고    scopus 로고
    • Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax
    • Han Z, Hong L, Han Y, Wu K, Han S, Shen H, Li C, Yao L, Qiao T, Fan D: Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax. J Exp Clin Cancer Res 2007;26:261-8.
    • (2007) J Exp Clin Cancer Res , vol.26 , pp. 261-268
    • Han, Z.1    Hong, L.2    Han, Y.3    Wu, K.4    Han, S.5    Shen, H.6    Li, C.7    Yao, L.8    Qiao, T.9    Fan, D.10
  • 45
    • 84869053223 scopus 로고    scopus 로고
    • Quercetin suppresses drugresistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells
    • Chen SF, Nieh S, Jao SW, Liu CL, Wu CH, Chang YC, Yang CY, Lin YS: Quercetin suppresses drugresistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells. PLoS One 2012; 7:e49275.
    • (2012) PLoS One , vol.7 , pp. e49275
    • Chen, S.F.1    Nieh, S.2    Jao, S.W.3    Liu, C.L.4    Wu, C.H.5    Chang, Y.C.6    Yang, C.Y.7    Lin, Y.S.8
  • 46
    • 79960283982 scopus 로고    scopus 로고
    • The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1
    • Lander R, Nordin K, LaBonne C: The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1. J Cell Biol 2011; 194:17-25.
    • (2011) J Cell Biol , vol.194 , pp. 17-25
    • Lander, R.1    Nordin, K.2    Labonne, C.3
  • 47
    • 84891532512 scopus 로고    scopus 로고
    • Metformin reverses multidrug resistance and epithelial- mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
    • Qu C, Zhang W, Zheng G, Zhang Z, Yin J, He Z: Metformin reverses multidrug resistance and epithelial- mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells. Mol Cell Biochem 2014; 386:63-71.
    • (2014) Mol Cell Biochem , vol.386 , pp. 63-71
    • Qu, C.1    Zhang, W.2    Zheng, G.3    Zhang, Z.4    Yin, J.5    He, Z.6
  • 48
    • 81855224576 scopus 로고    scopus 로고
    • Epigenetics and genetics. MicroRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy
    • Kasinski AL, Slack FJ: Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer 2011;11:849-64.
    • (2011) Nat Rev Cancer , vol.11 , pp. 849-864
    • Kasinski, A.L.1    Slack, F.J.2
  • 49
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - Micro- RNAs with a role in cancer
    • Esquela-Kerscher A, Slack FJ: Oncomirs - micro- RNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-69.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 50
    • 82755182755 scopus 로고    scopus 로고
    • MicroRNA-9 up-regulates E-cadherin through inhibition of NF- B1-Snail1 pathway in melanoma
    • Liu S, Kumar SM, Lu H, Liu A, Yang R, Pushparajan A, Guo W, Xu X: MicroRNA-9 up-regulates E-cadherin through inhibition of NF- B1-Snail1 pathway in melanoma. J Pathol 2012;226:61-72.
    • (2012) J Pathol , vol.226 , pp. 61-72
    • Liu, S.1    Kumar, S.M.2    Lu, H.3    Liu, A.4    Yang, R.5    Pushparajan, A.6    Guo, W.7    Xu, X.8
  • 51
    • 80052316514 scopus 로고    scopus 로고
    • Targeting epigenetic regulation of miR- 34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
    • Nalls D, Tan SN, Rodova M, Srivastava RK, Shankar S: Targeting epigenetic regulation of miR- 34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS ONE 2011;6:1-12.
    • (2011) PLoS ONE , vol.6 , pp. 1-12
    • Nalls, D.1    Tan, S.N.2    Rodova, M.3    Srivastava, R.K.4    Shankar, S.5
  • 53
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIPI and the microRNA-200 family regulates epithelial-mesenchymal transition
    • Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, Goodall GJ: A double-negative feedback loop between ZEB1-SIPI and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 2008;68:7846-54.
    • (2008) Cancer Res , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6    Goodall, G.J.7
  • 54
    • 41649091906 scopus 로고    scopus 로고
    • The miR- 200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park SM, Gaur AB, Lengyel E, Peter ME: The miR- 200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008;22:894-907.
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 55
    • 66849113786 scopus 로고    scopus 로고
    • MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells
    • Pan YZ, Morris ME, Yu AM: MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells. Mol Pharmacol 2009;75:1374-9.
    • (2009) Mol Pharmacol , vol.75 , pp. 1374-1379
    • Pan, Y.Z.1    Morris, M.E.2    Yu, A.M.3
  • 56
    • 84884575302 scopus 로고    scopus 로고
    • MiR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/catenin pathway in hepatocellular carcinoma cells
    • Chen Z, Ma T, Huang C, Zhang L, Lv X, Xu T, Hu T, Li J: MiR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/catenin pathway in hepatocellular carcinoma cells. Cell Signal 2013;25: 2693-701.
    • (2013) Cell Signal , vol.25 , pp. 2693-2701
    • Chen, Z.1    Ma, T.2    Huang, C.3    Zhang, L.4    Lv, X.5    Xu, T.6    Hu, T.7    Li, J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.