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Volumn 75, Issue , 2017, Pages 94-105

Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia

Author keywords

Bilateral common carotid arteries occlusion; Cannabidiol; Neuroplasticity; Neuroprotection; White matter

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CANNABIDIOL; DOUBLECORTIN; MICROTUBULE ASSOCIATED PROTEIN 2; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; ANTIINFLAMMATORY AGENT; CALCIUM BINDING PROTEIN; DOUBLECORTIN PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; NEUROPEPTIDE;

EID: 85010450370     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2016.11.005     Document Type: Article
Times cited : (111)

References (86)
  • 1
    • 57849168951 scopus 로고    scopus 로고
    • Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets
    • Alvarez, F.J., Lafuente, H., Rey-Santano, M.C., Mielgo, V.E., Gastiasoro, E., Rueda, M., et al. Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. Pediatr. Res. 64 (2008), 653–658.
    • (2008) Pediatr. Res. , vol.64 , pp. 653-658
    • Alvarez, F.J.1    Lafuente, H.2    Rey-Santano, M.C.3    Mielgo, V.E.4    Gastiasoro, E.5    Rueda, M.6
  • 2
    • 84975506122 scopus 로고    scopus 로고
    • Postischemic fish oil treatment restores long-term retrograde memory and dendritic density: an analysis of the time window of efficacy
    • Bacarin, C.C., Godinho, J., de Oliveira, R.M., Matsushita, M., Gohara, A.K., Cardozo-Filho, L., et al. Postischemic fish oil treatment restores long-term retrograde memory and dendritic density: an analysis of the time window of efficacy. Behav. Brain Res. 311 (2016), 425–439.
    • (2016) Behav. Brain Res. , vol.311 , pp. 425-439
    • Bacarin, C.C.1    Godinho, J.2    de Oliveira, R.M.3    Matsushita, M.4    Gohara, A.K.5    Cardozo-Filho, L.6
  • 3
    • 84872809579 scopus 로고    scopus 로고
    • Characterization of long-term functional outcome in a murine model of mild brain ischemia
    • Balkaya, M., Krober, J., Gertz, K., Peruzzaro, S., Endres, M., Characterization of long-term functional outcome in a murine model of mild brain ischemia. J. Neurosci. Methods 213 (2013), 179–187.
    • (2013) J. Neurosci. Methods , vol.213 , pp. 179-187
    • Balkaya, M.1    Krober, J.2    Gertz, K.3    Peruzzaro, S.4    Endres, M.5
  • 5
    • 84981271785 scopus 로고    scopus 로고
    • Risk factors associated with early vs delayed dementia after intracerebral hemorrhage
    • Biffi, A., Bailey, D., Anderson, C.D., Ayres, A.M., Gurol, E.M., Greenberg, S.M., et al. Risk factors associated with early vs delayed dementia after intracerebral hemorrhage. JAMA Neurology 73 (2016), 969–976.
    • (2016) JAMA Neurology , vol.73 , pp. 969-976
    • Biffi, A.1    Bailey, D.2    Anderson, C.D.3    Ayres, A.M.4    Gurol, E.M.5    Greenberg, S.M.6
  • 8
    • 84867894237 scopus 로고    scopus 로고
    • The association between cognitive function and white matter lesion location in older adults: a systematic review
    • Bolandzadeh, N., Davis, J.C., Tam, R., Handy, T.C., Liu-Ambrose, T., The association between cognitive function and white matter lesion location in older adults: a systematic review. BMC Neurol., 12, 2012, 126.
    • (2012) BMC Neurol. , vol.12 , pp. 126
    • Bolandzadeh, N.1    Davis, J.C.2    Tam, R.3    Handy, T.C.4    Liu-Ambrose, T.5
  • 9
    • 0037707636 scopus 로고    scopus 로고
    • Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils
    • Braida, D., Pegorini, S., Arcidiacono, M.V., Consalez, G.G., Croci, L., Sala, M., Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils. Neurosci. Lett. 346 (2003), 61–64.
    • (2003) Neurosci. Lett. , vol.346 , pp. 61-64
    • Braida, D.1    Pegorini, S.2    Arcidiacono, M.V.3    Consalez, G.G.4    Croci, L.5    Sala, M.6
  • 10
    • 33645728922 scopus 로고    scopus 로고
    • Behaviorally induced synaptogenesis and dendritic growth in the hippocampal region following transient global cerebral ischemia are accompanied by improvement in spatial learning
    • Briones, T.L., Suh, E., Jozsa, L., Woods, J., Behaviorally induced synaptogenesis and dendritic growth in the hippocampal region following transient global cerebral ischemia are accompanied by improvement in spatial learning. Exp. Neurol. 198 (2006), 530–538.
    • (2006) Exp. Neurol. , vol.198 , pp. 530-538
    • Briones, T.L.1    Suh, E.2    Jozsa, L.3    Woods, J.4
  • 12
    • 46649094780 scopus 로고    scopus 로고
    • Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
    • Campos, A.C., Guimaraes, F.S., Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology 199 (2008), 223–230.
    • (2008) Psychopharmacology , vol.199 , pp. 223-230
    • Campos, A.C.1    Guimaraes, F.S.2
  • 14
    • 84921854170 scopus 로고    scopus 로고
    • Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria
    • Campos, A.C., Brant, F., Miranda, A.S., Machado, F.S., Teixeira, A.L., Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. Neuroscience 289 (2015), 166–180.
    • (2015) Neuroscience , vol.289 , pp. 166-180
    • Campos, A.C.1    Brant, F.2    Miranda, A.S.3    Machado, F.S.4    Teixeira, A.L.5
  • 15
    • 84866942852 scopus 로고    scopus 로고
    • Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors
    • Campos, A.C., Ferreira, F.R., Guimaraes, F.S., Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors. J. Psychiatr. Res. 46 (2012), 1501–1510.
    • (2012) J. Psychiatr. Res. , vol.46 , pp. 1501-1510
    • Campos, A.C.1    Ferreira, F.R.2    Guimaraes, F.S.3
  • 18
    • 0037151258 scopus 로고    scopus 로고
    • Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice
    • Carola, V., D'Olimpio, F., Brunamonti, E., Mangia, F., Renzi, P., Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behav. Brain Res. 134 (2002), 49–57.
    • (2002) Behav. Brain Res. , vol.134 , pp. 49-57
    • Carola, V.1    D'Olimpio, F.2    Brunamonti, E.3    Mangia, F.4    Renzi, P.5
  • 19
    • 72749107868 scopus 로고    scopus 로고
    • The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors
    • Castillo, A., Tolon, M.R., Fernandez-Ruiz, J., Romero, J., Martinez-Orgado, J., The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. Neurobiol. Dis. 37 (2010), 434–440.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 434-440
    • Castillo, A.1    Tolon, M.R.2    Fernandez-Ruiz, J.3    Romero, J.4    Martinez-Orgado, J.5
  • 21
    • 84907972104 scopus 로고    scopus 로고
    • Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice
    • Cheng, D., Spiro, A.S., Jenner, A.M., Garner, B., Karl, T., Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice. Journal of Alzheimer's Disease: JAD 42 (2014), 1383–1396.
    • (2014) Journal of Alzheimer's Disease: JAD , vol.42 , pp. 1383-1396
    • Cheng, D.1    Spiro, A.S.2    Jenner, A.M.3    Garner, B.4    Karl, T.5
  • 23
    • 84894372100 scopus 로고    scopus 로고
    • Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection
    • da Silva, V.K., de Freitas, B.S., da Silva, D.A., Nery, L.R., Falavigna, L., Ferreira, R.D., et al. Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection. Mol. Neurobiol. 49 (2014), 222–233.
    • (2014) Mol. Neurobiol. , vol.49 , pp. 222-233
    • da Silva, V.K.1    de Freitas, B.S.2    da Silva, D.A.3    Nery, L.R.4    Falavigna, L.5    Ferreira, R.D.6
  • 24
    • 0034078621 scopus 로고    scopus 로고
    • Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice
    • Dellu, F., Contarino, A., Simon, H., Koob, G.F., Gold, L.H., Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice. Neurobiol. Learn. Mem. 73 (2000), 31–48.
    • (2000) Neurobiol. Learn. Mem. , vol.73 , pp. 31-48
    • Dellu, F.1    Contarino, A.2    Simon, H.3    Koob, G.F.4    Gold, L.H.5
  • 26
    • 84899917648 scopus 로고    scopus 로고
    • Found in translation: preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes
    • Dirnagl, U., Endres, M., Found in translation: preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes. Stroke; A Journal of Cerebral Circulation 45 (2014), 1510–1518.
    • (2014) Stroke; A Journal of Cerebral Circulation , vol.45 , pp. 1510-1518
    • Dirnagl, U.1    Endres, M.2
  • 27
    • 84872256489 scopus 로고    scopus 로고
    • Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
    • Fernandez-Ruiz, J., Sagredo, O., Pazos, M.R., Garcia, C., Pertwee, R., Mechoulam, R., et al. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?. Br. J. Clin. Pharmacol. 75 (2013), 323–333.
    • (2013) Br. J. Clin. Pharmacol. , vol.75 , pp. 323-333
    • Fernandez-Ruiz, J.1    Sagredo, O.2    Pazos, M.R.3    Garcia, C.4    Pertwee, R.5    Mechoulam, R.6
  • 29
    • 84971652209 scopus 로고    scopus 로고
    • The Mouse Brain in Stereotaxic Coordinates
    • 2th Edn. Academic Press San Diego
    • Franklin, K.B.J., Paxinos, G., The Mouse Brain in Stereotaxic Coordinates. 2th Edn., 1997, Academic Press, San Diego.
    • (1997)
    • Franklin, K.B.J.1    Paxinos, G.2
  • 30
    • 33846401540 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties
    • Garcia-Arencibia, M., Gonzalez, S., de Lago, E., Ramos, J.A., Mechoulam, R., Fernandez-Ruiz, J., Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain Res. 1134 (2007), 162–170.
    • (2007) Brain Res. , vol.1134 , pp. 162-170
    • Garcia-Arencibia, M.1    Gonzalez, S.2    de Lago, E.3    Ramos, J.A.4    Mechoulam, R.5    Fernandez-Ruiz, J.6
  • 31
    • 55749104684 scopus 로고    scopus 로고
    • Long-term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons, following global cerebral ischemia and neuroprotective melatonin treatment, in rats
    • Garcia-Chavez, D., Gonzalez-Burgos, I., Letechipia-Vallejo, G., Lopez-Loeza, E., Morali, G., Cervantes, M., Long-term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons, following global cerebral ischemia and neuroprotective melatonin treatment, in rats. Neurosci. Lett. 448 (2008), 148–152.
    • (2008) Neurosci. Lett. , vol.448 , pp. 148-152
    • Garcia-Chavez, D.1    Gonzalez-Burgos, I.2    Letechipia-Vallejo, G.3    Lopez-Loeza, E.4    Morali, G.5    Cervantes, M.6
  • 34
    • 62949204563 scopus 로고    scopus 로고
    • Current status of neuroprotection for cerebral ischemia: synoptic overview
    • Ginsberg, M.D., Current status of neuroprotection for cerebral ischemia: synoptic overview. Stroke; A Journal of Cerebral Circulation 40 (2009), S111–S114.
    • (2009) Stroke; A Journal of Cerebral Circulation , vol.40 , pp. S111-S114
    • Ginsberg, M.D.1
  • 36
    • 81755173570 scopus 로고    scopus 로고
    • Role of microglia in CNS inflammation
    • Graeber, M.B., Li, W., Rodriguez, M.L., Role of microglia in CNS inflammation. FEBS Lett. 585 (2011), 3798–3805.
    • (2011) FEBS Lett. , vol.585 , pp. 3798-3805
    • Graeber, M.B.1    Li, W.2    Rodriguez, M.L.3
  • 39
    • 69949148000 scopus 로고    scopus 로고
    • Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism
    • Hayakawa, K., Irie, K., Sano, K., Watanabe, T., Higuchi, S., Enoki, M., et al. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism. Biol. Pharm. Bull. 32 (2009), 1538–1544.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 1538-1544
    • Hayakawa, K.1    Irie, K.2    Sano, K.3    Watanabe, T.4    Higuchi, S.5    Enoki, M.6
  • 40
    • 56249131093 scopus 로고    scopus 로고
    • Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism
    • Hayakawa, K., Mishima, K., Irie, K., Hazekawa, M., Mishima, S., Fujioka, M., et al. Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism. Neuropharmacology 55 (2008), 1280–1286.
    • (2008) Neuropharmacology , vol.55 , pp. 1280-1286
    • Hayakawa, K.1    Mishima, K.2    Irie, K.3    Hazekawa, M.4    Mishima, S.5    Fujioka, M.6
  • 41
    • 0021350250 scopus 로고
    • Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat
    • Johansen, F.F., Jorgensen, M.B., Ekstrom von Lubitz, D.K., Diemer, N.H., Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat. Brain Res.(291), 1984, 373–377.
    • (1984) Brain Res. , Issue.291 , pp. 373-377
    • Johansen, F.F.1    Jorgensen, M.B.2    Ekstrom von Lubitz, D.K.3    Diemer, N.H.4
  • 42
    • 0030010734 scopus 로고    scopus 로고
    • Nonuniform alteration of dendritic development in the cerebral cortex following prenatal cocaine exposure
    • Jones, L., Fischer, I., Levitt, P., Nonuniform alteration of dendritic development in the cerebral cortex following prenatal cocaine exposure. Cereb. Cortex 6 (1996), 431–445.
    • (1996) Cereb. Cortex , vol.6 , pp. 431-445
    • Jones, L.1    Fischer, I.2    Levitt, P.3
  • 43
    • 79961030495 scopus 로고    scopus 로고
    • Global variation in the relative burden of stroke and ischemic heart disease
    • Kim, A.S., Johnston, S.C., Global variation in the relative burden of stroke and ischemic heart disease. Circulation 124 (2011), 314–323.
    • (2011) Circulation , vol.124 , pp. 314-323
    • Kim, A.S.1    Johnston, S.C.2
  • 44
    • 84958750179 scopus 로고    scopus 로고
    • Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke
    • Kim, Y.R., Kim, H.N., Hong, K.W., Shin, H.K., Choi, B.T., Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke. Psychopharmacology 233 (2016), 1055–1066.
    • (2016) Psychopharmacology , vol.233 , pp. 1055-1066
    • Kim, Y.R.1    Kim, H.N.2    Hong, K.W.3    Shin, H.K.4    Choi, B.T.5
  • 45
    • 33947678712 scopus 로고    scopus 로고
    • Effects of fluoxetine on ischemic cells and expressions in BDNF and some antioxidants in the gerbil hippocampal CA1 region induced by transient ischemia
    • Kim, D.H., Li, H., Yoo, K.Y., Lee, B.H., Hwang, I.K., Won, M.H., Effects of fluoxetine on ischemic cells and expressions in BDNF and some antioxidants in the gerbil hippocampal CA1 region induced by transient ischemia. Exp. Neurol. 204 (2007), 748–758.
    • (2007) Exp. Neurol. , vol.204 , pp. 748-758
    • Kim, D.H.1    Li, H.2    Yoo, K.Y.3    Lee, B.H.4    Hwang, I.K.5    Won, M.H.6
  • 46
    • 33745788420 scopus 로고    scopus 로고
    • HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain
    • Kim, J.B., Sig Choi, J., Yu, Y.M., Nam, K., Piao, C.S., Kim, S.W., et al. HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J. Neurosci. Off. J. Soc. Neurosci. 26 (2006), 6413–6421.
    • (2006) J. Neurosci. Off. J. Soc. Neurosci. , vol.26 , pp. 6413-6421
    • Kim, J.B.1    Sig Choi, J.2    Yu, Y.M.3    Nam, K.4    Piao, C.S.5    Kim, S.W.6
  • 47
    • 78651246491 scopus 로고    scopus 로고
    • Transient brain ischemia due to cardiac arrest causes irreversible long-lasting cognitive injury
    • Kiryk, A., Pluta, R., Figiel, I., Mikosz, M., Ulamek, M., Niewiadomska, G., et al. Transient brain ischemia due to cardiac arrest causes irreversible long-lasting cognitive injury. Behav. Brain Res. 219 (2011), 1–7.
    • (2011) Behav. Brain Res. , vol.219 , pp. 1-7
    • Kiryk, A.1    Pluta, R.2    Figiel, I.3    Mikosz, M.4    Ulamek, M.5    Niewiadomska, G.6
  • 48
    • 79955929145 scopus 로고    scopus 로고
    • Microinjection of l-arginine into corpus callosum cause reduction in myelin concentration and neuroinflammation
    • Kouhsar, S.S., Karami, M., Tafreshi, A.P., Roghani, M., Nadoushan, M.R., Microinjection of l-arginine into corpus callosum cause reduction in myelin concentration and neuroinflammation. Brain Res. 1392 (2011), 93–100.
    • (2011) Brain Res. , vol.1392 , pp. 93-100
    • Kouhsar, S.S.1    Karami, M.2    Tafreshi, A.P.3    Roghani, M.4    Nadoushan, M.R.5
  • 49
    • 84907873949 scopus 로고    scopus 로고
    • Of mice and men: modelling post-stroke depression experimentally
    • Kronenberg, G., Gertz, K., Heinz, A., Endres, M., Of mice and men: modelling post-stroke depression experimentally. Br. J. Pharmacol. 171 (2014), 4673–4689.
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 4673-4689
    • Kronenberg, G.1    Gertz, K.2    Heinz, A.3    Endres, M.4
  • 50
    • 80051774451 scopus 로고    scopus 로고
    • Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
    • Lafuente, H., Alvarez, F.J., Pazos, M.R., Alvarez, A., Rey-Santano, M.C., Mielgo, V., et al. Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs. Pediatr. Res. 70 (2011), 272–277.
    • (2011) Pediatr. Res. , vol.70 , pp. 272-277
    • Lafuente, H.1    Alvarez, F.J.2    Pazos, M.R.3    Alvarez, A.4    Rey-Santano, M.C.5    Mielgo, V.6
  • 51
    • 79956155995 scopus 로고    scopus 로고
    • Pre- and post-treatments with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress
    • Lee, C.H., Park, J.H., Yoo, K.Y., Choi, J.H., Hwang, I.K., Ryu, P.D., et al. Pre- and post-treatments with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress. Exp. Neurol. 229 (2011), 450–459.
    • (2011) Exp. Neurol. , vol.229 , pp. 450-459
    • Lee, C.H.1    Park, J.H.2    Yoo, K.Y.3    Choi, J.H.4    Hwang, I.K.5    Ryu, P.D.6
  • 52
    • 84940092659 scopus 로고    scopus 로고
    • Pre- and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats
    • Lei, S., Zhang, P., Li, W., Gao, M., He, X., Zheng, J., et al. Pre- and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats. ASN Neuro., 6, 2014.
    • (2014) ASN Neuro. , vol.6
    • Lei, S.1    Zhang, P.2    Li, W.3    Gao, M.4    He, X.5    Zheng, J.6
  • 53
    • 84961614087 scopus 로고    scopus 로고
    • Cannabidiol and epilepsy: rationale and therapeutic potential
    • Leo, A., Russo, E., Elia, M., Cannabidiol and epilepsy: rationale and therapeutic potential. Pharmacol. Res. 107 (2016), 85–92.
    • (2016) Pharmacol. Res. , vol.107 , pp. 85-92
    • Leo, A.1    Russo, E.2    Elia, M.3
  • 54
    • 0031692291 scopus 로고    scopus 로고
    • Neuronal damage and plasticity identified by microtubule-associated protein 2, growth-associated protein 43, and cyclin D1 immunoreactivity after focal cerebral ischemia in rats
    • (discussion 80-1)
    • Li, Y., Jiang, N., Powers, C., Chopp, M., Neuronal damage and plasticity identified by microtubule-associated protein 2, growth-associated protein 43, and cyclin D1 immunoreactivity after focal cerebral ischemia in rats. Stroke; A Journal of Cerebral Circulation 29 (1998), 1972–1980 (discussion 80-1).
    • (1998) Stroke; A Journal of Cerebral Circulation , vol.29 , pp. 1972-1980
    • Li, Y.1    Jiang, N.2    Powers, C.3    Chopp, M.4
  • 55
    • 79956293339 scopus 로고    scopus 로고
    • Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease
    • Martin-Moreno, A.M., Reigada, D., Ramirez, B.G., Mechoulam, R., Innamorato, N., Cuadrado, A., et al. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease. Mol. Pharmacol. 79 (2011), 964–973.
    • (2011) Mol. Pharmacol. , vol.79 , pp. 964-973
    • Martin-Moreno, A.M.1    Reigada, D.2    Ramirez, B.G.3    Mechoulam, R.4    Innamorato, N.5    Cuadrado, A.6
  • 56
    • 0001123407 scopus 로고
    • A total synthesis of DL-delta-1-tetrahydrocannabinol, the active constituent of hashish
    • Mechoulam, R., Gaoni, Y., A total synthesis of DL-delta-1-tetrahydrocannabinol, the active constituent of hashish. J. Am. Chem. Soc. 87 (1965), 3273–3275.
    • (1965) J. Am. Chem. Soc. , vol.87 , pp. 3273-3275
    • Mechoulam, R.1    Gaoni, Y.2
  • 57
    • 18244396915 scopus 로고    scopus 로고
    • Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
    • Mishima, K., Hayakawa, K., Abe, K., Ikeda, T., Egashira, N., Iwasaki, K., et al. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke; A Journal of Cerebral Circulation 36 (2005), 1077–1082.
    • (2005) Stroke; A Journal of Cerebral Circulation , vol.36 , pp. 1077-1082
    • Mishima, K.1    Hayakawa, K.2    Abe, K.3    Ikeda, T.4    Egashira, N.5    Iwasaki, K.6
  • 59
    • 80052326280 scopus 로고    scopus 로고
    • Intravenous injection of neural progenitor cells improved depression-like behavior after cerebral ischemia
    • Moriyama, Y., Takagi, N., Tanonaka, K., Intravenous injection of neural progenitor cells improved depression-like behavior after cerebral ischemia. Transl. Psychiatry, 1, 2011, e29.
    • (2011) Transl. Psychiatry , vol.1
    • Moriyama, Y.1    Takagi, N.2    Tanonaka, K.3
  • 61
    • 0038054329 scopus 로고    scopus 로고
    • Possible role of nitric oxide in anxiety following transient cerebral ischemia in mice
    • Nakashima, M.N., Ajiki, K., Nakashima, K., Takahashi, M., Possible role of nitric oxide in anxiety following transient cerebral ischemia in mice. J. Pharmacol. Sci. 91 (2003), 47–52.
    • (2003) J. Pharmacol. Sci. , vol.91 , pp. 47-52
    • Nakashima, M.N.1    Ajiki, K.2    Nakashima, K.3    Takahashi, M.4
  • 63
    • 84931282585 scopus 로고    scopus 로고
    • The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis
    • Pang, C., Cao, L., Wu, F., Wang, L., Wang, G., Yu, Y., et al. The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis. Neuropharmacology 97 (2015), 447–456.
    • (2015) Neuropharmacology , vol.97 , pp. 447-456
    • Pang, C.1    Cao, L.2    Wu, F.3    Wang, L.4    Wang, G.5    Yu, Y.6
  • 64
    • 84864439799 scopus 로고    scopus 로고
    • Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
    • Pazos, M.R., Cinquina, V., Gomez, A., Layunta, R., Santos, M., Fernandez-Ruiz, J., et al. Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. Neuropharmacology 63 (2012), 776–783.
    • (2012) Neuropharmacology , vol.63 , pp. 776-783
    • Pazos, M.R.1    Cinquina, V.2    Gomez, A.3    Layunta, R.4    Santos, M.5    Fernandez-Ruiz, J.6
  • 65
    • 84878128163 scopus 로고    scopus 로고
    • Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors
    • Pazos, M.R., Mohammed, N., Lafuente, H., Santos, M., Martinez-Pinilla, E., Moreno, E., et al. Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors. Neuropharmacology 71 (2013), 282–291.
    • (2013) Neuropharmacology , vol.71 , pp. 282-291
    • Pazos, M.R.1    Mohammed, N.2    Lafuente, H.3    Santos, M.4    Martinez-Pinilla, E.5    Moreno, E.6
  • 66
    • 19444386763 scopus 로고    scopus 로고
    • Evidence that (−)-7-hydroxy-4′-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens
    • Pertwee, R.G., Thomas, A., Stevenson, L.A., Maor, Y., Mechoulam, R., Evidence that (−)-7-hydroxy-4′-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens. Neuropharmacology 48 (2005), 1139–1146.
    • (2005) Neuropharmacology , vol.48 , pp. 1139-1146
    • Pertwee, R.G.1    Thomas, A.2    Stevenson, L.A.3    Maor, Y.4    Mechoulam, R.5
  • 67
    • 0018196837 scopus 로고
    • Behavioural despair in rats and mice: strain differences and the effects of imipramine
    • Porsolt, R.D., Bertin, A., Jalfre, M., Behavioural despair in rats and mice: strain differences and the effects of imipramine. Eur. J. Pharmacol. 51 (1978), 291–294.
    • (1978) Eur. J. Pharmacol. , vol.51 , pp. 291-294
    • Porsolt, R.D.1    Bertin, A.2    Jalfre, M.3
  • 68
    • 33746647403 scopus 로고    scopus 로고
    • Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats
    • Resstel, L.B., Joca, S.R., Moreira, F.A., Correa, F.M., Guimaraes, F.S., Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats. Behav. Brain Res. 172 (2006), 294–298.
    • (2006) Behav. Brain Res. , vol.172 , pp. 294-298
    • Resstel, L.B.1    Joca, S.R.2    Moreira, F.A.3    Correa, F.M.4    Guimaraes, F.S.5
  • 69
    • 34247596903 scopus 로고    scopus 로고
    • The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat
    • Rutten, K., Lieben, C., Smits, L., Blokland, A., The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat. Psychopharmacology 192 (2007), 275–282.
    • (2007) Psychopharmacology , vol.192 , pp. 275-282
    • Rutten, K.1    Lieben, C.2    Smits, L.3    Blokland, A.4
  • 71
    • 84919385687 scopus 로고    scopus 로고
    • Protective effects of cannabidiol against hippocampal cell death and cognitive impairment induced by bilateral common carotid artery occlusion in mice
    • Schiavon, A.P., Soares, L.M., Bonato, J.M., Milani, H., Guimaraes, F.S., Weffort de Oliveira, R.M., Protective effects of cannabidiol against hippocampal cell death and cognitive impairment induced by bilateral common carotid artery occlusion in mice. Neurotox. Res. 26 (2014), 307–316.
    • (2014) Neurotox. Res. , vol.26 , pp. 307-316
    • Schiavon, A.P.1    Soares, L.M.2    Bonato, J.M.3    Milani, H.4    Guimaraes, F.S.5    Weffort de Oliveira, R.M.6
  • 72
    • 0026523687 scopus 로고
    • Prevention of ischemia-induced cerebral hypothermia by controlling the environmental temperature
    • Seif el Nasr, M., Nuglisch, J., Krieglstein, J., Prevention of ischemia-induced cerebral hypothermia by controlling the environmental temperature. J. Pharmacol. Toxicol. Methods 27 (1992), 23–26.
    • (1992) J. Pharmacol. Toxicol. Methods , vol.27 , pp. 23-26
    • Seif el Nasr, M.1    Nuglisch, J.2    Krieglstein, J.3
  • 74
    • 84963612235 scopus 로고    scopus 로고
    • Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia
    • Soares, L.M., De Vry, J., Steinbusch, H.W., Milani, H., Prickaerts, J., Weffort de Oliveira, R.M., Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia. Neuroscience 326 (2016), 69–83.
    • (2016) Neuroscience , vol.326 , pp. 69-83
    • Soares, L.M.1    De Vry, J.2    Steinbusch, H.W.3    Milani, H.4    Prickaerts, J.5    Weffort de Oliveira, R.M.6
  • 75
    • 84877818111 scopus 로고    scopus 로고
    • Cognitive impairment and persistent anxiety-related responses following bilateral common carotid artery occlusion in mice
    • Soares, L.M., Schiavon, A.P., Milani, H., de Oliveira, R.M., Cognitive impairment and persistent anxiety-related responses following bilateral common carotid artery occlusion in mice. Behav. Brain Res. 249 (2013), 28–37.
    • (2013) Behav. Brain Res. , vol.249 , pp. 28-37
    • Soares, L.M.1    Schiavon, A.P.2    Milani, H.3    de Oliveira, R.M.4
  • 76
    • 33750589667 scopus 로고    scopus 로고
    • Differential microglial regulation in the human spinal cord under normal and pathological conditions
    • Stoll, M., Capper, D., Dietz, K., Warth, A., Schleich, A., Schlaszus, H., et al. Differential microglial regulation in the human spinal cord under normal and pathological conditions. Neuropathol. Appl. Neurobiol. 32 (2006), 650–661.
    • (2006) Neuropathol. Appl. Neurobiol. , vol.32 , pp. 650-661
    • Stoll, M.1    Capper, D.2    Dietz, K.3    Warth, A.4    Schleich, A.5    Schlaszus, H.6
  • 77
    • 84970021364 scopus 로고    scopus 로고
    • Single administration of soluble epoxide hydrolase inhibitor suppresses neuroinflammation and improves neuronal damage after cardiac arrest in mice
    • Taguchi, N., Nakayama, S., Tanaka, M., Single administration of soluble epoxide hydrolase inhibitor suppresses neuroinflammation and improves neuronal damage after cardiac arrest in mice. Neurosci. Res., 2016.
    • (2016) Neurosci. Res.
    • Taguchi, N.1    Nakayama, S.2    Tanaka, M.3
  • 78
    • 67649367539 scopus 로고    scopus 로고
    • Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model
    • Ueno, Y., Zhang, N., Miyamoto, N., Tanaka, R., Hattori, N., Urabe, T., Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model. Neuroscience 162 (2009), 317–327.
    • (2009) Neuroscience , vol.162 , pp. 317-327
    • Ueno, Y.1    Zhang, N.2    Miyamoto, N.3    Tanaka, R.4    Hattori, N.5    Urabe, T.6
  • 79
    • 0037016322 scopus 로고    scopus 로고
    • Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat
    • Wakita, H., Tomimoto, H., Akiguchi, I., Matsuo, A., Lin, J.X., Ihara, M., McGeer, P.L., Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat. Brain Res. 924 (2002), 63–70.
    • (2002) Brain Res. , vol.924 , pp. 63-70
    • Wakita, H.1    Tomimoto, H.2    Akiguchi, I.3    Matsuo, A.4    Lin, J.X.5    Ihara, M.6    McGeer, P.L.7
  • 80
    • 0033524392 scopus 로고    scopus 로고
    • Neuroprotection with noninvasive neurotrophin delivery to the brain
    • Wu, D., Pardridge, W.M., Neuroprotection with noninvasive neurotrophin delivery to the brain. Proc. Natl. Acad. Sci. U. S. A. 96 (1999), 254–259.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 254-259
    • Wu, D.1    Pardridge, W.M.2
  • 81
    • 84878549874 scopus 로고    scopus 로고
    • Postsynaptic density protein (PSD)-95 expression is markedly decreased in the hippocampal CA1 region after experimental ischemia-reperfusion injury
    • Yan, B.C., Park, J.H., Ahn, J.H., Lee, J.C., Won, M.H., Kang, I.J., Postsynaptic density protein (PSD)-95 expression is markedly decreased in the hippocampal CA1 region after experimental ischemia-reperfusion injury. J. Neurol. Sci. 330 (2013), 111–116.
    • (2013) J. Neurol. Sci. , vol.330 , pp. 111-116
    • Yan, B.C.1    Park, J.H.2    Ahn, J.H.3    Lee, J.C.4    Won, M.H.5    Kang, I.J.6
  • 82
    • 79959362175 scopus 로고    scopus 로고
    • Temporal and sequential changes of glial cells and cytokine expression during neuronal degeneration after transient global ischemia in rats
    • Yasuda, Y., Shimoda, T., Uno, K., Tateishi, N., Furuya, S., Tsuchihashi, Y., et al. Temporal and sequential changes of glial cells and cytokine expression during neuronal degeneration after transient global ischemia in rats. J. Neuroinflammation, 8, 2011, 70.
    • (2011) J. Neuroinflammation , vol.8 , pp. 70
    • Yasuda, Y.1    Shimoda, T.2    Uno, K.3    Tateishi, N.4    Furuya, S.5    Tsuchihashi, Y.6
  • 83
    • 79953814728 scopus 로고    scopus 로고
    • Consistent injury to medium spiny neurons and white matter in the mouse striatum after prolonged transient global cerebral ischemia
    • Yoshioka, H., Niizuma, K., Katsu, M., Sakata, H., Okami, N., Chan, P.H., Consistent injury to medium spiny neurons and white matter in the mouse striatum after prolonged transient global cerebral ischemia. J. Neurotrauma 28 (2011), 649–660.
    • (2011) J. Neurotrauma , vol.28 , pp. 649-660
    • Yoshioka, H.1    Niizuma, K.2    Katsu, M.3    Sakata, H.4    Okami, N.5    Chan, P.H.6
  • 84
    • 1442275744 scopus 로고    scopus 로고
    • Functional reorganization of visual cortex maps after ischemic lesions is accompanied by changes in expression of cytoskeletal proteins and NMDA and GABA(A) receptor subunits
    • Zepeda, A., Sengpiel, F., Guagnelli, M.A., Vaca, L., Arias, C., Functional reorganization of visual cortex maps after ischemic lesions is accompanied by changes in expression of cytoskeletal proteins and NMDA and GABA(A) receptor subunits. J. Neurosci. Off. J. Soc. Neurosci. 24 (2004), 1812–1821.
    • (2004) J. Neurosci. Off. J. Soc. Neurosci. , vol.24 , pp. 1812-1821
    • Zepeda, A.1    Sengpiel, F.2    Guagnelli, M.A.3    Vaca, L.4    Arias, C.5
  • 85
    • 80051755292 scopus 로고    scopus 로고
    • Role of transcription factors in neurogenesis after cerebral ischemia
    • Zhang, C., Wu, H., Zhu, X., Wang, Y., Guo, J., Role of transcription factors in neurogenesis after cerebral ischemia. Rev. Neurosci. 22 (2011), 457–465.
    • (2011) Rev. Neurosci. , vol.22 , pp. 457-465
    • Zhang, C.1    Wu, H.2    Zhu, X.3    Wang, Y.4    Guo, J.5
  • 86
    • 3042817392 scopus 로고    scopus 로고
    • Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat
    • Zhang, R., Zhang, Z., Zhang, C., Zhang, L., Robin, A., Wang, Y., et al. Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat. J. Neurosci. Off. J. Soc. Neurosci. 24 (2004), 5810–5815.
    • (2004) J. Neurosci. Off. J. Soc. Neurosci. , vol.24 , pp. 5810-5815
    • Zhang, R.1    Zhang, Z.2    Zhang, C.3    Zhang, L.4    Robin, A.5    Wang, Y.6


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