메뉴 건너뛰기




Volumn 6, Issue 6, 2015, Pages

Pre- and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats

Author keywords

Cerebral ischemia; Edaravone; Neural stem progenitor cells; Neurogenesis; Neuroprotection; Reactive oxygen species

Indexed keywords

BROXURIDINE; CASPASE 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NORPHENAZONE; REACTIVE OXYGEN METABOLITE;

EID: 84940092659     PISSN: None     EISSN: 17590914     Source Type: Journal    
DOI: 10.1177/1759091414558417     Document Type: Article
Times cited : (26)

References (57)
  • 1
    • 34249026344 scopus 로고    scopus 로고
    • Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger
    • Akiyama, Y., & Miwa, S. (2007). Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger. Journal of Pharmacological Sciences, 104(1), 99–102.
    • (2007) Journal of Pharmacological Sciences , vol.104 , Issue.1 , pp. 99-102
    • Akiyama, Y.1    Miwa, S.2
  • 2
    • 1542268981 scopus 로고    scopus 로고
    • For the long run: Maintaining germinal niches in the adult brain
    • Alvarez-Buylla, A., & Lim, D. A. (2004). For the long run: Maintaining germinal niches in the adult brain. Neuron, 41, 1–686.
    • (2004) Neuron , vol.41 , pp. 1-686
    • Alvarez-Buylla, A.1    Lim, D.A.2
  • 4
    • 58149159724 scopus 로고    scopus 로고
    • Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model
    • Aoyama, T., Hida, K., Kuroda, S., Seki, T., Yano, S., Shichinohe, H., Iwasaki, Y. (2008). Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model. Neurologia Medico-chirurgica (Tokyo), 48, 539–545.
    • (2008) Neurologia Medico-Chirurgica (Tokyo) , vol.48 , pp. 539-545
    • Aoyama, T.1    Hida, K.2    Kuroda, S.3    Seki, T.4    Yano, S.5    Shichinohe, H.6    Iwasaki, Y.7
  • 5
    • 33847052793 scopus 로고    scopus 로고
    • Activation of leukocyte-endothelial interactions and reduction of selective neuronal death after global cerebral ischemia
    • Beck, J., Stummer, W., Lehmberg, J., Baethmann, A., & Uhl, E. (2007). Activation of leukocyte-endothelial interactions and reduction of selective neuronal death after global cerebral ischemia. Neuroscience Letters, 414, 159–164.
    • (2007) Neuroscience Letters , vol.414 , pp. 159-164
    • Beck, J.1    Stummer, W.2    Lehmberg, J.3    Baethmann, A.4    Uhl, E.5
  • 7
    • 26244436807 scopus 로고    scopus 로고
    • Ischemia-stimulated neurogenesis is regulated by proliferation, migration, differentiation and caspase activation of hippocampal precursor cells
    • Bingham, B., Liu, D., Wood, A., & Cho, S. (2005). Ischemia-stimulated neurogenesis is regulated by proliferation, migration, differentiation and caspase activation of hippocampal precursor cells. Brain Research, 1058, 167–177.
    • (2005) Brain Research , vol.1058 , pp. 167-177
    • Bingham, B.1    Liu, D.2    Wood, A.3    Cho, S.4
  • 9
    • 0029549426 scopus 로고
    • A cautionary note on the use of the TUNEL stain to determine apoptosis
    • Charriaut-Marlangue, C., & Ben-Ari, Y. (1995). A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport, 7, 61–64.
    • (1995) Neuroreport , vol.7 , pp. 61-64
    • Charriaut-Marlangue, C.1    Ben-Ari, Y.2
  • 10
    • 73049105131 scopus 로고    scopus 로고
    • Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro
    • Chen, X., Tian, Y., Yao, L., Zhang, J., & Liu, Y. (2010). Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro. Neuroscience, 165, 705–714.
    • (2010) Neuroscience , vol.165 , pp. 705-714
    • Chen, X.1    Tian, Y.2    Yao, L.3    Zhang, J.4    Liu, Y.5
  • 12
    • 0031953599 scopus 로고    scopus 로고
    • Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: Evidence for region-specific sensitivity and delayed damage
    • Dijkhuizen, R. M., Knollema, S., van der Worp, H. B., Ter Horst, G. J., De Wildt, D. J., Berkelbach van der Sprenkel, J. W., Nicolay, K. (1998). Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: Evidence for region-specific sensitivity and delayed damage. Stroke, 29(3), 695–704.
    • (1998) Stroke , vol.29 , Issue.3 , pp. 695-704
    • Dijkhuizen, R.M.1    Knollema, S.2    Van Der Worp, H.B.3    Ter Horst, G.J.4    De Wildt, D.J.5    Berkelbach Van Der Sprenkel, J.W.6    Nicolay, K.7
  • 14
    • 0024516804 scopus 로고
    • Simultaneous recording of local electrical activity, partial oxygen tension and temperature in the rat hippocampus with a chamber-type microelectrode. Effects of anaesthesia, ischemia and epilepsy
    • Freund, T. F., Buzsaki, G., Prohaska, O. J., Leon, A., & Somogyi, P. (1989). Simultaneous recording of local electrical activity, partial oxygen tension and temperature in the rat hippocampus with a chamber-type microelectrode. Effects of anaesthesia, ischemia and epilepsy. Neuroscience, 28(3), 539–549.
    • (1989) Neuroscience , vol.28 , Issue.3 , pp. 539-549
    • Freund, T.F.1    Buzsaki, G.2    Prohaska, O.J.3    Leon, A.4    Somogyi, P.5
  • 15
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • Gage, F. H. (2000). Mammalian neural stem cells. Science, 287, 1433–1438.
    • (2000) Science , vol.287 , pp. 1433-1438
    • Gage, F.H.1
  • 16
    • 70349540940 scopus 로고    scopus 로고
    • Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage
    • Gao, Y., Ding, X. S., Xu, S., Wang, W., Zuo, Q. L., & Kuai, F. (2009). Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage. Chinese Medical Journal (England), 122(16), 1935–1940.
    • (2009) Chinese Medical Journal (England) , vol.122 , Issue.16 , pp. 1935-1940
    • Gao, Y.1    Ding, X.S.2    Xu, S.3    Wang, W.4    Zuo, Q.L.5    Kuai, F.6
  • 17
    • 59249091238 scopus 로고    scopus 로고
    • Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells
    • Guan, S., Ge, D., Liu, T. Q., Ma, X. H., & Cui, Z. F. (2009). Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells. Toxicology in Vitro, 23(2), 201–208.
    • (2009) Toxicology in Vitro , vol.23 , Issue.2 , pp. 201-208
    • Guan, S.1    Ge, D.2    Liu, T.Q.3    Ma, X.H.4    Cui, Z.F.5
  • 18
    • 52049112539 scopus 로고    scopus 로고
    • Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells
    • Hwang, K. Y., Oh, Y. T., Yoon, H., Lee, J., Kim, H., Choe, W., Kang, I. (2008). Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells. Neuroscience Letters, 444, 264–269.
    • (2008) Neuroscience Letters , vol.444 , pp. 264-269
    • Hwang, K.Y.1    Oh, Y.T.2    Yoon, H.3    Lee, J.4    Kim, H.5    Choe, W.6    Kang, I.7
  • 19
    • 84872841796 scopus 로고    scopus 로고
    • Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region
    • Iscru, E., Ahmed, T., Coremans, V., Bozzi, Y., Caleo, M., Conway, E. M., Balschun, D. (2013). Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region. Neuroscience, 231, 413–419.
    • (2013) Neuroscience , vol.231 , pp. 413-419
    • Iscru, E.1    Ahmed, T.2    Coremans, V.3    Bozzi, Y.4    Caleo, M.5    Conway, E.M.6    Balschun, D.7
  • 20
    • 34548018803 scopus 로고    scopus 로고
    • The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress
    • Ishii, J., Natsume, A., Wakabayashi, T., Takeuchi, H., Hasegawa, H., Kim, S. U., Yoshida, J. (2007). The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress. Neuroscience Letters, 423, 225–230.
    • (2007) Neuroscience Letters , vol.423 , pp. 225-230
    • Ishii, J.1    Natsume, A.2    Wakabayashi, T.3    Takeuchi, H.4    Hasegawa, H.5    Kim, S.U.6    Yoshida, J.7
  • 21
    • 76849086226 scopus 로고    scopus 로고
    • Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumaticbrain injury in rats
    • Itoh, T., Satou, T., Nishida, S., Tsubaki, M., Imano, M., Hashimoto, S., Ito, H. (2010). Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumaticbrain injury in rats. Neurochemical Research, 35(2), 348–355.
    • (2010) Neurochemical Research , vol.35 , Issue.2 , pp. 348-355
    • Itoh, T.1    Satou, T.2    Nishida, S.3    Tsubaki, M.4    Imano, M.5    Hashimoto, S.6    Ito, H.7
  • 23
    • 0030979729 scopus 로고    scopus 로고
    • Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model
    • Kawai, H., Nakai, H., Suga, M., Yuki, S., Watanabe, T., & Saito, K. I. (1997). Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. Journal of Pharmacology and Experimental Therapeutics, 281, 921–927.
    • (1997) Journal of Pharmacology and Experimental Therapeutics , vol.281 , pp. 921-927
    • Kawai, H.1    Nakai, H.2    Suga, M.3    Yuki, S.4    Watanabe, T.5    Saito, K.I.6
  • 25
    • 84873876068 scopus 로고    scopus 로고
    • In vivo and in vitro treatment with edaravone promotes proliferation of neural progenitor cells generated following neuronal loss in the mouse dentate gyrus
    • Kikuta, M., Shiba, T., Yoneyama, M., Kawada, K., Yamaguchi, T., Hinoi, E., Ogita, K. (2013). In vivo and in vitro treatment with edaravone promotes proliferation of neural progenitor cells generated following neuronal loss in the mouse dentate gyrus. Journal of Pharmacological Sciences, 121(1), 74–83.
    • (2013) Journal of Pharmacological Sciences , vol.121 , Issue.1 , pp. 74-83
    • Kikuta, M.1    Shiba, T.2    Yoneyama, M.3    Kawada, K.4    Yamaguchi, T.5    Hinoi, E.6    Ogita, K.7
  • 26
    • 70450278715 scopus 로고    scopus 로고
    • Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway
    • Koshikawa, N., Hayashi, J., Nakagawara, A., & Takenaga, K. (2009). Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. Journal of Biological Chemistry, 284, 33185–33194.
    • (2009) Journal of Biological Chemistry , vol.284 , pp. 33185-33194
    • Koshikawa, N.1    Hayashi, J.2    Nakagawara, A.3    Takenaga, K.4
  • 27
    • 67649414918 scopus 로고    scopus 로고
    • Edaravone, a free radical scavenger, mitigates both gray and white matter damages after global cerebral ischemia in rats
    • Kubo, K., Nakao, S., Jomura, S., Sakamoto, S., Miyamoto, E., Xu, Y., Shingu, K. (2009). Edaravone, a free radical scavenger, mitigates both gray and white matter damages after global cerebral ischemia in rats. Brain Research, 1279, 139–146.
    • (2009) Brain Research , pp. 139-146
    • Kubo, K.1    Nakao, S.2    Jomura, S.3    Sakamoto, S.4    Miyamoto, E.5    Xu, Y.6    Shingu, K.7
  • 28
    • 0037377286 scopus 로고    scopus 로고
    • Optimisation of cell-based assays for medium throughput screening of oxidative stress
    • Lautraite, S., Bigot-Lasserre, D., Bars, R., & Carmichael, N. (2003). Optimisation of cell-based assays for medium throughput screening of oxidative stress. Toxicology in Vitro, 17, 207–220.
    • (2003) Toxicology in Vitro , vol.17 , pp. 207-220
    • Lautraite, S.1    Bigot-Lasserre, D.2    Bars, R.3    Carmichael, N.4
  • 29
    • 57449099856 scopus 로고    scopus 로고
    • Cilostazol preserves CA1 hippocampus and enhances generation of immature neuroblasts in dentate gyrus after transient forebrain ischemia in rats
    • Lee, J. H., Shin, H. K., Park, S. Y., Kim, C. D., Lee, W. S., & Hong, K. W. (2009). Cilostazol preserves CA1 hippocampus and enhances generation of immature neuroblasts in dentate gyrus after transient forebrain ischemia in rats. Experimental Neurology, 215(1), 87–94.
    • (2009) Experimental Neurology , vol.215 , Issue.1 , pp. 87-94
    • Lee, J.H.1    Shin, H.K.2    Park, S.Y.3    Kim, C.D.4    Lee, W.S.5    Hong, K.W.6
  • 30
    • 0032189609 scopus 로고    scopus 로고
    • Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils
    • Liu, J., Solway, K., Messing, R. O., & Sharp, F. R. (1998). Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. Journal of Neuroscience, 18, 7768–7778.
    • (1998) Journal of Neuroscience , vol.18 , pp. 7768-7778
    • Liu, J.1    Solway, K.2    Messing, R.O.3    Sharp, F.R.4
  • 31
    • 84855188430 scopus 로고    scopus 로고
    • Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils
    • Lu, F., Nakamura, T., Toyoshima, T., Liu, Y., Hirooka, K., Kawai, N., Itano, T. (2012). Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils. Neuroscience Letters, 506, 28–32.
    • (2012) Neuroscience Letters , vol.506 , pp. 28-32
    • Lu, F.1    Nakamura, T.2    Toyoshima, T.3    Liu, Y.4    Hirooka, K.5    Kawai, N.6    Itano, T.7
  • 33
    • 77957245349 scopus 로고    scopus 로고
    • A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation
    • Motomura, K., Ogura, M., Natsume, A., Yokoyama, H., & Wakabayashi, T. (2010). A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation. Neuroscience Letters, 485, 65–70.
    • (2010) Neuroscience Letters , vol.485 , pp. 65-70
    • Motomura, K.1    Ogura, M.2    Natsume, A.3    Yokoyama, H.4    Wakabayashi, T.5
  • 34
    • 13244267045 scopus 로고    scopus 로고
    • A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano [4,3-d]-pyrimidine-4-one]: Pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats
    • Nakajima, H., Kakui, N., Ohkuma, K., Ishikawa, M., & Hasegawa, T. (2005). A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano [4,3-d]-pyrimidine-4-one]: Pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. Journal of Pharmacology and Experimental Therapeutics, 312(2), 472–481.
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.2 , pp. 472-481
    • Nakajima, H.1    Kakui, N.2    Ohkuma, K.3    Ishikawa, M.4    Hasegawa, T.5
  • 35
    • 0037162691 scopus 로고    scopus 로고
    • Regenera tion of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    • Nakatomi, H., Kuriu, T., Okabe, S., Yamamoto, S., Hatano, O., Kawahara, N., Nakafuku, M. (2002). Regenera tion of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell, 110(4), 429–441.
    • (2002) Cell , vol.110 , Issue.4 , pp. 429-441
    • Nakatomi, H.1    Kuriu, T.2    Okabe, S.3    Yamamoto, S.4    Hatano, O.5    Kawahara, N.6    Nakafuku, M.7
  • 36
    • 0028924890 scopus 로고
    • Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis
    • Nitatori, T., Sato, N., Waguri, S., Karasawa, Y., Araki, H., Shibanai, K., Uchiyama, Y. (1995). Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. Journal of Neuroscience, 15, 1001–1011.
    • (1995) Journal of Neuroscience , vol.15 , pp. 1001-1011
    • Nitatori, T.1    Sato, N.2    Waguri, S.3    Karasawa, Y.4    Araki, H.5    Shibanai, K.6    Uchiyama, Y.7
  • 37
    • 0018347695 scopus 로고
    • A new model of bilateral hemispheric ischemia in the unanesthetized rat
    • Pulsinelli, W. A., & Brierley, J. B. (1979). A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke, 10, 267–272.
    • (1979) Stroke , vol.10 , pp. 267-272
    • Pulsinelli, W.A.1    Brierley, J.B.2
  • 40
    • 7944234144 scopus 로고    scopus 로고
    • Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia
    • Shichinohe, H., Kuroda, S., Yasuda, H., Ishikawa, T., Iwai, M., Horiuchi, M., Iwasaki, Y. (2004). Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia. Brain Research, 1029, 200–206.
    • (2004) Brain Research , pp. 200-206
    • Shichinohe, H.1    Kuroda, S.2    Yasuda, H.3    Ishikawa, T.4    Iwai, M.5    Horiuchi, M.6    Iwasaki, Y.7
  • 42
    • 0034703350 scopus 로고    scopus 로고
    • Effect of hypotension severity on hippocampal CA1 neurons in a rat global ischemia model
    • Sugawara, T., Kawase, M., Lewen, A., Noshita, N., Gasche, Y., Fujimura, M., Chan, P. H. (2000). Effect of hypotension severity on hippocampal CA1 neurons in a rat global ischemia model. Brain Research, 877, 281–287.
    • (2000) Brain Research , vol.877 , pp. 281-287
    • Sugawara, T.1    Kawase, M.2    Lewen, A.3    Noshita, N.4    Gasche, Y.5    Fujimura, M.6    Chan, P.H.7
  • 43
    • 0033582526 scopus 로고    scopus 로고
    • Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
    • Sun, X. M., MacFarlane, M., Zhuang, J., Wolf, B. B., Green, D. R., & Cohen, G. M. (1999). Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. Journal of Biological Chemistry, 274(8), 5053–5060.
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.8 , pp. 5053-5060
    • Sun, X.M.1    Macfarlane, M.2    Zhuang, J.3    Wolf, B.B.4    Green, D.R.5    Cohen, G.M.6
  • 44
    • 84862227916 scopus 로고    scopus 로고
    • Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatalhippocampus after cerebral hypoxia-ischemia
    • Sun, Y. D., Zhang, Y. D., Wang, X. D., Blomgren, K. D., & Zhu, C. D. (2012). Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatalhippocampus after cerebral hypoxia-ischemia. Molecular Neurodegeneration, 7, 17.
    • (2012) Molecular Neurodegeneration , vol.7 , pp. 17
    • Sun, Y.D.1    Zhang, Y.D.2    Wang, X.D.3    Blomgren, K.D.4    Zhu, C.D.5
  • 45
    • 40049088310 scopus 로고    scopus 로고
    • Caspase-2 activation in neural stem cells undergoing oxidative stressinduced apoptosis
    • Tamm, C., Zhivotovsky, B., & Ceccatelli, S. (2008). Caspase-2 activation in neural stem cells undergoing oxidative stressinduced apoptosis. Apoptosis, 13, 354–363.
    • (2008) Apoptosis , vol.13 , pp. 354-363
    • Tamm, C.1    Zhivotovsky, B.2    Ceccatelli, S.3
  • 46
    • 77953533810 scopus 로고    scopus 로고
    • AMN082 promotes the proliferation and differenti ationof neural progenitor cells with influence on phosphorylation of MAPK signaling pathways
    • Tian, Y., Liu, Y., Chen, X., Kang, Q., Zhang, J., Shi, Q., Zhang, H. (2010). AMN082 promotes the proliferation and differenti ationof neural progenitor cells with influence on phosphorylation of MAPK signaling pathways. Neurochemistry International, 57, 8–15.
    • (2010) Neurochemistry International , vol.57 , pp. 8-15
    • Tian, Y.1    Liu, Y.2    Chen, X.3    Kang, Q.4    Zhang, J.5    Shi, Q.6    Zhang, H.7
  • 48
    • 4344669774 scopus 로고    scopus 로고
    • Bimodal effect of hypoxia in cancer: Role of hypoxia inducible factor in apoptosis
    • Wang, Y., Pakunlu, R. I., Tsao, W., Pozharov, V., & Minko, T. (2004). Bimodal effect of hypoxia in cancer: Role of hypoxia inducible factor in apoptosis. Molecular Pharmacology, 1, 156–165.
    • (2004) Molecular Pharmacology , vol.1 , pp. 156-165
    • Wang, Y.1    Pakunlu, R.I.2    Tsao, W.3    Pozharov, V.4    Minko, T.5
  • 49
    • 46849106962 scopus 로고    scopus 로고
    • The novel antioxidant edaravone: From bench to bedside
    • Watanabe, T., Tahara, M., & Todo, S. (2008). The novel antioxidant edaravone: From bench to bedside. Cardiovascular Therapeutics, 26, 101–114.
    • (2008) Cardiovascular Therapeutics , vol.26 , pp. 101-114
    • Watanabe, T.1    Tahara, M.2    Todo, S.3
  • 50
    • 34548009382 scopus 로고    scopus 로고
    • Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia
    • Yan, X. B., Hou, H. L., Wu, L. M., Liu, J., & Zhou, J. N. (2007). Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia. Neuropharmacology, 53(4), 487–495.
    • (2007) Neuropharmacology , vol.53 , Issue.4 , pp. 487-495
    • Yan, X.B.1    Hou, H.L.2    Wu, L.M.3    Liu, J.4    Zhou, J.N.5
  • 51
    • 77952291931 scopus 로고    scopus 로고
    • Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells
    • Yoneyama, M., Kawada, K., Gotoh, Y., Shiba, T., & Ogita, K. (2010). Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells. Neurochemistry International, 56, 740–746.
    • (2010) Neurochemistry International , vol.56 , pp. 740-746
    • Yoneyama, M.1    Kawada, K.2    Gotoh, Y.3    Shiba, T.4    Ogita, K.5
  • 52
    • 84855531670 scopus 로고    scopus 로고
    • Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury
    • Zhang, P., Li, W., Li, L., Wang, N., Li, X., Gao, M., Liu, Y. (2012). Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. Neuroscience, 201, 297–306.
    • (2012) Neuroscience , vol.201 , pp. 297-306
    • Zhang, P.1    Li, W.2    Li, L.3    Wang, N.4    Li, X.5    Gao, M.6    Liu, Y.7
  • 53
    • 48849093105 scopus 로고    scopus 로고
    • Ischemic stroke and neurogenesis in the subventricular zone
    • Zhang, R. L., Zhang, Z. G., & Chopp, M. (2008). Ischemic stroke and neurogenesis in the subventricular zone. Neuropharmacology, 55, 345–352.
    • (2008) Neuropharmacology , vol.55 , pp. 345-352
    • Zhang, R.L.1    Zhang, Z.G.2    Chopp, M.3
  • 54
    • 0035898233 scopus 로고    scopus 로고
    • Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia
    • Zhang, R. L., Zhang, Z. G., Zhang, L., & Chopp, M. (2001). Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience, 105, 33–41.
    • (2001) Neuroscience , vol.105 , pp. 33-41
    • Zhang, R.L.1    Zhang, Z.G.2    Zhang, L.3    Chopp, M.4
  • 55
    • 83155175115 scopus 로고    scopus 로고
    • MGluR5 is involved in proliferation of rat neural progenitor cells exposed to hypoxia with activation of mitogen- activated protein kinase signaling pathway
    • Zhao, L., Jiao, Q., Chen, X., Yang, P., Zhao, B., Zheng, P., Liu, Y. (2012). mGluR5 is involved in proliferation of rat neural progenitor cells exposed to hypoxia with activation of mitogen- activated protein kinase signaling pathway. Journal of Neuroscience Research, 90, 447–460.
    • (2012) Journal of Neuroscience Research , vol.90 , pp. 447-460
    • Zhao, L.1    Jiao, Q.2    Chen, X.3    Yang, P.4    Zhao, B.5    Zheng, P.6    Liu, Y.7
  • 56
    • 84871795002 scopus 로고    scopus 로고
    • Post-stroke estradiol treatment enhances neurogenesis in the subventricular zone of rats after permanent focal cerebral ischemia
    • Zheng, J., Zhang, P., Li, X., Lei, S., Li, W., He, X., Liu, Y. (2012). Post-stroke estradiol treatment enhances neurogenesis in the subventricular zone of rats after permanent focal cerebral ischemia. Neuroscience, 231C, 82–90.
    • (2012) Neuroscience , vol.231C , pp. 82-90
    • Zheng, J.1    Zhang, P.2    Li, X.3    Lei, S.4    Li, W.5    He, X.6    Liu, Y.7
  • 57
    • 24044495875 scopus 로고    scopus 로고
    • Neurogenesis in the adult rat brain after intermittent hypoxia
    • Zhu, L. L., Zhao, T., Li, H. S., Zhao, H., Wu, L. Y., Ding, A. S., Fan, M. (2005). Neurogenesis in the adult rat brain after intermittent hypoxia. Brain Research, 1055(1–2), 1–6.
    • (2005) Brain Research , vol.1055 , Issue.1-2 , pp. 1-6
    • Zhu, L.L.1    Zhao, T.2    Li, H.S.3    Zhao, H.4    Wu, L.Y.5    Ding, A.S.6    Fan, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.