메뉴 건너뛰기




Volumn 49, Issue 1, 2014, Pages 222-233

Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: Implications for neuroprotection

Author keywords

Apoptosis; Cannabidiol; Iron; Mitochondria; Neurodegenerative disorders

Indexed keywords

BRAIN PROTEIN; CANNABIDIOL; CASPASE 3; IRON; MITOCHONDRIAL PROTEIN; PROTEIN DNM1L; PROTEIN OPA1; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

EID: 84894372100     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8514-7     Document Type: Review
Times cited : (76)

References (61)
  • 1
    • 58149123408 scopus 로고    scopus 로고
    • Role of iron in neurotoxicity: A cause for concern in the elderly?
    • 1:CAS:528:DC%2BD1cXhsVKntLjJ 10.1097/MCO.0b013e32831ba07c 19057183
    • Stankiewicz JM, Brass SD (2009) Role of iron in neurotoxicity: a cause for concern in the elderly? Curr Opin Clin Nutr Metab Care 12(1):22-29
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , Issue.1 , pp. 22-29
    • Stankiewicz, J.M.1    Brass, S.D.2
  • 2
    • 77952672976 scopus 로고    scopus 로고
    • Mechanisms of brain iron transport: Insight into neurodegeneration and CNS disorders
    • 1:CAS:528:DC%2BC3cXotl2mtQ%3D%3D 10.4155/fmc.09.140 2812924 20161623
    • Mills E, Dong XP, Wang F, Xu H (2010) Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders. Future Med Chem 2(1):51-64
    • (2010) Future Med Chem , vol.2 , Issue.1 , pp. 51-64
    • Mills, E.1    Dong, X.P.2    Wang, F.3    Xu, H.4
  • 3
    • 0025821265 scopus 로고
    • Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia
    • 10.1093/brain/114.4.1953 1832073
    • Dexter DT, Carayon A, Javoy-Agid F, Agid Y, Wells FR, Daniel SE et al (1991) Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114(Pt 4):1953-1975
    • (1991) Brain , vol.114 , Issue.PART 4 , pp. 1953-1975
    • Dexter, D.T.1    Carayon, A.2    Javoy-Agid, F.3    Agid, Y.4    Wells, F.R.5    Daniel, S.E.6
  • 4
    • 0026034279 scopus 로고
    • Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: An X-ray microanalysis
    • 1:CAS:528:DyaK3MXnvFKitA%3D%3D 10.1111/j.1471-4159.1991.tb08170.x 1988548
    • Hirsch EC, Brandel JP, Galle P, Javoy-Agid F, Agid Y (1991) Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J Neurochem 56(2):446-451
    • (1991) J Neurochem , vol.56 , Issue.2 , pp. 446-451
    • Hirsch, E.C.1    Brandel, J.P.2    Galle, P.3    Javoy-Agid, F.4    Agid, Y.5
  • 5
    • 0026573467 scopus 로고
    • Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study
    • 1:STN:280:DyaK38zksVentA%3D%3D 10.1002/ana.410310310 1637136
    • Good PF, Perl DP, Bierer LM, Schmeidler J (1992) Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study. Ann Neurol 31(3):286-292
    • (1992) Ann Neurol , vol.31 , Issue.3 , pp. 286-292
    • Good, P.F.1    Perl, D.P.2    Bierer, L.M.3    Schmeidler, J.4
  • 6
    • 8344265251 scopus 로고    scopus 로고
    • Iron, brain ageing and neurodegenerative disorders
    • 1:CAS:528:DC%2BD2cXos1Ojtrc%3D 10.1038/nrn1537 15496864
    • Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR (2004) Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 5(11):863-873
    • (2004) Nat Rev Neurosci , vol.5 , Issue.11 , pp. 863-873
    • Zecca, L.1    Youdim, M.B.2    Riederer, P.3    Connor, J.R.4    Crichton, R.R.5
  • 7
    • 34247562371 scopus 로고    scopus 로고
    • High-field magnetic resonance imaging of brain iron in Alzheimer disease
    • 10.1097/01.rmr.0000245455.59912.40 17179896
    • Schenck JF, Zimmerman EA, Li Z, Adak S, Saha A, Tandon R et al (2006) High-field magnetic resonance imaging of brain iron in Alzheimer disease. Top Magn Reson Imaging 17(1):41-50
    • (2006) Top Magn Reson Imaging , vol.17 , Issue.1 , pp. 41-50
    • Schenck, J.F.1    Zimmerman, E.A.2    Li, Z.3    Adak, S.4    Saha, A.5    Tandon, R.6
  • 8
    • 34249034604 scopus 로고    scopus 로고
    • Individual dopaminergic neurons show raised iron levels in Parkinson disease
    • 1:STN:280:DC%2BD2szgsVynuw%3D%3D 10.1212/01.wnl.0000262033.01945.9a 17515544
    • Oakley AE, Collingwood JF, Dobson J, Love G, Perrott HR, Edwardson JA et al (2007) Individual dopaminergic neurons show raised iron levels in Parkinson disease. Neurology 68(21):1820-1825
    • (2007) Neurology , vol.68 , Issue.21 , pp. 1820-1825
    • Oakley, A.E.1    Collingwood, J.F.2    Dobson, J.3    Love, G.4    Perrott, H.R.5    Edwardson, J.A.6
  • 9
    • 77950118979 scopus 로고    scopus 로고
    • Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease
    • 10.1148/radiol.2532082324 19709998
    • Zhu WZ, Zhong WD, Wang W, Zhan CJ, Wang CY, Qi JP et al (2009) Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease. Radiology 253(2):497-504
    • (2009) Radiology , vol.253 , Issue.2 , pp. 497-504
    • Zhu, W.Z.1    Zhong, W.D.2    Wang, W.3    Zhan, C.J.4    Wang, C.Y.5    Qi, J.P.6
  • 10
    • 0026659796 scopus 로고
    • Biological significance of iron-related magnetic resonance imaging changes in the brain
    • 1:STN:280:DyaK38zlvFOhsg%3D%3D 10.1001/archneur.1992.00530310053012 1497497
    • Pujol J, Junqué C, Vendrell P, Grau JM, Martí-Vilalta JL, Olivé C et al (1992) Biological significance of iron-related magnetic resonance imaging changes in the brain. Arch Neurol 49(7):711-717
    • (1992) Arch Neurol , vol.49 , Issue.7 , pp. 711-717
    • Pujol, J.1    Junqué, C.2    Vendrell, P.3    Grau, J.M.4    Martí-Vilalta, J.L.5    Olivé, C.6
  • 11
    • 77949653881 scopus 로고    scopus 로고
    • Relevance of iron deposition in deep gray matter brain structures to cognitive and motor performance in healthy elderly men and women: Exploratory findings
    • 10.1007/s11682-008-9059-7 2727611 20161183
    • Sullivan EV, Adalsteinsson E, Rohlfing T, Pfefferbaum A (2009) Relevance of iron deposition in deep gray matter brain structures to cognitive and motor performance in healthy elderly men and women: exploratory findings. Brain Imaging Behav 3(2):167-175
    • (2009) Brain Imaging Behav , vol.3 , Issue.2 , pp. 167-175
    • Sullivan, E.V.1    Adalsteinsson, E.2    Rohlfing, T.3    Pfefferbaum, A.4
  • 12
    • 79956032674 scopus 로고    scopus 로고
    • Gender and iron genes may modify associations between brain iron and memory in healthy aging
    • 1:CAS:528:DC%2BC3MXmtVOqtLo%3D 10.1038/npp.2011.22 21389980
    • Bartzokis G, Lu PH, Tingus K, Peters DG, Amar CP, Tishler TA et al (2011) Gender and iron genes may modify associations between brain iron and memory in healthy aging. Neuropsychopharmacology 36(7):1375-1384
    • (2011) Neuropsychopharmacology , vol.36 , Issue.7 , pp. 1375-1384
    • Bartzokis, G.1    Lu, P.H.2    Tingus, K.3    Peters, D.G.4    Amar, C.P.5    Tishler, T.A.6
  • 13
    • 84855761095 scopus 로고    scopus 로고
    • Brain iron deposits are associated with general cognitive ability and cognitive aging
    • 1:CAS:528:DC%2BC38XotVeqsQ%3D%3D 10.1016/j.neurobiolaging.2010.04.032 20542597
    • Penke L, Valdés Hernandéz MC, Maniega SM, Gow AJ, Murray C, Starr JM et al (2012) Brain iron deposits are associated with general cognitive ability and cognitive aging. Neurobiol Aging 33(3):510-517
    • (2012) Neurobiol Aging , vol.33 , Issue.3 , pp. 510-517
    • Penke, L.1    Valdés Hernandéz, M.C.2    Maniega, S.M.3    Gow, A.J.4    Murray, C.5    Starr, J.M.6
  • 14
    • 84878857244 scopus 로고    scopus 로고
    • The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory
    • DOI: 10.1093/cercor/bhs139
    • Rodrigue KM, Daugherty AM, Haacke EM, Raz N (2012) The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory. Cereb Cortex, DOI: 10.1093/cercor/bhs139
    • (2012) Cereb Cortex
    • Rodrigue, K.M.1    Daugherty, A.M.2    Haacke, E.M.3    Raz, N.4
  • 15
    • 33746547762 scopus 로고    scopus 로고
    • Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis
    • 1:STN:280:DC%2BD28vns12nug%3D%3D 10.1191/135248506ms1301oa 16900757
    • Brass SD, Benedict RH, Weinstock-Guttman B, Munschauer F, Bakshi R (2006) Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis. Mult Scler 12(4):437-444
    • (2006) Mult Scler , vol.12 , Issue.4 , pp. 437-444
    • Brass, S.D.1    Benedict, R.H.2    Weinstock-Guttman, B.3    Munschauer, F.4    Bakshi, R.5
  • 16
    • 33645744011 scopus 로고    scopus 로고
    • Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss
    • 1:STN:280:DC%2BD28%2Fps1Cnuw%3D%3D 16484425
    • House MJ, St Pierre TG, Foster JK, Martins RN, Clarnette R (2006) Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss. AJNR Am J Neuroradiol 27(2):430-439
    • (2006) AJNR Am J Neuroradiol , vol.27 , Issue.2 , pp. 430-439
    • House, M.J.1    St Pierre, T.G.2    Foster, J.K.3    Martins, R.N.4    Clarnette, R.5
  • 17
    • 65249141710 scopus 로고    scopus 로고
    • Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease
    • 10.1002/jmri.21730 19306401
    • Ding B, Chen KM, Ling HW, Sun F, Li X, Wan T et al (2009) Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease. J Magn Reson Imaging 29(4):793-798
    • (2009) J Magn Reson Imaging , vol.29 , Issue.4 , pp. 793-798
    • Ding, B.1    Chen, K.M.2    Ling, H.W.3    Sun, F.4    Li, X.5    Wan, T.6
  • 18
    • 0345281624 scopus 로고    scopus 로고
    • Neonatal iron exposure induces neurobehavioural dysfunctions in adult mice
    • 1:CAS:528:DyaK1MXltFSgs70%3D 10.1006/taap.1999.8711 10448122
    • Fredriksson A, Schröder N, Eriksson P, Izquierdo I, Archer T (1999) Neonatal iron exposure induces neurobehavioural dysfunctions in adult mice. Toxicol Appl Pharmacol 159(1):25-30
    • (1999) Toxicol Appl Pharmacol , vol.159 , Issue.1 , pp. 25-30
    • Fredriksson, A.1    Schröder, N.2    Eriksson, P.3    Izquierdo, I.4    Archer, T.5
  • 20
    • 20444470817 scopus 로고    scopus 로고
    • Recognition memory impairment and brain oxidative stress induced by postnatal iron administration
    • 10.1111/j.1460-9568.2005.04083.x 15932609
    • de Lima MN, Polydoro M, Laranja DC, Bonatto F, Bromberg E, Moreira JC et al (2005) Recognition memory impairment and brain oxidative stress induced by postnatal iron administration. Eur J Neurosci 21(9):2521-2528
    • (2005) Eur J Neurosci , vol.21 , Issue.9 , pp. 2521-2528
    • De Lima, M.N.1    Polydoro, M.2    Laranja, D.C.3    Bonatto, F.4    Bromberg, E.5    Moreira, J.C.6
  • 21
    • 84876361328 scopus 로고    scopus 로고
    • Role of brain iron accumulation in cognitive dysfunction: Evidence from animal models and human studies
    • 23271321
    • Schröder N, Figueiredo LS, de Lima MNM (2013) Role of brain iron accumulation in cognitive dysfunction: evidence from animal models and human studies. J Alzheimers Dis 34(4):797-812
    • (2013) J Alzheimers Dis , vol.34 , Issue.4 , pp. 797-812
    • Schröder, N.1    Figueiredo, L.S.2    De Lima, M.N.M.3
  • 22
    • 84862786010 scopus 로고    scopus 로고
    • Dynamic changes of mitochondrial fusion and fission proteins after transient cerebral ischemia in mice
    • 1:CAS:528:DC%2BC38XitlKnu78%3D 10.1002/jnr.23016 22345048
    • Liu W, Tian F, Kurata T, Morimoto N, Abe K (2012) Dynamic changes of mitochondrial fusion and fission proteins after transient cerebral ischemia in mice. J Neurosci Res 90(6):1183-1189
    • (2012) J Neurosci Res , vol.90 , Issue.6 , pp. 1183-1189
    • Liu, W.1    Tian, F.2    Kurata, T.3    Morimoto, N.4    Abe, K.5
  • 23
    • 64349099993 scopus 로고    scopus 로고
    • The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease
    • 1:CAS:528:DC%2BD1MXlsFyksbk%3D 10.1111/j.1471-4159.2009.05867.x 2720030 19393022
    • Wang X, Su B, Zheng L, Perry G, Smith MA, Zhu X (2009) The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Neurochem 109(1):153-159
    • (2009) J Neurochem , vol.109 , Issue.1 , pp. 153-159
    • Wang, X.1    Su, B.2    Zheng, L.3    Perry, G.4    Smith, M.A.5    Zhu, X.6
  • 24
    • 0344413426 scopus 로고    scopus 로고
    • Mitochondrial fission in apoptosis, neurodegeneration and aging
    • 1:CAS:528:DC%2BD3sXptlyks7o%3D 10.1016/j.ceb.2003.10.015 14644195
    • Bossy-Wetzel E, Barsoum MJ, Godzik A, Schwarzenbacher R, Lipton SA (2003) Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol 15(6):706-716
    • (2003) Curr Opin Cell Biol , vol.15 , Issue.6 , pp. 706-716
    • Bossy-Wetzel, E.1    Barsoum, M.J.2    Godzik, A.3    Schwarzenbacher, R.4    Lipton, S.A.5
  • 25
    • 84865961091 scopus 로고    scopus 로고
    • Synaptic energy use and supply
    • 1:CAS:528:DC%2BC38XhtlSkurvN 10.1016/j.neuron.2012.08.019 22958818
    • Harris JJ, Jolivet R, Attwell D (2012) Synaptic energy use and supply. Neuron 75(5):762-777
    • (2012) Neuron , vol.75 , Issue.5 , pp. 762-777
    • Harris, J.J.1    Jolivet, R.2    Attwell, D.3
  • 26
    • 0037448153 scopus 로고    scopus 로고
    • Age-related loss of synapses in the frontal cortex of SAMP10 mouse: A model of cerebral degeneration
    • 1:CAS:528:DC%2BD3sXjsFCkt7o%3D 10.1002/syn.10209 12687639
    • Shimada A, Keino H, Satoh M, Kishikawa M, Hosokawa M (2003) Age-related loss of synapses in the frontal cortex of SAMP10 mouse: a model of cerebral degeneration. Synapse 48(4):198-204
    • (2003) Synapse , vol.48 , Issue.4 , pp. 198-204
    • Shimada, A.1    Keino, H.2    Satoh, M.3    Kishikawa, M.4    Hosokawa, M.5
  • 27
    • 14244261959 scopus 로고    scopus 로고
    • Apoptosis in the central nervous system: Mechanisms and protective strategies
    • 10.1211/0022357041172961 15662081
    • Kajta M (2004) Apoptosis in the central nervous system: Mechanisms and protective strategies. Pol J Pharmacol 56(6):689-700
    • (2004) Pol J Pharmacol , vol.56 , Issue.6 , pp. 689-700
    • Kajta, M.1
  • 28
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-) Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • 1:CAS:528:DyaK1cXks1SltL0%3D 10.1073/pnas.95.14.8268 20965 9653176
    • Hampson AJ, Grimaldi M, Axelrod J, Wink D (1998) Cannabidiol and (-) Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A 95(14):8268-8273
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.14 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 29
    • 33846401540 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: Importance of antioxidant and cannabinoid receptor-independent properties
    • 10.1016/j.brainres.2006.11.063 17196181
    • García-Arencibia M, González S, de Lago E, Ramos JA, Mechoulam R, Fernández-Ruiz J (2007) Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain Res 1134(1):162-170
    • (2007) Brain Res , vol.1134 , Issue.1 , pp. 162-170
    • García-Arencibia, M.1    González, S.2    De Lago, E.3    Ramos, J.A.4    Mechoulam, R.5    Fernández-Ruiz, J.6
  • 30
    • 72749107868 scopus 로고    scopus 로고
    • The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors
    • 1:CAS:528:DC%2BC3cXos1Gn 10.1016/j.nbd.2009.10.023 19900555
    • Castillo A, Tolón MR, Fernández-Ruiz J, Romero J, Martinez-Orgado J (2010) The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. Neurobiol Dis 37(2):434-440
    • (2010) Neurobiol Dis , vol.37 , Issue.2 , pp. 434-440
    • Castillo, A.1    Tolón, M.R.2    Fernández-Ruiz, J.3    Romero, J.4    Martinez-Orgado, J.5
  • 31
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    • 1:CAS:528:DC%2BD2cXjtValtrw%3D 10.1111/j.1471-4159.2003.02327.x 15030397
    • Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, Izzo AA (2004) Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem 89(1):134-141
    • (2004) J Neurochem , vol.89 , Issue.1 , pp. 134-141
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di Rosa, M.5    Izzo, A.A.6
  • 32
    • 84864439799 scopus 로고    scopus 로고
    • Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
    • 1:CAS:528:DC%2BC38XhtVCjtLnN 10.1016/j.neuropharm.2012.05.034 22659086
    • Pazos MR, Cinquina V, Gómez A, Layunta R, Santos M, Fernández-Ruiz J et al (2012) Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. Neuropharmacology 63(5):776-783
    • (2012) Neuropharmacology , vol.63 , Issue.5 , pp. 776-783
    • Pazos, M.R.1    Cinquina, V.2    Gómez, A.3    Layunta, R.4    Santos, M.5    Fernández-Ruiz, J.6
  • 33
    • 34547984234 scopus 로고    scopus 로고
    • Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors
    • 10.1111/j.1460-9568.2007.05717.x 17672854
    • Sagredo O, Ramos JA, Decio A, Mechoulam R, Fernández-Ruiz J (2007) Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors. Eur J Neurosci 26(4):843-851
    • (2007) Eur J Neurosci , vol.26 , Issue.4 , pp. 843-851
    • Sagredo, O.1    Ramos, J.A.2    Decio, A.3    Mechoulam, R.4    Fernández-Ruiz, J.5
  • 34
    • 84856644638 scopus 로고    scopus 로고
    • Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
    • 1:CAS:528:DC%2BC3MXhtVOrtb7E 10.1007/s00213-011-2449-3
    • Fagherazzi EV, Garcia VA, Maurmann N, Bervanger T, Halmenschlager LH, Busato SB et al (2012) Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders. Psychopharmacology (Berlin) 219(4):1133-1140
    • (2012) Psychopharmacology (Berlin) , vol.219 , Issue.4 , pp. 1133-1140
    • Fagherazzi, E.V.1    Garcia, V.A.2    Maurmann, N.3    Bervanger, T.4    Halmenschlager, L.H.5    Busato, S.B.6
  • 35
    • 84859614049 scopus 로고    scopus 로고
    • The therapeutic potential of the endocannabinoid system for Alzheimer's disease
    • 1:CAS:528:DC%2BC38Xlt1Smtbc%3D 10.1517/14728222.2012.671812 22448595
    • Karl T, Cheng D, Garner B, Arnold JC (2012) The therapeutic potential of the endocannabinoid system for Alzheimer's disease. Expert Opin Ther Targets 16(4):407-420
    • (2012) Expert Opin Ther Targets , vol.16 , Issue.4 , pp. 407-420
    • Karl, T.1    Cheng, D.2    Garner, B.3    Arnold, J.C.4
  • 36
    • 84855207460 scopus 로고    scopus 로고
    • Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate
    • 10.1016/j.neuroscience.2011.10.038 22067609
    • Silva PF, Garcia VA, da Dornelles AS, Silva VK, Maurmann N, Portal BC et al (2012) Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate. Neuroscience 200:42-49
    • (2012) Neuroscience , vol.200 , pp. 42-49
    • Silva, P.F.1    Garcia, V.A.2    Da Dornelles, A.S.3    Silva, V.K.4    Maurmann, N.5    Portal, B.C.6
  • 37
    • 71649098280 scopus 로고    scopus 로고
    • Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide
    • 1:CAS:528:DC%2BC3cXhs1Ghuw%3D%3D 10.1111/j.1471-4159.2009.06441.x 19845829
    • Arciello M, Capo CR, Cozzolino M, Ferri A, Nencini M, Carrì MT et al (2010) Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide. J Neurochem 112(1):183-192
    • (2010) J Neurochem , vol.112 , Issue.1 , pp. 183-192
    • Arciello, M.1    Capo, C.R.2    Cozzolino, M.3    Ferri, A.4    Nencini, M.5    Carrì, M.T.6
  • 38
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • 1:CAS:528:DyaE28XksVehtrY%3D 10.1016/0003-2697(76)90527-3 942051
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 39
    • 84867898648 scopus 로고    scopus 로고
    • Reduction of Na(+), K(+)-ATPase activity and expression in cerebral cortex of glutaryl-CoA dehydrogenase deficient mice: A possible mechanism for brain injury in glutaric aciduria type i
    • 1:CAS:528:DC%2BC38Xhtl2ksbrL 10.1016/j.ymgme.2012.08.016 22999741
    • Amaral AU, Seminotti B, Cecatto C, Fernandes CG, Busanello EN, Zanatta A et al (2012) Reduction of Na(+), K(+)-ATPase activity and expression in cerebral cortex of glutaryl-CoA dehydrogenase deficient mice: A possible mechanism for brain injury in glutaric aciduria type I. Mol Genet Metab 107(3):375-382
    • (2012) Mol Genet Metab , vol.107 , Issue.3 , pp. 375-382
    • Amaral, A.U.1    Seminotti, B.2    Cecatto, C.3    Fernandes, C.G.4    Busanello, E.N.5    Zanatta, A.6
  • 40
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • 1:STN:280:DC%2BD38nis12jtw%3D%3D 10.1093/nar/29.9.e45 55695 11328886
    • Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
    • (2001) Nucleic Acids Res , vol.29 , pp. 45
    • Pfaffl, M.W.1
  • 41
    • 40549112638 scopus 로고    scopus 로고
    • Reference genes for normalization: A study of rat brain tissue
    • 1:CAS:528:DC%2BD1cXjt1Cnurg%3D 10.1002/syn.20496 18241047
    • Bonefeld BE, Elfving B, Wegener G (2008) Reference genes for normalization: a study of rat brain tissue. Synapse 62:302-309
    • (2008) Synapse , vol.62 , pp. 302-309
    • Bonefeld, B.E.1    Elfving, B.2    Wegener, G.3
  • 42
    • 77956267202 scopus 로고    scopus 로고
    • Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1
    • 1:CAS:528:DC%2BC3cXhtFamsLnI 10.1016/j.bbrc.2010.07.108 2942079 20678484
    • Kar R, Mishra N, Singha PK, Venkatachalam MA, Saikumar P (2010) Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. Biochem Biophys Res Commun 399(4):548-554
    • (2010) Biochem Biophys Res Commun , vol.399 , Issue.4 , pp. 548-554
    • Kar, R.1    Mishra, N.2    Singha, P.K.3    Venkatachalam, M.A.4    Saikumar, P.5
  • 43
    • 58149314033 scopus 로고    scopus 로고
    • Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis
    • 1:CAS:528:DC%2BD1MXkt1WisA%3D%3D 10.1016/j.brainres.2008.10.081 2771186 19046944
    • Loucks FA, Schroeder EK, Zommer AE, Hilger S, Kelsey NA, Bouchard RJ et al (2009) Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis. Brain Res 1250:63-74
    • (2009) Brain Res , vol.1250 , pp. 63-74
    • Loucks, F.A.1    Schroeder, E.K.2    Zommer, A.E.3    Hilger, S.4    Kelsey, N.A.5    Bouchard, R.J.6
  • 44
    • 84859868760 scopus 로고    scopus 로고
    • Differential effect of intrauterine hypoxia on caspase 3 and DNA fragmentation in fetal guinea pig hearts and brains
    • 1:CAS:528:DC%2BC38XlvFShurs%3D 10.1177/1933719111420883 22383778
    • Evans LC, Liu H, Thompson LP (2012) Differential effect of intrauterine hypoxia on caspase 3 and DNA fragmentation in fetal guinea pig hearts and brains. Reprod Sci 19(3):298-305
    • (2012) Reprod Sci , vol.19 , Issue.3 , pp. 298-305
    • Evans, L.C.1    Liu, H.2    Thompson, L.P.3
  • 45
    • 84861130196 scopus 로고    scopus 로고
    • Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: Implications for mitochondrial dysfunction and neuronal damage
    • 1:CAS:528:DC%2BC38XmvVyns7g%3D 10.1093/hmg/dds072 22367970
    • Manczak M, Reddy PH (2012) Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. Hum Mol Genet 21(11):2538-2547
    • (2012) Hum Mol Genet , vol.21 , Issue.11 , pp. 2538-2547
    • Manczak, M.1    Reddy, P.H.2
  • 46
    • 58049218922 scopus 로고    scopus 로고
    • Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
    • 1:CAS:528:DC%2BD1cXhsFamu73E 10.1073/pnas.0804871105 2614759 19050078
    • Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y et al (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A 105(49):19318-19323
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.49 , pp. 19318-19323
    • Wang, X.1    Su, B.2    Siedlak, S.L.3    Moreira, P.I.4    Fujioka, H.5    Wang, Y.6
  • 47
    • 77956218282 scopus 로고    scopus 로고
    • Mitochondrial iron metabolism and its role in neurodegeneration
    • 3085540 20463401
    • Horowitz MP, Greenamyre JT (2010) Mitochondrial iron metabolism and its role in neurodegeneration. J Alzheimers Dis 20(Suppl 2):S551-S568
    • (2010) J Alzheimers Dis , vol.20 , Issue.SUPPL. 2
    • Horowitz, M.P.1    Greenamyre, J.T.2
  • 49
    • 0030872413 scopus 로고    scopus 로고
    • Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease
    • 1:STN:280:DyaK2svgt1yrtw%3D%3D 10.1097/00005072-199708000-00011 9258263
    • Sze CI, Troncoso JC, Kawas C, Mouton P, Price DL, Martin LJ (1997) Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exp Neurol 56(8):933-944
    • (1997) J Neuropathol Exp Neurol , vol.56 , Issue.8 , pp. 933-944
    • Sze, C.I.1    Troncoso, J.C.2    Kawas, C.3    Mouton, P.4    Price, D.L.5    Martin, L.J.6
  • 50
    • 17844378691 scopus 로고    scopus 로고
    • Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction
    • 1:CAS:528:DC%2BD2MXjsVSjs70%3D 15851848
    • Reddy PH, Mani G, Park BS, Jacques J, Murdoch G, Whetsell W Jr et al (2005) Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction. J Alzheimers Dis 7(2):103-117
    • (2005) J Alzheimers Dis , vol.7 , Issue.2 , pp. 103-117
    • Reddy, P.H.1    Mani, G.2    Park, B.S.3    Jacques, J.4    Murdoch, G.5    Whetsell, Jr.W.6
  • 51
    • 23144451432 scopus 로고    scopus 로고
    • Mitochondrial fission in apoptosis
    • 1:CAS:528:DC%2BD2MXmvVGhtrs%3D 10.1038/nrm1697 16025099
    • Youle RJ, Karbowski M (2005) Mitochondrial fission in apoptosis. Nat Rev Mol Cell Biol 6(8):657-663
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.8 , pp. 657-663
    • Youle, R.J.1    Karbowski, M.2
  • 52
    • 33745274726 scopus 로고    scopus 로고
    • Mitochondria: Dynamic organelles in disease, aging, and development
    • 1:CAS:528:DC%2BD28XmvVGrsrk%3D 10.1016/j.cell.2006.06.010 16814712
    • Chan DC (2006) Mitochondria: dynamic organelles in disease, aging, and development. Cell 125(7):1241-1252
    • (2006) Cell , vol.125 , Issue.7 , pp. 1241-1252
    • Chan, D.C.1
  • 53
    • 79958107465 scopus 로고    scopus 로고
    • Neonatal iron treatment increases apoptotic markers in hippocampal and cortical areas of adult rats
    • 1:CAS:528:DC%2BC3MXltVKqsrY%3D 10.1007/s12640-010-9181-3 20369315
    • Miwa CP, de Lima MN, Scalco F, Vedana G, Mattos R, Fernandez LL et al (2011) Neonatal iron treatment increases apoptotic markers in hippocampal and cortical areas of adult rats. Neurotox Res 19(4):527-535
    • (2011) Neurotox Res , vol.19 , Issue.4 , pp. 527-535
    • Miwa, C.P.1    De Lima, M.N.2    Scalco, F.3    Vedana, G.4    Mattos, R.5    Fernandez, L.L.6
  • 54
    • 78951471098 scopus 로고    scopus 로고
    • Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells
    • 1:CAS:528:DC%2BC3MXhtlSmtbs%3D 10.1016/j.neuro.2010.11.006 21130806
    • Salvador GA, Oteiza PI (2011) Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells. Neurotoxicology 32(1):75-82
    • (2011) Neurotoxicology , vol.32 , Issue.1 , pp. 75-82
    • Salvador, G.A.1    Oteiza, P.I.2
  • 55
    • 34548695421 scopus 로고    scopus 로고
    • Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron-chelating-antioxidants, M-30 and green tea polyphenol, EGCG
    • 1:CAS:528:DC%2BD2sXhtlSitL%2FN 10.2174/156720507781788927 17908043
    • Avramovich-Tirosh Y, Reznichenko L, Mit T, Zheng H, Fridkin M, Weinreb O et al (2007) Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron-chelating-antioxidants, M-30 and green tea polyphenol, EGCG. Curr Alzheimer Res 4(4):403-411
    • (2007) Curr Alzheimer Res , vol.4 , Issue.4 , pp. 403-411
    • Avramovich-Tirosh, Y.1    Reznichenko, L.2    Mit, T.3    Zheng, H.4    Fridkin, M.5    Weinreb, O.6
  • 56
    • 79952696792 scopus 로고    scopus 로고
    • Diminished gray matter in the hippocampus of cannabis users: Possible protective effects of cannabidiol
    • 1:CAS:528:DC%2BC3MXjs1yrtb8%3D 21050680
    • Demirakca T, Sartorius A, Ende G, Meyer N, Welzel H, Skopp G et al (2011) Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol. Drug Alcohol Depend 114(2-3):242-245
    • (2011) Drug Alcohol Depend , vol.114 , Issue.2-3 , pp. 242-245
    • Demirakca, T.1    Sartorius, A.2    Ende, G.3    Meyer, N.4    Welzel, H.5    Skopp, G.6
  • 57
    • 84871534813 scopus 로고    scopus 로고
    • Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment
    • 10.1177/0269881112460109 23042808
    • Englund A, Morrison PD, Nottage J, Hague D, Kane F, Bonaccorso S et al (2013) Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. J Psychopharmacol 27(1):19-27
    • (2013) J Psychopharmacol , vol.27 , Issue.1 , pp. 19-27
    • Englund, A.1    Morrison, P.D.2    Nottage, J.3    Hague, D.4    Kane, F.5    Bonaccorso, S.6
  • 59
    • 84874616379 scopus 로고    scopus 로고
    • Iron accumulation in multiple sclerosis: An early pathogenic event
    • 1:CAS:528:DC%2BC3sXjtlGru74%3D 10.1586/ern.13.14 23448214
    • LeVine SM, Bilgen M, Lynch SG (2013) Iron accumulation in multiple sclerosis: an early pathogenic event. Expert Rev Neurother 13(3):247-250
    • (2013) Expert Rev Neurother , vol.13 , Issue.3 , pp. 247-250
    • Levine, S.M.1    Bilgen, M.2    Lynch, S.G.3
  • 60
    • 50849087682 scopus 로고    scopus 로고
    • Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats
    • 10.1016/j.neuropharm.2008.06.025 18619476
    • de Lima MN, Presti-Torres J, Garcia VA, Guimarães MR, Scalco FS, Roesler R et al (2008) Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. Neuropharmacology 55(5):788-792
    • (2008) Neuropharmacology , vol.55 , Issue.5 , pp. 788-792
    • De Lima, M.N.1    Presti-Torres, J.2    Garcia, V.A.3    Guimarães, M.R.4    Scalco, F.S.5    Roesler, R.6
  • 61
    • 77949699432 scopus 로고    scopus 로고
    • Iron leads to memory impairment that is associated with a decrease in acetylcholinesterase pathways
    • 1:CAS:528:DC%2BC3cXms1amsL4%3D 10.2174/156720210790820172 20158466
    • Perez VP, de Lima MN, da Silva RS, Dornelles AS, Vedana G, Bogo MR et al (2010) Iron leads to memory impairment that is associated with a decrease in acetylcholinesterase pathways. Curr Neurovasc Res 7(1):15-22
    • (2010) Curr Neurovasc Res , vol.7 , Issue.1 , pp. 15-22
    • Perez, V.P.1    De Lima, M.N.2    Da Silva, R.S.3    Dornelles, A.S.4    Vedana, G.5    Bogo, M.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.