-
1
-
-
0024592713
-
The ocular route for systemic insulin delivery in the albino rabbit
-
Yamamoto A, Luo AM, Dodda-Kashi S, Lee VHL: The ocular route for systemic insulin delivery in the albino rabbit. J Pharmacol Exp Ther 249: 249-255, 1989.
-
(1989)
J Pharmacol Exp Ther
, vol.249
, pp. 249-255
-
-
Yamamoto, A.1
Luo, A.M.2
Dodda-Kashi, S.3
Lee, V.H.L.4
-
2
-
-
0024344406
-
Effect of sodium glycocholate and polyoxyethylene-9-lauryl ether on the hydrolysis of varying concentrations of insulin in the nasal homogenates of the albino rabbit
-
Hayakawa E, Yamamoto A, Shoji Y, Lee VHL: Effect of sodium glycocholate and polyoxyethylene-9-lauryl ether on the hydrolysis of varying concentrations of insulin in the nasal homogenates of the albino rabbit. Life Sci 45: 167-174, 1989.
-
(1989)
Life Sci
, vol.45
, pp. 167-174
-
-
Hayakawa, E.1
Yamamoto, A.2
Shoji, Y.3
Lee, V.H.L.4
-
3
-
-
0025599403
-
Insulin and proinsulin proteolysis in mucosal homogenates of the albino rabbit: implications in peptide delivery from nonoral routes
-
Yamamoto A, Hayakawa E, Lee VHL: Insulin and proinsulin proteolysis in mucosal homogenates of the albino rabbit: implications in peptide delivery from nonoral routes. Life Sci 47: 2465-2474, 1990.
-
(1990)
Life Sci
, vol.47
, pp. 2465-2474
-
-
Yamamoto, A.1
Hayakawa, E.2
Lee, V.H.L.3
-
4
-
-
0024836302
-
Penetration and enzymatic barriers to peptide and protein absorption
-
Lee VHL, Yamamoto A: Penetration and enzymatic barriers to peptide and protein absorption. Adv Drug Delivery Rev 4: 171-207, 1990.
-
(1990)
Adv Drug Delivery Rev
, vol.4
, pp. 171-207
-
-
Lee, V.H.L.1
Yamamoto, A.2
-
5
-
-
0026329336
-
Mucosal penetration enhancers for facilitation of peptide and protein drug absorption
-
Lee VHL, Yamamoto A, Kompella UB: Mucosal penetration enhancers for facilitation of peptide and protein drug absorption. Crit Rev Ther Drug Carrier Syst 8: 91-192, 1991.
-
(1991)
Crit Rev Ther Drug Carrier Syst
, vol.8
, pp. 91-192
-
-
Lee, V.H.L.1
Yamamoto, A.2
Kompella, U.B.3
-
6
-
-
0026611375
-
Conjunctival penetration of insulin and peptide drugs in the albino rabbit
-
Hayakawa E, Chien DS, Inagaki K, Yamamoto A, Wang W, Lee VHL: Conjunctival penetration of insulin and peptide drugs in the albino rabbit. Pharm Res 9: 769-775, 1992.
-
(1992)
Pharm Res
, vol.9
, pp. 769-775
-
-
Hayakawa, E.1
Chien, D.S.2
Inagaki, K.3
Yamamoto, A.4
Wang, W.5
Lee, V.H.L.6
-
7
-
-
0026738064
-
A mechanistic study on enhancement of rectal permeability to insulin in the albino rabbit
-
Yamamoto A, Hayakawa E, Kato Y, Nishiura A, Lee VHL: A mechanistic study on enhancement of rectal permeability to insulin in the albino rabbit. J Pharmacol Exp Ther 263: 25-31, 1992.
-
(1992)
J Pharmacol Exp Ther
, vol.263
, pp. 25-31
-
-
Yamamoto, A.1
Hayakawa, E.2
Kato, Y.3
Nishiura, A.4
Lee, V.H.L.5
-
8
-
-
26844567547
-
Rectal and Vaginal Absorption of Peptides and Proteins in Biological Barriers to Protein Delivery
-
eds. Audus KL et al Plenum Press, New York
-
Muranishi S, Yamamoto A, Okada H: Rectal and Vaginal Absorption of Peptides and Proteins in Biological Barriers to Protein Delivery. (eds. Audus KL et al.), Plenum Press, New York, 1993, 199-227.
-
(1993)
, pp. 199-227
-
-
Muranishi, S.1
Yamamoto, A.2
Okada, H.3
-
9
-
-
0028131415
-
Susceptibility of ebiratide to proteolysis in rat intestinal fluid and homogenates and its protection by various protease inhibitors
-
Okagawa T, Fujita T, Murakami M, Yamamoto A, Shimura T et al.: Susceptibility of ebiratide to proteolysis in rat intestinal fluid and homogenates and its protection by various protease inhibitors. Life Sci 55: 677-683, 1994.
-
(1994)
Life Sci
, vol.55
, pp. 677-683
-
-
Okagawa, T.1
Fujita, T.2
Murakami, M.3
Yamamoto, A.4
Shimura, T.5
-
10
-
-
0027942594
-
Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. 1. Possible factors for the low oral bioavailability in rats
-
Sasaki I, Fujita T, Murakami M, Yamamoto A, Nakamura E et al.: Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. 1. Possible factors for the low oral bioavailability in rats. Biol Pharm Bull 17: 1256-1261, 1994.
-
(1994)
Biol Pharm Bull
, vol.17
, pp. 1256-1261
-
-
Sasaki, I.1
Fujita, T.2
Murakami, M.3
Yamamoto, A.4
Nakamura, E.5
-
11
-
-
0027988721
-
Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats
-
Yamamoto A, Taniguchi T, Rikyuu K, Tsuji T, Fujita T et al.: Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm Res 11: 1496-1500, 1994.
-
(1994)
Pharm Res
, vol.11
, pp. 1496-1500
-
-
Yamamoto, A.1
Taniguchi, T.2
Rikyuu, K.3
Tsuji, T.4
Fujita, T.5
-
12
-
-
0002280015
-
Mechanisms of Absorption Enhancement through Gastrointestinal Epithelium in Drug Absorption Enhancement - Concepts, Possibilities
-
(ed. deBoer A), Harwood Academic Publishers, Switzerland
-
Muranishi S, Yamamoto A: Mechanisms of Absorption Enhancement through Gastrointestinal Epithelium in Drug Absorption Enhancement - Concepts, Possibilities, Limitations and Trends. (ed. deBoer A), Harwood Academic Publishers, Switzerland, 1994, 67-100.
-
(1994)
Limitations and Trends
, pp. 67-100
-
-
Muranishi, S.1
Yamamoto, A.2
-
13
-
-
0029150558
-
Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. 2. In situ and in vivo absorption characteristics of azetirelin from the rat intestine
-
Sasaki I, Tanaka K, Fujita T, Murakami M, Yamamoto A et al.: Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. 2. In situ and in vivo absorption characteristics of azetirelin from the rat intestine. Biol Pharm Bull 18: 976-979, 1995.
-
(1995)
Biol Pharm Bull
, vol.18
, pp. 976-979
-
-
Sasaki, I.1
Tanaka, K.2
Fujita, T.3
Murakami, M.4
Yamamoto, A.5
-
14
-
-
0029072575
-
Does bacitracin have an absorption enhancing effect in the intestine?
-
Gotoh S, Nakamura R, Nishiyama M, Fujita T, Yamamoto A et al.: Does bacitracin have an absorption enhancing effect in the intestine? Biol Pharm Bull 18: 794-796, 1995.
-
(1995)
Biol Pharm Bull
, vol.18
, pp. 794-796
-
-
Gotoh, S.1
Nakamura, R.2
Nishiyama, M.3
Fujita, T.4
Yamamoto, A.5
-
15
-
-
0029776014
-
Effects of protease inhibitors on the absorption of phenol red and fluorescein isothiocyanate dextrans from the rat intestine
-
Gotoh S, Nakamura R, Nishiyama M, Quan YS, Fujita T et al.: Effects of protease inhibitors on the absorption of phenol red and fluorescein isothiocyanate dextrans from the rat intestine. J Pharm Sci 85: 858-862, 1996.
-
(1996)
J Pharm Sci
, vol.85
, pp. 858-862
-
-
Gotoh, S.1
Nakamura, R.2
Nishiyama, M.3
Quan, Y.S.4
Fujita, T.5
-
16
-
-
0030446148
-
Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: Effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane
-
Yamamoto A, Uchiyama T, Nishikawa R, Fujita T, Muranishi S: Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: Effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane. J Pharm Pharmacol 48: 1285-1289, 1996.
-
(1996)
J Pharm Pharmacol
, vol.48
, pp. 1285-1289
-
-
Yamamoto, A.1
Uchiyama, T.2
Nishikawa, R.3
Fujita, T.4
Muranishi, S.5
-
17
-
-
0030457767
-
Effectiveness and toxicity screening of various absorption enhancers in the large intestine: Intestinal absorption of phenol red and protein and phospholipid release from the intestinal membrane
-
Uchiyama T, Yamamoto A, Hatano H, Fujita T, Muranishi S: Effectiveness and toxicity screening of various absorption enhancers in the large intestine: Intestinal absorption of phenol red and protein and phospholipid release from the intestinal membrane. Biol Pharm Bull 19: 1618-1621, 1996.
-
(1996)
Biol Pharm Bull
, vol.19
, pp. 1618-1621
-
-
Uchiyama, T.1
Yamamoto, A.2
Hatano, H.3
Fujita, T.4
Muranishi, S.5
-
18
-
-
0031051266
-
Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat caecal contents: Implications in peptide delivery to the colon
-
Tozaki H, Emi Y, Horisaka E, Fujita T, Yamamoto A et al.: Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat caecal contents: Implications in peptide delivery to the colon. J Pharm Pharmacol 49: 164-168, 1997.
-
(1997)
J Pharm Pharmacol
, vol.49
, pp. 164-168
-
-
Tozaki, H.1
Emi, Y.2
Horisaka, E.3
Fujita, T.4
Yamamoto, A.5
-
19
-
-
0030795536
-
Effects of various absorption enhancers on the intestinal absorption of water soluble drugs by in vitro Ussing chamber method: Correlation with an in situ absorption experiment
-
Sugiyama T, Yamamoto A, Kawabe Y, Uchiyama T, Quan YS et al.: Effects of various absorption enhancers on the intestinal absorption of water soluble drugs by in vitro Ussing chamber method: Correlation with an in situ absorption experiment. Biol Pharm Bull 20: 812-814, 1997.
-
(1997)
Biol Pharm Bull
, vol.20
, pp. 812-814
-
-
Sugiyama, T.1
Yamamoto, A.2
Kawabe, Y.3
Uchiyama, T.4
Quan, Y.S.5
-
20
-
-
0030852411
-
Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms
-
Sasaki I, Tamura T, Shibakawa T, Fujita T, Murakami M et al.: Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms. Pharm Res 14: 1004-1007, 1997.
-
(1997)
Pharm Res
, vol.14
, pp. 1004-1007
-
-
Sasaki, I.1
Tamura, T.2
Shibakawa, T.3
Fujita, T.4
Murakami, M.5
-
21
-
-
0030714009
-
Effects of different absorption enhancers on the permeation of ebiratide, an ACTH analogue, across intestinal membranes
-
Yamamoto A, Okagawa T, Kotani A, Uchiyama T, Shimura T et al.: Effects of different absorption enhancers on the permeation of ebiratide, an ACTH analogue, across intestinal membranes. J Pharm Pharmacol 49: 1057-1061, 1997.
-
(1997)
J Pharm Pharmacol
, vol.49
, pp. 1057-1061
-
-
Yamamoto, A.1
Okagawa, T.2
Kotani, A.3
Uchiyama, T.4
Shimura, T.5
-
22
-
-
0031925733
-
Effects of various protease inhibitors on the stability and permeability of (D-Ala2, D-Leu5)enkephalin in the rat intestine: Comparison with leucine enkephalin
-
Uchiyama T, Kotani A, Kishida T, Tatsumi H, Okamoto A et al.: Effects of various protease inhibitors on the stability and permeability of (D-Ala2, D-Leu5)enkephalin in the rat intestine: Comparison with leucine enkephalin. J Pharm Sci 87: 448-452, 1998.
-
(1998)
J Pharm Sci
, vol.87
, pp. 448-452
-
-
Uchiyama, T.1
Kotani, A.2
Kishida, T.3
Tatsumi, H.4
Okamoto, A.5
-
23
-
-
0031820780
-
Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers
-
Quan YS, Hattori K, Lundborg E, Fujita T, Murakami M et al.: Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers. Biol Pharm Bull 21: 615-620, 1998.
-
(1998)
Biol Pharm Bull
, vol.21
, pp. 615-620
-
-
Quan, Y.S.1
Hattori, K.2
Lundborg, E.3
Fujita, T.4
Murakami, M.5
-
24
-
-
0031663610
-
Use of protease inhibitors to improve calcitonin absorption from the small and large intestine in rats
-
Tozaki H, Odoriba T, Iseki T, Taniguchi T, Fujita T et al.: Use of protease inhibitors to improve calcitonin absorption from the small and large intestine in rats. J Pharm Pharmacol 50: 913-920, 1998.
-
(1998)
J Pharm Pharmacol
, vol.50
, pp. 913-920
-
-
Tozaki, H.1
Odoriba, T.2
Iseki, T.3
Taniguchi, T.4
Fujita, T.5
-
25
-
-
0033605051
-
Transport kinetics of leucine enkephalin across Caco-2 monolayers: Quantitative analysis for contribution of enzymatic and transport barrier
-
Quan YS, Fujita T, Tohara D, Tsuji M, Kohyama M et al.: Transport kinetics of leucine enkephalin across Caco-2 monolayers: Quantitative analysis for contribution of enzymatic and transport barrier. Life Sci 64: 1243-1252, 1999.
-
(1999)
Life Sci
, vol.64
, pp. 1243-1252
-
-
Quan, Y.S.1
Fujita, T.2
Tohara, D.3
Tsuji, M.4
Kohyama, M.5
-
26
-
-
0032970713
-
Development of an oral formulation of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, using n-lauryl-β-D-maltopyranoside as an absorption enhancer
-
Sasaki I, Tozaki H, Matsumoto K, Ito Y, Fujita T et al.: Development of an oral formulation of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, using n-lauryl-β-D-maltopyranoside as an absorption enhancer. Biol Pharm Bull 22: 611-615, 1999.
-
(1999)
Biol Pharm Bull
, vol.22
, pp. 611-615
-
-
Sasaki, I.1
Tozaki, H.2
Matsumoto, K.3
Ito, Y.4
Fujita, T.5
-
27
-
-
0033456147
-
Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: Their intestinal mucosal toxicity and absorption enhancing mechanism of n-lauryl-β-D-maltopyranoside
-
Uchiyama T, Sugiyama T, Quan YS, Kotani A, Okada N et al.: Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: Their intestinal mucosal toxicity and absorption enhancing mechanism of n-lauryl-β-D-maltopyranoside. J Pharm Pharmacol 51: 1241-1250, 1999.
-
(1999)
J Pharm Pharmacol
, vol.51
, pp. 1241-1250
-
-
Uchiyama, T.1
Sugiyama, T.2
Quan, Y.S.3
Kotani, A.4
Okada, N.5
-
28
-
-
0035198046
-
Modulation of intestinal permeability by nitric oxide donors: Implications in intestinal delivery of poorly absorbable drugs
-
Yamamoto A, Tatsumi H, Maruyama M, Uchiyama T, Okada N et al.: Modulation of intestinal permeability by nitric oxide donors: Implications in intestinal delivery of poorly absorbable drugs. J Pharmacol Exp Ther 296: 84-90, 2001.
-
(2001)
J Pharmacol Exp Ther
, vol.296
, pp. 84-90
-
-
Yamamoto, A.1
Tatsumi, H.2
Maruyama, M.3
Uchiyama, T.4
Okada, N.5
-
29
-
-
23944457122
-
Nitric oxide donors can enhance the intestinal transport and absorption of insulin and (Asu1,7)-eel calcitonin in rats
-
press
-
Fetih G, Habib F, Okada N, Fujita T, Attia M etl al.: Nitric oxide donors can enhance the intestinal transport and absorption of insulin and (Asu1,7)-eel calcitonin in rats. J Controlled Release, 2005, (in press).
-
(2005)
J Controlled Release
-
-
Fetih, G.1
Habib, F.2
Okada, N.3
Fujita, T.4
Attia, M.5
-
30
-
-
0347824359
-
A new principle for tight junction modulation based on occluding peptides
-
Tavelin S, Hashimoto K, Malkinson J, Lazorova L, Toth I et al.: A new principle for tight junction modulation based on occluding peptides. Mol Pharmacol 64: 1530-1540, 2005.
-
(2005)
Mol Pharmacol
, vol.64
, pp. 1530-1540
-
-
Tavelin, S.1
Hashimoto, K.2
Malkinson, J.3
Lazorova, L.4
Toth, I.5
-
31
-
-
0030815879
-
Gastrointestinal absorption of recombinant human insulin-like growth factor-I in rats
-
Kimura T, Murakawa Y, Ohno M, Ohtani S, Higaki K: Gastrointestinal absorption of recombinant human insulin-like growth factor-I in rats. J Pharmacol Exp Ther 283: 611-618, 1997.
-
(1997)
J Pharmacol Exp Ther
, vol.283
, pp. 611-618
-
-
Kimura, T.1
Murakawa, Y.2
Ohno, M.3
Ohtani, S.4
Higaki, K.5
-
32
-
-
0029075144
-
Gastrointestinal absorption of peptide drug: Quantitative evaluation of the degradation and the permeation of metkephamide in rat small intestine
-
Taki Y, Sakane T, Nadai T, Sezaki H, Amidon GL et al.: Gastrointestinal absorption of peptide drug: Quantitative evaluation of the degradation and the permeation of metkephamide in rat small intestine. J Pharmacol Exp Ther 274: 373-377, 1995.
-
(1995)
J Pharmacol Exp Ther
, vol.274
, pp. 373-377
-
-
Taki, Y.1
Sakane, T.2
Nadai, T.3
Sezaki, H.4
Amidon, G.L.5
-
33
-
-
0027538539
-
Site-dependent effect of aprotinin, sodium caprate, Na2-EDTA and sodium glycocholate on intestinal absorption of insulin
-
Morishita M, Morishita I, Takayama K, Machida Y, Nagai T: Site-dependent effect of aprotinin, sodium caprate, Na2-EDTA and sodium glycocholate on intestinal absorption of insulin. Biol Pharm Bull 16: 68-72, 1993.
-
(1993)
Biol Pharm Bull
, vol.16
, pp. 68-72
-
-
Morishita, M.1
Morishita, I.2
Takayama, K.3
Machida, Y.4
Nagai, T.5
-
34
-
-
0031800880
-
Nitric oxide donors enhance rectal absorption of macromolecules in rabbits
-
Utoguchi N, Watanabe Y, Shida T, Matsumoto M: Nitric oxide donors enhance rectal absorption of macromolecules in rabbits. Pharm Res 15: 870-876, 1998.
-
(1998)
Pharm Res
, vol.15
, pp. 870-876
-
-
Utoguchi, N.1
Watanabe, Y.2
Shida, T.3
Matsumoto, M.4
-
35
-
-
0031574261
-
Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers
-
Kotze AF, de Leeuw BJ, LueBen HL, de Boer AG, Verhoef JC et al.: Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers. Int J Pharm 159: 243-253, 1997.
-
(1997)
Int J Pharm
, vol.159
, pp. 243-253
-
-
Kotze, A.F.1
de Leeuw, B.J.2
LueBen, H.L.3
de Boer, A.G.4
Verhoef, J.C.5
-
36
-
-
0030839517
-
N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: in vitro evaluation in intestinal epithelial cells (Caco-2)
-
Kotze AF, de LueBen HL, Leeuw BJ, de Boer AG, Verhoef JC et al.: N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: in vitro evaluation in intestinal epithelial cells (Caco-2). Pharm Res 14: 1197-1202, 1997.
-
(1997)
Pharm Res
, vol.14
, pp. 1197-1202
-
-
Kotze, A.F.1
de LueBen, H.L.2
Leeuw, B.J.3
de Boer, A.G.4
Verhoef, J.C.5
-
37
-
-
0029875543
-
The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system
-
Nerurkar MM, Burton PS, Borchardt RT: The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm Res 13: 528-534. 1996.
-
(1996)
Pharm Res
, vol.13
, pp. 528-534
-
-
Nerurkar, M.M.1
Burton, P.S.2
Borchardt, R.T.3
-
38
-
-
0030790290
-
Mechanistic roles of neutral surfactants on concurrent polarized and passive transport of a model peptide in Caco-2 cells
-
Nerurkar MM, Ho NFH, Burton PS, Vidmar TJ, Borchardt RT: Mechanistic roles of neutral surfactants on concurrent polarized and passive transport of a model peptide in Caco-2 cells. J Pharm Sci 86: 813-821, 1997.
-
(1997)
J Pharm Sci
, vol.86
, pp. 813-821
-
-
Nerurkar, M.M.1
Ho, N.F.H.2
Burton, P.S.3
Vidmar, T.J.4
Borchardt, R.T.5
-
39
-
-
1842587393
-
Modulation of intestinal P-glycoprotein function by Cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes
-
Shono Y, Nishihara H, Matsuda Y, Furukawa S, Okada N et al.: Modulation of intestinal P-glycoprotein function by Cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes. J Pharm Sci 93: 877-885, 2004.
-
(2004)
J Pharm Sci
, vol.93
, pp. 877-885
-
-
Shono, Y.1
Nishihara, H.2
Matsuda, Y.3
Furukawa, S.4
Okada, N.5
-
40
-
-
0026720001
-
Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid in rats
-
Hashizume M, Douen T, Murakami M, Yamamoto A, Takada K et al.: Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid in rats. J Pharm Pharmacol 44: 555-559, 1992.
-
(1992)
J Pharm Pharmacol
, vol.44
, pp. 555-559
-
-
Hashizume, M.1
Douen, T.2
Murakami, M.3
Yamamoto, A.4
Takada, K.5
-
41
-
-
0026646625
-
Improvement of intestinal absorption of thyrotropin-releasing hormone by chemical modification with lauric acid
-
Yamada K, Murakami M, Yamamoto A, Takada K, Muranishi S: Improvement of intestinal absorption of thyrotropin-releasing hormone by chemical modification with lauric acid. J Pharm Pharmacol 44: 717-721, 1992.
-
(1992)
J Pharm Pharmacol
, vol.44
, pp. 717-721
-
-
Yamada, K.1
Murakami, M.2
Yamamoto, A.3
Takada, K.4
Muranishi, S.5
-
42
-
-
0027423724
-
Development of new lipophilic derivatives of tetragastrin: physicochemical characteristics and intestinal absorption of acyl-tetragastrin derivatives in rats
-
Tenma T, Yodoya E, Tashima S, Fujita T, Murakami M et al.: Development of new lipophilic derivatives of tetragastrin: physicochemical characteristics and intestinal absorption of acyl-tetragastrin derivatives in rats. Pharm Res 10: 1488-1492, 1993.
-
(1993)
Pharm Res
, vol.10
, pp. 1488-1492
-
-
Tenma, T.1
Yodoya, E.2
Tashima, S.3
Fujita, T.4
Murakami, M.5
-
43
-
-
0345264179
-
Modification of Peptide for Intestinal Delivery
-
(eds. Crommelin DJA et al.), Medpharm Scientific Publishers, Stuttgart
-
Muranishi S, Yamamoto A: Modification of Peptide for Intestinal Delivery in Topics in Pharmaceutical Sciences 1993. (eds. Crommelin DJA et al.), Medpharm Scientific Publishers, Stuttgart, 1994, 372-382.
-
(1994)
Topics in Pharmaceutical Sciences 1993
, pp. 372-382
-
-
Muranishi, S.1
Yamamoto, A.2
-
44
-
-
0028137058
-
Stability of acyl derivatives of insulin in the small intestine: Relative importance of insulin association characteristics in aqueous solution
-
Asada H, Douen T, Mizokoshi Y, Fujita T, Murakami M et al.: Stability of acyl derivatives of insulin in the small intestine: Relative importance of insulin association characteristics in aqueous solution. Pharm Res 11: 1115-1120, 1994.
-
(1994)
Pharm Res
, vol.11
, pp. 1115-1120
-
-
Asada, H.1
Douen, T.2
Mizokoshi, Y.3
Fujita, T.4
Murakami, M.5
-
45
-
-
0027941981
-
Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids
-
Yodoya E, Uemura K, Tenma T, Fujita T, Murakami M et al.: Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids. J Pharmacol Exp Ther 271: 1509-1513, 1994.
-
(1994)
J Pharmacol Exp Ther
, vol.271
, pp. 1509-1513
-
-
Yodoya, E.1
Uemura, K.2
Tenma, T.3
Fujita, T.4
Murakami, M.5
-
46
-
-
0029056705
-
Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine
-
Asada H, Douen T, Waki M, Adachi S, Fujita T et al.: Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine. J Pharm Sci 84: 682-687, 1995.
-
(1995)
J Pharm Sci
, vol.84
, pp. 682-687
-
-
Asada, H.1
Douen, T.2
Waki, M.3
Adachi, S.4
Fujita, T.5
-
47
-
-
0028866639
-
Improvement of transdermal delivery of tetragastrin by lipophilic modification with fatty acids
-
Setoh K, Murakami M, Araki N, Fujita T, Yamamoto A et al.: Improvement of transdermal delivery of tetragastrin by lipophilic modification with fatty acids. J Pharm Pharmacol 47: 808-811, 1995.
-
(1995)
J Pharm Pharmacol
, vol.47
, pp. 808-811
-
-
Setoh, K.1
Murakami, M.2
Araki, N.3
Fujita, T.4
Yamamoto, A.5
-
48
-
-
0030039663
-
Improvement of intestinal absorption of human calcitonin by chemical modification with fatty acids: Synergistic effects of acylation and absorption enhancers
-
Fujita T, Fujita T, Morikawa K, Tanaka H, Iemura O et al.: Improvement of intestinal absorption of human calcitonin by chemical modification with fatty acids: Synergistic effects of acylation and absorption enhancers. Int J Pharm 134: 47-57, 1996.
-
(1996)
Int J Pharm
, vol.134
, pp. 47-57
-
-
Fujita, T.1
Fujita, T.2
Morikawa, K.3
Tanaka, H.4
Iemura, O.5
-
49
-
-
0030583211
-
Enhancement of intestinal transport of thyrotropin-releasing hormone via a carrier-mediated transport system by chemical modification with lauric acid
-
Tanaka K, Fujita T, Yamamoto Y, Murakami M, Yamamoto A et al.: Enhancement of intestinal transport of thyrotropin-releasing hormone via a carrier-mediated transport system by chemical modification with lauric acid. Biochim Biophys Acta 1283: 119-126, 1996.
-
(1996)
Biochim Biophys Acta
, vol.1283
, pp. 119-126
-
-
Tanaka, K.1
Fujita, T.2
Yamamoto, Y.3
Murakami, M.4
Yamamoto, A.5
-
50
-
-
0031567719
-
Enhancement of the small intestinal uptake of phenylalanyl-glycine via a H+/oligopeptide transport system by chemical modification with fatty acids
-
Fujita T, Morishita Y, Ito H, Kuribayashi D, Yamamoto A et al.: Enhancement of the small intestinal uptake of phenylalanyl-glycine via a H+/oligopeptide transport system by chemical modification with fatty acids. Life Sci 61: 2455-2465, 1997.
-
(1997)
Life Sci
, vol.61
, pp. 2455-2465
-
-
Fujita, T.1
Morishita, Y.2
Ito, H.3
Kuribayashi, D.4
Yamamoto, A.5
-
51
-
-
0031563893
-
Rectal drug delivery systems
-
Improvement of rectal peptide absorption by absorption enhancers, protease inhibitors and chemical modification
-
Yamamoto A, Muranishi S: Rectal drug delivery systems. Improvement of rectal peptide absorption by absorption enhancers, protease inhibitors and chemical modification. Adv Drug Delivery Rev 28: 275-299, 1997.
-
(1997)
Adv Drug Delivery Rev
, vol.28
, pp. 275-299
-
-
Yamamoto, A.1
Muranishi, S.2
-
52
-
-
0031784784
-
Permeability characteristics of tetragastrin across intestinal membranes using the Caco-2 monolayer system: comparison between acylation and application of protease inhibitors
-
Fujita T, Kawahara I, Quan YS, Hattori K, Takenaka K et al.: Permeability characteristics of tetragastrin across intestinal membranes using the Caco-2 monolayer system: comparison between acylation and application of protease inhibitors. Pharm Res 15: 1387-1392, 1998.
-
(1998)
Pharm Res
, vol.15
, pp. 1387-1392
-
-
Fujita, T.1
Kawahara, I.2
Quan, Y.S.3
Hattori, K.4
Takenaka, K.5
-
53
-
-
0034467999
-
Development of novel lipophilic derivatives of DADLE (Leucine enkephalin analogue): Intestinal permeability characteristics of DADLE derivatives in rats
-
Uchiyama T, Kotani A, Tatsumi H, Kishida T, Okamoto A et al.: Development of novel lipophilic derivatives of DADLE (Leucine enkephalin analogue): Intestinal permeability characteristics of DADLE derivatives in rats. Pharm Res 17: 1461-1467, 2000.
-
(2000)
Pharm Res
, vol.17
, pp. 1461-1467
-
-
Uchiyama, T.1
Kotani, A.2
Tatsumi, H.3
Kishida, T.4
Okamoto, A.5
-
54
-
-
0037413378
-
Enhanced transdermal delivery of phenylalanyl-glycine by chemical modification with various fatty acids
-
Yamamoto A, Setoh K, Murakami M, Shironoshita M, Kobayashi T et al.: Enhanced transdermal delivery of phenylalanyl-glycine by chemical modification with various fatty acids. Int J Pharm 250, 119-128, 2003.
-
(2003)
Int J Pharm
, vol.250
, pp. 119-128
-
-
Yamamoto, A.1
Setoh, K.2
Murakami, M.3
Shironoshita, M.4
Kobayashi, T.5
-
55
-
-
85010103676
-
Enhanced permeability of phenylalanyl-glycine (Phe-Gly) across the intestinal membranes by chemical modification with various fatty acids
-
Yamamoto A, Morishita Y, Sugishita S, Hayami T, Okada N et al.: Enhanced permeability of phenylalanyl-glycine (Phe-Gly) across the intestinal membranes by chemical modification with various fatty acids. Drug Metab Pharmacokinet 18: 23-32, 2003.
-
(2003)
Drug Metab Pharmacokinet
, vol.18
, pp. 23-32
-
-
Yamamoto, A.1
Morishita, Y.2
Sugishita, S.3
Hayami, T.4
Okada, N.5
-
56
-
-
0036804013
-
Arginin-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms
-
Futaki S: Arginin-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms. Int J Pharm 245: 1-7, 2002.
-
(2002)
Int J Pharm
, vol.245
, pp. 1-7
-
-
Futaki, S.1
-
57
-
-
0031773397
-
Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1
-
Tamai I, Nakanishi T, Nakahara H, Sai Y, Ganapathy V et al.: Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1. J Pharm Sci 87: 1542-1546, 1998.
-
(1998)
J Pharm Sci
, vol.87
, pp. 1542-1546
-
-
Tamai, I.1
Nakanishi, T.2
Nakahara, H.3
Sai, Y.4
Ganapathy, V.5
-
58
-
-
0029781483
-
Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors
-
Mizuma T, Ohta K, Koyanagi A, Awazu S: Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors. J Pharm Sci 85: 854-857, 1996.
-
(1996)
J Pharm Sci
, vol.85
, pp. 854-857
-
-
Mizuma, T.1
Ohta, K.2
Koyanagi, A.3
Awazu, S.4
-
59
-
-
0030951623
-
Intestinal transport and metabolism of analgesic dipeptide, kyotorphin: ratelimiting factor in intestinal absorption of peptide as drug
-
Mizuma T, Koyanagi A, Awazu S: Intestinal transport and metabolism of analgesic dipeptide, kyotorphin: ratelimiting factor in intestinal absorption of peptide as drug. Biochim Biophys Acta 1335: 111-119, 1997.
-
(1997)
Biochim Biophys Acta
, vol.1335
, pp. 111-119
-
-
Mizuma, T.1
Koyanagi, A.2
Awazu, S.3
-
60
-
-
0031944490
-
Improvement of intestinal absorption of peptide drugs by glycosylation: transport of tetrapeptide by the sodium ion dependent D-glucose transporter
-
Nomoto M, Yamada K, Haga M, Hayashi M: Improvement of intestinal absorption of peptide drugs by glycosylation: transport of tetrapeptide by the sodium ion dependent D-glucose transporter. J Pharm Sci 87: 326-332, 1998.
-
(1998)
J Pharm Sci
, vol.87
, pp. 326-332
-
-
Nomoto, M.1
Yamada, K.2
Haga, M.3
Hayashi, M.4
-
61
-
-
0031039653
-
Modified bile acids as carriers for peptides and drugs
-
Kramer W, Wess G, Enhsen A, Falk E, Hoffmann A et al.: Modified bile acids as carriers for peptides and drugs. J Controlled Release 46: 17-30, 1997.
-
(1997)
J Controlled Release
, vol.46
, pp. 17-30
-
-
Kramer, W.1
Wess, G.2
Enhsen, A.3
Falk, E.4
Hoffmann, A.5
-
62
-
-
0030581085
-
Use of the intestinal and hepatic bile acid transporters for drug delivery
-
Swaan PW, Szoka FC, Oie S: Use of the intestinal and hepatic bile acid transporters for drug delivery. Adv Drug Delivery Rev 20: 59-82, 1996.
-
(1996)
Adv Drug Delivery Rev
, vol.20
, pp. 59-82
-
-
Swaan, P.W.1
Szoka, F.C.2
Oie, S.3
-
63
-
-
0032217158
-
Use of vitamin B12 conjugates to deliver protein drugs by the oral route
-
Russell-Jones GJ: Use of vitamin B12 conjugates to deliver protein drugs by the oral route. Crit Rev Ther Drug Carrier Syst 15: 557-586, 1998.
-
(1998)
Crit Rev Ther Drug Carrier Syst
, vol.15
, pp. 557-586
-
-
Russell-Jones, G.J.1
-
64
-
-
0030457349
-
Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells
-
Shah D, Shen WC: Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells. J Pharm Sci 85: 1306-1311, 1996.
-
(1996)
J Pharm Sci
, vol.85
, pp. 1306-1311
-
-
Shah, D.1
Shen, W.C.2
-
65
-
-
0030612306
-
Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon
-
Tozaki H, Komoike J, Tada C, Maruyama T, Terabe A et al.: Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon. J Pharm Sci 86: 1016-1021, 1997.
-
(1997)
J Pharm Sci
, vol.86
, pp. 1016-1021
-
-
Tozaki, H.1
Komoike, J.2
Tada, C.3
Maruyama, T.4
Terabe, A.5
-
66
-
-
0033582731
-
Colon-specific delivery of R68070, a new thromboxane synthase inhibitor, using chitosan capsules: Therapeutic effects against 2,4,6-trinitrobenzene sulphonic acid-induced ulcerative colitis in rats
-
Tozaki H, Fujita T, Odoriba T, Terabe A, Suzuki T et al.: Colon-specific delivery of R68070, a new thromboxane synthase inhibitor, using chitosan capsules: Therapeutic effects against 2,4,6-trinitrobenzene sulphonic acid-induced ulcerative colitis in rats. Life Sci 64: 1155-1162, 1999.
-
(1999)
Life Sci
, vol.64
, pp. 1155-1162
-
-
Tozaki, H.1
Fujita, T.2
Odoriba, T.3
Terabe, A.4
Suzuki, T.5
-
67
-
-
0032937730
-
Colon-specific delivery of budesonide with azopolymer-coated pellets: Therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats
-
Tozaki H, Fujita T, Komoike J, Kim SI, Terashima H et al.: Colon-specific delivery of budesonide with azopolymer-coated pellets: Therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats. J Pharm Pharmacol 51: 257-261, 1999.
-
(1999)
J Pharm Pharmacol
, vol.51
, pp. 257-261
-
-
Tozaki, H.1
Fujita, T.2
Komoike, J.3
Kim, S.I.4
Terashima, H.5
-
68
-
-
0032710037
-
Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats
-
Tozaki H, Fujita T, Odoriba T, Terabe A, Okabe S et al.: Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats. J Pharm Pharmacol 51: 1107-1112, 1999.
-
(1999)
J Pharm Pharmacol
, vol.51
, pp. 1107-1112
-
-
Tozaki, H.1
Fujita, T.2
Odoriba, T.3
Terabe, A.4
Okabe, S.5
-
69
-
-
0033994494
-
Colon-specific delivery of peptide drugs and anti-inflammatory drugs using chitosan capsules
-
Yamamoto A, Tozaki H, Okada N, Fujita T: Colon-specific delivery of peptide drugs and anti-inflammatory drugs using chitosan capsules. STP Pharma Sciences 10: 23-34, 2000.
-
(2000)
STP Pharma Sciences
, vol.10
, pp. 23-34
-
-
Yamamoto, A.1
Tozaki, H.2
Okada, N.3
Fujita, T.4
-
70
-
-
0035158172
-
Enhanced absorption of insulin and (Asul.7)eel-calcitonin using novel azopolymer-coated pellets for colon-specific drug delivery
-
Tozaki H, Nishioka J, Komoike J, Okada N, Fujita T et al.: Enhanced absorption of insulin and (Asul.7)eel-calcitonin using novel azopolymer-coated pellets for colon-specific drug delivery. J Pharm Sci 90: 89-97, 2001.
-
(2001)
J Pharm Sci
, vol.90
, pp. 89-97
-
-
Tozaki, H.1
Nishioka, J.2
Komoike, J.3
Okada, N.4
Fujita, T.5
-
71
-
-
0037130218
-
Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats
-
Tozaki H, Odoriba T, Okada N, Fujita T, Terabe A et al.: Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats. J Controlled Release 82: 51-61, 2002.
-
(2002)
J Controlled Release
, vol.82
, pp. 51-61
-
-
Tozaki, H.1
Odoriba, T.2
Okada, N.3
Fujita, T.4
Terabe, A.5
-
72
-
-
15044359147
-
Improvement of absorption enhancing effects of n-dodecyl-β-D-maltopyranoside by its colon-specific delivery using chitosan capsules
-
Fetih G, Lindberg S, Itoh K, Okada N, Fujita T et al.: Improvement of absorption enhancing effects of n-dodecyl-β-D-maltopyranoside by its colon-specific delivery using chitosan capsules. Int J Pharm 293: 127-135, 2005.
-
(2005)
Int J Pharm
, vol.293
, pp. 127-135
-
-
Fetih, G.1
Lindberg, S.2
Itoh, K.3
Okada, N.4
Fujita, T.5
-
73
-
-
0022468493
-
A new approach to the oral administration of insulin and other peptide drugs
-
Saffran M, Kumar GS, Savariar C, Burnham JC, Williams F et al.: A new approach to the oral administration of insulin and other peptide drugs. Science 233: 1081-1084, 1986.
-
(1986)
Science
, vol.233
, pp. 1081-1084
-
-
Saffran, M.1
Kumar, G.S.2
Savariar, C.3
Burnham, J.C.4
Williams, F.5
-
74
-
-
0031710609
-
Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid
-
Suzuki A, Morishita M, Kajita M, Takayama K, Isowa K et al.: Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid. J Pharm Sci 87: 1196-1202, 1998.
-
(1998)
J Pharm Sci
, vol.87
, pp. 1196-1202
-
-
Suzuki, A.1
Morishita, M.2
Kajita, M.3
Takayama, K.4
Isowa, K.5
-
75
-
-
0029895328
-
Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes
-
Takeuchi H, Yamamoto H, Niwa T, Hino T, Kawashima Y: Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes. Pharm Res 13: 896-901, 1996.
-
(1996)
Pharm Res
, vol.13
, pp. 896-901
-
-
Takeuchi, H.1
Yamamoto, H.2
Niwa, T.3
Hino, T.4
Kawashima, Y.5
-
76
-
-
0030801601
-
Oral delivery of insulin by using surface coating Liposomes
-
Improvement of stability of insulin in GI tract
-
Iwanaga K, Ono S, Narioka K, Morimoto K, Kakemi M et al.: Oral delivery of insulin by using surface coating Liposomes. Improvement of stability of insulin in GI tract. Int J Pharm 157: 73-80, 1997.
-
(1997)
Int J Pharm
, vol.157
, pp. 73-80
-
-
Iwanaga, K.1
Ono, S.2
Narioka, K.3
Morimoto, K.4
Kakemi, M.5
-
77
-
-
0030895036
-
Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches
-
Sakuma S, Suzuki N, Kikuchi H, Hiwatari K, Arikawa K et al.: Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches. Int J Pharm 149: 93-106. 1997.
-
(1997)
Int J Pharm
, vol.149
, pp. 93-106
-
-
Sakuma, S.1
Suzuki, N.2
Kikuchi, H.3
Hiwatari, K.4
Arikawa, K.5
-
78
-
-
0031446134
-
Poly (alkyl cyanoacrylate) nanospheres for oral administration of insulin
-
Damge C, Vranckx H, Balschmidt P, Couvreur P: Poly (alkyl cyanoacrylate) nanospheres for oral administration of insulin. J Pharm Sci 86: 1403-1409, 1997.
-
(1997)
J Pharm Sci
, vol.86
, pp. 1403-1409
-
-
Damge, C.1
Vranckx, H.2
Balschmidt, P.3
Couvreur, P.4
-
79
-
-
0025987560
-
Effect of absorption enhancers on pulmonary absorption of fluorescein isothiocyanate dextrans with various molecular weights
-
Ohtani T, Murakami M, Yamamoto A, Takada K, Muranishi S: Effect of absorption enhancers on pulmonary absorption of fluorescein isothiocyanate dextrans with various molecular weights. Int J Pharm 77: 141-150, 1991.
-
(1991)
Int J Pharm
, vol.77
, pp. 141-150
-
-
Ohtani, T.1
Murakami, M.2
Yamamoto, A.3
Takada, K.4
Muranishi, S.5
-
80
-
-
0027178382
-
Effects of various absorption promoters on pulmonary absorption of drugs with different molecular weights
-
Morita T, Yamamoto A, Hashida M, Sezaki H: Effects of various absorption promoters on pulmonary absorption of drugs with different molecular weights. Biol Pharm Bull 16: 259-262, 1993.
-
(1993)
Biol Pharm Bull
, vol.16
, pp. 259-262
-
-
Morita, T.1
Yamamoto, A.2
Hashida, M.3
Sezaki, H.4
-
81
-
-
0027241704
-
Effect of absorption promoters on the nasal absorption of drugs with various molecular weights
-
Yamamoto A, Morita T, Hashida M, Sezaki H: Effect of absorption promoters on the nasal absorption of drugs with various molecular weights. Int J Pharm 93: 91-99, 1993.
-
(1993)
Int J Pharm
, vol.93
, pp. 91-99
-
-
Yamamoto, A.1
Morita, T.2
Hashida, M.3
Sezaki, H.4
-
82
-
-
0027955697
-
Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats
-
Yamamoto A, Umemori S, Muranishi S: Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats. J Pharm Pharmacol 46: 14-18, 1994.
-
(1994)
J Pharm Pharmacol
, vol.46
, pp. 14-18
-
-
Yamamoto, A.1
Umemori, S.2
Muranishi, S.3
-
83
-
-
0028309587
-
Improvement of the pulmonary absorption of (Asu1.7)-eelcalcitonin by various protease inhibitors in rats
-
Morita T, Yamamoto A, Takakura Y, Hashida M, Sezaki H: Improvement of the pulmonary absorption of (Asu1.7)-eelcalcitonin by various protease inhibitors in rats. Pharm Res 11: 909-913, 1994.
-
(1994)
Pharm Res
, vol.11
, pp. 909-913
-
-
Morita, T.1
Yamamoto, A.2
Takakura, Y.3
Hashida, M.4
Sezaki, H.5
-
84
-
-
0029055776
-
Susceptibility of insulin to proteolysis in rat lung homogenate and its protection from proteolysis by various protease inhibitors
-
Fukuda Y, Tsuji T, Fujita T, Yamamoto A, Muranishi S: Susceptibility of insulin to proteolysis in rat lung homogenate and its protection from proteolysis by various protease inhibitors. Biol Pharm Bull 18: 891-894, 1995.
-
(1995)
Biol Pharm Bull
, vol.18
, pp. 891-894
-
-
Fukuda, Y.1
Tsuji, T.2
Fujita, T.3
Yamamoto, A.4
Muranishi, S.5
-
85
-
-
0029598821
-
Molecular weight-dependent lymphatic transfer of fluorescein isothiocyanate-labeled dextrans after intrapulmonary administration and effects of various absorption enhancers on the lymphatic transfer of drugs in rats
-
Hanatani K, Takada K, Yoshida N, Nakasuji M, Morishita Y et al.: Molecular weight-dependent lymphatic transfer of fluorescein isothiocyanate-labeled dextrans after intrapulmonary administration and effects of various absorption enhancers on the lymphatic transfer of drugs in rats. J Drug Targeting 3: 263-271, 1995.
-
(1995)
J Drug Targeting
, vol.3
, pp. 263-271
-
-
Hanatani, K.1
Takada, K.2
Yoshida, N.3
Nakasuji, M.4
Morishita, Y.5
-
86
-
-
0030222306
-
Pulmonary absorption enhancement of peptides by absorption enhancers and protease inhibitors
-
Yamamoto A, Fujita T, Muranishi S: Pulmonary absorption enhancement of peptides by absorption enhancers and protease inhibitors. J Controlled Release 41: 57-67, 1996.
-
(1996)
J Controlled Release
, vol.41
, pp. 57-67
-
-
Yamamoto, A.1
Fujita, T.2
Muranishi, S.3
-
87
-
-
0029783378
-
Transport of drugs across the Xenopus pulmonary membrane and their absorption enhancement by various absorption enhancers
-
Okumura S, Fukuda Y, Takahashi K, Fujita T, Yamamoto A et al.: Transport of drugs across the Xenopus pulmonary membrane and their absorption enhancement by various absorption enhancers: Pharm Res 13: 1247-1251, 1996.
-
(1996)
Pharm Res
, vol.13
, pp. 1247-1251
-
-
Okumura, S.1
Fukuda, Y.2
Takahashi, K.3
Fujita, T.4
Yamamoto, A.5
-
88
-
-
0030873810
-
Evaluation of drug absorption after intrapulmonary administration using Xenopus pulmonary membranes: correlation with in vivo pulmonary absorption studies in rats
-
Okumura S, Tanaka H, Shinsako K, Ito M, Yamamoto A et al.: Evaluation of drug absorption after intrapulmonary administration using Xenopus pulmonary membranes: correlation with in vivo pulmonary absorption studies in rats. Pharm Res 14: 1282-1285, 1997.
-
(1997)
Pharm Res
, vol.14
, pp. 1282-1285
-
-
Okumura, S.1
Tanaka, H.2
Shinsako, K.3
Ito, M.4
Yamamoto, A.5
-
89
-
-
0030922813
-
Improvement of the pulmonary absorption of (Asu1.7)-eel calcitonin by various absorption enhancers and their pulmonary toxicity in rats
-
Yamamoto A, Okumura S, Fukuda Y, Fukui M, Takahashi K et al.: Improvement of the pulmonary absorption of (Asu1.7)-eel calcitonin by various absorption enhancers and their pulmonary toxicity in rats. J Pharm Sci 86: 1144-1147. 1997.
-
(1997)
J Pharm Sci
, vol.86
, pp. 1144-1147
-
-
Yamamoto, A.1
Okumura, S.2
Fukuda, Y.3
Fukui, M.4
Takahashi, K.5
-
90
-
-
0035914224
-
Absorption of water-soluble compounds with different molecular weights and (Asu1.7)-eel calcitonin from various mucosal administration sites
-
Yamamoto A, Iseki T, Ochi-Sugiyama M, Okada N, Fujita T et al.: Absorption of water-soluble compounds with different molecular weights and (Asu1.7)-eel calcitonin from various mucosal administration sites. J Controlled Release 76: 363-374, 2001.
-
(2001)
J Controlled Release
, vol.76
, pp. 363-374
-
-
Yamamoto, A.1
Iseki, T.2
Ochi-Sugiyama, M.3
Okada, N.4
Fujita, T.5
-
91
-
-
4444233923
-
Control of pulmonary absorption of water-soluble compounds by various viscous vehicles
-
Yamamoto A, Yamada K, Muramatsu H, Nishinaka A, Okumura S et al.: Control of pulmonary absorption of water-soluble compounds by various viscous vehicles. It J Pharm 282: 141-149, 2004.
-
(2004)
It J Pharm
, vol.282
, pp. 141-149
-
-
Yamamoto, A.1
Yamada, K.2
Muramatsu, H.3
Nishinaka, A.4
Okumura, S.5
-
92
-
-
15044347224
-
Carageenans can regulate the pulmonary absorption of antiasthmatic drugs and their retiontion in the lung tissues without any membrane damage
-
Yamada K, Kamada N, Odomi M, Okada N, Nabe T: Carageenans can regulate the pulmonary absorption of antiasthmatic drugs and their retiontion in the lung tissues without any membrane damage. Int J Pharm 293: 63-72, 2005.
-
(2005)
Int J Pharm
, vol.293
, pp. 63-72
-
-
Yamada, K.1
Kamada, N.2
Odomi, M.3
Okada, N.4
Nabe, T.5
-
93
-
-
30544453617
-
Chitosan oligomers as potential and safe absorption enhancers for improving the pulmonary absorption of interferon-α in rats
-
press
-
Yamada K, Odomi M, Okada N, Fujita T, Yamamoto A: Chitosan oligomers as potential and safe absorption enhancers for improving the pulmonary absorption of interferon-α in rats. J Pharm Sci, 2005, (in press).
-
(2005)
J Pharm Sci
-
-
Yamada, K.1
Odomi, M.2
Okada, N.3
Fujita, T.4
Yamamoto, A.5
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