N-Trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: In vitro evaluation in intestinal epithelial cells (Caco-2)

Pharmaceutical Research

Volumn 14, Issue 9, 1997, Pages 1197-1202

  Kotzé, Awie F ^a,b   Lueßen, Henrik L ^b   De Leeuw, Bas J ^b   De Boer, Bert G ^b   Verhoef, J Coos ^b   Junginger, Hans E ^b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Absorption enhancer; Caco 2 cell monolayers; N trimethyl chitosan chloride; Paracellular transport; Transepithelial electrical resistance

Indexed keywords

BUSERELIN; CHITOSAN DERIVATIVE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MANNITOL; N TRIMETHYLCHITOSAN CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONFOCAL LASER MICROSCOPY; DRUG ABSORPTION; DRUG SYNTHESIS; DRUG TRANSPORT; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; TRANSCYTOSIS;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CHELATING AGENTS; CHITIN; CHITOSAN; EPITHELIUM; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA;

EID: 0030839517     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012106907708     Document Type: Article

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