Pulmonary absorption enhancement of peptides by absorption enhancers and protease inhibitors

Journal of Controlled Release

Volumn 41, Issue 1-2, 1996, Pages 57-67

  Yamamoto, Akira ^a   Fujita, Takuya ^a   Muranishi, Shozo ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Absorption enhancers; Peptides; Protease inhibitors; Pulmonary absorption; Stability

Indexed keywords

APROTININ; BACITRACIN; CALCITONIN DERIVATIVE; DECANOATE SODIUM; EDETATE DISODIUM; EDETIC ACID; ELCATONIN; EVANS BLUE; GLYCOCHOLATE SODIUM; INSULIN; LINOLEIC ACID; PENETRATION ENHANCING AGENT; PEPTIDE; PROTEINASE INHIBITOR; SALICYLATE SODIUM; SOYBEAN TRYPSIN INHIBITOR; SURFACTANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DEGRADATION; DRUG POTENCY; DRUG STABILITY; HYPOCALCEMIA; HYPOGLYCEMIA; INTRAVENOUS DRUG ADMINISTRATION; LUNG; LUNG INJURY; MALE; MICELLE; MUCOSA; NONHUMAN; PRIORITY JOURNAL; RAT; TOPICAL DRUG ADMINISTRATION;

EID: 0030222306     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(96)01480-0     Document Type: Conference Paper

References (41)

1. [1] S. Hirai, T. Yashiki and H. Mima, Effect of surfactants on the nasal absorption of insulin in rats, Int. J. Pharm. 9 (1981) 165-172.
2. [2] M. Ishida, Y. Machida, N. Nambu and T. Nagai, New mucosal dosage form of insulin, Chem. Pharm. Bull. 29 (1981) 810-816.
3. [3] T. Nishihata, J.H. Rytting, A. Kamada, T. Higuchi, M. Routh and L. Caldwell, Enhancement of rectal absorption of insulin using salicylates in dogs, J. Pharm. Pharmacol. 35 (1983) 148-151.
4. [4] H. Okada, I. Yamazaki, Y. Ogawa, S. Hirai, T. Yashiki and H. Mima, Vaginal absorption of a potent luteinizing hormonereleasing hormone analog (leuprolide) in rat I: absorption by various routes and absorption enhancement, J. Pharm. Sci. 71 (1982) 1367-1371.
5. [5] A. Yamamoto, A.M. Luo, S. Dodda-Kashi and V.H.L. Lee, The ocular route for systemic insulin delivery in the albino rabbit, J. Pharmacol. Exp. Ther. 249 (1989) 249-255.
6. [6] H. Yoshida, K. Okumura, R. Hori, T. Anmo and H. Yamaguchi, Absorption of insulin delivered to rabbit trachea using aerosol dosage form, J. Pharm. Sci. 68 (1979) 670-671.
7. [7] D.T. O'Hagan and L. Illum, Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine, Crit. Rev. Ther. Drug Carrier Syst. 7 (1990) 35-97.
8. [8] S.J. Enna and L.S. Schanker, Absorption of saccharides and urea from the rat lung, Am. J. Physiol. 222 (1972a) 409-414.
9. [9] F.M. Wigley, J.H. Londono, S.H. Wood, J.C. Shipp and R.H. Waldman, Insulin across respiratory mucosae by aerosol delivery, Diabetes 20 (1971) 552-556.
10. [10] K. Takada, M. Yamamoto, H. Nakae and S. Asada, Enhancement of pulmonary absorption of fluorescein isothiocyanate-labelled dextran (FITC-dextran) by sodium glycocholate in rats, Chem. Pharm. Bull. 28 (1980) 2806-2808.
11. [11] R.W. Niven and P.R. Byron, Solute absorption from the airways of the isolated rat lung. II. Effect of surfactants on absorption of fluorescein, Pharm. Res. 7 (1990) 8-13.
12. [12] V.H.L. Lee and A. Yamamoto, Penetration and enzymatic barriers to peptide and protein absorption, Adv. Drug Delivery Rev. 4 (1990) 171-207.
13. [13] T. Ohtani, M. Murakami, A. Yamamoto, K. Takada and S. Muranishi, Effect of absorption enhancers on pulmonary absorption of fluorescein isothiocyanate dextrans with various molecular weights, Int. J. Pharm. 77 (1991) 141-150.
14. [14] T. Morita, A. Yamamoto, M. Hashida and H. Sezaki, Effect of various absorption promoters on pulmonary absorption of drugs with different molecular weights, Biol. Pharm. Bull. 16 (1993) 259-262.
15. [15] S.J. Enna and L.S. Schanker, Absorption of drugs from the rat lung, Am. J. Physiol. 223 (1972b) 1227-1231.
16. [16] Y. Fukuda, T. Tsuji, T. Fujita, A. Yamamoto and S. Muranishi, Susceptibility of insulin to proteolysis in rat lung homogenate and its protection from proteolysis by various protease inhibitors, Biol. Pharm. Bull. 18 (1995) 891-894.
17. [17] O.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randall, Protein measurement with folin phenol reagent, J. Biol. Chem. 193 (1951) 265-275.
18. [18] K. Okumura, S. Iwakawa, T. Yoshida, T. Seki and F. Komada, Intratracheal delivery of insulin absorption from solution and aerosol by rat lung, Int. J. Pharm. 88 (1992) 63-73.
19. [19] A. Yamamoto, S. Umemori and S. Muranishi, Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats, J. Pharm. Pharmacol. 46 (1994) 14-18.
20. 1,7) eel-calcitonin by various protease inhibitors, Pharm. Res. 11 (1994) 909-913.
21. [21] S. Kobayashi, S. Kondo and K. Juni, Study on pulmonary delivery of salmon calcitonin in rats: effects of protease inhibitors and absorption enhancers, Pharm. Res. 11 (1994) 1239-1243.
22. [22] S.J. Hersey and R.T. Jackson, Effect of bile salts on nasal permeability in vitro, J. Pharm. Sci. 76 (1987) 876-879.
23. [23] G.S. Gordon, A.C. Moses, R.D. Silver, J.S. Flier and M.C. Carey, Nasal absorption of insulin: Enhancement by hydrophobic bile salts, Proc. Natl. Acad. Sci. USA 82 (1985) 7419-7423.
24. [24] S. Hirai, T. Yashiki and H. Mima, Mechanisms for the enhancement of the nasal absorption of insulin by surfactants, Int. J. Pharm. 9 (1981b) 173-184.
25. [25] A. Yamamoto, E. Hayakawa and V.H.L. Lee, Insulin and proinsulin proteolysis in mucosal homogenates of the albino rabbit: implications in peptide delivery from nonoral route, Life Sci. 47 (1990) 2465-2474.
26. [26] A. Yamamoto, E. Hayakawa, Y. Kato, A. Nishiura and V.H.L. Lee, A mechanistic study on enhancement of rectal permeability to insulin in the albino rabbit, J. Pharmacol. Exp. Ther. 263 (1992) 25-31.
27. [27] S. Muranishi, Modification of intestinal absorption of drugs by lipoidal adjuvants, Pharm. Res. 2 (1985) 108-118.
28. [28] S. Muranishi, Absorption enhancers, Crit. Rev. Ther. Drug Carrier Syst. 7 (1990) 1-33.
29. [29] N. Muranushi, N. Takagi, S. Muranishi and H. Sezaki, Effect of fatty acids and monoglycerides on permeability of lipid bilayer, Chem. Phys. Lipid 28 (1981) 269-279.
30. [30] M. Murakami, K. Takada, T. Fujii and S. Muranishi, Intestinal absorption enhanced by unsaturated fatty acids: inhibitory effect of sulfhydryl modifiers, Biochim. Biophys. Acta 939 (1988) 238-246.
31. [31] M. Murakami, Y. Kusanoi, K. Takada and S. Muranishi, Assessment of enhancing ability of medium-chain alkyl saccharides as new absorption enhancers in rat rectum, Int. J. Pharm. 79 (1992) 159-169.
32. [32] M.M. Cassidy and C.S. Tidball, Cellular mechanism of intestinal permeability alteration produced by chelation depletion, J. Cell Biol. 32 (1967) 685-698.
33. [33] T. Nishihata, M. Miyake and A. Kamada, Study on the mechanism behind adjuvant action of diethylethoxymethylene malonate enhancing the rectal absorption of cefmetazole and lysozyme, J. Pharmacobio-Dyn. 7 (1984) 607-613.
34. [34] T. Nishihata, B.T. Ngheim, H. Yoshitomi, C.-S., Lee, M. Dillsaver, T. Higuchi, R. Choh, T. Suzuka, A. Furuya and A. Kamada, Changes in intestinal mucosal permeability caused by nonprotein thiol loss in rats, Pharm. Res. 3 (1986a) 345-351.
35. 1,7)-eel calcitonin in rats: concentration dependent absorption pathway, Int. J. Pharm. 33 (1986b) 89-97.
36. 2-EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery, Pharm. Res. 5 (1988) 305-308.
37. [37] M. Tomita, M. Shiga, M. Hayashi and S. Awazu, Enhancement of colonic drug absorption by the paracellular permeation route, Pharm. Res. 5 (1988) 341-346.
38. [38] M. Tomita, M. Hayashi, T. Horie and S. Awazu, Enhancement of colonic drug absorption by the transcellular permeation route, Pharm. Res. 5 (1988) 786-789.
39. [39] A. Yamamoto, T. Taniguchi, K. Rikyuu, T. Tsuji, T. Fujita, M. Murakami and S. Muranishi, Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats, Pharm. Res. 11 (1994) 1496-1500.
40. [40] S. Gotoh, R. Nakamura, M. Nishiyama, T. Fujita, A. Yamamoto and S. Muranishi, Does bacitracin have an absorption-enhancing effect in the intestine? Biol. Pharm. Bull. 18 (1995) 794-796.
41. [41] F. Liu, D.O. Kildsig and A.K. Mitra, Pulmonary biotransformation of insulin in rat and rabbit, Life Sci. 51 (1992) 1683-1689.