-
1
-
-
0036247430
-
Drugs and steatohepatitis
-
Farrell GC., Drugs and steatohepatitis. Semin Liver Dis. 2002;22:185–194.
-
(2002)
Semin Liver Dis
, vol.22
, pp. 185-194
-
-
Farrell, G.C.1
-
2
-
-
79960029926
-
Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
-
Vernon G, Baranova A, Younossi ZM. Systematic review:the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011;34:274–285.
-
(2011)
Aliment Pharmacol Ther
, vol.34
, pp. 274-285
-
-
Vernon, G.1
Baranova, A.2
Younossi, Z.M.3
-
4
-
-
84939184350
-
Drug induced steatohepatitis: an uncommon culprit of a common disease
-
Rabinowich L, Shibolet O. Drug induced steatohepatitis:an uncommon culprit of a common disease. Biomed Res Int. 2015;2015:168905.•• This review looks at the mechanistic underpinnings of the drugs more commonly associated with DISH.
-
(2015)
Biomed Res Int
, vol.2015
, pp. 168905
-
-
Rabinowich, L.1
Shibolet, O.2
-
5
-
-
84958213051
-
Clinical presentation and patient evaluation in nonalcoholic fatty liver disease
-
Patel V, Sanyal AJ, Sterling R. Clinical presentation and patient evaluation in nonalcoholic fatty liver disease. Clin Liver Dis. 2016;20:277–292.•• This review covers the clinical approach to diagnosing and treating fatty liver arising from different causes including drugs.
-
(2016)
Clin Liver Dis
, vol.20
, pp. 277-292
-
-
Patel, V.1
Sanyal, A.J.2
Sterling, R.3
-
6
-
-
79952702137
-
Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver
-
Begriche K, Massart J, Robin MA, et al. Drug-induced toxicity on mitochondria and lipid metabolism:mechanistic diversity and deleterious consequences for the liver. J Hepatol. 2011;54:773–794.
-
(2011)
J Hepatol
, vol.54
, pp. 773-794
-
-
Begriche, K.1
Massart, J.2
Robin, M.A.3
-
7
-
-
84945485781
-
Mechanistic review of drug-induced steatohepatitis
-
Schumacher JD, Guo GL., Mechanistic review of drug-induced steatohepatitis. Toxicol Appl Pharmacol. 2015;289:40–47.
-
(2015)
Toxicol Appl Pharmacol
, vol.289
, pp. 40-47
-
-
Schumacher, J.D.1
Guo, G.L.2
-
8
-
-
30144440445
-
CASH (chemotherapy-associated steatohepatitis) costs
-
Fong Y, Bentrem DJ., CASH (chemotherapy-associated steatohepatitis) costs. Ann Surg. 2006;243:8–9.
-
(2006)
Ann Surg
, vol.243
, pp. 8-9
-
-
Fong, Y.1
Bentrem, D.J.2
-
9
-
-
84875701816
-
Toxicant-associated steatohepatitis
-
Wahlang B, Beier JI, Clair HB, et al. Toxicant-associated steatohepatitis. Toxicol Pathol. 2013;41:343–360.•• This review is interesting as it describes specific chemical structural attributes of drugs associated with DISH.
-
(2013)
Toxicol Pathol
, vol.41
, pp. 343-360
-
-
Wahlang, B.1
Beier, J.I.2
Clair, H.B.3
-
11
-
-
84875851903
-
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells)
-
Kazmi F, Hensley T, Pope C, et al. Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells). Drug Metab Dispos. 2013;41:897–905.
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 897-905
-
-
Kazmi, F.1
Hensley, T.2
Pope, C.3
-
12
-
-
84862651254
-
Predicting the mechanism of phospholipidosis
-
Lowe R, Mussa HY, Nigsch F, et al. Predicting the mechanism of phospholipidosis. J Cheminform. 2012;4:2.
-
(2012)
J Cheminform
, vol.4
, pp. 2
-
-
Lowe, R.1
Mussa, H.Y.2
Nigsch, F.3
-
13
-
-
84873192192
-
Drug induced phospholipidosis: an acquired lysosomal storage disorder
-
Shayman JA, Abe A. Drug induced phospholipidosis:an acquired lysosomal storage disorder. Biochim Biophys Acta. 2013;1831:602–611.
-
(2013)
Biochim Biophys Acta
, vol.1831
, pp. 602-611
-
-
Shayman, J.A.1
Abe, A.2
-
14
-
-
79960542143
-
The mechanistic basis for the induction of hepatic steatosis by xenobiotics
-
Amacher DE. The mechanistic basis for the induction of hepatic steatosis by xenobiotics. Expert Opin Drug Metab Toxicol. 2011;7:949–965.•• This is another excellent review comparing different diverse mechanisms that are associated with DISH caused by different drugs.
-
(2011)
Expert Opin Drug Metab Toxicol
, vol.7
, pp. 949-965
-
-
Amacher, D.E.1
-
15
-
-
77957961658
-
Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis
-
Cole LK, Jacobs RL, Vance DE. Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis. Hepatology. 2010;52:1258–1265.
-
(2010)
Hepatology
, vol.52
, pp. 1258-1265
-
-
Cole, L.K.1
Jacobs, R.L.2
Vance, D.E.3
-
16
-
-
84896473042
-
The effect and mechanism of tamoxifen-induced hepatocyte steatosis in vitro
-
Zhao F, Xie P, Jiang J, et al. The effect and mechanism of tamoxifen-induced hepatocyte steatosis in vitro. Int J Mol Sci. 2014;15:4019–4030.
-
(2014)
Int J Mol Sci
, vol.15
, pp. 4019-4030
-
-
Zhao, F.1
Xie, P.2
Jiang, J.3
-
17
-
-
77949916811
-
Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile
-
Moya M, Gomez-Lechon MJ, Castell JV, et al. Enhanced steatosis by nuclear receptor ligands:a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. Chem Biol Interact. 2010;184:376–387.
-
(2010)
Chem Biol Interact
, vol.184
, pp. 376-387
-
-
Moya, M.1
Gomez-Lechon, M.J.2
Castell, J.V.3
-
18
-
-
78650018055
-
Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies
-
Amacher DE. Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies. Toxicology. 2011;279:10–18.•• This review details the preclinical models and assays used to detect DISH.
-
(2011)
Toxicology
, vol.279
, pp. 10-18
-
-
Amacher, D.E.1
-
19
-
-
55949124005
-
Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies
-
Labbe G, Pessayre D, Fromenty B. Drug-induced liver injury through mitochondrial dysfunction:mechanisms and detection during preclinical safety studies. Fundam Clin Pharmacol. 2008;22:335–353.
-
(2008)
Fundam Clin Pharmacol
, vol.22
, pp. 335-353
-
-
Labbe, G.1
Pessayre, D.2
Fromenty, B.3
-
20
-
-
84886558949
-
Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
-
Kawano Y, Cohen DE. Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol. 2013;48:434–441.
-
(2013)
J Gastroenterol
, vol.48
, pp. 434-441
-
-
Kawano, Y.1
Cohen, D.E.2
-
21
-
-
66349126859
-
Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
-
Goldberg IJ, Eckel RH, Abumrad NA. Regulation of fatty acid uptake into tissues:lipoprotein lipase- and CD36-mediated pathways. J Lipid Res. 2009;50(Suppl):S86–90.
-
(2009)
J Lipid Res
, vol.50
, pp. S86-S90
-
-
Goldberg, I.J.1
Eckel, R.H.2
Abumrad, N.A.3
-
22
-
-
63849130333
-
AMP-activated protein kinase control of fat metabolism in skeletal muscle
-
Thomson DM, Winder WW. AMP-activated protein kinase control of fat metabolism in skeletal muscle. Acta Physiol (Oxf). 2009;196:147–154.
-
(2009)
Acta Physiol (Oxf)
, vol.196
, pp. 147-154
-
-
Thomson, D.M.1
Winder, W.W.2
-
23
-
-
77954238025
-
Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells
-
Blas-Garcia A, Apostolova N, Ballesteros D, et al. Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells. Hepatology. 2010;52:115–125.
-
(2010)
Hepatology
, vol.52
, pp. 115-125
-
-
Blas-Garcia, A.1
Apostolova, N.2
Ballesteros, D.3
-
24
-
-
38649096259
-
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis
-
Zhou J, Febbraio M, Wada T, et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology. 2008;134:556–567.
-
(2008)
Gastroenterology
, vol.134
, pp. 556-567
-
-
Zhou, J.1
Febbraio, M.2
Wada, T.3
-
25
-
-
84915805690
-
Whole genome transcript profiling of drug induced steatosis in rats reveals a gene signature predictive of outcome
-
Sahini N, Selvaraj S, Borlak J. Whole genome transcript profiling of drug induced steatosis in rats reveals a gene signature predictive of outcome. PLoS One. 2014;9:e114085.•• This paper describes a transcriptomic approach using animal models to help predict DISH.
-
(2014)
PLoS One
, vol.9
, pp. e114085
-
-
Sahini, N.1
Selvaraj, S.2
Borlak, J.3
-
26
-
-
84897111483
-
A simple transcriptomic signature able to predict drug-induced hepatic steatosis
-
Benet M, Moya M, Donato MT, et al. A simple transcriptomic signature able to predict drug-induced hepatic steatosis. Arch Toxicol. 2014;88:967–982.
-
(2014)
Arch Toxicol
, vol.88
, pp. 967-982
-
-
Benet, M.1
Moya, M.2
Donato, M.T.3
-
27
-
-
84964067949
-
Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades
-
Liu Z, Wang Y, Borlak J, et al. Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades. Sci Rep. 2016;6:23709.
-
(2016)
Sci Rep
, vol.6
, pp. 23709
-
-
Liu, Z.1
Wang, Y.2
Borlak, J.3
-
28
-
-
29144523498
-
Lessons from animal models of NASH
-
Diehl AM. Lessons from animal models of NASH. Hepatol Res. 2005;33:138–144.
-
(2005)
Hepatol Res
, vol.33
, pp. 138-144
-
-
Diehl, A.M.1
-
29
-
-
80052947518
-
NASH animal models: are we there yet?
-
Kohli R, Feldstein AE. NASH animal models:are we there yet? J Hepatol. 2011;55:941–943.•• This paper highlights the challenges of animal models of fatty liver.
-
(2011)
J Hepatol
, vol.55
, pp. 941-943
-
-
Kohli, R.1
Feldstein, A.E.2
-
30
-
-
56549117448
-
Animal models of NASH: getting both pathology and metabolic context right
-
Larter CZ, Yeh MM. Animal models of NASH:getting both pathology and metabolic context right. J Gastroenterol Hepatol. 2008;23:1635–1648.
-
(2008)
J Gastroenterol Hepatol
, vol.23
, pp. 1635-1648
-
-
Larter, C.Z.1
Yeh, M.M.2
-
31
-
-
34249681974
-
Pathogenesis of NASH: animal models
-
London RM, George J. Pathogenesis of NASH:animal models. Clin Liver Dis. 2007;11:55–74, viii.
-
(2007)
Clin Liver Dis
, vol.11
, pp. 55-74, viii
-
-
London, R.M.1
George, J.2
-
32
-
-
84930706791
-
Increased hepatic fatty acid uptake and esterification contribute to tetracycline-induced steatosis in mice
-
Choi YJ, Lee CH, Lee KY, et al. Increased hepatic fatty acid uptake and esterification contribute to tetracycline-induced steatosis in mice. Toxicol Sci. 2015;145:273–282.
-
(2015)
Toxicol Sci
, vol.145
, pp. 273-282
-
-
Choi, Y.J.1
Lee, C.H.2
Lee, K.Y.3
-
33
-
-
34247203727
-
Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver
-
Larosche I, Letteron P, Fromenty B, et al. Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver. J Pharmacol Exp Ther. 2007;321:526–535.
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 526-535
-
-
Larosche, I.1
Letteron, P.2
Fromenty, B.3
-
34
-
-
21744460524
-
Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis
-
Lelliott CJ, Lopez M, Curtis RK, et al. Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. Faseb J. 2005;19:1108–1119.
-
(2005)
Faseb J
, vol.19
, pp. 1108-1119
-
-
Lelliott, C.J.1
Lopez, M.2
Curtis, R.K.3
-
35
-
-
33845593130
-
Causes and prevention of tamoxifen-induced accumulation of triacylglycerol in rat liver
-
Gudbrandsen OA, Rost TH, Berge RK. Causes and prevention of tamoxifen-induced accumulation of triacylglycerol in rat liver. J Lipid Res. 2006;47:2223–2232.
-
(2006)
J Lipid Res
, vol.47
, pp. 2223-2232
-
-
Gudbrandsen, O.A.1
Rost, T.H.2
Berge, R.K.3
-
36
-
-
84873381429
-
Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach
-
Van Summeren A, Renes J, Lizarraga D, et al. Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds:an omics-guided approach. Omics. 2013;17:71–83.
-
(2013)
Omics
, vol.17
, pp. 71-83
-
-
Van Summeren, A.1
Renes, J.2
Lizarraga, D.3
-
37
-
-
84906926491
-
Uridine prevents tamoxifen-induced liver lipid droplet accumulation
-
Le TT, Urasaki Y, Pizzorno G. Uridine prevents tamoxifen-induced liver lipid droplet accumulation. BMC Pharmacol Toxicol. 2014;15:27.
-
(2014)
BMC Pharmacol Toxicol
, vol.15
, pp. 27
-
-
Le, T.T.1
Urasaki, Y.2
Pizzorno, G.3
-
38
-
-
0028302917
-
Inhibition by perhexiline of oxidative phosphorylation and the beta-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions
-
Deschamps D, DeBeco V, Fisch C, et al. Inhibition by perhexiline of oxidative phosphorylation and the beta-oxidation of fatty acids:possible role in pseudoalcoholic liver lesions. Hepatology. 1994;19:948–961.
-
(1994)
Hepatology
, vol.19
, pp. 948-961
-
-
Deschamps, D.1
DeBeco, V.2
Fisch, C.3
-
39
-
-
0031921972
-
Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes
-
Berson A, De Beco V, Letteron P, et al. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology. 1998;114:764–774.
-
(1998)
Gastroenterology
, vol.114
, pp. 764-774
-
-
Berson, A.1
De Beco, V.2
Letteron, P.3
-
40
-
-
26444592296
-
Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes
-
Tong V, Teng XW, Chang TK, et al. Valproic acid II:effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes. Toxicol Sci. 2005;86:436–443.
-
(2005)
Toxicol Sci
, vol.86
, pp. 436-443
-
-
Tong, V.1
Teng, X.W.2
Chang, T.K.3
-
41
-
-
85033532182
-
Tetracycline-induced steatosis in primary canine hepatocyte cultures
-
Amacher DE, Martin BA. Tetracycline-induced steatosis in primary canine hepatocyte cultures. Fundam Appl Toxicol. 1997;40:256–263.
-
(1997)
Fundam Appl Toxicol
, vol.40
, pp. 256-263
-
-
Amacher, D.E.1
Martin, B.A.2
-
42
-
-
0023124661
-
Drug metabolism by the human hepatoma cell, hep G2
-
Sassa S, Sugita O, Galbraith RA, et al. Drug metabolism by the human hepatoma cell, hep G2. Biochem Biophys Res Commun. 1987;143:52–57.
-
(1987)
Biochem Biophys Res Commun
, vol.143
, pp. 52-57
-
-
Sassa, S.1
Sugita, O.2
Galbraith, R.A.3
-
43
-
-
84929579986
-
Prediction of drug-induced liver injury in hepG2 cells cultured with human liver microsomes
-
Choi JM, Oh SJ, Lee JY, et al. Prediction of drug-induced liver injury in hepG2 cells cultured with human liver microsomes. Chem Res Toxicol. 2015;28:872–885.
-
(2015)
Chem Res Toxicol
, vol.28
, pp. 872-885
-
-
Choi, J.M.1
Oh, S.J.2
Lee, J.Y.3
-
44
-
-
77953391746
-
Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells
-
Cui W, Chen SL, Hu KQ. Quantification and mechanisms of oleic acid-induced steatosis in HepG2 cells. Am J Transl Res. 2010;2:95–104.
-
(2010)
Am J Transl Res
, vol.2
, pp. 95-104
-
-
Cui, W.1
Chen, S.L.2
Hu, K.Q.3
-
45
-
-
70249107777
-
Cytometric analysis for drug-induced steatosis in HepG2 cells
-
Donato MT, Martinez-Romero A, Jimenez N, et al. Cytometric analysis for drug-induced steatosis in HepG2 cells. Chem Biol Interact. 2009;181:417–423.
-
(2009)
Chem Biol Interact
, vol.181
, pp. 417-423
-
-
Donato, M.T.1
Martinez-Romero, A.2
Jimenez, N.3
-
46
-
-
84924984759
-
The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death
-
Kamalian L, Chadwick AE, Bayliss M, et al. The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death. Toxicol In Vitro. 2015;29:732–740.
-
(2015)
Toxicol In Vitro
, vol.29
, pp. 732-740
-
-
Kamalian, L.1
Chadwick, A.E.2
Bayliss, M.3
-
47
-
-
84859163249
-
Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
-
Gerets HH, Tilmant K, Gerin B, et al. Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012;28:69–87.•• This paper highlights the suboptimal relevance of cell lines when compared to primary human hepatocytes.
-
(2012)
Cell Biol Toxicol
, vol.28
, pp. 69-87
-
-
Gerets, H.H.1
Tilmant, K.2
Gerin, B.3
-
48
-
-
0037180522
-
Infection of a human hepatoma cell line by hepatitis B virus
-
Gripon P, Rumin S, Urban S, et al. Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci U S A. 2002;99:15655–15660.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15655-15660
-
-
Gripon, P.1
Rumin, S.2
Urban, S.3
-
49
-
-
60849106634
-
Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions
-
Lambert CB, Spire C, Renaud MP, et al. Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009;23:466–475.
-
(2009)
Toxicol In Vitro
, vol.23
, pp. 466-475
-
-
Lambert, C.B.1
Spire, C.2
Renaud, M.P.3
-
50
-
-
76749107104
-
Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells
-
Antherieu S, Chesne C, Li R, et al. Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos. 2010;38:516–525.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 516-525
-
-
Antherieu, S.1
Chesne, C.2
Li, R.3
-
51
-
-
85009968857
-
Farnesol suppresses lipid accumulation in a HepaRG-based model of hepatic steatosis (1142.8)
-
Pant A, Kocarek T. Farnesol suppresses lipid accumulation in a HepaRG-based model of hepatic steatosis (1142.8). The FASEB Journal. 2014;28:1142.1148.
-
(2014)
The FASEB Journal
, vol.28
-
-
Pant, A.1
Kocarek, T.2
-
52
-
-
84896034306
-
PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells
-
Rogue A, Antherieu S, Vluggens A, et al. PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells. Toxicol Appl Pharmacol. 2014;276:73–81.
-
(2014)
Toxicol Appl Pharmacol
, vol.276
, pp. 73-81
-
-
Rogue, A.1
Antherieu, S.2
Vluggens, A.3
-
53
-
-
84873332657
-
Production of hepatocyte-like cells from human pluripotent stem cells
-
Hannan NR, Segeritz CP, Touboul T, et al. Production of hepatocyte-like cells from human pluripotent stem cells. Nat Protoc. 2013;8:430–437.
-
(2013)
Nat Protoc
, vol.8
, pp. 430-437
-
-
Hannan, N.R.1
Segeritz, C.P.2
Touboul, T.3
-
54
-
-
77956354416
-
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
-
Rashid ST, Corbineau S, Hannan N, et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest. 2010;120:3127–3136.
-
(2010)
J Clin Invest
, vol.120
, pp. 3127-3136
-
-
Rashid, S.T.1
Corbineau, S.2
Hannan, N.3
-
55
-
-
84896696047
-
High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells
-
Sirenko O, Hesley J, Rusyn I, et al. High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells. Assay Drug Dev Technol. 2014;12:43–54.
-
(2014)
Assay Drug Dev Technol
, vol.12
, pp. 43-54
-
-
Sirenko, O.1
Hesley, J.2
Rusyn, I.3
-
56
-
-
84925307610
-
Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro
-
Berger DR, Ware BR, Davidson MD, et al. Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro. Hepatology. 2015;61:1370–1381.
-
(2015)
Hepatology
, vol.61
, pp. 1370-1381
-
-
Berger, D.R.1
Ware, B.R.2
Davidson, M.D.3
-
57
-
-
84864564708
-
Hepatocyte-like cells differentiated from human induced pluripotent stem cells: relevance to cellular therapies
-
Yu Y, Liu H, Ikeda Y, et al. Hepatocyte-like cells differentiated from human induced pluripotent stem cells:relevance to cellular therapies. Stem Cell Res. 2012;9:196–207.
-
(2012)
Stem Cell Res
, vol.9
, pp. 196-207
-
-
Yu, Y.1
Liu, H.2
Ikeda, Y.3
-
58
-
-
0042904900
-
Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties
-
Wilkening S, Stahl F, Bader A. Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. Drug Metab Dispos. 2003;31:1035–1042.•• This paper describes the differences between primary hepatocytes and cell lines.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1035-1042
-
-
Wilkening, S.1
Stahl, F.2
Bader, A.3
-
59
-
-
0036301269
-
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells
-
Rodriguez-Antona C, Donato MT, Boobis A, et al. Cytochrome P450 expression in human hepatocytes and hepatoma cell lines:molecular mechanisms that determine lower expression in cultured cells. Xenobiotica. 2002;32:505–520.
-
(2002)
Xenobiotica
, vol.32
, pp. 505-520
-
-
Rodriguez-Antona, C.1
Donato, M.T.2
Boobis, A.3
-
60
-
-
0034813961
-
Temporal gene expression analysis of monolayer cultured rat hepatocytes
-
Baker TK, Carfagna MA, Gao H, et al. Temporal gene expression analysis of monolayer cultured rat hepatocytes. Chem Res Toxicol. 2001;14:1218–1231.•• This paper demonstrates the rapid decline of liver specific phenotype of primary hepatocytes in conventional cultures.
-
(2001)
Chem Res Toxicol
, vol.14
, pp. 1218-1231
-
-
Baker, T.K.1
Carfagna, M.A.2
Gao, H.3
-
61
-
-
0038172423
-
Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems
-
Boess F, Kamber M, Romer S, et al. Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats:possible implications for toxicogenomics use of in vitro systems. Toxicol Sci. 2003;73:386–402.
-
(2003)
Toxicol Sci
, vol.73
, pp. 386-402
-
-
Boess, F.1
Kamber, M.2
Romer, S.3
-
62
-
-
52049103091
-
Pancreas islets in metabolic signaling–focus on the beta-cell
-
Suckale J, Solimena M. Pancreas islets in metabolic signaling–focus on the beta-cell. Front Biosci. 2008;13:7156–7171.
-
(2008)
Front Biosci
, vol.13
, pp. 7156-7171
-
-
Suckale, J.1
Solimena, M.2
-
63
-
-
0028810979
-
Insulin activates nuclear factor kappa B in mammalian cells through a Raf-1-mediated pathway
-
Bertrand F, Philippe C, Antoine PJ, et al. Insulin activates nuclear factor kappa B in mammalian cells through a Raf-1-mediated pathway. J Biol Chem. 1995;270:24435–24441.
-
(1995)
J Biol Chem
, vol.270
, pp. 24435-24441
-
-
Bertrand, F.1
Philippe, C.2
Antoine, P.J.3
-
64
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D, Yuan M, Frantz DF, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005;11:183–190.
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
-
65
-
-
84976297627
-
Inactivation of NF-kappaB p65 (RelA) in liver improves insulin sensitivity and inhibits cAMP/PKA pathway
-
Ke B, Zhao Z, Ye X, et al. Inactivation of NF-kappaB p65 (RelA) in liver improves insulin sensitivity and inhibits cAMP/PKA pathway. Diabetes. 2015;64:3355–3362.
-
(2015)
Diabetes
, vol.64
, pp. 3355-3362
-
-
Ke, B.1
Zhao, Z.2
Ye, X.3
-
66
-
-
70349399012
-
Liver tissue engineering in the evaluation of drug safety
-
Dash A, Inman W, Hoffmaster K, et al. Liver tissue engineering in the evaluation of drug safety. Expert Opin Drug Metab Toxicol. 2009;5:1159–1174.•• This review details the evolution of organotypic models designed to restore physiological relevance.
-
(2009)
Expert Opin Drug Metab Toxicol
, vol.5
, pp. 1159-1174
-
-
Dash, A.1
Inman, W.2
Hoffmaster, K.3
-
67
-
-
33745686447
-
Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes
-
Kane BJ, Zinner MJ, Yarmush ML, et al. Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. Anal Chem. 2006;78:4291–4298.
-
(2006)
Anal Chem
, vol.78
, pp. 4291-4298
-
-
Kane, B.J.1
Zinner, M.J.2
Yarmush, M.L.3
-
68
-
-
69249206581
-
Laminar-flow immediate-overlay hepatocyte sandwich perfusion system for drug hepatotoxicity testing
-
Xia L, Ng S, Han R, et al. Laminar-flow immediate-overlay hepatocyte sandwich perfusion system for drug hepatotoxicity testing. Biomaterials. 2009;30:5927–5936.
-
(2009)
Biomaterials
, vol.30
, pp. 5927-5936
-
-
Xia, L.1
Ng, S.2
Han, R.3
-
69
-
-
77951919817
-
Perfused multiwell plate for 3D liver tissue engineering
-
Domansky K, Inman W, Serdy J, et al. Perfused multiwell plate for 3D liver tissue engineering. Lab Chip. 2010;10:51–58.
-
(2010)
Lab Chip
, vol.10
, pp. 51-58
-
-
Domansky, K.1
Inman, W.2
Serdy, J.3
-
70
-
-
37149021751
-
Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming
-
Hastings NE, Simmers MB, McDonald OG, et al. Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming. Am J Physiol Cell Physiol. 2007;293:C1824–1833.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
, pp. C1824-C1833
-
-
Hastings, N.E.1
Simmers, M.B.2
McDonald, O.G.3
-
71
-
-
84878645515
-
Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro
-
Dash A, Simmers MB, Deering TG, et al. Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro. Am J Physiol Cell Physiol. 2013;304:C1053- C1063.•• This paper was the first publication of the model described in this paper to demonstrate amiodarone induced steatohepatitis.
-
(2013)
Am J Physiol Cell Physiol
, vol.304
, pp. C1053-C1063
-
-
Dash, A.1
Simmers, M.B.2
Deering, T.G.3
-
72
-
-
85009945018
-
-
52nd Annual Meeting of the Society of ToxicologySan Antonio, Texas:
-
Dash A, Deering TG, Marukian S, et al., Human primary hepatocytes under controlled hemodynamics elicit induction responses to drugs at clinical cmax concentrations, 52nd Annual Meeting of the Society of ToxicologySan Antonio, Texas., 2013, pp. 10.
-
(2013)
Human primary hepatocytes under controlled hemodynamics elicit induction responses to drugs at clinical cmax concentrations
, pp. 10
-
-
Dash, A.1
Deering, T.G.2
Marukian, S.3
-
73
-
-
85026342341
-
Physiological Hemodynamics and Transport Restore Insulin and Glucagon Responses in a Normal Glucose Milieu in Hepatocytes in Vitro
-
Dash A, Deering T, Marukian S, et al. Physiological Hemodynamics and Transport Restore Insulin and Glucagon Responses in a Normal Glucose Milieu in Hepatocytes in Vitro. (2013) In late breaking ADA abstracts. Diabetes Vol 62 (Suppl. 1A) pLB37
-
(2013)
In late breaking ADA abstracts. Diabetes
, vol.62
, pp. pLB37
-
-
Dash, A.1
Deering, T.2
Marukian, S.3
-
74
-
-
85026341732
-
Development of an in vitro model of hepatic steatosis using rat hepatocytes under controlled hemodynamics in a diabetic milieu
-
Deering TG, Thomas JT, Blackman BR, Wamhoff BR, Dash A., Development of an in vitro model of hepatic steatosis using rat hepatocytes under controlled hemodynamics in a diabetic milieu. (2012), In AASLD Abstracts. Hepatology, Vol 56: p868A.
-
(2012)
In AASLD Abstracts. Hepatology
, vol.56
, pp. 868A
-
-
Deering, T.G.1
Thomas, J.T.2
Blackman, B.R.3
Wamhoff, B.R.4
Dash, A.5
-
75
-
-
84954305068
-
Transcriptional profiling suggests that nevirapine and ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes
-
Terelius Y, Figler RA, Marukian S, et al. Transcriptional profiling suggests that nevirapine and ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31–44.
-
(2016)
Chem Biol Interact
-
-
Terelius, Y.1
Figler, R.A.2
Marukian, S.3
-
76
-
-
84867834721
-
Proton density fat-fraction: a standardized MR-based biomarker of tissue fat concentration
-
Reeder SB, Hu HH, Sirlin CB. Proton density fat-fraction:a standardized MR-based biomarker of tissue fat concentration. J Magn Reson Imaging. 2012;36:1011–1014.
-
(2012)
J Magn Reson Imaging
, vol.36
, pp. 1011-1014
-
-
Reeder, S.B.1
Hu, H.H.2
Sirlin, C.B.3
-
77
-
-
84941788436
-
Liver steatosis assessed by Controlled Attenuation Parameter (CAP) measured with the xl probe of the fibroscan: a pilot study assessing diagnostic accuracy
-
Sasso M, Audiere S, Kemgang A, et al. Liver steatosis assessed by Controlled Attenuation Parameter (CAP) measured with the xl probe of the fibroscan:a pilot study assessing diagnostic accuracy. Ultrasound Med Biol. 2016;42:92–103.
-
(2016)
Ultrasound Med Biol
, vol.42
, pp. 92-103
-
-
Sasso, M.1
Audiere, S.2
Kemgang, A.3
-
78
-
-
84856708238
-
The controlled attenuation parameter (CAP): a novel tool for the non-invasive evaluation of steatosis using Fibroscan
-
Sasso M, Miette V, Sandrin L, et al. The controlled attenuation parameter (CAP):a novel tool for the non-invasive evaluation of steatosis using Fibroscan. Clin Res Hepatol Gastroenterol. 2012;36:13–20.
-
(2012)
Clin Res Hepatol Gastroenterol
, vol.36
, pp. 13-20
-
-
Sasso, M.1
Miette, V.2
Sandrin, L.3
-
79
-
-
84922238825
-
Investigating liver stiffness and viscosity for fibrosis, steatosis and activity staging using shear wave elastography
-
Deffieux T, Gennisson JL, Bousquet L, et al. Investigating liver stiffness and viscosity for fibrosis, steatosis and activity staging using shear wave elastography. J Hepatol. 2015;62:317–324.
-
(2015)
J Hepatol
, vol.62
, pp. 317-324
-
-
Deffieux, T.1
Gennisson, J.L.2
Bousquet, L.3
-
80
-
-
84979019785
-
Steatosis and liver stiffness measurements using transient elastography
-
Eddowes P, Sasso M, Fournier C, et al. Steatosis and liver stiffness measurements using transient elastography. Hepatology. 2016;64:700-700.
-
(2016)
Hepatology
, vol.64
, pp. 700
-
-
Eddowes, P.1
Sasso, M.2
Fournier, C.3
-
81
-
-
84906315672
-
Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C
-
Macaluso FS, Maida M, Camma C, et al. Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C. J Hepatol. 2014;61:523–529.
-
(2014)
J Hepatol
, vol.61
, pp. 523-529
-
-
Macaluso, F.S.1
Maida, M.2
Camma, C.3
-
82
-
-
84993675348
-
The independent predictors of NASH and its individual histological features. Insulin resistance, serum uric acid, metabolic syndrome, ALT and serum total cholesterol are a clue to pathogenesis and candidate targets for treatment
-
Ballestri S, Nascimbeni F, Romagnoli D, et al. The independent predictors of NASH and its individual histological features. Insulin resistance, serum uric acid, metabolic syndrome, ALT and serum total cholesterol are a clue to pathogenesis and candidate targets for treatment. Hepatol Res. 2016;46:1074–1087.
-
(2016)
Hepatol Res
, vol.46
, pp. 1074-1087
-
-
Ballestri, S.1
Nascimbeni, F.2
Romagnoli, D.3
-
83
-
-
84899035652
-
NAFLD: predictive value of ALT levels for NASH and advanced fibrosis
-
Torres DM, Harrison SA. NAFLD:predictive value of ALT levels for NASH and advanced fibrosis. Nat Rev Gastroenterol Hepatol. 2013;10:510–511.
-
(2013)
Nat Rev Gastroenterol Hepatol
, vol.10
, pp. 510-511
-
-
Torres, D.M.1
Harrison, S.A.2
-
84
-
-
33644535823
-
Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery
-
Harnois F, Msika S, Sabate JM, et al. Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery. Obes Surg. 2006;16:183–188.
-
(2006)
Obes Surg
, vol.16
, pp. 183-188
-
-
Harnois, F.1
Msika, S.2
Sabate, J.M.3
-
85
-
-
84945271446
-
Non-Alcoholic Steatohepatitis (NASH): risk factors in morbidly obese patients
-
Losekann A, Weston AC, De Mattos AA, et al. Non-Alcoholic Steatohepatitis (NASH):risk factors in morbidly obese patients. Int J Mol Sci. 2015;16:25552–25559.
-
(2015)
Int J Mol Sci
, vol.16
, pp. 25552-25559
-
-
Losekann, A.1
Weston, A.C.2
De Mattos, A.A.3
-
86
-
-
70349292887
-
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease
-
Fisher CD, Lickteig AJ, Augustine LM, et al. Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab Dispos. 2009;37:2087–2094.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 2087-2094
-
-
Fisher, C.D.1
Lickteig, A.J.2
Augustine, L.M.3
-
87
-
-
80053162318
-
Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease
-
Lake AD, Novak P, Fisher CD, et al. Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease. Drug Metab Dispos. 2011;39:1954–1960.
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 1954-1960
-
-
Lake, A.D.1
Novak, P.2
Fisher, C.D.3
-
88
-
-
34447306293
-
Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis
-
Chtioui H, Semela D, Ledermann M, et al. Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis. Liver Int. 2007;27:764–771.
-
(2007)
Liver Int
, vol.27
, pp. 764-771
-
-
Chtioui, H.1
Semela, D.2
Ledermann, M.3
-
89
-
-
84908690423
-
Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling
-
Schattenberg JM, Czaja MJ. Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling. Redox Biol. 2014;3:7–15.
-
(2014)
Redox Biol
, vol.3
, pp. 7-15
-
-
Schattenberg, J.M.1
Czaja, M.J.2
-
90
-
-
84985034325
-
Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis
-
Hardwick RN, Clarke JD, Lake AD, et al. Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis. Toxicol Sci. 2014;142:45–55.
-
(2014)
Toxicol Sci
, vol.142
, pp. 45-55
-
-
Hardwick, R.N.1
Clarke, J.D.2
Lake, A.D.3
-
91
-
-
84958087641
-
Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid
-
Ijssennagger N, Janssen AW, Milona A, et al. Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid. J Hepatol. 2016;64:1158–1166.•• This recent paper highlights the challenges of rapid decline of metabolic activity in liver slices.
-
(2016)
J Hepatol
, vol.64
, pp. 1158-1166
-
-
Ijssennagger, N.1
Janssen, A.W.2
Milona, A.3
-
92
-
-
84887598629
-
Steatohepatitis secondary to long-term glucocorticoid treatment for congenital adrenal hyperplasia: a potential diagnostic pitfall
-
Ding X, Thung SN, Grewal P. Steatohepatitis secondary to long-term glucocorticoid treatment for congenital adrenal hyperplasia:a potential diagnostic pitfall. Semin Liver Dis. 2013;33:389–392.
-
(2013)
Semin Liver Dis
, vol.33
, pp. 389-392
-
-
Ding, X.1
Thung, S.N.2
Grewal, P.3
-
93
-
-
84961198810
-
Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study
-
He J, Li G, Chen J, et al. Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice:a systems toxicology study. Arch Toxicol. (2016). doi:10.1007/s00204-016-1681-3
-
(2016)
Arch Toxicol
-
-
He, J.1
Li, G.2
Chen, J.3
|