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Volumn 15, Issue 3, 2014, Pages 4019-4030

The effect and mechanism of tamoxifen-induced hepatocyte steatosis in Vitro

Author keywords

HepG 2 Cells; Non alcoholic fatty liver disease; Tamoxifen; Triglyceride

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE; CARNITINE PALMITOYLTRANSFERASE I; CCAAT ENHANCER BINDING PROTEIN ALPHA; CHOLECYSTOKININ OCTAPEPTIDE; FATTY ACID SYNTHASE; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TAMOXIFEN; TRIACYLGLYCEROL; ANTIESTROGEN; FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84896473042     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15034019     Document Type: Article
Times cited : (57)

References (30)
  • 1
    • 84867123853 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Epidemiological considerations and recommendations
    • Boyle, P. Triple-negative breast cancer: Epidemiological considerations and recommendations. Ann. Oncol. 2012, 23, vi7-vi12.
    • (2012) Ann. Oncol , vol.23
    • Boyle, P.1
  • 2
    • 84882997683 scopus 로고    scopus 로고
    • Optimal combination of radiotherapy and endocrine drugs in breast cancer treatment
    • Zeng, Z. J.; Li, J. H.; Zhang, Y. J.; Zhao, S. T. Optimal combination of radiotherapy and endocrine drugs in breast cancer treatment. Cancer Radiother. 2013, 17, 208-214.
    • (2013) Cancer Radiother , vol.17 , pp. 208-214
    • Zeng, Z.J.1    Li, J.H.2    Zhang, Y.J.3    Zhao, S.T.4
  • 3
    • 58549096710 scopus 로고    scopus 로고
    • Women at high risk for breast cancer-What the primary care provider needs to know
    • Afonso, N. Women at high risk for breast cancer-What the primary care provider needs to know. J. Am. Board Fam. Med. 2009, 22, 43-50.
    • (2009) J. Am. Board Fam. Med , vol.22 , pp. 43-50
    • Afonso, N.1
  • 4
    • 49649086922 scopus 로고    scopus 로고
    • Aromatase inhibitors: A new reality for the adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women
    • Colozza, M.; Califano, R.; Minenza, E.; Dinh, P.; Azambuja, E. Aromatase inhibitors: A new reality for the adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women. Mini Rev. Med. Chem. 2008, 8, 564-574.
    • (2008) Mini Rev. Med. Chem , vol.8 , pp. 564-574
    • Colozza, M.1    Califano, R.2    Minenza, E.3    Dinh, P.4    Azambuja, E.5
  • 6
    • 78650509559 scopus 로고    scopus 로고
    • Gene expression profiling of murine hepatic steatosis induced by tamoxifen
    • Lee, M. H.; Kim, J. W.; Kim, J. H.; Kang, K. S.; Kong, G.; Lee, M. O. Gene expression profiling of murine hepatic steatosis induced by tamoxifen. Toxicol. Lett. 2010, 199, 416-424.
    • (2010) Toxicol. Lett , vol.199 , pp. 416-424
    • Lee, M.H.1    Kim, J.W.2    Kim, J.H.3    Kang, K.S.4    Kong, G.5    Lee, M.O.6
  • 7
    • 77957961658 scopus 로고    scopus 로고
    • Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis
    • Cole, L. K.; Jacobs, R. L.; Vance, D. E. Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis. Hepatology 2010, 52, 1258-1265.
    • (2010) Hepatology , vol.52 , pp. 1258-1265
    • Cole, L.K.1    Jacobs, R.L.2    Vance, D.E.3
  • 8
    • 0043092060 scopus 로고    scopus 로고
    • Human hepatocytes as a tool for studying toxicity and drug metabolism
    • Gómez-Lechón, M. J.; Donato, M. T.; Castell, J. V.; Jover, R. Human hepatocytes as a tool for studying toxicity and drug metabolism. Curr. Drug Metab. 2003, 4, 292-312.
    • (2003) Curr. Drug Metab , vol.4 , pp. 292-312
    • Gómez-Lechón, M.J.1    Donato, M.T.2    Castell, J.V.3    Jover, R.4
  • 9
    • 4644341747 scopus 로고    scopus 로고
    • Human hepatocytes in primary culture: The choice to investigate drug metabolism in man
    • Gómez-Lechón, M. J.; Donato, M. T.; Castell, J. V.; Jover, R. Human hepatocytes in primary culture: The choice to investigate drug metabolism in man. Curr. Drug Metab. 2004, 5, 443-462.
    • (2004) Curr. Drug Metab , vol.5 , pp. 443-462
    • Gómez-Lechón, M.J.1    Donato, M.T.2    Castell, J.V.3    Jover, R.4
  • 11
    • 0037216370 scopus 로고    scopus 로고
    • Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: High frequency of involve-ment and rapid reversal after completion of tamoxifen therapy
    • Nishino, M.; Hayakawa, K.; Nakamura, Y.; Morimoto, T.; Mukaihara S. Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: High frequency of involve-ment and rapid reversal after completion of tamoxifen therapy. AJR Am. J. Roentgenol. 2003, 180, 129-134.
    • (2003) AJR Am. J. Roentgenol , vol.180 , pp. 129-134
    • Nishino, M.1    Hayakawa, K.2    Nakamura, Y.3    Morimoto, T.4    Mukaihara, S.5
  • 13
  • 14
    • 79952486373 scopus 로고    scopus 로고
    • Incidence and risk factors for non-alcoholic steatohepatitis in females treated with tamoxifen for breast cancer
    • Akhondi-Meybodi, M.; Mortazavy-Zadah, M. R.; Hashemian, Z.; Moaiedi, M. Incidence and risk factors for non-alcoholic steatohepatitis in females treated with tamoxifen for breast cancer. Arab. J. Gastroenterol. 2011, 12, 34-36.
    • (2011) Arab. J. Gastroenterol , vol.12 , pp. 34-36
    • Akhondi-Meybodi, M.1    Mortazavy-Zadah, M.R.2    Hashemian, Z.3    Moaiedi, M.4
  • 15
    • 21744460524 scopus 로고    scopus 로고
    • Transcirpt and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis
    • Lelliott, C. J.; López, M.; Curtis, R. K.; Parker, N.; Laudes, M.; Yeo, G.; Jimenez-Liñan, M.; Grosse, J.; Saha, A. K.; Wiggins, D.; et al. Transcirpt and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. FASEB J. 2005, 19, 1108-1119.
    • (2005) FASEB J , vol.19 , pp. 1108-1119
    • Lelliott, C.J.1    López, M.2    Curtis, R.K.3    Parker, N.4    Laudes, M.5    Yeo, G.6    Jimenez-Liñan, M.7    Grosse, J.8    Saha, A.K.9    Wiggins, D.10
  • 16
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly, K. L.; Smith, C. I.; Schwarzenberg S. J.; Jessurun J.; Boldt, M. D.; Parks E. J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Investig. 2005, 115, 1343-1351.
    • (2005) J. Clin. Investig , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 17
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown, M. S.; Goldstein J. L. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89, 331-340.
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 18
    • 79957943690 scopus 로고    scopus 로고
    • Molecular mechanisms of steatosis in nonalcoholic fatty liver disease
    • Pettinelli, P.; Obregón, A. M.; Videla, L. A. Molecular mechanisms of steatosis in nonalcoholic fatty liver disease. Nutr. Hosp. 2011, 26, 441-450.
    • (2011) Nutr. Hosp , vol.26 , pp. 441-450
    • Pettinelli, P.1    Obregón, A.M.2    Videla, L.A.3
  • 19
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton, J. D.; Goldstein, J. L.; Brown, M. S. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Investig. 2002, 109, 1125-1131.
    • (2002) J. Clin. Investig , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 20
    • 0142027805 scopus 로고    scopus 로고
    • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    • Horton, J. D.; Shah, N. A.; Warringto, J. A.; Anderson, N. N.; Park, S. W.; Brown, M. S.; Goldstein, J. L. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci. USA 2003, 100, 12027-12032.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12027-12032
    • Horton, J.D.1    Shah, N.A.2    Warringto, J.A.3    Anderson, N.N.4    Park, S.W.5    Brown, M.S.6    Goldstein, J.L.7
  • 21
    • 80052762932 scopus 로고    scopus 로고
    • As elective estrogen receptor an agonist ameliorates hepatic steatosis in the male aromatase knockout mouse
    • Chow, J. D.; Jones, M. E.; Prelle, K.; Simpson, E. R.; Boon, W. C. As elective estrogen receptor an agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. J. Endocrinol. 2011, 210, 323-334.
    • (2011) J. Endocrinol , vol.210 , pp. 323-334
    • Chow, J.D.1    Jones, M.E.2    Prelle, K.3    Simpson, E.R.4    Boon, W.C.5
  • 22
    • 77952863834 scopus 로고    scopus 로고
    • Genetic control of de novo lipogenesis: Role in diet-induced obesity
    • Strable, M. S.; Ntambi, J. M. Genetic control of de novo lipogenesis: Role in diet-induced obesity. Crit. Rev. Biochem. Mol. Biol. 2010, 45, 199-214.
    • (2010) Crit. Rev. Biochem. Mol. Biol , vol.45 , pp. 199-214
    • Strable, M.S.1    Ntambi, J.M.2
  • 23
    • 33845593130 scopus 로고    scopus 로고
    • Causes and prevention of tamoxifen-induced accumulation of triacylglycerol in rat liver
    • Gudbrandsen, O. A.; Rost, T. H.; Berge, R. K. Causes and prevention of tamoxifen-induced accumulation of triacylglycerol in rat liver. J. Lipid Res. 2006, 47, 2223-2232.
    • (2006) J. Lipid Res , vol.47 , pp. 2223-2232
    • Gudbrandsen, O.A.1    Rost, T.H.2    Berge, R.K.3
  • 24
    • 84878681350 scopus 로고    scopus 로고
    • Inhibitory effects of Hwangryunhaedok-Tang in 3T3-L1 adipogenesis by regulation of Raf/MEK1/ERK1/2 pathway and PDK1/Akt Phosphorylation
    • Kwak, D. H.; Lee, J. H.; Kim, D. G.; Kim, T.; Lee, K. J.; Ma, J. Y. Inhibitory effects of Hwangryunhaedok-Tang in 3T3-L1 adipogenesis by regulation of Raf/MEK1/ERK1/2 pathway and PDK1/Akt Phosphorylation. Evid. Based Complement. Alternat. Med. 2013, 2013, 413906.
    • (2013) Evid. Based Complement. Alternat. Med , vol.2013 , pp. 413906
    • Kwak, D.H.1    Lee, J.H.2    Kim, D.G.3    Kim, T.4    Lee, K.J.5    Ma, J.Y.6
  • 25
    • 0038498128 scopus 로고    scopus 로고
    • Transmembrane lipid transfer is crucial for providing neutral lipids during very low densitylipoprotein assembly in endoplasmic reticulum
    • Higashi, Y.; Itabe, H.; Fukase, H.; Mori, M.; Fujimoto, Y.; Takano, T. Transmembrane lipid transfer is crucial for providing neutral lipids during very low densitylipoprotein assembly in endoplasmic reticulum. J. Biol. Chem. 2003, 278, 21450-21458.
    • (2003) J. Biol. Chem , vol.278 , pp. 21450-21458
    • Higashi, Y.1    Itabe, H.2    Fukase, H.3    Mori, M.4    Fujimoto, Y.5    Takano, T.6
  • 26
    • 0037929972 scopus 로고    scopus 로고
    • Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells
    • Liang, J. S.; Kim, T.; Fang, S.; Yamaguchi, J.; Weissman, A. M.; Fisher, E. A.; Ginsberg, H. N. Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. J. Biol. Chem. 2003, 278, 23984-23988.
    • (2003) J. Biol. Chem , vol.278 , pp. 23984-23988
    • Liang, J.S.1    Kim, T.2    Fang, S.3    Yamaguchi, J.4    Weissman, A.M.5    Fisher, E.A.6    Ginsberg, H.N.7
  • 30
    • 84862266158 scopus 로고    scopus 로고
    • Direct drug metabolism monitoring in a live single hepatic cell by video mass spectrometry
    • Date, S.; Mizuno, H.; Tsuyama, N.; Harada, T.; Masujima, T. Direct drug metabolism monitoring in a live single hepatic cell by video mass spectrometry. Anal. Sci. 2012, 28, 201-203.
    • (2012) Anal. Sci , vol.28 , pp. 201-203
    • Date, S.1    Mizuno, H.2    Tsuyama, N.3    Harada, T.4    Masujima, T.5


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