Increased hepatic fatty acid uptake and esterification contribute to tetracycline-induced steatosis in mice

Toxicological Sciences

Volumn 145, Issue 2, 2015, Pages 273-282

  Choi, You Jin ^a   Lee, Chae Hyeon ^a   Lee, Kang Yo ^a   Jung, Seung Hwan ^a   Lee, Byung Hoon ^a  

^a Seoul National University   (South Korea)

Author keywords

CD36; DGAT; Drug induced liver injury; Fatty liver; Tetracycline

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; BORON; CD36 ANTIGEN; DIACYLGLYCEROL ACYLTRANSFERASE 2; MITOGEN ACTIVATED PROTEIN KINASE; OLEIC ACID; TETRACYCLINE; DGAT2 PROTEIN, HUMAN; DGAT2 PROTEIN, MOUSE; DIACYLGLYCEROL ACYLTRANSFERASE; FATTY ACID; PROTEIN KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOWN REGULATION; ESTERIFICATION; FATTY ACID TRANSPORT; FATTY LIVER; GENE SILENCING; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID METABOLISM; LIPID STORAGE; LIVER CELL; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; TRANSPORT AT THE CELLULAR LEVEL;

MUS;

ANIMALS; ANTIGENS, CD36; BIOLOGICAL TRANSPORT; DIACYLGLYCEROL O-ACYLTRANSFERASE; DISEASE MODELS, ANIMAL; ESTERIFICATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FATTY ACIDS; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER; MALE; MICE, INBRED ICR; NON-ALCOHOLIC FATTY LIVER DISEASE; PROTEIN KINASE INHIBITORS; RNA INTERFERENCE; TETRACYCLINE; TRANSFECTION; UP-REGULATION;

EID: 84930706791     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv049     Document Type: Article

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