메뉴 건너뛰기




Volumn 31, Issue , 2015, Pages 84-93

Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli

Author keywords

Biosynthetic pathway; Cell factory; Fisetin; Garbanzol; Polyphenols; Resokaempferol

Indexed keywords

AMINO ACIDS; ESCHERICHIA COLI; FLAVONOIDS; METABOLITES; MOLECULES; NEURODEGENERATIVE DISEASES;

EID: 84938397207     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2015.07.002     Document Type: Article
Times cited : (71)

References (50)
  • 1
    • 0029265842 scopus 로고
    • Medicago sativa cDNAs encoding chalcone reductase
    • Ballance G.M., Dixon R.A. Medicago sativa cDNAs encoding chalcone reductase. Plant Physiol. 1995, 107:1027-1028.
    • (1995) Plant Physiol. , vol.107 , pp. 1027-1028
    • Ballance, G.M.1    Dixon, R.A.2
  • 2
    • 33747115357 scopus 로고    scopus 로고
    • Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae
    • Chemler J.A., Yan Y., Koffas M.A. Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. Microb. Cell Fact. 2006, 5:20.
    • (2006) Microb. Cell Fact. , vol.5 , pp. 20
    • Chemler, J.A.1    Yan, Y.2    Koffas, M.A.3
  • 3
    • 84860132077 scopus 로고    scopus 로고
    • Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines
    • Cho N., Choi J.H., Yang H., Jeong E.J., Lee K.Y., Kim Y.C., Sung S.H. Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. Food Chem. Toxicol. 2012, 50:1940-1945.
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 1940-1945
    • Cho, N.1    Choi, J.H.2    Yang, H.3    Jeong, E.J.4    Lee, K.Y.5    Kim, Y.C.6    Sung, S.H.7
  • 6
    • 0026442122 scopus 로고
    • Gene-dose-dependent expression of soluble mammalian cytochrome b5 in Escherichia coli
    • Gallagher J., Kaderbhai N., Kaderbhai M.A. Gene-dose-dependent expression of soluble mammalian cytochrome b5 in Escherichia coli. Appl. Microbiol. Biotechnol. 1992, 38:77-83.
    • (1992) Appl. Microbiol. Biotechnol. , vol.38 , pp. 77-83
    • Gallagher, J.1    Kaderbhai, N.2    Kaderbhai, M.A.3
  • 8
    • 0028786298 scopus 로고
    • Cinnamate 4-hydroxylase from Catharanthus roseus, and a strategy for the functional expression of plant cytochrome P450 proteins as translational fusions with P450 reductase in Escherichia coli
    • Hotze M., Schroder G., Schroder J. Cinnamate 4-hydroxylase from Catharanthus roseus, and a strategy for the functional expression of plant cytochrome P450 proteins as translational fusions with P450 reductase in Escherichia coli. FEBS Lett. 1995, 374:345-350.
    • (1995) FEBS Lett. , vol.374 , pp. 345-350
    • Hotze, M.1    Schroder, G.2    Schroder, J.3
  • 9
    • 0037545559 scopus 로고    scopus 로고
    • Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster
    • Hwang E.I., Kaneko M., Ohnishi Y., Horinouchi S. Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster. Appl. Environ. Microbiol. 2003, 69:2699-2706.
    • (2003) Appl. Environ. Microbiol. , vol.69 , pp. 2699-2706
    • Hwang, E.I.1    Kaneko, M.2    Ohnishi, Y.3    Horinouchi, S.4
  • 10
    • 0033167145 scopus 로고    scopus 로고
    • Flavonoid hydroxylase from Catharanthus roseus: cDNA, heterologous expression, enzyme properties and cell-type specific expression in plants
    • Kaltenbach M., Schroder G., Schmelzer E., Lutz V., Schroder J. Flavonoid hydroxylase from Catharanthus roseus: cDNA, heterologous expression, enzyme properties and cell-type specific expression in plants. Plant J. 1999, 19:183-193.
    • (1999) Plant J. , vol.19 , pp. 183-193
    • Kaltenbach, M.1    Schroder, G.2    Schmelzer, E.3    Lutz, V.4    Schroder, J.5
  • 11
    • 84860355352 scopus 로고    scopus 로고
    • Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses in vitro
    • Kang S.Y., Kang J.Y., Oh M.J. Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses in vitro. J. Microbiol. 2012, 50:293-300.
    • (2012) J. Microbiol. , vol.50 , pp. 293-300
    • Kang, S.Y.1    Kang, J.Y.2    Oh, M.J.3
  • 12
    • 53449086128 scopus 로고    scopus 로고
    • Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway
    • Katsuyama Y., Matsuzawa M., Funa N., Horinouchi S. Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway. Microbiology 2008, 154:2620-2628.
    • (2008) Microbiology , vol.154 , pp. 2620-2628
    • Katsuyama, Y.1    Matsuzawa, M.2    Funa, N.3    Horinouchi, S.4
  • 14
    • 78649716727 scopus 로고    scopus 로고
    • Manufacturing molecules through metabolic engineering
    • Keasling J.D. Manufacturing molecules through metabolic engineering. Science 2010, 330:1355-1358.
    • (2010) Science , vol.330 , pp. 1355-1358
    • Keasling, J.D.1
  • 15
    • 84856329735 scopus 로고    scopus 로고
    • Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin
    • Khan N., Afaq F., Khusro F.H., Mustafa Adhami V., Suh Y., Mukhtar H. Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin. Int. J. Cancer 2012, 130:1695-1705.
    • (2012) Int. J. Cancer , vol.130 , pp. 1695-1705
    • Khan, N.1    Afaq, F.2    Khusro, F.H.3    Mustafa Adhami, V.4    Suh, Y.5    Mukhtar, H.6
  • 16
    • 84881223447 scopus 로고    scopus 로고
    • Biosynthesis of bioactive O-methylated flavonoids in Escherichia coli
    • Kim M.J., Kim B.G., Ahn J.H. Biosynthesis of bioactive O-methylated flavonoids in Escherichia coli. Appl. Microbiol. Biotechnol. 2013, 97:7195-7204.
    • (2013) Appl. Microbiol. Biotechnol. , vol.97 , pp. 7195-7204
    • Kim, M.J.1    Kim, B.G.2    Ahn, J.H.3
  • 17
    • 84863803189 scopus 로고    scopus 로고
    • Inhibition of c-Jun N-terminal kinase and nuclear factor kappa B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells
    • Kim S.C., Kang S.H., Jeong S.J., Kim S.H., Ko H.S., Kim S.H. Inhibition of c-Jun N-terminal kinase and nuclear factor kappa B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells. Immunopharmacol. Immunotoxicol. 2012, 34:645-650.
    • (2012) Immunopharmacol. Immunotoxicol. , vol.34 , pp. 645-650
    • Kim, S.C.1    Kang, S.H.2    Jeong, S.J.3    Kim, S.H.4    Ko, H.S.5    Kim, S.H.6
  • 18
    • 36649037393 scopus 로고    scopus 로고
    • Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli
    • Leonard E., Koffas M.A. Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli. Appl. Environ. Microbiol. 2007, 73:7246-7251.
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 7246-7251
    • Leonard, E.1    Koffas, M.A.2
  • 19
    • 33644816925 scopus 로고    scopus 로고
    • Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli
    • Leonard E., Yan Y., Koffas M.A. Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli. Metab. Eng. 2006, 8:172-181.
    • (2006) Metab. Eng. , vol.8 , pp. 172-181
    • Leonard, E.1    Yan, Y.2    Koffas, M.A.3
  • 20
    • 84892612919 scopus 로고    scopus 로고
    • Sensitivity to vinyl phenol derivatives produced by phenolic acid decarboxylase activity in Escherichia coli and several food-borne gram-negative species
    • Licandro-Seraut H., Roussel C., Perpetuini G., Gervais P., Cavin J.F. Sensitivity to vinyl phenol derivatives produced by phenolic acid decarboxylase activity in Escherichia coli and several food-borne gram-negative species. Appl. Microbiol. Biotechnol. 2013, 97:7853-7864.
    • (2013) Appl. Microbiol. Biotechnol. , vol.97 , pp. 7853-7864
    • Licandro-Seraut, H.1    Roussel, C.2    Perpetuini, G.3    Gervais, P.4    Cavin, J.F.5
  • 21
    • 71949125029 scopus 로고    scopus 로고
    • Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin
    • Maher P. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutr. 2009, 4:297-307.
    • (2009) Genes Nutr. , vol.4 , pp. 297-307
    • Maher, P.1
  • 22
    • 33750832268 scopus 로고    scopus 로고
    • Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
    • Maher P., Akaishi T., Abe K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16568-16573.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 16568-16573
    • Maher, P.1    Akaishi, T.2    Abe, K.3
  • 23
    • 79959596092 scopus 로고    scopus 로고
    • Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes
    • Maher P., Dargusch R., Ehren J.L., Okada S., Sharma K., Schubert D. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. PLoS One 2011, 6:e21226.
    • (2011) PLoS One , vol.6 , pp. e21226
    • Maher, P.1    Dargusch, R.2    Ehren, J.L.3    Okada, S.4    Sharma, K.5    Schubert, D.6
  • 24
    • 84862940870 scopus 로고    scopus 로고
    • Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli
    • Malla S., Koffas M.A., Kazlauskas R.J., Kim B.G. Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli. Appl. Environ. Microbiol. 2012, 78:684-694.
    • (2012) Appl. Environ. Microbiol. , vol.78 , pp. 684-694
    • Malla, S.1    Koffas, M.A.2    Kazlauskas, R.J.3    Kim, B.G.4
  • 25
    • 84880810277 scopus 로고    scopus 로고
    • Regiospecific modifications of naringenin for astragalin production in Escherichia coli
    • Malla S., Pandey R.P., Kim B.G., Sohng J.K. Regiospecific modifications of naringenin for astragalin production in Escherichia coli. Biotechnol. Bioeng. 2013, 110:2525-2535.
    • (2013) Biotechnol. Bioeng. , vol.110 , pp. 2525-2535
    • Malla, S.1    Pandey, R.P.2    Kim, B.G.3    Sohng, J.K.4
  • 26
    • 53149098916 scopus 로고    scopus 로고
    • Plant in vitro culture for the production of antioxidants - a review
    • Matkowski A. Plant in vitro culture for the production of antioxidants - a review. Biotechnol. Adv. 2008, 26:548-560.
    • (2008) Biotechnol. Adv. , vol.26 , pp. 548-560
    • Matkowski, A.1
  • 27
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer
    • Middleton E., Kandaswami C., Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 2000, 52:673-751.
    • (2000) Pharmacol. Rev. , vol.52 , pp. 673-751
    • Middleton, E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 29
    • 0021880264 scopus 로고
    • Expression of rat liver cytochrome P-450MC cDNA in Saccharomyces cerevisiae
    • Oeda K., Sakaki T., Ohkawa H. Expression of rat liver cytochrome P-450MC cDNA in Saccharomyces cerevisiae. DNA 1985, 4:203-210.
    • (1985) DNA , vol.4 , pp. 203-210
    • Oeda, K.1    Sakaki, T.2    Ohkawa, H.3
  • 30
    • 78651067589 scopus 로고    scopus 로고
    • Anti-inflammatory activity of natural dietary flavonoids
    • Pan M.H., Lai C.S., Ho C.T. Anti-inflammatory activity of natural dietary flavonoids. Food Funct. 2010, 1:15-31.
    • (2010) Food Funct. , vol.1 , pp. 15-31
    • Pan, M.H.1    Lai, C.S.2    Ho, C.T.3
  • 31
    • 27144547510 scopus 로고    scopus 로고
    • Chemistry. The renaissance of natural products as drug candidates
    • Paterson I., Anderson E.A. Chemistry. The renaissance of natural products as drug candidates. Science 2005, 310:451-453.
    • (2005) Science , vol.310 , pp. 451-453
    • Paterson, I.1    Anderson, E.A.2
  • 32
    • 0023279799 scopus 로고
    • Expression of a functional 78,000 Da mammalian flavoprotein, NADPH-cytochrome P-450 oxidoreductase, in Escherichia coli
    • Porter T.D., Wilson T.E., Kasper C.B. Expression of a functional 78,000 Da mammalian flavoprotein, NADPH-cytochrome P-450 oxidoreductase, in Escherichia coli. Arch. Biochem. Biophys. 1987, 254:353-367.
    • (1987) Arch. Biochem. Biophys. , vol.254 , pp. 353-367
    • Porter, T.D.1    Wilson, T.E.2    Kasper, C.B.3
  • 33
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: bioavailability, metabolic effects, and safety
    • Ross J.A., Kasum C.M. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu. Rev. Nutr. 2002, 22:19-34.
    • (2002) Annu. Rev. Nutr. , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 34
    • 4444360215 scopus 로고    scopus 로고
    • Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation
    • Sagara Y., Vanhnasy J., Maher P. Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation. J. Neurochem. 2004, 90:1144-1155.
    • (2004) J. Neurochem. , vol.90 , pp. 1144-1155
    • Sagara, Y.1    Vanhnasy, J.2    Maher, P.3
  • 36
    • 84887778351 scopus 로고    scopus 로고
    • Novel biosensors based on flavonoid-responsive transcriptional regulators introduced into Escherichia coli
    • Siedler S., Stahlhut S.G., Malla S., Maury J., Neves A.R. Novel biosensors based on flavonoid-responsive transcriptional regulators introduced into Escherichia coli. Metab. Eng. 2014, 21:2-8.
    • (2014) Metab. Eng. , vol.21 , pp. 2-8
    • Siedler, S.1    Stahlhut, S.G.2    Malla, S.3    Maury, J.4    Neves, A.R.5
  • 38
    • 0032054834 scopus 로고    scopus 로고
    • An Escherichia coli ccm (cytochrome c maturation) deletion strain substantially expresses Hydrogenobacter thermophilus cytochrome c552 in the cytoplasm: availability of haem influences cytochrome c552 maturation
    • Sinha N., Ferguson S.J. An Escherichia coli ccm (cytochrome c maturation) deletion strain substantially expresses Hydrogenobacter thermophilus cytochrome c552 in the cytoplasm: availability of haem influences cytochrome c552 maturation. FEMS Microbiol. Lett. 1998, 161:1-6.
    • (1998) FEMS Microbiol. Lett. , vol.161 , pp. 1-6
    • Sinha, N.1    Ferguson, S.J.2
  • 39
    • 84886594920 scopus 로고    scopus 로고
    • Differential expression of flavonoid 3'-hydroxylase during fruit development establishes the different B-ring hydroxylation patterns of flavonoids in Fragaria x ananassa and Fragaria vesca
    • Thill J., Miosic S., Gotame T.P., Mikulic-Petkovsek M., Gosch C., Veberic R., Preuss A., Schwab W., Stampar F., Stich K., Halbwirth H. Differential expression of flavonoid 3'-hydroxylase during fruit development establishes the different B-ring hydroxylation patterns of flavonoids in Fragaria x ananassa and Fragaria vesca. Plant Physiol. Biochem. 2013, 72:72-78.
    • (2013) Plant Physiol. Biochem. , vol.72 , pp. 72-78
    • Thill, J.1    Miosic, S.2    Gotame, T.P.3    Mikulic-Petkovsek, M.4    Gosch, C.5    Veberic, R.6    Preuss, A.7    Schwab, W.8    Stampar, F.9    Stich, K.10    Halbwirth, H.11
  • 40
    • 0026560676 scopus 로고
    • Expression cloning in Escherichia coli and preparative isolation of the reductase coacting with chalcone synthase during the key step in the biosynthesis of soybean phytoalexins
    • Welle R., Schroder J. Expression cloning in Escherichia coli and preparative isolation of the reductase coacting with chalcone synthase during the key step in the biosynthesis of soybean phytoalexins. Arch. Biochem. Biophys. 1992, 293:377-381.
    • (1992) Arch. Biochem. Biophys. , vol.293 , pp. 377-381
    • Welle, R.1    Schroder, J.2
  • 41
    • 0032695916 scopus 로고    scopus 로고
    • Evidence for enzyme complexes in the phenylpropanoid and flavonoid pathways
    • Winkel-Shirley B. Evidence for enzyme complexes in the phenylpropanoid and flavonoid pathways. Physiol. Plant. 1999, 107:142-149.
    • (1999) Physiol. Plant. , vol.107 , pp. 142-149
    • Winkel-Shirley, B.1
  • 42
    • 0034979805 scopus 로고    scopus 로고
    • Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology
    • Winkel-Shirley B. Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. Plant Physiol. 2001, 126:485-493.
    • (2001) Plant Physiol. , vol.126 , pp. 485-493
    • Winkel-Shirley, B.1
  • 43
    • 84872221971 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy
    • Wu J., Du G., Zhou J., Chen J. Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy. Metab. Eng. 2013, 16:48-55.
    • (2013) Metab. Eng. , vol.16 , pp. 48-55
    • Wu, J.1    Du, G.2    Zhou, J.3    Chen, J.4
  • 44
    • 80052021573 scopus 로고    scopus 로고
    • Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA
    • Xu P., Ranganathan S., Fowler Z.L., Maranas C.D., Koffas M.A. Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. Metab. Eng. 2011, 13:578-587.
    • (2011) Metab. Eng. , vol.13 , pp. 578-587
    • Xu, P.1    Ranganathan, S.2    Fowler, Z.L.3    Maranas, C.D.4    Koffas, M.A.5
  • 45
    • 84863832737 scopus 로고    scopus 로고
    • Molecular cloning, characterization and expression of a chalcone reductase gene from Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao
    • Xu R.Y., Nan P., Pan H., Zhou T., Chen J. Molecular cloning, characterization and expression of a chalcone reductase gene from Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao. Mol. Biol. Rep. 2012, 39:2275-2283.
    • (2012) Mol. Biol. Rep. , vol.39 , pp. 2275-2283
    • Xu, R.Y.1    Nan, P.2    Pan, H.3    Zhou, T.4    Chen, J.5
  • 46
    • 25144431998 scopus 로고    scopus 로고
    • Biosynthesis of natural flavanones in Saccharomyces cerevisiae
    • Yan Y., Kohli A., Koffas M.A. Biosynthesis of natural flavanones in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 2005, 71:5610-5613.
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 5610-5613
    • Yan, Y.1    Kohli, A.2    Koffas, M.A.3
  • 47
    • 35748974224 scopus 로고    scopus 로고
    • Biosynthesis of 5-deoxyflavanones in microorganisms
    • Yan Y., Huang L., Koffas M.A. Biosynthesis of 5-deoxyflavanones in microorganisms. Biotechnol. J. 2007, 2:1250-1262.
    • (2007) Biotechnol. J. , vol.2 , pp. 1250-1262
    • Yan, Y.1    Huang, L.2    Koffas, M.A.3
  • 48
    • 84856971145 scopus 로고    scopus 로고
    • Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway
    • Ying T.H., Yang S.F., Tsai S.J., Hsieh S.C., Huang Y.C., Bau D.T., Hsieh Y.H. Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway. Arch. Toxicol. 2012, 86:263-273.
    • (2012) Arch. Toxicol. , vol.86 , pp. 263-273
    • Ying, T.H.1    Yang, S.F.2    Tsai, S.J.3    Hsieh, S.C.4    Huang, Y.C.5    Bau, D.T.6    Hsieh, Y.H.7
  • 49
    • 84455173760 scopus 로고    scopus 로고
    • Antiviral activity of four types of bioflavonoid against dengue virus type-2
    • (560-422X-8-560)
    • Zandi K., Teoh B.T., Sam S.S., Wong P.F., Mustafa M.R., Abubakar S. Antiviral activity of four types of bioflavonoid against dengue virus type-2. Virol. J. 2011, 8. (560-422X-8-560).
    • (2011) Virol. J. , vol.8
    • Zandi, K.1    Teoh, B.T.2    Sam, S.S.3    Wong, P.F.4    Mustafa, M.R.5    Abubakar, S.6
  • 50
    • 84926646130 scopus 로고    scopus 로고
    • Distributing a metabolic pathway among a microbial consortium enhances production of natural products
    • Zhou K., Qiao K., Edgar S., Stephanopoulos G. Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat. Biotechnol. 2015, 33:377-383.
    • (2015) Nat. Biotechnol. , vol.33 , pp. 377-383
    • Zhou, K.1    Qiao, K.2    Edgar, S.3    Stephanopoulos, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.