Paris saponin-induced autophagy promotes breast cancer cell apoptosis via the Akt/mTOR signaling pathway

Chemico-Biological Interactions

Volumn 264, Issue , 2017, Pages 1-9

  Xie, Zhan Zhi ^a   Li, Man Mei ^a   Deng, Peng Fei ^a   Wang, Sheng ^a   Wang, Lei ^a   Lu, Xue Ping ^a   Hu, Liu Bing ^a   Chen, Zui ^a   Jie, Hui Yang ^a   Wang, Yi Fei ^a   Liu, Xiao Xiao ^b   Liu, Zhong ^a  

^a JINAN UNIVERSITY   (China)

^b Guangdong Institute for Drug Control   (China)

Author keywords

Apoptosis; Autophagy; Paris saponin

Indexed keywords

CASPASE 3; CASPASE 9; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; S6 KINASE; SAPONIN DERIVATIVE; ANTINEOPLASTIC AGENT; MTOR PROTEIN, HUMAN; SAPONIN; TARGET OF RAPAMYCIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC50; PARIS POLYPHYLLA; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION; BREAST; BREAST NEOPLASMS; CHEMISTRY; DRUG EFFECTS; FEMALE; ISOLATION AND PURIFICATION; LILIACEAE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; HUMANS; LILIACEAE; PROTO-ONCOGENE PROTEINS C-AKT; SAPONINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 85009807587     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2017.01.004     Document Type: Article

References (39)

1. [1] Zhang, S., He, Y., Tong, Q., Chen, Q., Wu, X., Huang, W., Deltonin induces apoptosis in MDAMB231 human breast cancer cells via reactive oxygen speciesmediated mitochondrial dysfunction and ERK/AKT signaling pathways. Mol. Med. Rep. 7 (2013), 1038–1044.
2. [2] Zhou, Y., Liang, X., Chang, H., Shu, F., Wu, Y., Zhang, T., Fu, Y., Zhang, Q., Zhu, J.D., Mi, M., Ampelopsin-induced autophagy protects breast cancer cells from apoptosis through Akt-mTOR pathway via endoplasmic reticulum stress. Cancer Sci. 105 (2014), 1279–1287.
3. [3] Wang, Y., Liu, J., Qiu, Y., Jin, M., Chen, X., Fan, G., Wang, R., Kong, D., ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells. Oncotarget 7 (2016), 19897–19909.
4. [4] Wu, J., Yang, C., Guo, C., Li, X., Yang, N., Zhao, L., Hang, H., Liu, S., Chu, P., Sun, Z., Sun, B., Lin, Y., Peng, J., Han, G., Wang, S., Tang, Z., SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells. Chemico-biological Interact. 244 (2016), 94–104.
5. [5] Polewska, J., Autophagy–molecular mechanism, apoptosis and cancer. Postepy Hig. i Med. doswiadczalnej 66 (2012), 921–936.
6. [6] Li, J., Cai, Y., The dual effects of autophagy in myocardial hypertrophy. Acta Cardiol. 70 (2015), 493–498.
7. [7] He, J.D., Wang, Z., Li, S.P., Xu, Y.J., Yu, Y., Ding, Y.J., Yu, W.L., Zhang, R.X., Zhang, H.M., Du, H.Y., Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway. Oncotarget 7 (2016), 1949–2553.
8. [8] Kiraz, Y., Adan, A., Kartal Yandim, M., Baran, Y., Major apoptotic mechanisms and genes involved in apoptosis. Tumour. biol. J. Int. Soc. Oncodevelopmental Biol. Med. 37 (2016), 8471–8486.
9. [9] Chen, C.T., Chen, Y.C., Yamaguchi, H., Hung, M.C., Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. Am. J. cancer Res. 5 (2015), 3560–3569.
10. [10] Tu, L.Y., Bai, H.H., Cai, J.Y., Deng, S.P., The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: from macro to nano. Scanning 38 (2016), 644–653.
11. [11] You, L., Wang, Z., Li, H., Shou, J., Jing, Z., Xie, J., Sui, X., Pan, H., Han, W., The role of STAT3 in autophagy. Autophagy 11 (2015), 729–739.
12. [12] Lv, L., Zheng, L., Dong, D., Xu, L., Yin, L., Xu, Y., Qi, Y., Han, X., Peng, J., Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. Food. chem. toxicol. Int. J. Publ. Br. Industrial Biol. Res. Assoc. 59 (2013), 657–669.
13. [13] Choi, J., Jung, W., Koo, J.S., Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer. Histopathology 62 (2013), 275–286.
14. [14] Shibutani, S.T., Saitoh, T., Nowag, H., Munz, C., Yoshimori, T., Autophagy and autophagy-related proteins in the immune system. Nat. Immunol. 16 (2015), 1014–1024.
15. [15] Kim, E.A., Jang, J.H., Lee, Y.H., Sung, E.G., Song, I.H., Kim, J.Y., Kim, S., Sohn, H.Y., Lee, T.J., Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells. Apoptosis. Int. J. Program. cell death 19 (2014), 1165–1175.
16. [16] Lee, J.C., Su, C.L., Chen, L.L., Won, S.J., Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. Cancer Sci. 100 (2009), 503–513.
17. [17] Chan, J.Y., Koon, J.C., Liu, X., Detmar, M., Yu, B., Kong, S.K., Fung, K.P., Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo. J. Ethnopharmacol. 137 (2011), 64–69.
18. [18] Liu, X.X., Wang, L., Long, Y., Sun, L.L., Wang, Q., Chemical constituents from Paris mairei. China J. Chine Mater. Medica 39 (2014), 3107–3111.
19. [19] Urig, S., Becker, K., On the potential of thioredoxin reductase inhibitors for cancer therapy. Semin. Cancer Biol. 16 (2006), 452–465.
20. [20] Dou, Q., Chen, H.N., Wang, K., Yuan, K., Lei, Y., Li, K., Lan, J., Chen, Y., Huang, Z., Xie, N., Zhang, L., Xiang, R., Nice, E.C., Wei, Y., Huang, C., Ivermectin induces cytostatic autophagy by blocking the PAK1/Akt Axis in breast cancer. Cancer Res. 76 (2016), 4457–4469.
21. [21] Chen, S., Jiang, Y.Z., Huang, L., Zhou, R.J., Yu, K.D., Liu, Y., Shao, Z.M., The residual tumor autophagy marker LC3B serves as a prognostic marker in local advanced breast cancer after neoadjuvant chemotherapy. Clin. cancer Res. official J. Am. Assoc. Cancer Res. 19 (2013), 6853–6862.
22. [22] Shinojima, N., Yokoyama, T., Kondo, Y., Kondo, S., Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy 3 (2007), 635–637.
23. [23] Seglen, P.O., Gordon, P.B., 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl. Acad. Sci. U. S. A. 79 (1982), 1889–1892.
24. [24] Wu, Y.T., Tan, H.L., Shui, G., Bauvy, C., Huang, Q., Wenk, M.R., Ong, C.N., Codogno, P., Shen, H.M., Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J. Biol. Chem. 285 (2010), 10850–10861.
25. [25] Newman, D.J., Cragg, G.M., Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 75 (2012), 311–335.
26. [26] Jiang, H., Zhao, P.J., Su, D., Feng, J., Ma, S.L., Paris saponin I induces apoptosis via increasing the Bax/Bcl-2 ratio and caspase-3 expression in gefitinib-resistant non-small cell lung cancer in vitro and in vivo. Mol. Med. Rep. 9 (2014), 2265–2272.
27. [27] Gao, L.L., Li, F.R., Jiao, P., Yang, M.F., Zhou, X.J., Si, Y.H., Jiang, W.J., Zheng, T.T., Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells. World J. gastroenterology. WJG 17 (2011), 4389–4395.
28. [28] Wang, L., Meng, Q., Wang, C., Liu, Q., Peng, J., Huo, X., Sun, H., Ma, X., Liu, K., Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-kappaB signaling inhibition. J. Nat. Prod. 76 (2013), 909–914.
29. [29] Xiao, X., Yang, M., Xiao, J., Zou, J., Huang, Q., Yang, K., Zhang, B., Yang, F., Liu, S., Wang, H., Bai, P., Paris Saponin II suppresses the growth of human ovarian cancer xenografts via modulating VEGF-mediated angiogenesis and tumor cell migration. Cancer Chemother. Pharmacol. 73 (2014), 807–818.
30. [30] Burgess, D.J., Apoptosis: refined and lethal. Nat. Rev. Cancer, 13, 2013, 79.
31. [31] Matsuzawa, A., Ichijo, H., Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling. Biochimica biophysica acta 1780 (2008), 1325–1336.
32. [32] Wang, Q., Chen, Z., Diao, X., Huang, S., Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells. Cancer Lett. 302 (2011), 29–36.
33. [33] Liu, B., Cheng, Y., Zhang, B., Bian, H.J., Bao, J.K., Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Lett. 275 (2009), 54–60.
34. [34] Park, J.H., Kim, K.P., Ko, J.J., Park, K.S., PI3K/Akt/mTOR activation by suppression of ELK3 mediates chemosensitivity of MDA-MB-231 cells to doxorubicin by inhibiting autophagy. Biochem. biophysical Res. Commun. 477 (2016), 277–282.
35. [35] Kumar, D., Shankar, S., Srivastava, R.K., Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. Cancer Lett. 343 (2014), 179–189.
36. [36] Jean, S., Kiger, A.A., Classes of phosphoinositide 3-kinases at a glance. J. cell Sci. 127 (2014), 923–928.
37. [37] Yu, J.S., Cui, W., Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination. Development 143 (2016), 3050–3060.
38. [38] Datta, K., Suman, S., Fornace, A.J. Jr., Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine. Int. J. Biochem. cell Biol. 57 (2014), 167–176.
39. [39] Alers, S., Loffler, A.S., Wesselborg, S., Stork, B., Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol. Cell. Biol. 32 (2012), 2–11.