SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells

Chemico-Biological Interactions

Volumn 244, Issue , 2016, Pages 94-104

  Wu, Jingjun ^a   Yang, Chun ^a   Guo, Chao ^c   Li, Xiaorui ^a   Yang, Nan ^a   Zhao, Lijian ^a   Hang, Hongdong ^a   Liu, Shumin ^a   Chu, Peng ^a   Sun, Zhengwu ^a   Sun, Bin ^a   Lin, Yuan ^a   Peng, Jinyong ^a   Han, Guozhu ^a   Wang, Shisheng ^b   Tang, Zeyao ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Apoptosis; Autophagy; Breast cancer; SZC015

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; CASPASE 3; CASPASE 9; CYTOCHROME C; DNA TOPOISOMERASE (ATP HYDROLYSING); DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLEANOLIC ACID DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SZC 015; UNCLASSIFIED DRUG; 2-MORPHOLINOMETHYL-3-OXOOLEAN-12-EN-28-OIC ACID; MORPHOLINE DERIVATIVE; OLEANOLIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CELL DEATH; CELL VIABILITY; DNA SYNTHESIS INHIBITION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME MODIFICATION; HUMAN; HUMAN CELL; IC50; MCF 7 CELL LINE; MOLECULAR DOCKING; PROTEIN SYNTHESIS INHIBITION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; UPREGULATION; ANALOGS AND DERIVATIVES; BREAST TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; FEMALE; PATHOLOGY; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MCF-7 CELLS; MOLECULAR CONFORMATION; MORPHOLINES; OLEANOLIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84950282133     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.11.013     Document Type: Article

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