Paris Saponin II suppresses the growth of human ovarian cancer xenografts via modulating VEGF-mediated angiogenesis and tumor cell migration

Cancer Chemotherapy and Pharmacology

Volumn 73, Issue 4, 2014, Pages 807-818

  Xiao, Xue ^a,b   Yang, Mei ^a   Xiao, Jianguo ^b   Zou, Juan ^a   Huang, Qin ^a   Yang, Kaixuan ^a   Zhang, Bo ^a   Yang, Fan ^a   Liu, Shanling ^a   Wang, He ^a   Bai, Peng ^a  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Bcl 2; PSII; Tumor angiogenesis; VEGF; VEGF receptor 2 (KDR Flk 1)

Indexed keywords

ANGIOGENESIS INHIBITOR; PARIS SAPONIN II; SAPONIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER THERAPY; CELL MIGRATION; COLOR ULTRASOUND FLOWMETRY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; TUMOR CELL; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR RING;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN NEOPLASMS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84898058225     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-014-2408-x     Document Type: Article

References (44)

1. Folkman J (2006) Angiogenesis. Annu Rev Med 57:1-18
2. Folkman J (2007) Angiogenesis: an organizing principle for drug discovery. Nat Rev Drug Discov 6:273-286
3. Gomez-Raposo C, Mendiola M, Barriuso J, Casado E, Hardisson D, Redondo A (2009) Angiogenesis and ovarian cancer. Clin Transl Oncol 11:564-571
4. Yap TA, Carden CP, Kaye SB (2009) Beyond chemotherapy: targeted therapies in ovarian cancer. Nat Rev Cancer 9:167-181
5. Schmitt J, Matei D (2012) Targeting angiogenesis in ovarian cancer. Cancer Treat Rev 38:272-283
6. Albini A, Indraccolo S, Noonan DM, Pfeffer U (2010) Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs. Clin Exp Metastasis 27:419-439
7. Nor JE, Christensen J, Mooney DJ, Polverini PJ (1999) Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol 154:375-384
8. Kaneko T, Zhang Z, Mantellini MG, Karl E, Zeitlin B, Verhaegen M, Soengas MS, Lingen M, Strieter RM, Nunez G, Nor JE (2007) Bcl-2 orchestrates a cross-talk between endothelial and tumor cells that promotes tumor growth. Cancer Res 67:9685-9693
9. Nor JE, Christensen J, Liu J, Peters M, Mooney DJ, Strieter RM, Polverini PJ (2001) Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Cancer Res 61:2183-2188
10. Karl E, Warner K, Zeitlin B, Kaneko T, Wurtzel L, Jin T, Chang J, Wang S, Wang CY, Strieter RM, Nunez G, Polverini PJ, Nor JE (2005) Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines. Cancer Res 65:5063-5069
11. Cosgrove D (2003) Angiogenesis imaging-ultrasound. Br J Radiol 76(1):S43-S49
12. Howard-Claudio C (2005) MRI methods for the detection of angiogenesis. Appl Radiol 34:9-24
13. Man S, Gao W, Zhang Y, Jin X, Ma C, Huang X, Li Q (2009) Characterization of steroidal saponins in saponin extract from Paris polyphylla by liquid chromatography tandem multi-stage mass spectrometry. Anal Bioanal Chem 395:495-505
14. Liang Y, Liu Z, Gao W, Man S (2012) Determination of nine steroidal saponins in Paris polyphylla from different areas of Guizhou province by HPLC. Zhongguo Zhong Yao Za Zhi 37:2309-2312
15. Man S, Gao W, Zhang Y, Wang J, Zhao W, Huang L, Liu C (2010) Qualitative and quantitative determination of major saponins in Paris and trillium by HPLC-ELSD and HPLC-MS/MS. J Chromatogr B Anal Technol Biomed Life Sci 878:2943-2948
16. Xiao X, Bai P, Bui NTM, Xiao J, Liu S, Yang G, Hu L, Chen X, Zhang X, Liu J, Wang H (2009) The antitumoral effect of Paris Saponin I associated with the induction of apoptosis through the mitochondrial pathway. Mol Cancer Ther 8:1179-1188
17. Siu FM, Ma DL, Cheung YW, Lok CN, Yan K, Yang Z, Yang M, Xu S, Ko BC, He QY, Che CM (2008) Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways. Proteomics 8:3105-3117
18. Yang YH, Dai LJ, He KH, Wei JR, Zhao TZ, Su B, Wang MH (2012) Relation between soil nutrient of artificially cultivated area and rhizome quality of Paris polyphylla var. yunnanensis. Zhong Yao Cai 35:1557-1561
19. Chiang HC, Wang JJ, Wu RT (1992) Immunomodulating effects of the hydrolysis products of formosanin C and beta-ecdysone from Paris formosana Hayata. Anticancer Res 12:1475-1478
20. Xiao X, Zou J, Bui-Nguyen TM, Bai P, Gao L, Liu J, Liu S, Xiao J, Chen X, Zhang X, Wang H (2012) Paris saponin II of Rhizoma Paridis: a novel inducer of apoptosis in human ovarian cancer cells. Biosci Trends 6:201-211
21. Finley SD, Popel AS (2013) Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions. J Natl Cancer Inst 105:802-811
22. Sun ZG, Zhang L, Li LJ, Tian JK (2007) Studies on the extraction process of total saponins from Paris polyphylla Smith. Zhong Yao Cai 30:726-729
23. Nguyen TM, Subramanian IV, Kelekar A, Ramakrishnan S (2007) Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells. Blood 109:4793-4802
24. Nicosia RF, Ottinetti A (1990) Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro. Lab Invest 63:115-122
25. Watanabe M, Fujioka-Kaneko Y, Kobayashi H, Kiniwa M, Kuwano M, Basaki Y (2005) Involvement of integrin-linked kinase in capillary/tube-like network formation of human vascular endothelial cells. Biol Proced Online 7:41-47
26. Bentink S, Haibe-Kains B, Risch T, Fan JB, Hirsch MS, Holton K, Rubio R, April C, Chen J, Wickham-Garcia E, Liu J, Culhane A, Drapkin R, Quackenbush J, Matulonis UA (2012) Angiogenic mRNA and microRNA gene expression signature predicts a novel subtype of serous ovarian cancer. PLoS ONE 7:e30269
27. Coultas L, Chawengsaksophak K, Rossant J (2005) Endothelial cells and VEGF in vascular development. Nature 438:937-945
28. Dias S, Hattori K, Heissig B, Zhu Z, Wu Y, Witte L, Hicklin DJ, Tateno M, Bohlen P, Moore MA, Rafii S (2001) Inhibition of both paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias. Proc Natl Acad Sci USA 98:10857-10862
29. Sakai Y, Goodison S, Cao W, Urquidi V, Namiki K, Porvasnik S, Urbanek C, Rosser CJ (2009) VEGF induces expression of Bcl-2 and multiple signaling factors in microvascular endothelial cells in a prostate cancer model. World J Urol 27:659-666
30. Markowska A, Lubin J, Madry R, Markowska J (2013) Development of antiangiogenic therapies for ovarian cancer. Eur J Gynaecol Oncol 34:303-306
31. Sia D, Alsinet C, Newell P, Villanueva A (2013) VEGF signaling in cancer treatment. Curr Pharm Des [Epub ahead of print]
32. Wei J (1998) Determination of steroidal saponins in Rhizoma Paridis by RP-HPLC. Yao Xue Xue Bao 33:465-468
33. Huang Y, Cui LJ, Liu WN, Wang Q (2006) Quantitative analysis of steroidal saponins in Chinese material medica Rhizoma Paridis by HPLC-ELSD. Zhongguo Zhong Yao Za Zhi 31:1230-1233
34. Li ZH, Wan JY, Wang GQ, Zhao FG, Wen JH (2013) Identification of compounds from Paris polyphylla (ChongLou) active against Dactylogyrus intermedius. Parasitology 140:952-958
35. Wen F, Yin H, Chen C, Liu X, Xue D, Chen T, He J, Zhang H (2012) Chemical characteristics of saponins from Paris fargesii var. brevipetala and cytotoxic activity of its main ingredient, paris saponin H. Fitoterapia 83:627-635
36. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
37. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184:39-51
38. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501
39. Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555-556
40. Namiki A, Brogi E, Kearney M, Kim EA, Wu T, Couffinhal T, Varticovski L, Isner JM (1995) Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem 270:31189-31195
41. Bertin S, Mohsen-Kanson T, Baque P, Gavelli A, Momier D, Anjuere F, Carle GF, Pierrefite-Carle V (2010) Tumor microenvironment modifications induced by soluble VEGF receptor expression in a rat liver metastasis model. Cancer Lett 298:264-272
42. Shuli M, Wenyuan G, Yanjun Z, Chaoyi M, Liu Y, Yiwen L (2011) Paridis saponins inhibiting carcinoma growth and metastasis in vitro and in vivo. Arch Pharm Res 34:43-50
43. Xiao X, Yang M, Bai P, Chen XL, Liu SL, Zou J, Wang H (2012) Observation on anticancer function of PS II isolated from Rhizoma Paridis. Sichuan Da Xue Xue Bao Yi Xue Ban 43:651-656
44. Cosgrove D, Lassau N (2009) Assessment of tumour angiogenesis using contrast-enhanced ultrasound. J Radiol 90:156-164