Icariside II activates EGFR-Akt-Nrf2 signaling and protects osteoblasts from dexamethasone

Oncotarget

Volumn 8, Issue 2, 2017, Pages 2594-2603

  Liu, Weidong ^a   Mao, Li ^a   Ji, Feng ^a   Chen, Fengli ^a   Wang, Shouguo ^a   Xie, Yue ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Dexamethasone; EGFR Akt; Icariside II; Nrf2 signaling; Oxidative stress

Indexed keywords

DEXAMETHASONE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOGEN SYNTHASE KINASE 3BETA; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; ICARISIDE II; PLANT MEDICINAL PRODUCT; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; BAOHUOSIDE I; CHROMONE DERIVATIVE; EGFR PROTEIN, MOUSE; FLAVONOID; FUSED HETEROCYCLIC RINGS; MORPHOLINE DERIVATIVE; NFE2L2 PROTEIN, MOUSE; PERIFOSINE; PHOSPHORYLCHOLINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GENE SILENCING; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN ACTIVATION; PROTEIN EXPRESSION; PROTEIN INDUCTION, SYNTHESIS AND MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSACTIVATION; ANIMAL; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM;

ANIMALS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; DEXAMETHASONE; ERBB RECEPTORS; FLAVONOIDS; HETEROCYCLIC COMPOUNDS, 3-RING; MICE; MORPHOLINES; NF-E2-RELATED FACTOR 2; OSTEOBLASTS; PHOSPHORYLCHOLINE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 85009733676     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.13732     Document Type: Article

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