메뉴 건너뛰기




Volumn 447, Issue 3, 2014, Pages 425-430

EGFR trans-activation mediates pleiotrophin-induced activation of Akt and Erk in cultured osteoblasts

Author keywords

Akt Erk signalings; ALP; Dex; EGF; EGFR; HB EGF; Osteoblasts and bone growth; Pleiotrophin; Ptn

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ALKALINE PHOSPHATASE; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PLEIOTROPHIN; PROTEIN KINASE B; SMALL INTERFERING RNA;

EID: 84900308736     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.04.002     Document Type: Article
Times cited : (32)

References (36)
  • 2
    • 0025162762 scopus 로고
    • Molecular cloning of the 18-kDa growth-associated protein of developing brain
    • Merenmies J., Rauvala H. Molecular cloning of the 18-kDa growth-associated protein of developing brain. J. Biol. Chem. 1990, 265:16721-16724.
    • (1990) J. Biol. Chem. , vol.265 , pp. 16721-16724
    • Merenmies, J.1    Rauvala, H.2
  • 3
    • 0027094288 scopus 로고
    • Structural and functional characterization of full-length heparin-binding growth associated molecule
    • Hampton B.S., Marshak D.R., Burgess W.H. Structural and functional characterization of full-length heparin-binding growth associated molecule. Mol. Biol. Cell 1992, 3:85-93.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 85-93
    • Hampton, B.S.1    Marshak, D.R.2    Burgess, W.H.3
  • 4
    • 20444432055 scopus 로고    scopus 로고
    • Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair
    • Li G., Bunn J.R., Mushipe M.T., He Q., Chen X. Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair. Calcif. Tissue Int. 2005, 76:299-306.
    • (2005) Calcif. Tissue Int. , vol.76 , pp. 299-306
    • Li, G.1    Bunn, J.R.2    Mushipe, M.T.3    He, Q.4    Chen, X.5
  • 5
    • 0036830216 scopus 로고    scopus 로고
    • Pleiotrophin/osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation
    • Tare R.S., Oreffo R.O., Clarke N.M., Roach H.I. Pleiotrophin/osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation. J. Bone Miner. Res. 2002, 17:2009-2020.
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 2009-2020
    • Tare, R.S.1    Oreffo, R.O.2    Clarke, N.M.3    Roach, H.I.4
  • 6
    • 0034646459 scopus 로고    scopus 로고
    • Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta
    • Meng K., Rodriguez-Pena A., Dimitrov T., Chen W., Yamin M., Noda M., Deuel T.F. Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:2603-2608.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 2603-2608
    • Meng, K.1    Rodriguez-Pena, A.2    Dimitrov, T.3    Chen, W.4    Yamin, M.5    Noda, M.6    Deuel, T.F.7
  • 7
    • 0032539011 scopus 로고    scopus 로고
    • Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM)
    • Imai S., Kaksonen M., Raulo E., Kinnunen T., Fages C., Meng X., Lakso M., Rauvala H. Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM). J. Cell Biol. 1998, 143:1113-1128.
    • (1998) J. Cell Biol. , vol.143 , pp. 1113-1128
    • Imai, S.1    Kaksonen, M.2    Raulo, E.3    Kinnunen, T.4    Fages, C.5    Meng, X.6    Lakso, M.7    Rauvala, H.8
  • 8
    • 0037215657 scopus 로고    scopus 로고
    • Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering
    • Yang X., Tare R.S., Partridge K.A., Roach H.I., Clarke N.M., Howdle S.M., Shakesheff K.M., Oreffo R.O. Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering. J. Bone Miner. Res. 2003, 18:47-57.
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 47-57
    • Yang, X.1    Tare, R.S.2    Partridge, K.A.3    Roach, H.I.4    Clarke, N.M.5    Howdle, S.M.6    Shakesheff, K.M.7    Oreffo, R.O.8
  • 10
    • 41949118550 scopus 로고    scopus 로고
    • Pleiotrophin, a multifunctional angiogenic factor: mechanisms and pathways in normal and pathological angiogenesis
    • Perez-Pinera P., Berenson J.R., Deuel T.F. Pleiotrophin, a multifunctional angiogenic factor: mechanisms and pathways in normal and pathological angiogenesis. Curr. Opin. Hematol. 2008, 15:210-214.
    • (2008) Curr. Opin. Hematol. , vol.15 , pp. 210-214
    • Perez-Pinera, P.1    Berenson, J.R.2    Deuel, T.F.3
  • 12
    • 0037184080 scopus 로고    scopus 로고
    • Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase
    • Bowden E.T., Stoica G.E., Wellstein A. Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase. J. Biol. Chem. 2002, 277:35862-35868.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35862-35868
    • Bowden, E.T.1    Stoica, G.E.2    Wellstein, A.3
  • 13
    • 0037134490 scopus 로고    scopus 로고
    • Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth
    • Powers C., Aigner A., Stoica G.E., McDonnell K., Wellstein A. Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth. J. Biol. Chem. 2002, 277:14153-14158.
    • (2002) J. Biol. Chem. , vol.277 , pp. 14153-14158
    • Powers, C.1    Aigner, A.2    Stoica, G.E.3    McDonnell, K.4    Wellstein, A.5
  • 14
    • 84890862301 scopus 로고    scopus 로고
    • EGF receptor trafficking: consequences for signaling and cancer
    • Tomas A., Futter C.E., Eden E.R. EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol. 2014, 24:26-34.
    • (2014) Trends Cell Biol. , vol.24 , pp. 26-34
    • Tomas, A.1    Futter, C.E.2    Eden, E.R.3
  • 15
    • 2342492317 scopus 로고    scopus 로고
    • Review of epidermal growth factor receptor biology
    • Herbst R.S. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys. 2004, 59:21-26.
    • (2004) Int. J. Radiat. Oncol. Biol. Phys. , vol.59 , pp. 21-26
    • Herbst, R.S.1
  • 16
    • 70349325677 scopus 로고    scopus 로고
    • Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway
    • Cao C., Huang X., Han Y., Wan Y., Birnbaumer L., Feng G.S., Marshall J., Jiang M., Chu W.M. Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway. Sci. Signal. 2009, 2:ra17.
    • (2009) Sci. Signal. , vol.2
    • Cao, C.1    Huang, X.2    Han, Y.3    Wan, Y.4    Birnbaumer, L.5    Feng, G.S.6    Marshall, J.7    Jiang, M.8    Chu, W.M.9
  • 18
    • 79952480540 scopus 로고    scopus 로고
    • Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17
    • Maretzky T., Evers A., Zhou W., Swendeman S.L., Wong P.M., Rafii S., Reiss K., Blobel C.P. Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. Nat. Commun. 2011, 2:229.
    • (2011) Nat. Commun. , vol.2 , pp. 229
    • Maretzky, T.1    Evers, A.2    Zhou, W.3    Swendeman, S.L.4    Wong, P.M.5    Rafii, S.6    Reiss, K.7    Blobel, C.P.8
  • 19
    • 83755183109 scopus 로고    scopus 로고
    • Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway
    • Oganesian A., Yarov-Yarovoy V., Parks W.C., Schwinn D.A. Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:19796-19801.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 19796-19801
    • Oganesian, A.1    Yarov-Yarovoy, V.2    Parks, W.C.3    Schwinn, D.A.4
  • 20
    • 84900327239 scopus 로고    scopus 로고
    • Transactivation of EGFR by G protein-coupled receptor in the pathophysiology of intimal hyperplasia
    • [Epub ahead of print]
    • Sur S., Agrawal D.K. Transactivation of EGFR by G protein-coupled receptor in the pathophysiology of intimal hyperplasia. Curr. Vasc. Pharmacol. 2014, [Epub ahead of print].
    • (2014) Curr. Vasc. Pharmacol.
    • Sur, S.1    Agrawal, D.K.2
  • 22
    • 84886076523 scopus 로고    scopus 로고
    • Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: new implications for osteonecrosis treatment?
    • She C., Zhu L.Q., Zhen Y.F., Wang X.D., Dong Q.R. Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: new implications for osteonecrosis treatment?. Cell. Signal. 2014, 26:1-8.
    • (2014) Cell. Signal. , vol.26 , pp. 1-8
    • She, C.1    Zhu, L.Q.2    Zhen, Y.F.3    Wang, X.D.4    Dong, Q.R.5
  • 24
    • 0033049978 scopus 로고    scopus 로고
    • The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells
    • Contessa J.N., Reardon D.B., Todd D., Dent P., Mikkelsen R.B., Valerie K., Bowers G.D., Schmidt-Ullrich R.K. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. Clin. Cancer Res. 1999, 5:405-411.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 405-411
    • Contessa, J.N.1    Reardon, D.B.2    Todd, D.3    Dent, P.4    Mikkelsen, R.B.5    Valerie, K.6    Bowers, G.D.7    Schmidt-Ullrich, R.K.8
  • 25
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • Chan D.W., Chen B.P., Prithivirajsingh S., Kurimasa A., Story M.D., Qin J., Chen D.J. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev. 2002, 16:2333-2338.
    • (2002) Genes Dev. , vol.16 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.2    Prithivirajsingh, S.3    Kurimasa, A.4    Story, M.D.5    Qin, J.6    Chen, D.J.7
  • 26
    • 84862592914 scopus 로고    scopus 로고
    • Pleiotrophin is a potential colorectal cancer prognostic factor that promotes VEGF expression and induces angiogenesis in colorectal cancer
    • Kong Y., Bai P.S., Nan K.J., Sun H., Chen N.Z., Qi X.G. Pleiotrophin is a potential colorectal cancer prognostic factor that promotes VEGF expression and induces angiogenesis in colorectal cancer. Int. J. Colorectal Dis. 2012, 27:287-298.
    • (2012) Int. J. Colorectal Dis. , vol.27 , pp. 287-298
    • Kong, Y.1    Bai, P.S.2    Nan, K.J.3    Sun, H.4    Chen, N.Z.5    Qi, X.G.6
  • 27
    • 0035839317 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells
    • Zhu X.F., Liu Z.C., Xie B.F., Li Z.M., Feng G.K., Yang D., Zeng Y.X. EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells. Cancer Lett. 2001, 169:27-32.
    • (2001) Cancer Lett. , vol.169 , pp. 27-32
    • Zhu, X.F.1    Liu, Z.C.2    Xie, B.F.3    Li, Z.M.4    Feng, G.K.5    Yang, D.6    Zeng, Y.X.7
  • 29
    • 18244364350 scopus 로고    scopus 로고
    • RhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells
    • Li G., Cui Y., McIlmurray L., Allen W.E., Wang H. RhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells. J. Orthop. Res. 2005, 23:680-685.
    • (2005) J. Orthop. Res. , vol.23 , pp. 680-685
    • Li, G.1    Cui, Y.2    McIlmurray, L.3    Allen, W.E.4    Wang, H.5
  • 31
    • 0035127927 scopus 로고    scopus 로고
    • Pleiotrophin induces angiogenesis: involvement of the phosphoinositide-3 kinase but not the nitric oxide synthase pathways
    • Souttou B., Raulais D., Vigny M. Pleiotrophin induces angiogenesis: involvement of the phosphoinositide-3 kinase but not the nitric oxide synthase pathways. J. Cell. Physiol. 2001, 187:59-64.
    • (2001) J. Cell. Physiol. , vol.187 , pp. 59-64
    • Souttou, B.1    Raulais, D.2    Vigny, M.3
  • 33
    • 0036810356 scopus 로고    scopus 로고
    • Mechanisms involved in the side effects of glucocorticoids
    • Schacke H., Docke W.D., Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol. Ther. 2002, 96:23-43.
    • (2002) Pharmacol. Ther. , vol.96 , pp. 23-43
    • Schacke, H.1    Docke, W.D.2    Asadullah, K.3
  • 35
    • 79960087488 scopus 로고    scopus 로고
    • Clinical practice. Glucocorticoid-induced bone disease
    • Weinstein R.S. Clinical practice. Glucocorticoid-induced bone disease. N. Engl. J. Med. 2011, 365:62-70.
    • (2011) N. Engl. J. Med. , vol.365 , pp. 62-70
    • Weinstein, R.S.1
  • 36
    • 63249102275 scopus 로고    scopus 로고
    • Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action
    • Kerachian M.A., Seguin C., Harvey E.J. Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action. J. Steroid Biochem. Mol. Biol. 2009, 114:121-128.
    • (2009) J. Steroid Biochem. Mol. Biol. , vol.114 , pp. 121-128
    • Kerachian, M.A.1    Seguin, C.2    Harvey, E.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.