α-Melanocyte stimulating hormone attenuates dexamethasone-induced osteoblast damages through activating melanocortin receptor 4-SphK1 signaling

Biochemical and Biophysical Research Communications

Volumn 469, Issue 2, 2016, Pages 281-287

  Guo, Shiguang ^a   Xie, Yue ^a   Fan, Jian Bo ^b   Ji, Feng ^a   Wang, Shouguo ^a   Fei, Haodong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANTONG UNIVERSITY   (China)

Author keywords

Dexamethasone; Melanocortin receptor 4 (MC4R) and sphingosine kinase 1 (SphK1); Osteoblasts; Melanocyte stimulating hormone ( MSH)

Indexed keywords

ALPHA INTERMEDIN; DEXAMETHASONE; MELANOCORTIN 4 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; N,N DIMETHYLSPHINGOSINE; PROTEIN KINASE B; SHORT HAIRPIN RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; PHOSPHOTRANSFERASE; SPHINGOSINE KINASE;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG INHIBITION; ENZYME INHIBITION; MOUSE; NONHUMAN; OSTEOBLAST; PRIMARY CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; DRUG INTERACTION; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ALPHA-MSH; ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; MICE; OSTEOBLASTS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTOR, MELANOCORTIN, TYPE 4; SIGNAL TRANSDUCTION;

EID: 84951094168     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.11.104     Document Type: Article

References (35)

1. H. Schacke, W.D. Docke, and K. Asadullah Mechanisms involved in the side effects of glucocorticoids Pharmacol. Ther. 96 2002 23 43
2. K.H. Koo, R. Kim, Y.S. Kim, I.O. Ahn, S.H. Cho, H.R. Song, Y.S. Park, H. Kim, and G.J. Wang Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment Clin. Rheumatol. 21 2002 299 303
3. D. den Uyl, I.E. Bultink, and W.F. Lems Advances in glucocorticoid-induced osteoporosis Curr. Rheumatol. Rep. 13 2011 233 240
4. R.S. Weinstein Clinical practice. Glucocorticoid-induced bone disease N. Engl. J. Med. 365 2011 62 70
5. M.A. Kerachian, C. Seguin, and E.J. Harvey Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action J. Steroid Biochem. Mol. Biol. 114 2009 121 128
6. F. Ji, L. Mao, Y. Liu, X. Cao, Y. Xie, S. Wang, and H. Fei K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling Biochem. Biophys. Res. Commun. 458 2015 568 575
7. B. Souttou, D. Raulais, and M. Vigny Pleiotrophin induces angiogenesis: involvement of the phosphoinositide-3 kinase but not the nitric oxide synthase pathways J. Cell Physiol. 187 2001 59 64
8. H.A. Himburg, G.G. Muramoto, P. Daher, S.K. Meadows, J.L. Russell, P. Doan, J.T. Chi, A.B. Salter, W.E. Lento, T. Reya, N.J. Chao, and J.P. Chute Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells Nat. Med. 16 2010 475 482
9. J.B. Fan, W. Liu, X.H. Zhu, K. Yuan, D.W. Xu, J.J. Chen, and Z.M. Cui EGFR-AKT-mTOR activation mediates epiregulin-induced pleiotropic functions in cultured osteoblasts Mol. Cell Biochem. 398 2015 105 113
10. S.C. Manolagas Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis Endocr. Rev. 21 2000 115 137
11. C.A. O'Brien, D. Jia, L.I. Plotkin, T. Bellido, C.C. Powers, S.A. Stewart, S.C. Manolagas, and R.S. Weinstein Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength Endocrinology 145 2004 1835 1841
12. S.I. Yun, H.Y. Yoon, S.Y. Jeong, and Y.S. Chung Glucocorticoid induces apoptosis of osteoblast cells through the activation of glycogen synthase kinase 3beta J. Bone Min. Metab. 27 2009 140 148
13. Y.F. Zhen, G.D. Wang, L.Q. Zhu, S.P. Tan, F.Y. Zhang, X.Z. Zhou, and X.D. Wang P53 dependent mitochondrial permeability transition pore opening is required for dexamethasone-induced death of osteoblasts J. Cell Physiol. 229 2014 1475 1483
14. T. Brzoska, T.A. Luger, C. Maaser, C. Abels, and M. Bohm Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases Endocr. Rev. 29 2008 581 602
15. E.G. Nabel, and E. Braunwald A tale of coronary artery disease and myocardial infarction N. Engl. J. Med. 366 2012 54 63
16. C.J. Murray, and A.D. Lopez Measuring the global burden of disease N. Engl. J. Med. 369 2013 448 457
17. A.L. Kadekaro, R. Kavanagh, H. Kanto, S. Terzieva, J. Hauser, N. Kobayashi, S. Schwemberger, J. Cornelius, G. Babcock, H.G. Shertzer, G. Scott, and Z.A. Abdel-Malek Alpha-melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes Cancer Res. 65 2005 4292 4299
18. M. Bohm, I. Wolff, T.E. Scholzen, S.J. Robinson, E. Healy, T.A. Luger, T. Schwarz, and A. Schwarz Alpha-melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage J. Biol. Chem. 280 2005 5795 5802
19. L.B. Cheng, L. Cheng, H.E. Bi, Z.Q. Zhang, J. Yao, X.Z. Zhou, and Q. Jiang Alpha-melanocyte stimulating hormone protects retinal pigment epithelium cells from oxidative stress through activation of melanocortin 1 receptor-Akt-mTOR signaling Biochem. Biophys. Res. Commun. 443 2014 447 452
20. H.T. Hassoun, L. Zou, F.A. Moore, R.A. Kozar, N.W. Weisbrodt, and B.C. Kone Alpha-melanocyte-stimulating hormone protects against mesenteric ischemia-reperfusion injury Am. J. Physiol. Gastrointest. Liver Physiol. 282 2002 G1059 G1068
21. E.J. Jung, D.J. Han, S.H. Chang, D.G. Lim, Y.M. Wee, J.H. Kim, Y.H. Kim, S.K. Koo, M. Choi, and S.C. Kim Protective effect of alpha-melanocyte-stimulating hormone on pancreas islet cell against peripheral blood mononuclear cell-mediated cytotoxicity in vitro Transpl. Proc. 39 2007 1604 1606
22. B.L. van der Hoeven, M.J. Schalij, and V. Delgado Multimodality imaging in interventional cardiology Nat. Rev. Cardiol. 9 2012 333 346
23. I.S. Farooqi, G.S. Yeo, J.M. Keogh, S. Aminian, S.A. Jebb, G. Butler, T. Cheetham, and S. O'Rahilly Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency J. Clin. Invest. 106 2000 271 279
24. L.M. Dumont, C.S. Wu, C.J. Aschkenasi, J.K. Elmquist, B.B. Lowell, and K.G. Mountjoy Mouse melanocortin-4 receptor gene 5'-flanking region imparts cell specific expression in vitro Mol. Cell Endocrinol. 184 2001 173 185
25. J. Cornish, K.E. Callon, K.G. Mountjoy, U. Bava, J.M. Lin, D.E. Myers, D. Naot, and I.R. Reid Alpha -melanocyte-stimulating hormone is a novel regulator of bone Am. J. Physiol. Endocrinol. Metab. 284 2003 E1181 E1190
26. J.C. Garza, C.S. Kim, J. Liu, W. Zhang, and X.Y. Lu Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity J. Endocrinol. 197 2008 471 482
27. A. Gohel, M.B. McCarthy, and G. Gronowicz Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro Endocrinology 140 1999 5339 5347
28. C. She, L.Q. Zhu, Y.F. Zhen, X.D. Wang, and Q.R. Dong Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: new implications for osteonecrosis treatment? Cell Signal 26 2014 1 8
29. Y. Yang, M. Chen, Y. Lai, I. Gantz, K.E. Georgeson, and C.M. Harmon Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activity J. Biol. Chem. 277 2002 20328 20335
30. B.K. Lim, K.W. Huang, B.A. Grueter, P.E. Rothwell, and R.C. Malenka Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens Nature 487 2012 183 189
31. J.H. Hong, J.K. Youm, M.J. Kwon, B.D. Park, Y.M. Lee, S.I. Lee, D.M. Shin, and S.H. Lee K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling J. Invest Dermatol 128 2008 2166 2178
32. Y.B. Kwon, C.D. Kim, J.K. Youm, H.S. Gwak, B.D. Park, S.H. Lee, S. Jeon, B.J. Kim, Y.J. Seo, J.K. Park, and J.H. Lee Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation J. Lipid Res. 48 2007 1936 1943
33. M. Maceyka, K.B. Harikumar, S. Milstien, and S. Spiegel Sphingosine-1-phosphate signaling and its role in disease Trends Cell Biol. 22 2012 50 60
34. D. Shida, K. Takabe, D. Kapitonov, S. Milstien, and S. Spiegel Targeting SphK1 as a new strategy against cancer Curr. Drug Targets 9 2008 662 673
35. C. Bode, and M.H. Graler Immune regulation by sphingosine 1-phosphate and its receptors, Arch Immunol Ther Exp (Warsz) 60 2012 3 12